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PubMed code 25488844

Compile data set for download or QSAR
Found 154 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ERG channel by patch clamp technique


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]Astemizole from human ERG channel


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040996
PNG
(CHEMBL3354947)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccncc1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,13-5-7-25-8-6-13)26-21(29)19-16-10-12-9-15(12)20(16)28(27-19)18-4-3-14(23)11-17(18)24/h3-8,11-12,15H,9-10H2,1-2H3,(H,26,29)/t12-,15-/s2
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n/an/an/an/a 5.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Mus musculus (Mouse))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at mouse recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040967
PNG
(CHEMBL3354935)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1C(C)(C)C)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C21H27N3O/c1-20(2,3)24-18-15-11-13(15)12-16(18)17(23-24)19(25)22-21(4,5)14-9-7-6-8-10-14/h6-10,13,15H,11-12H2,1-5H3,(H,22,25)/t13-,15-/s2
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n/an/an/an/a 33n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50041000
PNG
(CHEMBL3354943)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H21Cl2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 22n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040989
PNG
(CHEMBL3354955)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-12-3-4-16(15(22)9-12)25-18-13-7-11(13)8-14(18)17(24-25)19(27)23-20(10-26)5-1-2-6-20/h3-4,9,11,13,26H,1-2,5-8,10H2,(H,23,27)/t11-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040995
PNG
(CHEMBL3354948)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1cccnc1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,13-4-3-7-25-11-13)26-21(29)19-16-9-12-8-15(12)20(16)28(27-19)18-6-5-14(23)10-17(18)24/h3-7,10-12,15H,8-9H2,1-2H3,(H,26,29)/t12-,15-/s2
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n/an/an/an/a 1.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 13n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040989
PNG
(CHEMBL3354955)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-12-3-4-16(15(22)9-12)25-18-13-7-11(13)8-14(18)17(24-25)19(27)23-20(10-26)5-1-2-6-20/h3-4,9,11,13,26H,1-2,5-8,10H2,(H,23,27)/t11-,13-/s2
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n/an/an/an/a 1.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 88n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040977
PNG
(CHEMBL3354968)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-12-8-10-7-11(10)16(12)22(21-15)14-6-4-3-5-13(14)19/h3-6,10-11,23H,7-9H2,1-2H3,(H,20,24)/t10-,11-/s2
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n/an/an/an/a 32n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040989
PNG
(CHEMBL3354955)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-12-3-4-16(15(22)9-12)25-18-13-7-11(13)8-14(18)17(24-25)19(27)23-20(10-26)5-1-2-6-20/h3-4,9,11,13,26H,1-2,5-8,10H2,(H,23,27)/t11-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040976
PNG
(CHEMBL3354969)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccc(F)c1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-7-10-6-13(10)16(14)22(21-15)12-5-3-4-11(19)8-12/h3-5,8,10,13,23H,6-7,9H2,1-2H3,(H,20,24)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040978
PNG
(CHEMBL3354967)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H21N3O2/c1-18(2,10-22)19-17(23)15-14-9-11-8-13(11)16(14)21(20-15)12-6-4-3-5-7-12/h3-7,11,13,22H,8-10H2,1-2H3,(H,19,23)/t11-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1c(F)cccc1F)C(=O)NC(C)(C)CO |r,wU:1.0,3.4,(21.92,-31.59,;21.53,-33.09,;20.13,-32.44,;20.27,-33.98,;18.93,-33.2,;20.73,-35.45,;22.27,-35.46,;22.76,-34,;22.73,-36.93,;21.48,-37.82,;20.24,-36.9,;18.7,-36.94,;17.97,-38.29,;18.78,-39.6,;16.43,-38.33,;15.62,-37.01,;16.36,-35.65,;17.9,-35.62,;18.65,-34.27,;24.07,-37.69,;24.09,-39.23,;25.4,-36.9,;26.74,-37.66,;27.51,-38.99,;25.97,-38.98,;28.08,-36.88,;29.41,-37.65,)|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040971
PNG
(CHEMBL3354974)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-12-8-10-7-11(10)15(12)21(20-14)13-5-3-4-6-18-13/h3-6,10-11,22H,7-9H2,1-2H3,(H,19,23)/t10-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040968
PNG
