Found 22 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101747
(CHEMBL3394946)Show SMILES C[C@H](N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)c1cn(C)c2ccc(cc12)C(F)(F)F |r| Show InChI InChI=1S/C24H22F3N5O2/c1-14-11-30(13-28-14)20-6-7-21-23(34)31(8-9-32(21)22(20)33)15(2)18-12-29(3)19-5-4-16(10-17(18)19)24(25,26)27/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101749
(CHEMBL3394944)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cn(C)c4cc(F)c(cc34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C23H19F4N5O2/c1-13-9-31(12-28-13)18-3-4-19-21(33)30(5-6-32(19)22(18)34)11-14-10-29(2)20-8-17(24)16(7-15(14)20)23(25,26)27/h3-4,7-10,12H,5-6,11H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101748
(CHEMBL3394945)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cn(C)c4c(F)cc(cc34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C23H19F4N5O2/c1-13-9-31(12-28-13)18-3-4-19-21(33)30(5-6-32(19)22(18)34)11-14-10-29(2)20-16(14)7-15(8-17(20)24)23(25,26)27/h3-4,7-10,12H,5-6,11H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101800
(CHEMBL3394934)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C24H22F3N5O2/c1-3-29-12-16(18-10-17(24(25,26)27)4-5-19(18)29)13-30-8-9-32-21(22(30)33)7-6-20(23(32)34)31-11-15(2)28-14-31/h4-7,10-12,14H,3,8-9,13H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103134
(CHEMBL3394928)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cccc4ccc(cc34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H19F3N4O2/c1-15-12-30(14-28-15)20-7-8-21-22(32)29(9-10-31(21)23(20)33)13-17-4-2-3-16-5-6-18(11-19(16)17)24(25,26)27/h2-8,11-12,14H,9-10,13H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101792
(CHEMBL3394942)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cn(C)c4ccc(cc34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C23H20F3N5O2/c1-14-10-30(13-27-14)19-5-6-20-21(32)29(7-8-31(20)22(19)33)12-15-11-28(2)18-4-3-16(9-17(15)18)23(24,25)26/h3-6,9-11,13H,7-8,12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101791
(CHEMBL3394943)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cn(C)c4ccc(c(F)c34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C23H19F4N5O2/c1-13-9-31(12-28-13)17-5-6-18-21(33)30(7-8-32(18)22(17)34)11-14-10-29(2)16-4-3-15(23(25,26)27)20(24)19(14)16/h3-6,9-10,12H,7-8,11H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101801
(CHEMBL3394933)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C23H22ClN5O2/c1-3-26-12-16(18-10-17(24)4-5-19(18)26)13-27-8-9-29-21(22(27)30)7-6-20(23(29)31)28-11-15(2)25-14-28/h4-7,10-12,14H,3,8-9,13H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103135
(CHEMBL3394927)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cccc4ccc(Cl)cc34)CCn2c1=O Show InChI InChI=1S/C23H19ClN4O2/c1-15-12-27(14-25-15)20-7-8-21-22(29)26(9-10-28(21)23(20)30)13-17-4-2-3-16-5-6-18(24)11-19(16)17/h2-8,11-12,14H,9-10,13H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103132
(CHEMBL3394932)Show SMILES COn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C22H20ClN5O3/c1-14-10-26(13-24-14)19-5-6-20-21(29)25(7-8-27(20)22(19)30)11-15-12-28(31-2)18-4-3-16(23)9-17(15)18/h3-6,9-10,12-13H,7-8,11H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101795
(CHEMBL3394939)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(cnc12)C(F)(F)F Show InChI InChI=1S/C23H21F3N6O2/c1-3-29-11-15(17-8-16(23(24,25)26)9-27-20(17)29)12-30-6-7-32-19(21(30)33)5-4-18(22(32)34)31-10-14(2)28-13-31/h4-5,8-11,13H,3,6-7,12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101799
(CHEMBL3394935)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2ccc(cc12)C(F)(F)F Show InChI InChI=1S/C24H22F3N5O2/c1-3-29-12-16(18-5-4-17(10-21(18)29)24(25,26)27)13-30-8-9-32-20(22(30)33)7-6-19(23(32)34)31-11-15(2)28-14-31/h4-7,10-12,14H,3,8-9,13H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103138
