Affinity Data by PubMed id=25442307

PubMed code 25442307

Found 17 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035609 (CHEMBL3338455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0530	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035620 (CHEMBL3338445) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035617 (CHEMBL3338448) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035621 (CHEMBL3338444) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035613 (CHEMBL3338452) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50100662 (CHEMBL553371 \| CHEMBL77971 \| methyl 2-(4-aminophen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of PDE5 (unknown origin)				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035618 (CHEMBL3338447) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035611 (CHEMBL3338453) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of PDE5 (unknown origin)				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035615 (CHEMBL3338450) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035610 (CHEMBL3338454) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035652 (CHEMBL3338443) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035614 (CHEMBL3338451) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035616 (CHEMBL3338449) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035653 (CHEMBL3338442) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035619 (CHEMBL3338446) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50035654 (CHEMBL3338441) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide method				Bioorg Med Chem Lett 24: 5175-80 (2014) Article DOI: 10.1016/j.bmcl.2014.09.082 BindingDB Entry DOI: 10.7270/Q2F76F5Z
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%