(CHEMBL3352843)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccncn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,7-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-3-4-17-8-18-12/h3-4,8-10,22H,5-7H2,1-2H3,(H,19,23)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040966
PNG
(CHEMBL3354936)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1C(C)C)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C20H25N3O/c1-12(2)23-18-15-10-13(15)11-16(18)17(22-23)19(24)21-20(3,4)14-8-6-5-7-9-14/h5-9,12-13,15H,10-11H2,1-4H3,(H,21,24)/t13-,15-/s2
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n/an/an/an/a 51n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040970
PNG
(CHEMBL3354975)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccnc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-13-7-10-6-12(10)15(13)21(20-14)11-4-3-5-18-8-11/h3-5,8,10,12,22H,6-7,9H2,1-2H3,(H,19,23)/t10-,12-/s2
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n/an/an/an/a 809n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040971
PNG
(CHEMBL3354974)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-12-8-10-7-11(10)15(12)21(20-14)13-5-3-4-6-18-13/h3-6,10-11,22H,7-9H2,1-2H3,(H,19,23)/t10-,11-/s2
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cc(F)ccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 0.900n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H]1[C@]2(C)CC[C@@]([H])(C2)C1(C)C |r|
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 1.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040989
PNG
(CHEMBL3354955)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-12-3-4-16(15(22)9-12)25-18-13-7-11(13)8-14(18)17(24-25)19(27)23-20(10-26)5-1-2-6-20/h3-4,9,11,13,26H,1-2,5-8,10H2,(H,23,27)/t11-,13-/s2
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n/an/an/an/a 0.700n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040995
PNG
(CHEMBL3354948)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1cccnc1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,13-4-3-7-25-11-13)26-21(29)19-16-9-12-8-15(12)20(16)28(27-19)18-6-5-14(23)10-17(18)24/h3-7,10-12,15H,8-9H2,1-2H3,(H,26,29)/t12-,15-/s2
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n/an/an/an/a 5.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040985
PNG
(CHEMBL3354960)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CN1CCOCC1 |r|
Show InChI InChI=1/C22H26F2N4O2/c1-22(2,12-27-5-7-30-8-6-27)25-21(29)19-16-10-13-9-15(13)20(16)28(26-19)18-4-3-14(23)11-17(18)24/h3-4,11,13,15H,5-10,12H2,1-2H3,(H,25,29)/t13-,15-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040969
PNG
(CHEMBL3354976)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cnccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,8-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-7-17-3-4-18-12/h3-4,7,9-10,22H,5-6,8H2,1-2H3,(H,19,23)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040962
PNG
(CHEMBL3354940)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CCN1CCOCC1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H30N4O2/c1-23(2,17-6-4-3-5-7-17)24-22(28)20-19-15-16-14-18(16)21(19)27(25-20)9-8-26-10-12-29-13-11-26/h3-7,16,18H,8-15H2,1-2H3,(H,24,28)/t16-,18-/s2
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n/an/an/an/a 2.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50041002
PNG
(CHEMBL3354941)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1Cc1ccc(F)cc1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C24H24FN3O/c1-24(2,17-6-4-3-5-7-17)26-23(29)21-20-13-16-12-19(16)22(20)28(27-21)14-15-8-10-18(25)11-9-15/h3-11,16,19H,12-14H2,1-2H3,(H,26,29)/t16-,19-/s2
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n/an/an/an/a 0.300n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H]1[C@]2(C)CC[C@@]([H])(C2)C1(C)C |r|
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 591n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 12n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 59n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040994
PNG
(CHEMBL3354949)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccn1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,18-5-3-4-8-25-18)26-21(29)19-15-10-12-9-14(12)20(15)28(27-19)17-7-6-13(23)11-16(17)24/h3-8,11-12,14H,9-10H2,1-2H3,(H,26,29)/t12-,14-/s2
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n/an/an/an/a 43n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H]1[C@]2(C)CC[C@@]([H])(C2)C1(C)C |r|
