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PubMed code 25487422

Compile data set for download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040934
PNG
(CHEMBL3353833)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)n(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C24H17N5S/c25-14-18-10-4-5-11-19(18)16-30-24-26-23-22(27-28-24)20-12-6-7-13-21(20)29(23)15-17-8-2-1-3-9-17/h1-13H,15-16H2
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11n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040901
PNG
(CHEMBL3353822)
Show SMILES Brc1cccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c12
Show InChI InChI=1S/C17H10BrN5S/c18-12-6-3-7-13-14(12)15-16(20-13)21-17(23-22-15)24-9-11-5-2-1-4-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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23n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040944
PNG
(CHEMBL3354395)
Show SMILES O=C(C1CCCCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H21N5OS/c25-14-17-10-4-5-11-18(17)15-31-24-26-22-21(27-28-24)19-12-6-7-13-20(19)29(22)23(30)16-8-2-1-3-9-16/h4-7,10-13,16H,1-3,8-9,15H2
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30n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040934
PNG
(CHEMBL3353833)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)n(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C24H17N5S/c25-14-18-10-4-5-11-19(18)16-30-24-26-23-22(27-28-24)20-12-6-7-13-21(20)29(23)15-17-8-2-1-3-9-17/h1-13H,15-16H2
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61n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040891
PNG
(CHEMBL3353812)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H11N5O2S/c22-21(23)13-8-4-1-5-10(13)9-24-16-18-15-14(19-20-16)11-6-2-3-7-12(11)17-15/h1-8H,9H2,(H,17,18,20)
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155n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040935
PNG
(CHEMBL3353834)
Show SMILES Fc1ccccc1CSc1nnc2c3ccccc3n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C23H17FN4S/c24-19-12-6-4-10-17(19)15-29-23-25-22-21(26-27-23)18-11-5-7-13-20(18)28(22)14-16-8-2-1-3-9-16/h1-13H,14-15H2
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215n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040948
PNG
(CHEMBL3354399)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)n(C(=O)c1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H15N5O3S/c29-22(15-8-2-1-3-9-15)27-19-13-7-5-11-17(19)20-21(27)24-23(26-25-20)32-14-16-10-4-6-12-18(16)28(30)31/h1-13H,14H2
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235n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040935
PNG
(CHEMBL3353834)
Show SMILES Fc1ccccc1CSc1nnc2c3ccccc3n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C23H17FN4S/c24-19-12-6-4-10-17(19)15-29-23-25-22-21(26-27-23)18-11-5-7-13-20(18)28(22)14-16-8-2-1-3-9-16/h1-13H,14-15H2
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275n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040936
PNG
(CHEMBL3353835)
Show SMILES [O-][N+](=O)c1ccccc1Cn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H16N6O2S/c25-13-16-7-1-2-9-18(16)15-33-24-26-23-22(27-28-24)19-10-4-6-12-21(19)29(23)14-17-8-3-5-11-20(17)30(31)32/h1-12H,14-15H2
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290n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040947
PNG
(CHEMBL3354398)
Show SMILES O=C(c1ccccc1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H15N5OS/c25-14-17-10-4-5-11-18(17)15-31-24-26-22-21(27-28-24)19-12-6-7-13-20(19)29(22)23(30)16-8-2-1-3-9-16/h1-13H,15H2
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300n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040943
PNG
(CHEMBL3353842)
Show SMILES O=C(C1CCCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C23H19N5OS/c24-13-16-9-3-4-10-17(16)14-30-23-25-21-20(26-27-23)18-11-5-6-12-19(18)28(21)22(29)15-7-1-2-8-15/h3-6,9-12,15H,1-2,7-8,14H2
