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PubMed code 2542556

Compile data set for download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017233
PNG
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9|
Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017059
PNG
(3,4-Dibromo-N-methyl-N-(1-methyl-1-aza-spiro[4.5]d...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)c(Br)c1
Show InChI InChI=1S/C18H24Br2N2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)13-7-8-14(19)15(20)12-13/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017233
PNG
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9|
Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017065
PNG
(3,4-Dichloro-N-methyl-N-(1-methyl-1-aza-spiro[4.5]...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)13-7-8-14(19)15(20)12-13/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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n/an/a 6.30n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017060
PNG
(CHEMBL553991 | N-Methyl-N-(1-methyl-1-aza-spiro[4....)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H25F3N2O/c1-23-13-5-12-18(23)11-4-3-6-16(18)24(2)17(25)14-7-9-15(10-8-14)19(20,21)22/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017061
PNG
(4-Bromo-2-chloro-N-methyl-N-(1-methyl-1-aza-spiro[...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1Cl
Show InChI InChI=1S/C18H24BrClN2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)14-8-7-13(19)12-15(14)20/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017071
PNG
(4-Bromo-N-methyl-N-(1-methyl-1-aza-spiro[4.5]dec-6...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C18H25BrN2O/c1-20-13-5-12-18(20)11-4-3-6-16(18)21(2)17(22)14-7-9-15(19)10-8-14/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017078
PNG
(4-Bromo-2,N-dimethyl-N-(1-methyl-1-aza-spiro[4.5]d...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1C
Show InChI InChI=1S/C19H27BrN2O/c1-14-13-15(20)8-9-16(14)18(23)22(3)17-7-4-5-10-19(17)11-6-12-21(19)2/h8-9,13,17H,4-7,10-12H2,1-3H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017068
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-methyl-1-aza...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22-11-5-10-19(22)9-4-3-6-17(19)23(2)18(24)13-14-7-8-15(20)16(21)12-14/h7-8,12,17H,3-6,9-11,13H2,1-2H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor mu 1 of guinea pig brain using [3H]DAG0 radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017059
PNG
(3,4-Dibromo-N-methyl-N-(1-methyl-1-aza-spiro[4.5]d...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)c(Br)c1
Show InChI InChI=1S/C18H24Br2N2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)13-7-8-14(19)15(20)12-13/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017064
PNG
(4,N-Dimethyl-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H28N2O/c1-15-8-10-16(11-9-15)18(22)21(3)17-7-4-5-12-19(17)13-6-14-20(19)2/h8-11,17H,4-7,12-14H2,1-3H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017077
PNG
(3,4-Dichloro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H22Cl2N2O/c1-21-10-4-9-17(21)8-3-2-5-15(17)20-16(22)12-6-7-13(18)14(19)11-12/h6-7,11,15H,2-5,8-10H2,1H3,(H,20,22)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017072
PNG
(4-Bromo-N-cyclopropylmethyl-N-(1-methyl-1-aza-spir...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1N(CC1CC1)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C21H29BrN2O/c1-23-14-4-13-21(23)12-3-2-5-19(21)24(15-16-6-7-16)20(25)17-8-10-18(22)11-9-17/h8-11,16,19H,2-7,12-15H2,1H3/t19-,21+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017074
PNG
(2-(3,4-Dichloro-phenyl)-N-(1-methyl-1-aza-spiro[4....)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O/c1-22-10-4-9-18(22)8-3-2-5-16(18)21-17(23)12-13-6-7-14(19)15(20)11-13/h6-7,11,16H,2-5,8-10,12H2,1H3,(H,21,23)/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor mu 1 of guinea pig brain using [3H]DAG0 radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017065
PNG
(3,4-Dichloro-N-methyl-N-(1-methyl-1-aza-spiro[4.5]...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)13-7-8-14(19)15(20)12-13/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017079
PNG
(4-Chloro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-ben...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H23ClN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017070
PNG
(4-Bromo-N-isobutyl-N-(1-methyl-1-aza-spiro[4.5]dec...)