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 498n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cc(F)ccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 639n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040967
PNG
(CHEMBL3354935)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1C(C)(C)C)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C21H27N3O/c1-20(2,3)24-18-15-11-13(15)12-16(18)17(23-24)19(25)22-21(4,5)14-9-7-6-8-10-14/h6-10,13,15H,11-12H2,1-5H3,(H,22,25)/t13-,15-/s2
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n/an/an/an/a 86n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 7.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040986
PNG
(CHEMBL3354959)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a 21n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 1.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cc(F)ccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040964
PNG
(CHEMBL3354938)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CC1CCOCC1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H29N3O2/c1-23(2,17-6-4-3-5-7-17)24-22(27)20-19-13-16-12-18(16)21(19)26(25-20)14-15-8-10-28-11-9-15/h3-7,15-16,18H,8-14H2,1-2H3,(H,24,27)/t16-,18-/s2
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n/an/an/an/a 0.700n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040997
PNG
(CHEMBL3354946)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CC1)c1ccccc1 |r|
Show InChI InChI=1/C23H19F2N3O/c24-15-6-7-19(18(25)12-15)28-21-16-10-13(16)11-17(21)20(27-28)22(29)26-23(8-9-23)14-4-2-1-3-5-14/h1-7,12-13,16H,8-11H2,(H,26,29)/t13-,16-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040992
PNG
(CHEMBL3354951)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CF |r|
Show InChI InChI=1/C18H18F3N3O/c1-18(2,8-19)22-17(25)15-12-6-9-5-11(9)16(12)24(23-15)14-4-3-10(20)7-13(14)21/h3-4,7,9,11H,5-6,8H2,1-2H3,(H,22,25)/t9-,11-/s2
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n/an/an/an/a 3.40E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040986
PNG
(CHEMBL3354959)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040985
PNG
(CHEMBL3354960)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CN1CCOCC1 |r|
Show InChI InChI=1/C22H26F2N4O2/c1-22(2,12-27-5-7-30-8-6-27)25-21(29)19-16-10-13-9-15(13)20(16)28(26-19)18-4-3-14(23)11-17(18)24/h3-4,11,13,15H,5-10,12H2,1-2H3,(H,25,29)/t13-,15-/s2
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n/an/an/an/a 2.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a 67n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040970
PNG
(CHEMBL3354975)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccnc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-13-7-10-6-12(10)15(13)21(20-14)11-4-3-5-18-8-11/h3-5,8,10,12,22H,6-7,9H2,1-2H3,(H,19,23)/t10-,12-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040970
PNG
(CHEMBL3354975)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccnc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-13-7-10-6-12(10)15(13)21(20-14)11-4-3-5-18-8-11/h3-5,8,10,12,22H,6-7,9H2,1-2H3,(H,19,23)/t10-,12-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040972
PNG
(CHEMBL3354973)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19Cl2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 100n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040978
PNG
(CHEMBL3354967)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H21N3O2/c1-18(2,10-22)19-17(23)15-14-9-11-8-13(11)16(14)21(20-15)12-6-4-3-5-7-12/h3-7,11,13,22H,8-10H2,1-2H3,(H,19,23)/t11-,13-/s2
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n/an/an/an/a 101n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 3.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040971
PNG
(CHEMBL3354974)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-12-8-10-7-11(10)15(12)21(20-14)13-5-3-4-6-18-13/h3-6,10-11,22H,7-9H2,1-2H3,(H,19,23)/t10-,11-/s2
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n/an/an/an/a 3.60E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040968
PNG
(CHEMBL3352843)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccncn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,7-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-3-4-17-8-18-12/h3-4,8-10,22H,5-7H2,1-2H3,(H,19,23)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040999
PNG
(CHEMBL3354944)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccn1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C22H22N4O/c1-22(2,15-8-4-3-5-9-15)24-21(27)19-17-13-14-12-16(14)20(17)26(25-19)18-10-6-7-11-23-18/h3-11,14,16H,12-13H2,1-2H3,(H,24,27)/t14-,16-/s2
