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PubMed code 25556098

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50006228
PNG
(CHEMBL3235056)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@H]2CCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C18H21F3N4O2/c1-17(2,3)13-9-14(24-27-13)23-16(26)12-5-4-8-25(12)15-7-6-11(10-22-15)18(19,20)21/h6-7,9-10,12H,4-5,8H2,1-3H3,(H,23,24,26)/t12-/m1/s1
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n/an/an/an/a 33n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50006233
PNG
(CHEMBL3235059)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C19H23F3N4O2/c1-18(2,3)14-10-15(25-28-14)24-17(27)13-6-4-5-9-26(13)16-8-7-12(11-23-16)19(20,21)22/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,24,25,27)/t13-/m0/s1
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n/an/an/an/a 250n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063904
PNG
(CHEMBL3400940)
Show SMILES CC(C)(C)c1cc(NC(=O)N2CC3CC2CN3C(=O)c2ccc(cc2)C(F)(F)F)no1 |TLB:8:10:16.15:13,17:16:13:10.11|
Show InChI InChI=1/C21H23F3N4O3/c1-20(2,3)16-9-17(26-31-16)25-19(30)28-11-14-8-15(28)10-27(14)18(29)12-4-6-13(7-5-12)21(22,23)24/h4-7,9,14-15H,8,10-11H2,1-3H3,(H,25,26,30)
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n/an/an/an/a>20n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063924
PNG
(CHEMBL3400943)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ncc(cc2Cl)C(F)(F)F)no1 |r|
Show InChI InChI=1/C18H20ClF3N4O2/c1-17(2,3)13-8-14(25-28-13)24-16(27)12-5-4-6-26(12)15-11(19)7-10(9-23-15)18(20,21)22/h7-9,12H,4-6H2,1-3H3,(H,24,25,27)/t12-/s2
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n/an/an/an/a 0.0800n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50341030
PNG
(CHEMBL1762277 | N-(4-butylphenyl)-4-(3-cyclopentyl...)
Show SMILES CCCCc1ccc(NC(=O)N2CCCN(CC2)C(=O)CCC2CCCC2)cc1
Show InChI InChI=1S/C24H37N3O2/c1-2-3-7-21-10-13-22(14-11-21)25-24(29)27-17-6-16-26(18-19-27)23(28)15-12-20-8-4-5-9-20/h10-11,13-14,20H,2-9,12,15-19H2,1H3,(H,25,29)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063928
PNG
(CHEMBL3400947)
Show SMILES CC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)c2ccc(cn2)C(F)(F)F)no1
Show InChI InChI=1S/C17H20F3N3O4S/c1-15(2,3)11-8-12(23-27-11)22-14(24)16(4,5)28(25,26)13-7-6-10(9-21-13)17(18,19)20/h6-9H,1-5H3,(H,22,23,24)
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n/an/an/an/a 420n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50042590
PNG
(CHEMBL3353863)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ccc(Cl)cc2)no1 |r|
Show InChI InChI=1/C18H22ClN3O2/c1-18(2,3)15-11-16(21-24-15)20-17(23)14-5-4-10-22(14)13-8-6-12(19)7-9-13/h6-9,11,14H,4-5,10H2,1-3H3,(H,20,21,23)/t14-/s2
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n/an/an/an/a 0.190n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063925
PNG
(CHEMBL3400944)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@]2(C)CCCN2c2ccc(cc2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C20H24F3N3O2/c1-18(2,3)15-12-16(25-28-15)24-17(27)19(4)10-5-11-26(19)14-8-6-13(7-9-14)20(21,22)23/h6-9,12H,5,10-11H2,1-4H3,(H,24,25,27)/t19-/s2
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n/an/an/an/a 0.290n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063926
PNG
(CHEMBL3400945)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@]2(C)CCCN2c2ccc(Cl)cc2)no1 |r|
Show InChI InChI=1/C19H24ClN3O2/c1-18(2,3)15-12-16(22-25-15)21-17(24)19(4)10-5-11-23(19)14-8-6-13(20)7-9-14/h6-9,12H,5,10-11H2,1-4H3,(H,21,22,24)/t19-/s2