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320n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040880
PNG
(CHEMBL3353802)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11N5S/c18-9-11-5-1-2-6-12(11)10-23-17-20-16-15(21-22-17)13-7-3-4-8-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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355n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040945
PNG
(CHEMBL3354396)
Show SMILES COC(=O)CCC(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H17N5O3S/c1-30-19(29)11-10-18(28)27-17-9-5-4-8-16(17)20-21(27)24-22(26-25-20)31-13-15-7-3-2-6-14(15)12-23/h2-9H,10-11,13H2,1H3
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360n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040952
PNG
(CHEMBL3354403)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C25H14F3N5O2S/c26-25(27,28)35-18-11-9-15(10-12-18)23(34)33-20-8-4-3-7-19(20)21-22(33)30-24(32-31-21)36-14-17-6-2-1-5-16(17)13-29/h1-12H,14H2
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380n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040956
PNG
(CHEMBL3354407)
Show SMILES O=C(c1ccno1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C21H12N6O2S/c22-11-13-5-1-2-6-14(13)12-30-21-24-19-18(25-26-21)15-7-3-4-8-16(15)27(19)20(28)17-9-10-23-29-17/h1-10H,12H2
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450n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040955
PNG
(CHEMBL3354406)
Show SMILES O=C(c1ccco1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H13N5O2S/c23-12-14-6-1-2-7-15(14)13-30-22-24-20-19(25-26-22)16-8-3-4-9-17(16)27(20)21(28)18-10-5-11-29-18/h1-11H,13H2
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490n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN-55212-2 from human CB2R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040901
PNG
(CHEMBL3353822)
Show SMILES Brc1cccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c12
Show InChI InChI=1S/C17H10BrN5S/c18-12-6-3-7-13-14(12)15-16(20-13)21-17(23-22-15)24-9-11-5-2-1-4-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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3.20E+3n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040955
PNG
(CHEMBL3354406)
Show SMILES O=C(c1ccco1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H13N5O2S/c23-12-14-6-1-2-7-15(14)13-30-22-24-20-19(25-26-22)16-8-3-4-9-17(16)27(20)21(28)18-10-5-11-29-18/h1-11H,13H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040947
PNG
(CHEMBL3354398)
Show SMILES O=C(c1ccccc1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H15N5OS/c25-14-17-10-4-5-11-18(17)15-31-24-26-22-21(27-28-24)19-12-6-7-13-20(19)29(22)23(30)16-8-2-1-3-9-16/h1-13H,15H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040956
PNG
(CHEMBL3354407)
Show SMILES O=C(c1ccno1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C21H12N6O2S/c22-11-13-5-1-2-6-14(13)12-30-21-24-19-18(25-26-21)15-7-3-4-8-16(15)27(19)20(28)17-9-10-23-29-17/h1-10H,12H2
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040943
PNG
(CHEMBL3353842)
Show SMILES O=C(C1CCCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C23H19N5OS/c24-13-16-9-3-4-10-17(16)14-30-23-25-21-20(26-27-23)18-11-5-6-12-19(18)28(21)22(29)15-7-1-2-8-15/h3-6,9-12,15H,1-2,7-8,14H2
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040948
PNG
(CHEMBL3354399)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)n(C(=O)c1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H15N5O3S/c29-22(15-8-2-1-3-9-15)27-19-13-7-5-11-17(19)20-21(27)24-23(26-25-20)32-14-16-10-4-6-12-18(16)28(30)31/h1-13H,14H2
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040936
PNG
(CHEMBL3353835)
Show SMILES [O-][N+](=O)c1ccccc1Cn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H16N6O2S/c25-13-16-7-1-2-9-18(16)15-33-24-26-23-22(27-28-24)19-10-4-6-12-21(19)29(23)14-17-8-3-5-11-20(17)30(31)32/h1-12H,14-15H2
