Found 26 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036633
(CHEMBL3354285)Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)c1cnc(nc1NCc1ccc(OC)c(Cl)c1)N1CCC[C@H]1CO |r,wU:5.8,32.36,wD:2.1,(10.17,-30.98,;10.17,-29.44,;8.84,-28.67,;8.84,-27.13,;7.5,-26.35,;6.18,-27.13,;6.18,-28.67,;7.5,-29.44,;4.85,-26.36,;4.84,-24.82,;6.17,-24.05,;3.5,-24.05,;2.17,-24.83,;.84,-24.06,;.84,-22.52,;2.16,-21.74,;3.5,-22.51,;4.83,-21.73,;4.82,-20.19,;6.15,-19.41,;6.13,-17.88,;7.45,-17.1,;8.8,-17.86,;10.13,-17.09,;11.47,-17.85,;8.81,-19.41,;10.14,-20.17,;7.48,-20.18,;-.5,-21.75,;-1.92,-22.38,;-2.94,-21.24,;-2.18,-19.9,;-.67,-20.22,;.48,-19.19,;1.94,-19.66,)| Show InChI InChI=1S/C25H34ClN5O4/c1-34-19-8-6-17(7-9-19)29-24(33)20-14-28-25(31-11-3-4-18(31)15-32)30-23(20)27-13-16-5-10-22(35-2)21(26)12-16/h5,10,12,14,17-19,32H,3-4,6-9,11,13,15H2,1-2H3,(H,29,33)(H,27,28,30)/t17-,18-,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036625
(CHEMBL3354279)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CCC[C@H]2CO)cc1Cl |r| Show InChI InChI=1S/C24H27ClN6O3/c1-34-21-8-7-16(11-20(21)25)12-27-22-19(23(33)28-13-17-5-2-3-9-26-17)14-29-24(30-22)31-10-4-6-18(31)15-32/h2-3,5,7-9,11,14,18,32H,4,6,10,12-13,15H2,1H3,(H,28,33)(H,27,29,30)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036632
(CHEMBL3354284)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC[C@H]2CO)cc1Cl |r,wU:17.17,28.31,wD:20.21,(27.61,-1.23,;26.27,-.47,;24.94,-1.24,;23.59,-.48,;22.27,-1.26,;22.29,-2.79,;20.96,-3.57,;20.97,-5.11,;19.64,-5.89,;18.3,-5.12,;16.98,-5.9,;16.98,-7.44,;18.31,-8.21,;19.64,-7.43,;20.98,-8.2,;22.31,-7.43,;20.98,-9.74,;22.32,-10.51,;23.64,-9.73,;24.98,-10.51,;24.98,-12.05,;26.31,-12.82,;23.64,-12.82,;22.31,-12.05,;15.65,-5.13,;14.23,-5.76,;13.2,-4.62,;13.97,-3.28,;15.48,-3.6,;16.61,-2.57,;18.08,-3.03,;23.62,-3.56,;24.95,-2.79,;26.28,-3.55,)| Show InChI InChI=1S/C24H32ClN5O4/c1-34-21-9-4-15(11-20(21)25)12-26-22-19(23(33)28-16-5-7-18(32)8-6-16)13-27-24(29-22)30-10-2-3-17(30)14-31/h4,9,11,13,16-18,31-32H,2-3,5-8,10,12,14H2,1H3,(H,28,33)(H,26,27,29)/t16-,17-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036610
(CHEMBL3354264)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)OCc2ccccn2)cc1Cl Show InChI InChI=1S/C25H22ClN5O4/c1-33-22-9-8-17(12-21(22)26)13-29-23-20(24(32)34-15-18-6-2-4-10-27-18)14-30-25(31-23)35-16-19-7-3-5-11-28-19/h2-12,14H,13,15-16H2,1H3,(H,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036612
(CHEMBL3354266)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)NCc2ccccn2)cc1Cl Show InChI InChI=1S/C25H23ClN6O3/c1-34-22-9-8-17(12-21(22)26)13-29-23-20(24(33)30-14-18-6-2-4-10-27-18)15-31-25(32-23)35-16-19-7-3-5-11-28-19/h2-12,15H,13-14,16H2,1H3,(H,30,33)(H,29,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036619
(CHEMBL3354273)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)N[C@H]2CC[C@H](O)CC2)cc1Cl |r,wU:25.26,wD:28.30,(24.65,-12.85,;23.31,-12.09,;21.98,-12.86,;20.64,-12.1,;19.31,-12.88,;19.33,-14.41,;18,-15.19,;18.01,-16.73,;16.68,-17.51,;15.35,-16.74,;14.03,-17.52,;12.69,-16.75,;11.36,-17.52,;10.02,-16.76,;10.02,-15.21,;8.68,-14.44,;7.36,-15.21,;7.35,-16.76,;8.69,-17.53,;14.02,-19.06,;15.35,-19.83,;16.69,-19.05,;18.02,-19.82,;19.36,-19.05,;18.03,-21.36,;19.36,-22.13,;20.69,-21.34,;22.02,-22.12,;22.02,-23.66,;23.36,-24.43,;20.69,-24.43,;19.36,-23.66,;20.66,-15.18,;21.99,-14.41,;23.33,-15.17,)| Show InChI InChI=1S/C25H28ClN5O4/c1-34-22-10-5-16(12-21(22)26)13-28-23-20(24(33)30-17-6-8-19(32)9-7-17)14-29-25(31-23)35-15-18-4-2-3-11-27-18/h2-5,10-12,14,17,19,32H,6-9,13,15H2,1H3,(H,30,33)(H,28,29,31)/t17-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036611