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n/an/an/an/a 4.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040965
PNG
(CHEMBL3354937)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CC(C)(C)C)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C22H29N3O/c1-21(2,3)13-25-19-16-11-14(16)12-17(19)18(24-25)20(26)23-22(4,5)15-9-7-6-8-10-15/h6-10,14,16H,11-13H2,1-5H3,(H,23,26)/t14-,16-/s2
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n/an/an/an/a 0.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040966
PNG
(CHEMBL3354936)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1C(C)C)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C20H25N3O/c1-12(2)23-18-15-10-13(15)11-16(18)17(22-23)19(24)21-20(3,4)14-8-6-5-7-9-14/h5-9,12-13,15H,10-11H2,1-4H3,(H,21,24)/t13-,15-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040998
PNG
(CHEMBL3354945)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccnc1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C22H22N4O/c1-22(2,15-7-4-3-5-8-15)24-21(27)19-18-12-14-11-17(14)20(18)26(25-19)16-9-6-10-23-13-16/h3-10,13-14,17H,11-12H2,1-2H3,(H,24,27)/t14-,17-/s2
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n/an/an/an/a 341n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040995
PNG
(CHEMBL3354948)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1cccnc1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,13-4-3-7-25-11-13)26-21(29)19-16-9-12-8-15(12)20(16)28(27-19)18-6-5-14(23)10-17(18)24/h3-7,10-12,15H,8-9H2,1-2H3,(H,26,29)/t12-,15-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040994
PNG
(CHEMBL3354949)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccn1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,18-5-3-4-8-25-18)26-21(29)19-15-10-12-9-14(12)20(15)28(27-19)17-7-6-13(23)11-16(17)24/h3-8,11-12,14H,9-10H2,1-2H3,(H,26,29)/t12-,14-/s2
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n/an/an/an/a 43n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040993
PNG
(CHEMBL3354950)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040994
PNG
(CHEMBL3354949)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccn1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,18-5-3-4-8-25-18)26-21(29)19-15-10-12-9-14(12)20(15)28(27-19)17-7-6-13(23)11-16(17)24/h3-8,11-12,14H,9-10H2,1-2H3,(H,26,29)/t12-,14-/s2
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n/an/an/an/a 6.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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n/an/an/an/a 4.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040986
PNG
(CHEMBL3354959)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040976
PNG
(CHEMBL3354969)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccc(F)c1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-7-10-6-13(10)16(14)22(21-15)12-5-3-4-11(19)8-12/h3-5,8,10,13,23H,6-7,9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a 34n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cc(F)ccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 7.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040997
PNG
(CHEMBL3354946)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CC1)c1ccccc1 |r|
Show InChI InChI=1/C23H19F2N3O/c24-15-6-7-19(18(25)12-15)28-21-16-10-13(16)11-17(21)20(27-28)22(29)26-23(8-9-23)14-4-2-1-3-5-14/h1-7,12-13,16H,8-11H2,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 19n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040985
PNG
(CHEMBL3354960)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CN1CCOCC1 |r|
Show InChI InChI=1/C22H26F2N4O2/c1-22(2,12-27-5-7-30-8-6-27)25-21(29)19-16-10-13-9-15(13)20(16)28(26-19)18-4-3-14(23)11-17(18)24/h3-4,11,13,15H,5-10,12H2,1-2H3,(H,25,29)/t13-,15-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040977
PNG
(CHEMBL3354968)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-12-8-10-7-11(10)16(12)22(21-15)14-6-4-3-5-13(14)19/h3-6,10-11,23H,7-9H2,1-2H3,(H,20,24)/t10-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040987
PNG
(CHEMBL3354958)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a 15n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/s2
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n/an/an/an/a 5.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040960
PNG