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n/an/an/an/a 54n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063905
PNG
(CHEMBL3400941)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@H]2CCCN2c2ccc(cc2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C19H22F3N3O2/c1-18(2,3)15-11-16(24-27-15)23-17(26)14-5-4-10-25(14)13-8-6-12(7-9-13)19(20,21)22/h6-9,11,14H,4-5,10H2,1-3H3,(H,23,24,26)/t14-/s2
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n/an/an/an/a 99n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063902
PNG
(CHEMBL3400938)
Show SMILES FC(F)(F)c1cc(NC(=O)N2CCCN(CC2)C(=O)c2ccc(cc2)C(F)(F)F)no1
Show InChI InChI=1S/C18H16F6N4O3/c19-17(20,21)12-4-2-11(3-5-12)15(29)27-6-1-7-28(9-8-27)16(30)25-14-10-13(31-26-14)18(22,23)24/h2-5,10H,1,6-9H2,(H,25,26,30)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50006259
PNG
(CHEMBL3234706)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C18H21F3N4O2/c1-17(2,3)13-9-14(24-27-13)23-16(26)12-5-4-8-25(12)15-7-6-11(10-22-15)18(19,20)21/h6-7,9-10,12H,4-5,8H2,1-3H3,(H,23,24,26)/t12-/m0/s1
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n/an/an/an/a 53n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063927
PNG
(CHEMBL3400946)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@]2(C)CCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C19H23F3N4O2/c1-17(2,3)13-10-14(25-28-13)24-16(27)18(4)8-5-9-26(18)15-7-6-12(11-23-15)19(20,21)22/h6-7,10-11H,5,8-9H2,1-4H3,(H,24,25,27)/t18-/s2
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n/an/an/an/a 0.5n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063929
PNG
(CHEMBL3400948)
Show SMILES FC(F)(F)c1cc(NC(=O)N2CCCN(CC2)C(=O)c2ccc(cn2)C(F)(F)F)no1
Show InChI InChI=1S/C17H15F6N5O3/c18-16(19,20)10-2-3-11(24-9-10)14(29)27-4-1-5-28(7-6-27)15(30)25-13-8-12(31-26-13)17(21,22)23/h2-3,8-9H,1,4-7H2,(H,25,26,30)
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n/an/an/an/a 253n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063926
PNG
(CHEMBL3400945)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@]2(C)CCCN2c2ccc(Cl)cc2)no1 |r|
Show InChI InChI=1/C19H24ClN3O2/c1-18(2,3)15-12-16(22-25-15)21-17(24)19(4)10-5-11-23(19)14-8-6-13(20)7-9-14/h6-9,12H,5,10-11H2,1-4H3,(H,21,22,24)/t19-/s2
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n/an/an/an/a 0.210n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063901
PNG
(CHEMBL3400937)
Show SMILES CC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)c2ccc(cc2)C(F)(F)F)no1
Show InChI InChI=1S/C18H21F3N2O4S/c1-16(2,3)13-10-14(23-27-13)22-15(24)17(4,5)28(25,26)12-8-6-11(7-9-12)18(19,20)21/h6-10H,1-5H3,(H,22,23,24)
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n/an/an/an/a 420n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063923
PNG
(CHEMBL3400942)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@H]2CCCN2c2ccc(Cl)cc2)no1 |r|
Show InChI InChI=1/C18H22ClN3O2/c1-18(2,3)15-11-16(21-24-15)20-17(23)14-5-4-10-22(14)13-8-6-12(19)7-9-13/h6-9,11,14H,4-5,10H2,1-3H3,(H,20,21,23)/t14-/s2
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n/an/an/an/a 50n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50006259
PNG
(CHEMBL3234706)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C18H21F3N4O2/c1-17(2,3)13-9-14(24-27-13)23-16(26)12-5-4-8-25(12)15-7-6-11(10-22-15)18(19,20)21/h6-7,9-10,12H,4-5,8H2,1-3H3,(H,23,24,26)/t12-/m0/s1