Show SMILES CC(C)CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C21H31BrN2O/c1-16(2)15-24(20(25)17-8-10-18(22)11-9-17)19-7-4-5-12-21(19)13-6-14-23(21)3/h8-11,16,19H,4-7,12-15H2,1-3H3/t19-,21+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017063
PNG
(4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C17H23BrN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017071
PNG
(4-Bromo-N-methyl-N-(1-methyl-1-aza-spiro[4.5]dec-6...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C18H25BrN2O/c1-20-13-5-12-18(20)11-4-3-6-16(18)21(2)17(22)14-7-9-15(19)10-8-14/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017060
PNG
(CHEMBL553991 | N-Methyl-N-(1-methyl-1-aza-spiro[4....)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H25F3N2O/c1-23-13-5-12-18(23)11-4-3-6-16(18)24(2)17(25)14-7-9-15(10-8-14)19(20,21)22/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017076
PNG
(2-(4-Bromo-phenyl)-N-(1-methyl-1-aza-spiro[4.5]dec...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)Cc1ccc(Br)cc1
Show InChI InChI=1S/C18H25BrN2O/c1-21-12-4-11-18(21)10-3-2-5-16(18)20-17(22)13-14-6-8-15(19)9-7-14/h6-9,16H,2-5,10-13H2,1H3,(H,20,22)/t16-,18+/m0/s1
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n/an/a 720n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor mu 1 of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017078
PNG
(4-Bromo-2,N-dimethyl-N-(1-methyl-1-aza-spiro[4.5]d...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1C
Show InChI InChI=1S/C19H27BrN2O/c1-14-13-15(20)8-9-16(14)18(23)22(3)17-7-4-5-10-19(17)11-6-12-21(19)2/h8-9,13,17H,4-7,10-12H2,1-3H3/t17-,19+/m0/s1
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n/an/a 880n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017066
PNG
(4-Methoxy-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-be...)
Show SMILES COc1ccc(cc1)C(=O)N[C@H]1CCCC[C@@]11CCCN1C
Show InChI InChI=1S/C18H26N2O2/c1-20-13-5-12-18(20)11-4-3-6-16(18)19-17(21)14-7-9-15(22-2)10-8-14/h7-10,16H,3-6,11-13H2,1-2H3,(H,19,21)/t16-,18+/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017059
PNG
(3,4-Dibromo-N-methyl-N-(1-methyl-1-aza-spiro[4.5]d...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)c(Br)c1
Show InChI InChI=1S/C18H24Br2N2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)13-7-8-14(19)15(20)12-13/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017072
PNG
(4-Bromo-N-cyclopropylmethyl-N-(1-methyl-1-aza-spir...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1N(CC1CC1)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C21H29BrN2O/c1-23-14-4-13-21(23)12-3-2-5-19(21)24(15-16-6-7-16)20(25)17-8-10-18(22)11-9-17/h8-11,16,19H,2-7,12-15H2,1H3/t19-,21+/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017067
PNG
(CHEMBL25386 | N-(1-Methyl-1-aza-spiro[4.5]dec-6-yl...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)CCc1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-21-15-7-14-19(21)13-6-5-10-17(19)20-18(22)12-11-16-8-3-2-4-9-16/h2-4,8-9,17H,5-7,10-15H2,1H3,(H,20,22)/t17-,19+/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017074
PNG
(2-(3,4-Dichloro-phenyl)-N-(1-methyl-1-aza-spiro[4....)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O/c1-22-10-4-9-18(22)8-3-2-5-16(18)21-17(23)12-13-6-7-14(19)15(20)11-13/h6-7,11,16H,2-5,8-10,12H2,1H3,(H,21,23)/t16-,18+/m0/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor delta 1 of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017072
PNG
(4-Bromo-N-cyclopropylmethyl-N-(1-methyl-1-aza-spir...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1N(CC1CC1)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C21H29BrN2O/c1-23-14-4-13-21(23)12-3-2-5-19(21)24(15-16-6-7-16)20(25)17-8-10-18(22)11-9-17/h8-11,16,19H,2-7,12-15H2,1H3/t19-,21+/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017061
PNG
(4-Bromo-2-chloro-N-methyl-N-(1-methyl-1-aza-spiro[...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1Cl
Show InChI InChI=1S/C18H24BrClN2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)14-8-7-13(19)12-15(14)20/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017064
PNG
(4,N-Dimethyl-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H28N2O/c1-15-8-10-16(11-9-15)18(22)21(3)17-7-4-5-12-19(17)13-6-14-20(19)2/h8-11,17H,4-7,12-14H2,1-3H3/t17-,19+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017063
PNG
(4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C17H23BrN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017069
PNG
(4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NS(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C16H23BrN2O2S/c1-19-12-4-11-16(19)10-3-2-5-15(16)18-22(20,21)14-8-6-13(17)7-9-14/h6-9,15,18H,2-5,10-12H2,1H3/t15-,16+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against Opioid receptor kappa 1 of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017079
PNG
(4-Chloro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-ben...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H23ClN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017060
PNG
(CHEMBL553991 | N-Methyl-N-(1-methyl-1-aza-spiro[4....)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H25F3N2O/c1-23-13-5-12-18(23)11-4-3-6-16(18)24(2)17(25)14-7-9-15(10-8-14)19(20,21)22/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017079
PNG
(4-Chloro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-ben...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H23ClN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017077
PNG
(3,4-Dichloro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H22Cl2N2O/c1-21-10-4-9-17(21)8-3-2-5-15(17)20-16(22)12-6-7-13(18)14(19)11-12/h6-7,11,15H,2-5,8-10H2,1H3,(H,20,22)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017062