(CHEMBL3354956)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18-/s2
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n/an/an/an/a 39n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040992
PNG
(CHEMBL3354951)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CF |r|
Show InChI InChI=1/C18H18F3N3O/c1-18(2,8-19)22-17(25)15-12-6-9-5-11(9)16(12)24(23-15)14-4-3-10(20)7-13(14)21/h3-4,7,9,11H,5-6,8H2,1-2H3,(H,22,25)/t9-,11-/s2
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n/an/an/an/a 20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 2.87E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at mouse recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040984
PNG
(CHEMBL3354961)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H]1[C@]2(C)CC[C@@]([H])(C2)C1(C)C |r|
Show InChI InChI=1/C24H27F2N3O/c1-23(2)13-6-7-24(3,11-13)22(23)27-21(30)19-16-9-12-8-15(12)20(16)29(28-19)18-5-4-14(25)10-17(18)26/h4-5,10,12-13,15,22H,6-9,11H2,1-3H3,(H,27,30)/t12-,13+,15-,22+,24-/s2
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n/an/an/an/a 217n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040978
PNG
(CHEMBL3354967)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H21N3O2/c1-18(2,10-22)19-17(23)15-14-9-11-8-13(11)16(14)21(20-15)12-6-4-3-5-7-12/h3-7,11,13,22H,8-10H2,1-2H3,(H,19,23)/t11-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040970
PNG
(CHEMBL3354975)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccnc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-13-7-10-6-12(10)15(13)21(20-14)11-4-3-5-18-8-11/h3-5,8,10,12,22H,6-7,9H2,1-2H3,(H,19,23)/t10-,12-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040998
PNG
(CHEMBL3354945)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccnc1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C22H22N4O/c1-22(2,15-7-4-3-5-8-15)24-21(27)19-18-12-14-11-17(14)20(18)26(25-19)16-9-6-10-23-13-16/h3-10,13-14,17H,11-12H2,1-2H3,(H,24,27)/t14-,17-/s2
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n/an/an/an/a 22n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040960
PNG
(CHEMBL3354956)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040987
PNG
(CHEMBL3354958)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040993
PNG
(CHEMBL3354950)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 4.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040992
PNG
(CHEMBL3354951)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CF |r|
Show InChI InChI=1/C18H18F3N3O/c1-18(2,8-19)22-17(25)15-12-6-9-5-11(9)16(12)24(23-15)14-4-3-10(20)7-13(14)21/h3-4,7,9,11H,5-6,8H2,1-2H3,(H,22,25)/t9-,11-/s2
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n/an/an/an/a 18n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040969
PNG
(CHEMBL3354976)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cnccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,8-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-7-17-3-4-18-12/h3-4,7,9-10,22H,5-6,8H2,1-2H3,(H,19,23)/t9-,10-/s2
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n/an/an/an/a 50n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040960
PNG
(CHEMBL3354956)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18-/s2
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n/an/an/an/a 69n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040993
PNG
(CHEMBL3354950)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 768n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040987
PNG
(CHEMBL3354958)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040972
PNG
(CHEMBL3354973)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19Cl2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040963
PNG
(CHEMBL3354939)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CCC1CCOCC1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C24H31N3O2/c1-24(2,18-6-4-3-5-7-18)25-23(28)21-20-15-17-14-19(17)22(20)27(26-21)11-8-16-9-12-29-13-10-16/h3-7,16-17,19H,8-15H2,1-2H3,(H,25,28)/t17-,19-/s2
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n/an/an/an/a 4.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040977
PNG
(CHEMBL3354968)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-12-8-10-7-11(10)16(12)22(21-15)14-6-4-3-5-13(14)19/h3-6,10-11,23H,7-9H2,1-2H3,(H,20,24)/t10-,11-/s2
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n/an/an/an/a 19n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040981
PNG
(CHEMBL3354964)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040993