(CHEMBL3394931)Show SMILES COn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2ccc(Cl)cc12 Show InChI InChI=1S/C22H20ClN5O3/c1-14-10-26(13-24-14)18-5-6-19-21(29)25(7-8-27(19)22(18)30)11-15-12-28(31-2)20-9-16(23)3-4-17(15)20/h3-6,9-10,12-13H,7-8,11H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103139
(CHEMBL3394930)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3[nH]c4ccc(Cl)cc4c3Cl)CCn2c1=O Show InChI InChI=1S/C21H17Cl2N5O2/c1-12-9-27(11-24-12)17-4-5-18-20(29)26(6-7-28(18)21(17)30)10-16-19(23)14-8-13(22)2-3-15(14)25-16/h2-5,8-9,11,25H,6-7,10H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101794
(CHEMBL3394940)Show SMILES CCn1nc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C23H21F3N6O2/c1-3-32-18-5-4-15(23(24,25)26)10-16(18)17(28-32)12-29-8-9-31-20(21(29)33)7-6-19(22(31)34)30-11-14(2)27-13-30/h4-7,10-11,13H,3,8-9,12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101798
(CHEMBL3394936)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cccc(c12)C(F)(F)F Show InChI InChI=1S/C24H22F3N5O2/c1-3-29-12-16(17-5-4-6-18(21(17)29)24(25,26)27)13-30-9-10-32-20(22(30)33)8-7-19(23(32)34)31-11-15(2)28-14-31/h4-8,11-12,14H,3,9-10,13H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103140
(CHEMBL3394929)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3[nH]c4ccccc4c3Cl)CCn2c1=O Show InChI InChI=1S/C21H18ClN5O2/c1-13-10-26(12-23-13)17-6-7-18-20(28)25(8-9-27(18)21(17)29)11-16-19(22)14-4-2-3-5-15(14)24-16/h2-7,10,12,24H,8-9,11H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
antibodypedia
antibodypedia
antibodypedia
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 207 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103136
(CHEMBL3394926)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cccc4ccccc34)CCn2c1=O Show InChI InChI=1S/C23H20N4O2/c1-16-13-26(15-24-16)20-9-10-21-22(28)25(11-12-27(21)23(20)29)14-18-7-4-6-17-5-2-3-8-19(17)18/h2-10,13,15H,11-12,14H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 234 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101797
(CHEMBL3394937)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C23H21F3N6O2/c1-3-29-11-15(20-16(29)6-7-19(28-20)23(24,25)26)12-30-8-9-32-18(21(30)33)5-4-17(22(32)34)31-10-14(2)27-13-31/h4-7,10-11,13H,3,8-9,12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 361 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50103137
(CHEMBL3394947)Show SMILES C[C@@H](N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)c1cn(C)c2ccc(cc12)C(F)(F)F |r| Show InChI InChI=1S/C24H22F3N5O2/c1-14-11-30(13-28-14)20-6-7-21-23(34)31(8-9-32(21)22(20)33)15(2)18-12-29(3)19-5-4-16(10-17(18)19)24(25,26)27/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m1/s1 | PDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 389 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101796
(CHEMBL3394938)Show SMILES CCn1cc(CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(ncc12)C(F)(F)F Show InChI InChI=1S/C23H21F3N6O2/c1-3-29-11-15(16-8-20(23(24,25)26)27-9-19(16)29)12-30-6-7-32-18(21(30)33)5-4-17(22(32)34)31-10-14(2)28-13-31/h4-5,8-11,13H,3,6-7,12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50101793
(CHEMBL3394941)Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cnn4ccc(cc34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C21H17F3N6O2/c1-13-10-28(12-25-13)16-2-3-17-19(31)27(6-7-29(17)20(16)32)11-14-9-26-30-5-4-15(8-18(14)30)21(22,23)24/h2-5,8-10,12H,6-7,11H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 605 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev... |
Bioorg Med Chem Lett 25: 908-13 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R |
More data for this
Ligand-Target Pair | |
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