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040944
PNG
(CHEMBL3354395)
Show SMILES O=C(C1CCCCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H21N5OS/c25-14-17-10-4-5-11-18(17)15-31-24-26-22-21(27-28-24)19-12-6-7-13-20(19)29(22)23(30)16-8-2-1-3-9-16/h4-7,10-13,16H,1-3,8-9,15H2
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040952
PNG
(CHEMBL3354403)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C25H14F3N5O2S/c26-25(27,28)35-18-11-9-15(10-12-18)23(34)33-20-8-4-3-7-19(20)21-22(33)30-24(32-31-21)36-14-17-6-2-1-5-16(17)13-29/h1-12H,14H2
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040945
PNG
(CHEMBL3354396)
Show SMILES COC(=O)CCC(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H17N5O3S/c1-30-19(29)11-10-18(28)27-17-9-5-4-8-16(17)20-21(27)24-22(26-25-20)31-13-15-7-3-2-6-14(15)12-23/h2-9H,10-11,13H2,1H3
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040880
PNG
(CHEMBL3353802)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11N5S/c18-9-11-5-1-2-6-12(11)10-23-17-20-16-15(21-22-17)13-7-3-4-8-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040891
PNG
(CHEMBL3353812)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H11N5O2S/c22-21(23)13-8-4-1-5-10(13)9-24-16-18-15-14(19-20-16)11-6-2-3-7-12(11)17-15/h1-8H,9H2,(H,17,18,20)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1R expressed in CHO cells


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040937
PNG
(CHEMBL3353836)
Show SMILES O=S(=O)(c1ccccc1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C23H15N5O2S2/c24-14-16-8-4-5-9-17(16)15-31-23-25-22-21(26-27-23)19-12-6-7-13-20(19)28(22)32(29,30)18-10-2-1-3-11-18/h1-13H,15H2
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n/an/an/an/a 76n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040880
PNG
(CHEMBL3353802)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11N5S/c18-9-11-5-1-2-6-12(11)10-23-17-20-16-15(21-22-17)13-7-3-4-8-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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n/an/an/an/a 112n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040896
PNG
(CHEMBL3353817)
Show SMILES OC(=O)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H12N4O2S/c22-16(23)11-6-2-1-5-10(11)9-24-17-19-15-14(20-21-17)12-7-3-4-8-13(12)18-15/h1-8H,9H2,(H,22,23)(H,18,19,21)
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n/an/an/an/a 2.19E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040935
PNG
(CHEMBL3353834)
Show SMILES Fc1ccccc1CSc1nnc2c3ccccc3n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C23H17FN4S/c24-19-12-6-4-10-17(19)15-29-23-25-22-21(26-27-23)18-11-5-7-13-20(18)28(22)14-16-8-2-1-3-9-16/h1-13H,14-15H2
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n/an/an/an/a 850n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040939
PNG
(CHEMBL3353838)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C23H14N6O4S2/c24-13-15-7-1-2-8-16(15)14-34-23-25-22-21(26-27-23)17-9-3-4-10-18(17)28(22)35(32,33)20-12-6-5-11-19(20)29(30)31/h1-12H,14H2
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040949
PNG
(CHEMBL3354400)
Show SMILES Fc1ccc(cc1)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H14FN5OS/c25-18-11-9-15(10-12-18)23(31)30-20-8-4-3-7-19(20)21-22(30)27-24(29-28-21)32-14-17-6-2-1-5-16(17)13-26/h1-12H,14H2
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n/an/an/an/a 57n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040883
PNG
(CHEMBL587528 | GNF-Pf-1521 | GNF-Pf-472)
Show SMILES C(Sc1nnc2c(n1)[nH]c1ccccc21)c1ccccc1
Show InChI InChI=1S/C16H12N4S/c1-2-6-11(7-3-1)10-21-16-18-15-14(19-20-16)12-8-4-5-9-13(12)17-15/h1-9H,10H2,(H,17,18,20)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM40144
PNG
(2-Butylsulfanyl-9H-1,3,4,9-tetraaza-fluorene | 3-(...)
