Affinity Data by PubMed id=25461317

PubMed code 25461317

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5446 (CHEMBL553 \| ERLOTINIB HYDROCHLORIDE \| Erlotinib \| ...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50448067 (CHEMBL3115730) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of DHFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50448066 (CHEMBL3115731) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of DHFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50062329 (CHEMBL3397276) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50062292 (CHEMBL3397275) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50448061 (CHEMBL1807581) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of DHFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50448062 (CHEMBL1807580) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of DHFR (unknown origin)				Eur J Med Chem 90: 124-69 (2015) Article DOI: 10.1016/j.ejmech.2014.10.084 BindingDB Entry DOI: 10.7270/Q2QZ2CNM
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%