PNG
(3-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1cccc(Br)c1
Show InChI InChI=1S/C17H23BrN2O/c1-20-11-5-10-17(20)9-3-2-8-15(17)19-16(21)13-6-4-7-14(18)12-13/h4,6-7,12,15H,2-3,5,8-11H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017074
PNG
(2-(3,4-Dichloro-phenyl)-N-(1-methyl-1-aza-spiro[4....)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O/c1-22-10-4-9-18(22)8-3-2-5-16(18)21-17(23)12-13-6-7-14(19)15(20)11-13/h6-7,11,16H,2-5,8-10,12H2,1H3,(H,21,23)/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against Opioid receptor kappa 1 of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017073
PNG
(4-Fluoro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-ben...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C17H23FN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017073
PNG
(4-Fluoro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-ben...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C17H23FN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017071
PNG
(4-Bromo-N-methyl-N-(1-methyl-1-aza-spiro[4.5]dec-6...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C18H25BrN2O/c1-20-13-5-12-18(20)11-4-3-6-16(18)21(2)17(22)14-7-9-15(19)10-8-14/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017061
PNG
(4-Bromo-2-chloro-N-methyl-N-(1-methyl-1-aza-spiro[...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1Cl
Show InChI InChI=1S/C18H24BrClN2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)14-8-7-13(19)12-15(14)20/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017066
PNG
(4-Methoxy-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-be...)
Show SMILES COc1ccc(cc1)C(=O)N[C@H]1CCCC[C@@]11CCCN1C
Show InChI InChI=1S/C18H26N2O2/c1-20-13-5-12-18(20)11-4-3-6-16(18)19-17(21)14-7-9-15(22-2)10-8-14/h7-10,16H,3-6,11-13H2,1-2H3,(H,19,21)/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017078
PNG
(4-Bromo-2,N-dimethyl-N-(1-methyl-1-aza-spiro[4.5]d...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1C
Show InChI InChI=1S/C19H27BrN2O/c1-14-13-15(20)8-9-16(14)18(23)22(3)17-7-4-5-10-19(17)11-6-12-21(19)2/h8-9,13,17H,4-7,10-12H2,1-3H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017066
PNG
(4-Methoxy-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-be...)
Show SMILES COc1ccc(cc1)C(=O)N[C@H]1CCCC[C@@]11CCCN1C
Show InChI InChI=1S/C18H26N2O2/c1-20-13-5-12-18(20)11-4-3-6-16(18)19-17(21)14-7-9-15(22-2)10-8-14/h7-10,16H,3-6,11-13H2,1-2H3,(H,19,21)/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017067
PNG
(CHEMBL25386 | N-(1-Methyl-1-aza-spiro[4.5]dec-6-yl...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)CCc1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-21-15-7-14-19(21)13-6-5-10-17(19)20-18(22)12-11-16-8-3-2-4-9-16/h2-4,8-9,17H,5-7,10-15H2,1H3,(H,20,22)/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017068
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-methyl-1-aza...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22-11-5-10-19(22)9-4-3-6-17(19)23(2)18(24)13-14-7-8-15(20)16(21)12-14/h7-8,12,17H,3-6,9-11,13H2,1-2H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor delta 1 of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017070
PNG
(4-Bromo-N-isobutyl-N-(1-methyl-1-aza-spiro[4.5]dec...)
Show SMILES CC(C)CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C21H31BrN2O/c1-16(2)15-24(20(25)17-8-10-18(22)11-9-17)19-7-4-5-12-21(19)13-6-14-23(21)3/h8-11,16,19H,4-7,12-15H2,1-3H3/t19-,21+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017067
PNG
(CHEMBL25386 | N-(1-Methyl-1-aza-spiro[4.5]dec-6-yl...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)CCc1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-21-15-7-14-19(21)13-6-5-10-17(19)20-18(22)12-11-16-8-3-2-4-9-16/h2-4,8-9,17H,5-7,10-15H2,1H3,(H,20,22)/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017063
PNG
(4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C17H23BrN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017058
PNG
(2-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccccc1Br
Show InChI InChI=1S/C17H23BrN2O/c1-20-12-6-11-17(20)10-5-4-9-15(17)19-16(21)13-7-2-3-8-14(13)18/h2-3,7-8,15H,4-6,9-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017077
PNG
(3,4-Dichloro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H22Cl2N2O/c1-21-10-4-9-17(21)8-3-2-5-15(17)20-16(22)12-6-7-13(18)14(19)11-12/h6-7,11,15H,2-5,8-10H2,1H3,(H,20,22)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017062
PNG
(3-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1cccc(Br)c1
Show InChI InChI=1S/C17H23BrN2O/c1-20-11-5-10-17(20)9-3-2-8-15(17)19-16(21)13-6-4-7-14(18)12-13/h4,6-7,12,15H,2-3,5,8-11H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017076
PNG
(2-(4-Bromo-phenyl)-N-(1-methyl-1-aza-spiro[4.5]dec...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)Cc1ccc(Br)cc1
Show InChI InChI=1S/C18H25BrN2O/c1-21-12-4-11-18(21)10-3-2-5-16(18)20-17(22)13-14-6-8-15(19)9-7-14/h6-9,16H,2-5,10-13H2,1H3,(H,20,22)/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor delta 1 of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017069
PNG
(4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NS(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C16H23BrN2O2S/c1-19-12-4-11-16(19)10-3-2-5-15(16)18-22(20,21)14-8-6-13(17)7-9-14/h6-9,15,18H,2-5,10-12H2,1H3/t15-,16+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor delta 1 of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017070
PNG
(4-Bromo-N-isobutyl-N-(1-methyl-1-aza-spiro[4.5]dec...)