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n/an/an/an/a 0.0700n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063905
PNG
(CHEMBL3400941)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@H]2CCCN2c2ccc(cc2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C19H22F3N3O2/c1-18(2,3)15-11-16(24-27-15)23-17(26)14-5-4-10-25(14)13-8-6-12(7-9-13)19(20,21)22/h6-9,11,14H,4-5,10H2,1-3H3,(H,23,24,26)/t14-/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063925
PNG
(CHEMBL3400944)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@]2(C)CCCN2c2ccc(cc2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C20H24F3N3O2/c1-18(2,3)15-12-16(25-28-15)24-17(27)19(4)10-5-11-26(19)14-8-6-13(7-9-14)20(21,22)23/h6-9,12H,5,10-11H2,1-4H3,(H,24,25,27)/t19-/s2
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n/an/an/an/a 15n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50006232
PNG
(CHEMBL3235058)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C17H19F3N4O2/c1-16(2,3)12-8-13(23-26-12)22-15(25)11-6-7-24(11)14-5-4-10(9-21-14)17(18,19)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,22,23,25)/t11-/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50341030
PNG
(CHEMBL1762277 | N-(4-butylphenyl)-4-(3-cyclopentyl...)
Show SMILES CCCCc1ccc(NC(=O)N2CCCN(CC2)C(=O)CCC2CCCC2)cc1
Show InChI InChI=1S/C24H37N3O2/c1-2-3-7-21-10-13-22(14-11-21)25-24(29)27-17-6-16-26(18-19-27)23(28)15-12-20-8-4-5-9-20/h10-11,13-14,20H,2-9,12,15-19H2,1H3,(H,25,29)
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n/an/an/an/a 136n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50042591
PNG
(CHEMBL3353862)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ccc(cc2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C19H22F3N3O2/c1-18(2,3)15-11-16(24-27-15)23-17(26)14-5-4-10-25(14)13-8-6-12(7-9-13)19(20,21)22/h6-9,11,14H,4-5,10H2,1-3H3,(H,23,24,26)/t14-/s2
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n/an/an/an/a 0.230n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50006232
PNG
(CHEMBL3235058)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C17H19F3N4O2/c1-16(2,3)12-8-13(23-26-12)22-15(25)11-6-7-24(11)14-5-4-10(9-21-14)17(18,19)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,22,23,25)/t11-/m0/s1
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n/an/an/an/a 1.20n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50006233
PNG
(CHEMBL3235059)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C19H23F3N4O2/c1-18(2,3)14-10-15(25-28-14)24-17(27)13-6-4-5-9-26(13)16-8-7-12(11-23-16)19(20,21)22/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,24,25,27)/t13-/m0/s1
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n/an/an/an/a 0.0900n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50042591
PNG
(CHEMBL3353862)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ccc(cc2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C19H22F3N3O2/c1-18(2,3)15-11-16(24-27-15)23-17(26)14-5-4-10-25(14)13-8-6-12(7-9-13)19(20,21)22/h6-9,11,14H,4-5,10H2,1-3H3,(H,23,24,26)/t14-/s2
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n/an/an/an/a 307n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50042590
PNG
(CHEMBL3353863)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ccc(Cl)cc2)no1 |r|
Show InChI InChI=1/C18H22ClN3O2/c1-18(2,3)15-11-16(21-24-15)20-17(23)14-5-4-10-22(14)13-8-6-12(19)7-9-13/h6-9,11,14H,4-5,10H2,1-3H3,(H,20,21,23)/t14-/s2
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n/an/an/an/a 2.60E+3n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063923