Show SMILES CCCCSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C13H14N4S/c1-2-3-8-18-13-15-12-11(16-17-13)9-6-4-5-7-10(9)14-12/h4-7H,2-3,8H2,1H3,(H,14,15,17)
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n/an/an/an/a 296n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040895
PNG
(CHEMBL3353816)
Show SMILES CCOC(=O)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C19H16N4O2S/c1-2-25-18(24)13-8-4-3-7-12(13)11-26-19-21-17-16(22-23-19)14-9-5-6-10-15(14)20-17/h3-10H,2,11H2,1H3,(H,20,21,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040898
PNG
(CHEMBL3353819)
Show SMILES Brc1cccc2c1[nH]c1nc(SCc3ccccc3C#N)nnc21
Show InChI InChI=1S/C17H10BrN5S/c18-13-7-3-6-12-14(13)20-16-15(12)22-23-17(21-16)24-9-11-5-2-1-4-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040902
PNG
(CHEMBL3353823)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)[nH]c1cccc(Br)c21
Show InChI InChI=1S/C16H10BrN5O2S/c17-10-5-3-6-11-13(10)14-15(18-11)19-16(21-20-14)25-8-9-4-1-2-7-12(9)22(23)24/h1-7H,8H2,(H,18,19,21)
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n/an/an/an/a 37n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040905
PNG
(CHEMBL3353826)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)[nH]c1cccc(-c3ccsc3)c21
Show InChI InChI=1S/C21H13N5S2/c22-10-13-4-1-2-5-14(13)12-28-21-24-20-19(25-26-21)18-16(15-8-9-27-11-15)6-3-7-17(18)23-20/h1-9,11H,12H2,(H,23,24,26)
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n/an/an/an/a 1.76E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040910
PNG
(CHEMBL3353830)
Show SMILES CCCCn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C21H19N5S/c1-2-3-12-26-18-11-7-6-10-17(18)19-20(26)23-21(25-24-19)27-14-16-9-5-4-8-15(16)13-22/h4-11H,2-3,12,14H2,1H3
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n/an/an/an/a 106n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040948
PNG
(CHEMBL3354399)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)n(C(=O)c1ccccc1)c1ccccc21
Show InChI InChI=1S/C23H15N5O3S/c29-22(15-8-2-1-3-9-15)27-19-13-7-5-11-17(19)20-21(27)24-23(26-25-20)32-14-16-10-4-6-12-18(16)28(30)31/h1-13H,14H2
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n/an/an/an/a 75n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040950
PNG
(CHEMBL3354401)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C25H14F3N5OS/c26-25(27,28)18-9-5-8-15(12-18)23(34)33-20-11-4-3-10-19(20)21-22(33)30-24(32-31-21)35-14-17-7-2-1-6-16(17)13-29/h1-12H,14H2
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n/an/an/an/a 27n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040888
PNG
(CHEMBL3353809)
Show SMILES Clc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H11ClN4S/c17-12-7-3-1-5-10(12)9-22-16-19-15-14(20-21-16)11-6-2-4-8-13(11)18-15/h1-8H,9H2,(H,18,19,21)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040889
PNG
(CHEMBL3353810)
Show SMILES Clc1cccc(CSc2nnc3c(n2)[nH]c2ccccc32)c1
Show InChI InChI=1S/C16H11ClN4S/c17-11-5-3-4-10(8-11)9-22-16-19-15-14(20-21-16)12-6-1-2-7-13(12)18-15/h1-8H,9H2,(H,18,19,21)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040908
PNG
(CHEMBL3353829)
Show SMILES CCn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C19H15N5S/c1-2-24-16-10-6-5-9-15(16)17-18(24)21-19(23-22-17)25-12-14-8-4-3-7-13(14)11-20/h3-10H,2,12H2,1H3
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n/an/an/an/a 674n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040934
PNG
(CHEMBL3353833)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)n(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C24H17N5S/c25-14-18-10-4-5-11-19(18)16-30-24-26-23-22(27-28-24)20-12-6-7-13-21(20)29(23)15-17-8-2-1-3-9-17/h1-13H,15-16H2