(CHEMBL3354265)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)OCc2ncccn2)cc1Cl Show InChI InChI=1S/C24H21ClN6O4/c1-33-20-7-6-16(11-19(20)25)12-29-22-18(23(32)34-15-21-27-9-4-10-28-21)13-30-24(31-22)35-14-17-5-2-3-8-26-17/h2-11,13H,12,14-15H2,1H3,(H,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036629
(Avanafil | CHEBI:66876 | Stendra | TA-1790)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC[C@H]2CO)cc1Cl |r| Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036609
(CHEMBL3354287)Show SMILES CCOC(=O)c1cnc(OCc2ccccn2)nc1NCc1ccc(OC)c(Cl)c1 Show InChI InChI=1S/C21H21ClN4O4/c1-3-29-20(27)16-12-25-21(30-13-15-6-4-5-9-23-15)26-19(16)24-11-14-7-8-18(28-2)17(22)10-14/h4-10,12H,3,11,13H2,1-2H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036616
(CHEMBL3354270)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)NCCN2CCOCC2)cc1Cl Show InChI InChI=1S/C25H29ClN6O4/c1-34-22-6-5-18(14-21(22)26)15-29-23-20(24(33)28-8-9-32-10-12-35-13-11-32)16-30-25(31-23)36-17-19-4-2-3-7-27-19/h2-7,14,16H,8-13,15,17H2,1H3,(H,28,33)(H,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036634
(CHEMBL3354286)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCC2CN(C)CCO2)N2CCC[C@H]2CO)cc1Cl |r| Show InChI InChI=1S/C24H33ClN6O4/c1-30-8-9-35-18(14-30)12-27-23(33)19-13-28-24(31-7-3-4-17(31)15-32)29-22(19)26-11-16-5-6-21(34-2)20(25)10-16/h5-6,10,13,17-18,32H,3-4,7-9,11-12,14-15H2,1-2H3,(H,27,33)(H,26,28,29)/t17-,18?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036624
(CHEMBL3354278)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2Cc3ccccc3C[C@H]2CO)cc1Cl |r| Show InChI InChI=1S/C29H29ClN6O3/c1-39-26-10-9-19(12-25(26)30)14-32-27-24(28(38)33-15-22-8-4-5-11-31-22)16-34-29(35-27)36-17-21-7-3-2-6-20(21)13-23(36)18-37/h2-12,16,23,37H,13-15,17-18H2,1H3,(H,33,38)(H,32,34,35)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036631
(CHEMBL3352836)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCCO)N2CCC[C@H]2CO)cc1Cl |r| Show InChI InChI=1S/C21H28ClN5O4/c1-31-18-6-5-14(10-17(18)22)11-24-19-16(20(30)23-7-3-9-28)12-25-21(26-19)27-8-2-4-15(27)13-29/h5-6,10,12,15,28-29H,2-4,7-9,11,13H2,1H3,(H,23,30)(H,24,25,26)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036618
(CHEMBL3354272)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)NCCCCO)cc1Cl Show InChI InChI=1S/C23H26ClN5O4/c1-32-20-8-7-16(12-19(20)24)13-27-21-18(22(31)26-10-4-5-11-30)14-28-23(29-21)33-15-17-6-2-3-9-25-17/h2-3,6-9,12,14,30H,4-5,10-11,13,15H2,1H3,(H,26,31)(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036613
(CHEMBL3354267)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)NCc2ncccn2)cc1Cl Show InChI InChI=1S/C24H22ClN7O3/c1-34-20-7-6-16(11-19(20)25)12-29-22-18(23(33)30-14-21-27-9-4-10-28-21)13-31-24(32-22)35-15-17-5-2-3-8-26-17/h2-11,13H,12,14-15H2,1H3,(H,30,33)(H,29,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036617
(CHEMBL3354271)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)NCCCO)cc1Cl Show InChI InChI=1S/C22H24ClN5O4/c1-31-19-7-6-15(11-18(19)23)12-26-20-17(21(30)25-9-4-10-29)13-27-22(28-20)32-14-16-5-2-3-8-24-16/h2-3,5-8,11,13,29H,4,9-10,12,14H2,1H3,(H,25,30)(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036615
