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PubMed code 25466197

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM21283
PNG
(3-[(2-iodo-5-nitrophenyl)carbonyl]-1-[(1-methylpip...)
Show SMILES CN1CCCCC1Cn1cc(C(=O)c2cc(ccc2I)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
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22n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089965
PNG
(CHEMBL3581222)
Show SMILES CN(C)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O2S/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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29n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089958
PNG
(CHEMBL3581226)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(CCOCC1)N1CCCCC1
Show InChI InChI=1S/C27H40N2O2S/c1-25(2,3)20-16-19(17-21(23(20)30)26(4,5)6)22-18-32-24(28-22)27(10-14-31-15-11-27)29-12-8-7-9-13-29/h16-18,30H,7-15H2,1-6H3
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50n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089956
PNG
(CHEMBL3581228)
Show SMILES CN(C)C1(CCOCC1)c1nc(co1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O3/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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52n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089959
PNG
(CHEMBL3581225)
Show SMILES CCN(CC)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C26H40N2O2S/c1-9-28(10-2)26(11-13-30-14-12-26)23-27-21(17-31-23)18-15-19(24(3,4)5)22(29)20(16-18)25(6,7)8/h15-17,29H,9-14H2,1-8H3
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77n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089968
PNG
(CHEMBL3581220)
Show SMILES CN(C)C1(CCSCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2OS2/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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82n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089970
PNG
(CHEMBL3581229)
Show SMILES CN(C)C1(CCOCC1)c1nc(cs1)-c1cc(cc(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2OS/c1-22(2,3)18-13-17(14-19(15-18)23(4,5)6)20-16-28-21(25-20)24(26(7)8)9-11-27-12-10-24/h13-16H,9-12H2,1-8H3
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127n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089963
PNG
(CHEMBL3581224)
Show SMILES CNC1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C23H34N2O2S/c1-21(2,3)16-12-15(13-17(19(16)26)22(4,5)6)18-14-28-20(25-18)23(24-7)8-10-27-11-9-23/h12-14,24,26H,8-11H2,1-7H3
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144n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089957
PNG
(CHEMBL3581227)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(CCOCC1)N1CCOCC1
Show InChI InChI=1S/C26H38N2O3S/c1-24(2,3)19-15-18(16-20(22(19)29)25(4,5)6)21-17-32-23(27-21)26(7-11-30-12-8-26)28-9-13-31-14-10-28/h15-17,29H,7-14H2,1-6H3
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177n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089956
PNG
(CHEMBL3581228)
Show SMILES CN(C)C1(CCOCC1)c1nc(co1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O3/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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817n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089965
PNG
(CHEMBL3581222)
Show SMILES CN(C)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O2S/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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857n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM21283
PNG
(3-[(2-iodo-5-nitrophenyl)carbonyl]-1-[(1-methylpip...)
Show SMILES CN1CCCCC1Cn1cc(C(=O)c2cc(ccc2I)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
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2.08E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089958
PNG
(CHEMBL3581226)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(CCOCC1)N1CCCCC1
Show InChI InChI=1S/C27H40N2O2S/c1-25(2,3)20-16-19(17-21(23(20)30)26(4,5)6)22-18-32-24(28-22)27(10-14-31-15-11-27)29-12-8-7-9-13-29/h16-18,30H,7-15H2,1-6H3
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2.17E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089963
PNG
(CHEMBL3581224)
Show SMILES CNC1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C23H34N2O2S/c1-21(2,3)16-12-15(13-17(19(16)26)22(4,5)6)18-14-28-20(25-18)23(24-7)8-10-27-11-9-23/h12-14,24,26H,8-11H2,1-7H3
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2.27E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089968
PNG
(CHEMBL3581220)
Show SMILES CN(C)C1(CCSCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2OS2/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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2.34E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089964
PNG
(CHEMBL3581223)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(N)CCOCC1
Show InChI InChI=1S/C22H32N2O2S/c1-20(2,3)15-11-14(12-16(18(15)25)21(4,5)6)17-13-27-19(24-17)22(23)7-9-26-10-8-22/h11-13,25H,7-10,23H2,1-6H3
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2.70E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089959
PNG
(CHEMBL3581225)
Show SMILES CCN(CC)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C26H40N2O2S/c1-9-28(10-2)26(11-13-30-14-12-26)23-27-21(17-31-23)18-15-19(24(3,4)5)22(29)20(16-18)25(6,7)8/h15-17,29H,9-14H2,1-8H3
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3.30E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089970
PNG
(CHEMBL3581229)
Show SMILES CN(C)C1(CCOCC1)c1nc(cs1)-c1cc(cc(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2OS/c1-22(2,3)18-13-17(14-19(15-18)23(4,5)6)20-16-28-21(25-20)24(26(7)8)9-11-27-12-10-24/h13-16H,9-12H2,1-8H3
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4.71E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089966
PNG
(CHEMBL3581221)
Show SMILES CN(C)Cc1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C20H30N2OS/c1-19(2,3)14-9-13(10-15(18(14)23)20(4,5)6)16-12-24-17(21-16)11-22(7)8/h9-10,12,23H,11H2,1-8H3
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6.24E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089964
PNG
(CHEMBL3581223)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(N)CCOCC1
Show InChI InChI=1S/C22H32N2O2S/c1-20(2,3)15-11-14(12-16(18(15)25)21(4,5)6)17-13-27-19(24-17)22(23)7-9-26-10-8-22/h11-13,25H,7-10,23H2,1-6H3
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6.96E+3n/an/an/an/an/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO-K1 cell membrane by competitive displacement assay