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n/an/an/an/a 214n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040941
PNG
(CHEMBL3353840)
Show SMILES CC(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C19H13N5OS/c1-12(25)24-16-9-5-4-8-15(16)17-18(24)21-19(23-22-17)26-11-14-7-3-2-6-13(14)10-20/h2-9H,11H2,1H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040943
PNG
(CHEMBL3353842)
Show SMILES O=C(C1CCCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C23H19N5OS/c24-13-16-9-3-4-10-17(16)14-30-23-25-21-20(26-27-23)18-11-5-6-12-19(18)28(21)22(29)15-7-1-2-8-15/h3-6,9-12,15H,1-2,7-8,14H2
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n/an/an/an/a 49n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50399157
PNG
(CHEMBL2179724)
Show SMILES CCCCCCC(C)(C)c1cc(OC)c([C@H]2C=C(CO)[C@H]3C[C@@H]2C3(C)C)c(OC)c1 |r,t:16|
Show InChI InChI=1S/C27H42O3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28H,8-12,16-17H2,1-7H3/t20-,21+,22-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040891
PNG
(CHEMBL3353812)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H11N5O2S/c22-21(23)13-8-4-1-5-10(13)9-24-16-18-15-14(19-20-16)11-6-2-3-7-12(11)17-15/h1-8H,9H2,(H,17,18,20)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040955
PNG
(CHEMBL3354406)
Show SMILES O=C(c1ccco1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H13N5O2S/c23-12-14-6-1-2-7-15(14)13-30-22-24-20-19(25-26-22)16-8-3-4-9-17(16)27(20)21(28)18-10-5-11-29-18/h1-11H,13H2
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n/an/an/an/a 46n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040883
PNG
(CHEMBL587528 | GNF-Pf-1521 | GNF-Pf-472)
Show SMILES C(Sc1nnc2c(n1)[nH]c1ccccc21)c1ccccc1
Show InChI InChI=1S/C16H12N4S/c1-2-6-11(7-3-1)10-21-16-18-15-14(19-20-16)12-8-4-5-9-13(12)17-15/h1-9H,10H2,(H,17,18,20)
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n/an/an/an/a 1.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040884
PNG
(CHEMBL3353805)
Show SMILES N#Cc1cccc(CSc2nnc3c(n2)[nH]c2ccccc32)c1
Show InChI InChI=1S/C17H11N5S/c18-9-11-4-3-5-12(8-11)10-23-17-20-16-15(21-22-17)13-6-1-2-7-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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n/an/an/an/a 6.45E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040894
PNG
(CHEMBL3353815)
Show SMILES FC(F)(F)Oc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11F3N4OS/c18-17(19,20)25-13-8-4-1-5-10(13)9-26-16-22-15-14(23-24-16)11-6-2-3-7-12(11)21-15/h1-8H,9H2,(H,21,22,24)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040899
PNG
(CHEMBL3353820)
Show SMILES Brc1ccc2c(c1)[nH]c1nc(SCc3ccccc3C#N)nnc21
Show InChI InChI=1S/C17H10BrN5S/c18-12-5-6-13-14(7-12)20-16-15(13)22-23-17(21-16)24-9-11-4-2-1-3-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040901
PNG
(CHEMBL3353822)
Show SMILES Brc1cccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c12
Show InChI InChI=1S/C17H10BrN5S/c18-12-6-3-7-13-14(12)15-16(20-13)21-17(23-22-15)24-9-11-5-2-1-4-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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n/an/an/an/a 39n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040940
PNG
(CHEMBL3353839)
Show SMILES O=C(OCc1ccccc1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C25H17N5O2S/c26-14-18-10-4-5-11-19(18)16-33-24-27-23-22(28-29-24)20-12-6-7-13-21(20)30(23)25(31)32-15-17-8-2-1-3-9-17/h1-13H,15-16H2
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040944
PNG
(CHEMBL3354395)
Show SMILES O=C(C1CCCCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H21N5OS/c25-14-17-10-4-5-11-18(17)15-31-24-26-22-21(27-28-24)19-12-6-7-13-20(19)29(22)23(30)16-8-2-1-3-9-16/h4-7,10-13,16H,1-3,8-9,15H2
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n/an/an/an/a 32n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040951