PNG
(CHEMBL3354950)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 2.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040994
PNG
(CHEMBL3354949)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccn1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,18-5-3-4-8-25-18)26-21(29)19-15-10-12-9-14(12)20(15)28(27-19)17-7-6-13(23)11-16(17)24/h3-8,11-12,14H,9-10H2,1-2H3,(H,26,29)/t12-,14-/s2
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n/an/an/an/a 0.700n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040997
PNG
(CHEMBL3354946)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CC1)c1ccccc1 |r|
Show InChI InChI=1/C23H19F2N3O/c24-15-6-7-19(18(25)12-15)28-21-16-10-13(16)11-17(21)20(27-28)22(29)26-23(8-9-23)14-4-2-1-3-5-14/h1-7,12-13,16H,8-11H2,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 1.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1c(F)cccc1F)C(=O)NC(C)(C)CO |r,wU:1.0,3.4,(21.92,-31.59,;21.53,-33.09,;20.13,-32.44,;20.27,-33.98,;18.93,-33.2,;20.73,-35.45,;22.27,-35.46,;22.76,-34,;22.73,-36.93,;21.48,-37.82,;20.24,-36.9,;18.7,-36.94,;17.97,-38.29,;18.78,-39.6,;16.43,-38.33,;15.62,-37.01,;16.36,-35.65,;17.9,-35.62,;18.65,-34.27,;24.07,-37.69,;24.09,-39.23,;25.4,-36.9,;26.74,-37.66,;27.51,-38.99,;25.97,-38.98,;28.08,-36.88,;29.41,-37.65,)|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50041000
PNG
(CHEMBL3354943)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H21Cl2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 3.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 16n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 105n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 52n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 6.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a 183n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1c(F)cccc1F)C(=O)NC(C)(C)CO |r,wU:1.0,3.4,(21.92,-31.59,;21.53,-33.09,;20.13,-32.44,;20.27,-33.98,;18.93,-33.2,;20.73,-35.45,;22.27,-35.46,;22.76,-34,;22.73,-36.93,;21.48,-37.82,;20.24,-36.9,;18.7,-36.94,;17.97,-38.29,;18.78,-39.6,;16.43,-38.33,;15.62,-37.01,;16.36,-35.65,;17.9,-35.62,;18.65,-34.27,;24.07,-37.69,;24.09,-39.23,;25.4,-36.9,;26.74,-37.66,;27.51,-38.99,;25.97,-38.98,;28.08,-36.88,;29.41,-37.65,)|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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n/an/an/an/a 2.80E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040995
PNG
(CHEMBL3354948)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1cccnc1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,13-4-3-7-25-11-13)26-21(29)19-16-9-12-8-15(12)20(16)28(27-19)18-6-5-14(23)10-17(18)24/h3-7,10-12,15H,8-9H2,1-2H3,(H,26,29)/t12-,15-/s2
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n/an/an/an/a 5.40E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040992
PNG
(CHEMBL3354951)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CF |r|
Show InChI InChI=1/C18H18F3N3O/c1-18(2,8-19)22-17(25)15-12-6-9-5-11(9)16(12)24(23-15)14-4-3-10(20)7-13(14)21/h3-4,7,9,11H,5-6,8H2,1-2H3,(H,22,25)/t9-,11-/s2
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n/an/an/an/a 855n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/s2
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n/an/an/an/a 1.90E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040986
PNG
(CHEMBL3354959)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040960
PNG
(CHEMBL3354956)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@H](CO)c1ccccc1 |r|
Show InChI InChI=1/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18-/s2
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n/an/an/an/a 5.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040964
PNG
(CHEMBL3354938)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CC1CCOCC1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H29N3O2/c1-23(2,17-6-4-3-5-7-17)24-22(27)20-19-13-16-12-18(16)21(19)26(25-20)14-15-8-10-28-11-9-15/h3-7,15-16,18H,8-14H2,1-2H3,(H,24,27)/t16-,18-/s2
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n/an/an/an/a 2.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040968
PNG
(CHEMBL3352843)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccncn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,7-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-3-4-17-8-18-12/h3-4,8-10,22H,5-7H2,1-2H3,(H,19,23)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040969
PNG