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089968
PNG
(CHEMBL3581220)
Show SMILES CN(C)C1(CCSCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2OS2/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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n/an/an/an/a 59n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089956
PNG
(CHEMBL3581228)
Show SMILES CN(C)C1(CCOCC1)c1nc(co1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O3/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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n/an/an/an/a 44n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089956
PNG
(CHEMBL3581228)
Show SMILES CN(C)C1(CCOCC1)c1nc(co1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O3/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089959
PNG
(CHEMBL3581225)
Show SMILES CCN(CC)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C26H40N2O2S/c1-9-28(10-2)26(11-13-30-14-12-26)23-27-21(17-31-23)18-15-19(24(3,4)5)22(29)20(16-18)25(6,7)8/h15-17,29H,9-14H2,1-8H3
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n/an/an/an/a 4.04E+3n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089959
PNG
(CHEMBL3581225)
Show SMILES CCN(CC)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C26H40N2O2S/c1-9-28(10-2)26(11-13-30-14-12-26)23-27-21(17-31-23)18-15-19(24(3,4)5)22(29)20(16-18)25(6,7)8/h15-17,29H,9-14H2,1-8H3
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n/an/an/an/a 72n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089958
PNG
(CHEMBL3581226)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(CCOCC1)N1CCCCC1
Show InChI InChI=1S/C27H40N2O2S/c1-25(2,3)20-16-19(17-21(23(20)30)26(4,5)6)22-18-32-24(28-22)27(10-14-31-15-11-27)29-12-8-7-9-13-29/h16-18,30H,7-15H2,1-6H3
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n/an/an/an/a 2.26E+3n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089965
PNG
(CHEMBL3581222)
Show SMILES CN(C)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O2S/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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n/an/an/an/a 2.67E+3n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50089968
PNG
(CHEMBL3581220)
Show SMILES CN(C)C1(CCSCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2OS2/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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n/an/an/an/a 2.38E+3n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM21283
PNG
(3-[(2-iodo-5-nitrophenyl)carbonyl]-1-[(1-methylpip...)
Show SMILES CN1CCCCC1Cn1cc(C(=O)c2cc(ccc2I)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
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n/an/an/an/a 1.04E+3n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089965
PNG
(CHEMBL3581222)
Show SMILES CN(C)C1(CCOCC1)c1nc(cs1)-c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C24H36N2O2S/c1-22(2,3)17-13-16(14-18(20(17)27)23(4,5)6)19-15-29-21(25-19)24(26(7)8)9-11-28-12-10-24/h13-15,27H,9-12H2,1-8H3
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n/an/an/an/a 42n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM21283
PNG
(3-[(2-iodo-5-nitrophenyl)carbonyl]-1-[(1-methylpip...)
Show SMILES CN1CCCCC1Cn1cc(C(=O)c2cc(ccc2I)[N+]([O-])=O)c2ccccc12
Show InChI InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
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n/an/an/an/a 16n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50089958
PNG
(CHEMBL3581226)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1csc(n1)C1(CCOCC1)N1CCCCC1
Show InChI InChI=1S/C27H40N2O2S/c1-25(2,3)20-16-19(17-21(23(20)30)26(4,5)6)22-18-32-24(28-22)27(10-14-31-15-11-27)29-12-8-7-9-13-29/h16-18,30H,7-15H2,1-6H3
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n/an/an/an/a 40n/an/an/an/a



Ipsen Innovation

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production


Bioorg Med Chem Lett 25: 88-91 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.003
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%