PNG
(CHEMBL3354402)
Show SMILES Fc1ccc(C(=O)n2c3ccccc3c3nnc(SCc4ccccc4C#N)nc23)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H13F4N5OS/c26-16-9-10-17(19(11-16)25(27,28)29)23(35)34-20-8-4-3-7-18(20)21-22(34)31-24(33-32-21)36-13-15-6-2-1-5-14(15)12-30/h1-11H,13H2
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040953
PNG
(CHEMBL3354404)
Show SMILES CN(C)c1ccc(cc1)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C26H20N6OS/c1-31(2)20-13-11-17(12-14-20)25(33)32-22-10-6-5-9-21(22)23-24(32)28-26(30-29-23)34-16-19-8-4-3-7-18(19)15-27/h3-14H,16H2,1-2H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040934
PNG
(CHEMBL3353833)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)n(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C24H17N5S/c25-14-18-10-4-5-11-19(18)16-30-24-26-23-22(27-28-24)20-12-6-7-13-21(20)29(23)15-17-8-2-1-3-9-17/h1-13H,15-16H2
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n/an/an/an/a 1.55E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040936
PNG
(CHEMBL3353835)
Show SMILES [O-][N+](=O)c1ccccc1Cn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H16N6O2S/c25-13-16-7-1-2-9-18(16)15-33-24-26-23-22(27-28-24)19-10-4-6-12-21(19)29(23)14-17-8-3-5-11-20(17)30(31)32/h1-12H,14-15H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040890
PNG
(CHEMBL3353811)
Show SMILES Clc1ccc(CSc2nnc3c(n2)[nH]c2ccccc32)cc1
Show InChI InChI=1S/C16H11ClN4S/c17-11-7-5-10(6-8-11)9-22-16-19-15-14(20-21-16)12-3-1-2-4-13(12)18-15/h1-8H,9H2,(H,18,19,21)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040893
PNG
(CHEMBL3353814)
Show SMILES FC(F)(F)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11F3N4S/c18-17(19,20)12-7-3-1-5-10(12)9-25-16-22-15-14(23-24-16)11-6-2-4-8-13(11)21-15/h1-8H,9H2,(H,21,22,24)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040897
PNG
(CHEMBL3353818)
Show SMILES [O-][S+](Cc1ccccc1C#N)c1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1/C17H11N5OS/c18-9-11-5-1-2-6-12(11)10-24(23)17-20-16-15(21-22-17)13-7-3-4-8-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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n/an/an/an/a 3.55E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040906
PNG
(CHEMBL3353827)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)[nH]c1cccc(C3CC3)c21
Show InChI InChI=1S/C20H15N5S/c21-10-13-4-1-2-5-14(13)11-26-20-23-19-18(24-25-20)17-15(12-8-9-12)6-3-7-16(17)22-19/h1-7,12H,8-9,11H2,(H,22,23,25)
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n/an/an/an/a 231n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040907
PNG
(CHEMBL3353828)
Show SMILES Cn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C18H13N5S/c1-23-15-9-5-4-8-14(15)16-17(23)20-18(22-21-16)24-11-13-7-3-2-6-12(13)10-19/h2-9H,11H2,1H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040938
PNG
(CHEMBL3353837)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H17N5O2S2/c1-16-10-12-19(13-11-16)33(30,31)29-21-9-5-4-8-20(21)22-23(29)26-24(28-27-22)32-15-18-7-3-2-6-17(18)14-25/h2-13H,15H2,1H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040945
PNG
(CHEMBL3354396)
Show SMILES COC(=O)CCC(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H17N5O3S/c1-30-19(29)11-10-18(28)27-17-9-5-4-8-16(17)20-21(27)24-22(26-25-20)31-13-15-7-3-2-6-14(15)12-23/h2-9H,10-11,13H2,1H3
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n/an/an/an/a 48n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040946
PNG
(CHEMBL3354397)
Show SMILES COC(=O)CCCC(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C23H19N5O3S/c1-31-20(30)12-6-11-19(29)28-18-10-5-4-9-17(18)21-22(28)25-23(27-26-21)32-14-16-8-3-2-7-15(16)13-24/h2-5,7-10H,6,11-12,14H2,1H3