PNG
(CHEMBL3400942)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@H]2CCCN2c2ccc(Cl)cc2)no1 |r|
Show InChI InChI=1/C18H22ClN3O2/c1-18(2,3)15-11-16(21-24-15)20-17(23)14-5-4-10-22(14)13-8-6-12(19)7-9-13/h6-9,11,14H,4-5,10H2,1-3H3,(H,20,21,23)/t14-/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50006228
PNG
(CHEMBL3235056)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@H]2CCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1S/C18H21F3N4O2/c1-17(2,3)13-9-14(24-27-13)23-16(26)12-5-4-8-25(12)15-7-6-11(10-22-15)18(19,20)21/h6-7,9-10,12H,4-5,8H2,1-3H3,(H,23,24,26)/t12-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50063924
PNG
(CHEMBL3400943)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2c2ncc(cc2Cl)C(F)(F)F)no1 |r|
Show InChI InChI=1/C18H20ClF3N4O2/c1-17(2,3)13-8-14(25-28-13)24-16(27)12-5-4-6-26(12)15-11(19)7-10(9-23-15)18(20,21)22/h7-9,12H,4-6H2,1-3H3,(H,24,25,27)/t12-/s2
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n/an/an/an/a 7n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063901
PNG
(CHEMBL3400937)
Show SMILES CC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)c2ccc(cc2)C(F)(F)F)no1
Show InChI InChI=1S/C18H21F3N2O4S/c1-16(2,3)13-10-14(23-27-13)22-15(24)17(4,5)28(25,26)12-8-6-11(7-9-12)18(19,20)21/h6-10H,1-5H3,(H,22,23,24)
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n/an/an/an/a 0.770n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063902
PNG
(CHEMBL3400938)
Show SMILES FC(F)(F)c1cc(NC(=O)N2CCCN(CC2)C(=O)c2ccc(cc2)C(F)(F)F)no1
Show InChI InChI=1S/C18H16F6N4O3/c19-17(20,21)12-4-2-11(3-5-12)15(29)27-6-1-7-28(9-8-27)16(30)25-14-10-13(31-26-14)18(22,23)24/h2-5,10H,1,6-9H2,(H,25,26,30)
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n/an/an/an/a 1.40n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063927
PNG
(CHEMBL3400946)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@]2(C)CCCN2c2ccc(cn2)C(F)(F)F)no1 |r|
Show InChI InChI=1/C19H23F3N4O2/c1-17(2,3)13-10-14(25-28-13)24-16(27)18(4)8-5-9-26(18)15-7-6-12(11-23-15)19(20,21)22/h6-7,10-11H,5,8-9H2,1-4H3,(H,24,25,27)/t18-/s2
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n/an/an/an/a 0.0400n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063928
PNG
(CHEMBL3400947)
Show SMILES CC(C)(C)c1cc(NC(=O)C(C)(C)S(=O)(=O)c2ccc(cn2)C(F)(F)F)no1
Show InChI InChI=1S/C17H20F3N3O4S/c1-15(2,3)11-8-12(23-27-11)22-14(24)16(4,5)28(25,26)13-7-6-10(9-21-13)17(18,19)20/h6-9H,1-5H3,(H,22,23,24)
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n/an/an/an/a 3n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063929
PNG
(CHEMBL3400948)
Show SMILES FC(F)(F)c1cc(NC(=O)N2CCCN(CC2)C(=O)c2ccc(cn2)C(F)(F)F)no1
Show InChI InChI=1S/C17H15F6N5O3/c18-16(19,20)10-2-3-11(24-9-10)14(29)27-4-1-5-28(7-6-27)15(30)25-13-8-12(31-26-13)17(21,22)23/h2-3,8-9H,1,4-7H2,(H,25,26,30)
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n/an/an/an/a 5n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50063903
PNG
(CHEMBL3400939)
Show SMILES CCCCc1ccc(NC(=O)N2CCN(CC2)C(=O)CCC2CCCC2)cc1
Show InChI InChI=1S/C23H35N3O2/c1-2-3-6-20-9-12-21(13-10-20)24-23(28)26-17-15-25(16-18-26)22(27)14-11-19-7-4-5-8-19/h9-10,12-13,19H,2-8,11,14-18H2,1H3,(H,24,28)
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n/an/an/an/a>20n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins


Bioorg Med Chem Lett 25: 575-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.033
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%