(CHEMBL3354976)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cnccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,8-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-7-17-3-4-18-12/h3-4,7,9-10,22H,5-6,8H2,1-2H3,(H,19,23)/t9-,10-/s2
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040972
PNG
(CHEMBL3354973)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19Cl2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 15n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040973
PNG
(CHEMBL3354972)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1c(F)cccc1F)C(=O)NC(C)(C)CO |r,wU:1.0,3.4,(21.92,-31.59,;21.53,-33.09,;20.13,-32.44,;20.27,-33.98,;18.93,-33.2,;20.73,-35.45,;22.27,-35.46,;22.76,-34,;22.73,-36.93,;21.48,-37.82,;20.24,-36.9,;18.7,-36.94,;17.97,-38.29,;18.78,-39.6,;16.43,-38.33,;15.62,-37.01,;16.36,-35.65,;17.9,-35.62,;18.65,-34.27,;24.07,-37.69,;24.09,-39.23,;25.4,-36.9,;26.74,-37.66,;27.51,-38.99,;25.97,-38.98,;28.08,-36.88,;29.41,-37.65,)|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)14-11-7-9-6-10(9)15(11)23(22-14)16-12(19)4-3-5-13(16)20/h3-5,9-10,24H,6-8H2,1-2H3,(H,21,25)/t9-,10-/s2
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n/an/an/an/a 2.30E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040985
PNG
(CHEMBL3354960)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CN1CCOCC1 |r|
Show InChI InChI=1/C22H26F2N4O2/c1-22(2,12-27-5-7-30-8-6-27)25-21(29)19-16-10-13-9-15(13)20(16)28(26-19)18-4-3-14(23)11-17(18)24/h3-4,11,13,15H,5-10,12H2,1-2H3,(H,25,29)/t13-,15-/s2
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n/an/an/an/a 0.400n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040977
PNG
(CHEMBL3354968)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-12-8-10-7-11(10)16(12)22(21-15)14-6-4-3-5-13(14)19/h3-6,10-11,23H,7-9H2,1-2H3,(H,20,24)/t10-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040976
PNG
(CHEMBL3354969)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccc(F)c1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-7-10-6-13(10)16(14)22(21-15)12-5-3-4-11(19)8-12/h3-5,8,10,13,23H,6-7,9H2,1-2H3,(H,20,24)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040972
PNG
(CHEMBL3354973)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19Cl2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040999
PNG
(CHEMBL3354944)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccn1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C22H22N4O/c1-22(2,15-8-4-3-5-9-15)24-21(27)19-17-13-14-12-16(14)20(17)26(25-19)18-10-6-7-11-23-18/h3-11,14,16H,12-13H2,1-2H3,(H,24,27)/t14-,16-/s2
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n/an/an/an/a 381n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040996
PNG
(CHEMBL3354947)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccncc1 |r|
Show InChI InChI=1/C22H20F2N4O/c1-22(2,13-5-7-25-8-6-13)26-21(29)19-16-10-12-9-15(12)20(16)28(27-19)18-4-3-14(23)11-17(18)24/h3-8,11-12,15H,9-10H2,1-2H3,(H,26,29)/t12-,15-/s2
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n/an/an/an/a 1.30E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040991
PNG
(CHEMBL3354953)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CC1 |r|
Show InChI InChI=1/C18H17F2N3O2/c19-10-1-2-14(13(20)7-10)23-16-11-5-9(11)6-12(16)15(22-23)17(25)21-18(8-24)3-4-18/h1-2,7,9,11,24H,3-6,8H2,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 47n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040982
PNG
(CHEMBL3354963)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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n/an/an/an/a 39n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040978
PNG
(CHEMBL3354967)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H21N3O2/c1-18(2,10-22)19-17(23)15-14-9-11-8-13(11)16(14)21(20-15)12-6-4-3-5-7-12/h3-7,11,13,22H,8-10H2,1-2H3,(H,19,23)/t11-,13-/s2
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n/an/an/an/a 326n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040971
PNG
(CHEMBL3354974)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C17H20N4O2/c1-17(2,9-22)19-16(23)14-12-8-10-7-11(10)15(12)21(20-14)13-5-3-4-6-18-13/h3-6,10-11,22H,7-9H2,1-2H3,(H,19,23)/t10-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040968
PNG
(CHEMBL3352843)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccncn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,7-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-3-4-17-8-18-12/h3-4,8-10,22H,5-7H2,1-2H3,(H,19,23)/t9-,10-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040961