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n/an/an/an/a 42n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040954
PNG
(CHEMBL3354405)
Show SMILES COc1ccc(cc1OC)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C26H19N5O3S/c1-33-21-12-11-16(13-22(21)34-2)25(32)31-20-10-6-5-9-19(20)23-24(31)28-26(30-29-23)35-15-18-8-4-3-7-17(18)14-27/h3-13H,15H2,1-2H3
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n/an/an/an/a 160n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040957
PNG
(CHEMBL3354408)
Show SMILES O=C(N1CCOCC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C22H18N6O2S/c23-13-15-5-1-2-6-16(15)14-31-21-24-20-19(25-26-21)17-7-3-4-8-18(17)28(20)22(29)27-9-11-30-12-10-27/h1-8H,9-12,14H2
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n/an/an/an/a 92n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040901
PNG
(CHEMBL3353822)
Show SMILES Brc1cccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c12
Show InChI InChI=1S/C17H10BrN5S/c18-12-6-3-7-13-14(12)15-16(20-13)21-17(23-22-15)24-9-11-5-2-1-4-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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n/an/an/an/a 2.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040881
PNG
(CHEMBL3353803)
Show SMILES CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C10H8N4S/c1-15-10-12-9-8(13-14-10)6-4-2-3-5-7(6)11-9/h2-5H,1H3,(H,11,12,14)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040882
PNG
(CHEMBL3353804)
Show SMILES C(Sc1nnc2c(n1)[nH]c1ccccc21)C1CCCCC1
Show InChI InChI=1S/C16H18N4S/c1-2-6-11(7-3-1)10-21-16-18-15-14(19-20-16)12-8-4-5-9-13(12)17-15/h4-5,8-9,11H,1-3,6-7,10H2,(H,17,18,20)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040887
PNG
(CHEMBL3353808)
Show SMILES Fc1cccc(F)c1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H10F2N4S/c17-11-5-3-6-12(18)10(11)8-23-16-20-15-14(21-22-16)9-4-1-2-7-13(9)19-15/h1-7H,8H2,(H,19,20,22)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040891
PNG
(CHEMBL3353812)
Show SMILES [O-][N+](=O)c1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H11N5O2S/c22-21(23)13-8-4-1-5-10(13)9-24-16-18-15-14(19-20-16)11-6-2-3-7-12(11)17-15/h1-8H,9H2,(H,17,18,20)
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n/an/an/an/a 33n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040900
PNG
(CHEMBL3353821)
Show SMILES Brc1ccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c2c1
Show InChI InChI=1S/C17H10BrN5S/c18-12-5-6-14-13(7-12)15-16(20-14)21-17(23-22-15)24-9-11-4-2-1-3-10(11)8-19/h1-7H,9H2,(H,20,21,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040904
PNG
(CHEMBL3353825)
Show SMILES Cc1ccc(cc1)-c1cccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c12
Show InChI InChI=1S/C24H17N5S/c1-15-9-11-16(12-10-15)19-7-4-8-20-21(19)22-23(26-20)27-24(29-28-22)30-14-18-6-3-2-5-17(18)13-25/h2-12H,14H2,1H3,(H,26,27,29)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040932
PNG
(CHEMBL3353831)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)n(CC1CC1)c1ccccc21
Show InChI InChI=1S/C21H17N5S/c22-11-15-5-1-2-6-16(15)13-27-21-23-20-19(24-25-21)17-7-3-4-8-18(17)26(20)12-14-9-10-14/h1-8,14H,9-10,12-13H2
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n/an/an/an/a 144n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040936
PNG
(CHEMBL3353835)
Show SMILES [O-][N+](=O)c1ccccc1Cn1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H16N6O2S/c25-13-16-7-1-2-9-18(16)15-33-24-26-23-22(27-28-24)19-10-4-6-12-21(19)29(23)14-17-8-3-5-11-20(17)30(31)32/h1-12H,14-15H2
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n/an/an/an/a 53n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040942
PNG
(CHEMBL3353841)