Show SMILES CC(C)CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C21H31BrN2O/c1-16(2)15-24(20(25)17-8-10-18(22)11-9-17)19-7-4-5-12-21(19)13-6-14-23(21)3/h8-11,16,19H,4-7,12-15H2,1-3H3/t19-,21+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017058
PNG
(2-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccccc1Br
Show InChI InChI=1S/C17H23BrN2O/c1-20-12-6-11-17(20)10-5-4-9-15(17)19-16(21)13-7-2-3-8-14(13)18/h2-3,7-8,15H,4-6,9-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017068
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-methyl-1-aza...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22-11-5-10-19(22)9-4-3-6-17(19)23(2)18(24)13-14-7-8-15(20)16(21)12-14/h7-8,12,17H,3-6,9-11,13H2,1-2H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against Opioid receptor kappa 1 of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017064
PNG
(4,N-Dimethyl-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H28N2O/c1-15-8-10-16(11-9-15)18(22)21(3)17-7-4-5-12-19(17)13-6-14-20(19)2/h8-11,17H,4-7,12-14H2,1-3H3/t17-,19+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50017065
PNG
(3,4-Dichloro-N-methyl-N-(1-methyl-1-aza-spiro[4.5]...)
Show SMILES CN([C@H]1CCCC[C@@]11CCCN1C)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O/c1-21-11-5-10-18(21)9-4-3-6-16(18)22(2)17(23)13-7-8-14(19)15(20)12-13/h7-8,12,16H,3-6,9-11H2,1-2H3/t16-,18+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor delta of guinea pig was determined by using [3H]DADLE radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017058
PNG
(2-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccccc1Br
Show InChI InChI=1S/C17H23BrN2O/c1-20-12-6-11-17(20)10-5-4-9-15(17)19-16(21)13-7-2-3-8-14(13)18/h2-3,7-8,15H,4-6,9-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
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Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017069
PNG
(4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NS(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C16H23BrN2O2S/c1-19-12-4-11-16(19)10-3-2-5-15(16)18-22(20,21)14-8-6-13(17)7-9-14/h6-9,15,18H,2-5,10-12H2,1H3/t15-,16+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against Opioid receptor mu 1 of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50017062
PNG
(3-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benz...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1cccc(Br)c1
Show InChI InChI=1S/C17H23BrN2O/c1-20-11-5-10-17(20)9-3-2-8-15(17)19-16(21)13-6-4-7-14(18)12-13/h4,6-7,12,15H,2-3,5,8-11H2,1H3,(H,19,21)/t15-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against opioid receptor mu of guinea pig brain using [3H]DAGO radioligand

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017076
PNG
(2-(4-Bromo-phenyl)-N-(1-methyl-1-aza-spiro[4.5]dec...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)Cc1ccc(Br)cc1
Show InChI InChI=1S/C18H25BrN2O/c1-21-12-4-11-18(21)10-3-2-5-16(18)20-17(22)13-14-6-8-15(19)9-7-14/h6-9,16H,2-5,10-13H2,1H3,(H,20,22)/t16-,18+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against Opioid receptor kappa 1 of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017073
PNG
(4-Fluoro-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-ben...)
Show SMILES CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C17H23FN2O/c1-20-12-4-11-17(20)10-3-2-5-15(17)19-16(21)13-6-8-14(18)9-7-13/h6-9,15H,2-5,10-12H2,1H3,(H,19,21)/t15-,17+/m0/s1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Ciba-Geigy Corporation

Curated by ChEMBL


Assay Description
Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine

J Med Chem 32: 1259-65 (1989)


BindingDB Entry DOI: 10.7270/Q280536X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%