PNG
(CHEMBL3354952)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-4-3-10(19)7-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040962
PNG
(CHEMBL3354940)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CCN1CCOCC1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H30N4O2/c1-23(2,17-6-4-3-5-7-17)24-22(28)20-19-15-16-14-18(16)21(19)27(25-20)9-8-26-10-12-29-13-11-26/h3-7,16,18H,8-15H2,1-2H3,(H,24,28)/t16-,18-/s2
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n/an/an/an/a 19n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040965
PNG
(CHEMBL3354937)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CC(C)(C)C)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C22H29N3O/c1-21(2,3)13-25-19-16-11-14(16)12-17(19)18(24-25)20(26)23-22(4,5)15-9-7-6-8-10-15/h6-10,14,16H,11-13H2,1-5H3,(H,23,26)/t14-,16-/s2
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n/an/an/an/a 7.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040976
PNG
(CHEMBL3354969)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cccc(F)c1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-7-10-6-13(10)16(14)22(21-15)12-5-3-4-11(19)8-12/h3-5,8,10,13,23H,6-7,9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a 7.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040979
PNG
(CHEMBL3354966)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/s2
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n/an/an/an/a 76n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50040980
PNG
(CHEMBL3354965)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50041001
PNG
(CHEMBL3354942)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C23H21F2N3O/c1-23(2,14-6-4-3-5-7-14)26-22(29)20-17-11-13-10-16(13)21(17)28(27-20)19-9-8-15(24)12-18(19)25/h3-9,12-13,16H,10-11H2,1-2H3,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 0.900n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50041002
PNG
(CHEMBL3354941)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1Cc1ccc(F)cc1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C24H24FN3O/c1-24(2,17-6-4-3-5-7-17)26-23(29)21-20-13-16-12-19(16)22(20)28(27-21)14-15-8-10-18(25)11-9-15/h3-11,16,19H,12-14H2,1-2H3,(H,26,29)/t16-,19-/s2
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n/an/an/an/a 0.200n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50040963
PNG
(CHEMBL3354939)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1CCC1CCOCC1)C(=O)NC(C)(C)c1ccccc1 |r|
Show InChI InChI=1/C24H31N3O2/c1-24(2,18-6-4-3-5-7-18)25-23(28)21-20-15-17-14-19(17)22(20)27(26-21)11-8-16-9-12-29-13-10-16/h3-7,16-17,19H,8-15H2,1-2H3,(H,25,28)/t17-,19-/s2
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n/an/an/an/a 1.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040997
PNG
(CHEMBL3354946)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CC1)c1ccccc1 |r|
Show InChI InChI=1/C23H19F2N3O/c24-15-6-7-19(18(25)12-15)28-21-16-10-13(16)11-17(21)20(27-28)22(29)26-23(8-9-23)14-4-2-1-3-5-14/h1-7,12-13,16H,8-11H2,(H,26,29)/t13-,16-/s2
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n/an/an/an/a 5.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040987
PNG
(CHEMBL3354958)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCOCC1 |r|
Show InChI InChI=1/C19H19F2N3O2/c20-11-1-2-16(15(21)9-11)24-18-13-7-10(13)8-14(18)17(23-24)19(25)22-12-3-5-26-6-4-12/h1-2,9-10,12-13H,3-8H2,(H,22,25)/t10-,13-/s2
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n/an/an/an/a 18n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50040975
PNG
(CHEMBL3354970)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C18H20FN3O2/c1-18(2,9-23)20-17(24)15-14-8-10-7-13(10)16(14)22(21-15)12-5-3-11(19)4-6-12/h3-6,10,13,23H,7-9H2,1-2H3,(H,20,24)/t10-,13-/s2
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n/an/an/an/a 35n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/s2
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n/an/an/an/a 8.90E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50040969
PNG
(CHEMBL3354976)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cnccn1)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1/C16H19N5O2/c1-16(2,8-22)19-15(23)13-11-6-9-5-10(9)14(11)21(20-13)12-7-17-3-4-18-12/h3-4,7,9-10,22H,5-6,8H2,1-2H3,(H,19,23)/t9-,10-/s2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method


Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%