Show SMILES O=C(C1CC1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C21H15N5OS/c22-11-14-5-1-2-6-15(14)12-28-21-23-19-18(24-25-21)16-7-3-4-8-17(16)26(19)20(27)13-9-10-13/h1-8,13H,9-10,12H2
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n/an/an/an/a 181n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040947
PNG
(CHEMBL3354398)
Show SMILES O=C(c1ccccc1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C24H15N5OS/c25-14-17-10-4-5-11-18(17)15-31-24-26-22-21(27-28-24)19-12-6-7-13-20(19)29(22)23(30)16-8-2-1-3-9-16/h1-13H,15H2
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n/an/an/an/a 113n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040952
PNG
(CHEMBL3354403)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C25H14F3N5O2S/c26-25(27,28)35-18-11-9-15(10-12-18)23(34)33-20-8-4-3-7-19(20)21-22(33)30-24(32-31-21)36-14-17-6-2-1-5-16(17)13-29/h1-12H,14H2
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n/an/an/an/a 73n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040956
PNG
(CHEMBL3354407)
Show SMILES O=C(c1ccno1)n1c2ccccc2c2nnc(SCc3ccccc3C#N)nc12
Show InChI InChI=1S/C21H12N6O2S/c22-11-13-5-1-2-6-14(13)12-30-21-24-19-18(25-26-21)15-7-3-4-8-16(15)27(19)20(28)17-9-10-23-29-17/h1-10H,12H2
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n/an/an/an/a 19n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040880
PNG
(CHEMBL3353802)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11N5S/c18-9-11-5-1-2-6-12(11)10-23-17-20-16-15(21-22-17)13-7-3-4-8-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040884
PNG
(CHEMBL3353805)
Show SMILES N#Cc1cccc(CSc2nnc3c(n2)[nH]c2ccccc32)c1
Show InChI InChI=1S/C17H11N5S/c18-9-11-4-3-5-12(8-11)10-23-17-20-16-15(21-22-17)13-6-1-2-7-14(13)19-16/h1-8H,10H2,(H,19,20,22)
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB1R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040885
PNG
(CHEMBL3353806)
Show SMILES Fc1ccccc1CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H11FN4S/c17-12-7-3-1-5-10(12)9-22-16-19-15-14(20-21-16)11-6-2-4-8-13(11)18-15/h1-8H,9H2,(H,18,19,21)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040886
PNG
(CHEMBL3353807)
Show SMILES Fc1ccc(CSc2nnc3c(n2)[nH]c2ccccc32)cc1
Show InChI InChI=1S/C16H11FN4S/c17-11-7-5-10(6-8-11)9-22-16-19-15-14(20-21-16)12-3-1-2-4-13(12)18-15/h1-8H,9H2,(H,18,19,21)
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n/an/an/an/a>3.00E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040892
PNG
(CHEMBL3353813)
Show SMILES [O-][N+](=O)c1ccc(CSc2nnc3c(n2)[nH]c2ccccc32)cc1
Show InChI InChI=1S/C16H11N5O2S/c22-21(23)11-7-5-10(6-8-11)9-24-16-18-15-14(19-20-16)12-3-1-2-4-13(12)17-15/h1-8H,9H2,(H,17,18,20)
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n/an/an/an/a 617n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040903
PNG
(CHEMBL3353824)
Show SMILES Cc1ccccc1-c1cccc2[nH]c3nc(SCc4ccccc4C#N)nnc3c12
Show InChI InChI=1S/C24H17N5S/c1-15-7-2-5-10-18(15)19-11-6-12-20-21(19)22-23(26-20)27-24(29-28-22)30-14-17-9-4-3-8-16(17)13-25/h2-12H,14H2,1H3,(H,26,27,29)
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n/an/an/an/a 4.30E+3n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040933
PNG
(CHEMBL3353832)
Show SMILES N#Cc1ccccc1CSc1nnc2c(n1)n(CC1CCCCC1)c1ccccc21
Show InChI InChI=1S/C24H23N5S/c25-14-18-10-4-5-11-19(18)16-30-24-26-23-22(27-28-24)20-12-6-7-13-21(20)29(23)15-17-8-2-1-3-9-17/h4-7,10-13,17H,1-3,8-9,15-16H2
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n/an/an/an/a 270n/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Agonist activity at human CB2R expressed in CHO cells assessed as reduction in forskolin-induced cAMP accumulation by beta-galactosidase based comple...


Bioorg Med Chem 23: 241-63 (2014)


Article DOI: 10.1016/j.bmc.2014.11.002
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%