(CHEMBL3354269)Show SMILES COCCCNC(=O)c1cnc(OCc2ccccn2)nc1NCc1ccc(OC)c(Cl)c1 Show InChI InChI=1S/C23H26ClN5O4/c1-31-11-5-10-26-22(30)18-14-28-23(33-15-17-6-3-4-9-25-17)29-21(18)27-13-16-7-8-20(32-2)19(24)12-16/h3-4,6-9,12,14H,5,10-11,13,15H2,1-2H3,(H,26,30)(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036628
(CHEMBL3354282)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC(CO)C2)cc1Cl Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-4-3-15(9-18(19)24)10-27-21-17(22(33)28-12-20-25-6-2-7-26-20)11-29-23(30-21)31-8-5-16(13-31)14-32/h2-4,6-7,9,11,16,32H,5,8,10,12-14H2,1H3,(H,28,33)(H,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036620
(CHEMBL3354274)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N(C)CCO)cc1Cl Show InChI InChI=1S/C22H25ClN6O3/c1-29(9-10-30)22-27-14-17(21(31)26-13-16-5-3-4-8-24-16)20(28-22)25-12-15-6-7-19(32-2)18(23)11-15/h3-8,11,14,30H,9-10,12-13H2,1-2H3,(H,26,31)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036621
(CHEMBL3354275)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CCOC(CO)C2)cc1Cl Show InChI InChI=1S/C24H27ClN6O4/c1-34-21-6-5-16(10-20(21)25)11-27-22-19(23(33)28-12-17-4-2-3-7-26-17)13-29-24(30-22)31-8-9-35-18(14-31)15-32/h2-7,10,13,18,32H,8-9,11-12,14-15H2,1H3,(H,28,33)(H,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036630
(CHEMBL3354283)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC[C@@H]2CO)cc1Cl |r| Show InChI InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036623
(CHEMBL3354277)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CCCCC2CO)cc1Cl Show InChI InChI=1S/C25H29ClN6O3/c1-35-22-9-8-17(12-21(22)26)13-28-23-20(24(34)29-14-18-6-2-4-10-27-18)15-30-25(31-23)32-11-5-3-7-19(32)16-33/h2,4,6,8-10,12,15,19,33H,3,5,7,11,13-14,16H2,1H3,(H,29,34)(H,28,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036622
(CHEMBL3354276)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CCC(O)CC2)cc1Cl Show InChI InChI=1S/C24H27ClN6O3/c1-34-21-6-5-16(12-20(21)25)13-27-22-19(23(33)28-14-17-4-2-3-9-26-17)15-29-24(30-22)31-10-7-18(32)8-11-31/h2-6,9,12,15,18,32H,7-8,10-11,13-14H2,1H3,(H,28,33)(H,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036627
(CHEMBL3354281)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCCC(CO)C2)cc1Cl Show InChI InChI=1S/C24H28ClN7O3/c1-35-20-6-5-16(10-19(20)25)11-28-22-18(23(34)29-13-21-26-7-3-8-27-21)12-30-24(31-22)32-9-2-4-17(14-32)15-33/h3,5-8,10,12,17,33H,2,4,9,11,13-15H2,1H3,(H,29,34)(H,28,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036614
(CHEMBL3354268)Show SMILES COc1ccc(CNc2nc(OCc3ccccn3)ncc2C(=O)N(C)Cc2ccccn2)cc1Cl Show InChI InChI=1S/C26H25ClN6O3/c1-33(16-19-7-3-5-11-28-19)25(34)21-15-31-26(36-17-20-8-4-6-12-29-20)32-24(21)30-14-18-9-10-23(35-2)22(27)13-18/h3-13,15H,14,16-17H2,1-2H3,(H,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Canis lupus familiaris) | BDBM50036626
(CHEMBL3354280)Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCOC[C@H]2CO)cc1Cl |r| Show InChI InChI=1S/C23H26ClN7O4/c1-34-19-4-3-15(9-18(19)24)10-27-21-17(22(33)28-12-20-25-5-2-6-26-20)11-29-23(30-21)31-7-8-35-14-16(31)13-32/h2-6,9,11,16,32H,7-8,10,12-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of dog lungs PDE5 using [3H]cGMP as substrate after 30 mins by scintillation counting analysis |
Bioorg Med Chem Lett 24: 5460-5 (2015)
Article DOI: 10.1016/j.bmcl.2014.10.008
BindingDB Entry DOI: 10.7270/Q2JS9S1W |
More data for this
Ligand-Target Pair | |
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