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PubMed code 25587631

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50050937
PNG
((S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-b...)
Show SMILES CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
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PubMed
n/an/an/a>300n/an/an/an/an/a



Sorbonne Universit£s

Curated by ChEMBL


Assay Description
Binding affinity to human FPR2 receptor


J Med Chem 58: 1089-99 (2015)


Article DOI: 10.1021/jm501018q
BindingDB Entry DOI: 10.7270/Q2CN75KX
More data for this
Ligand-Target Pair
Formyl peptide receptor-related sequence 1


(Mus musculus)
BDBM50050937
PNG
((S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-b...)
Show SMILES CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
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PubMed
n/an/an/a>300n/an/an/an/an/a



Sorbonne Universit£s

Curated by ChEMBL


Assay Description
Binding affinity to mouse FPR2 receptor


J Med Chem 58: 1089-99 (2015)


Article DOI: 10.1021/jm501018q
BindingDB Entry DOI: 10.7270/Q2CN75KX
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM50050937
PNG
((S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-b...)
Show SMILES CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
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PubMed
n/an/an/a 3n/an/an/an/an/a



Sorbonne Universit£s

Curated by ChEMBL


Assay Description
Binding affinity to human FPR1 receptor


J Med Chem 58: 1089-99 (2015)


Article DOI: 10.1021/jm501018q
BindingDB Entry DOI: 10.7270/Q2CN75KX
More data for this
Ligand-Target Pair
Formyl peptide receptor-related sequence 1


(Mus musculus)
BDBM50071956
PNG
(CHEMBL3407845)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(O)=O |r|
Show InChI InChI=1/C27H51N7O10/c1-14(2)9-18(31-26(42)20(12-36)33-22(38)16(29)11-35)24(40)34-21(13-37)25(41)30-17(7-5-6-8-28)23(39)32-19(27(43)44)10-15(3)4/h14-21,35-37H,5-13,28-29H2,1-4H3,(H,30,41)(H,31,42)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t16-,17-,18-,19-,20-,21-/s2
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n/an/an/an/a 9.00E+3n/an/an/an/a



Sorbonne Universit£s

Curated by ChEMBL


Assay Description
Induction of calcium release in mouse FPR2 receptor-expressed HEK cell by cytosolic-free calcium assay


J Med Chem 58: 1089-99 (2015)


Article DOI: 10.1021/jm501018q
BindingDB Entry DOI: 10.7270/Q2CN75KX
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50071956
PNG
(CHEMBL3407845)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(O)=O |r|
Show InChI InChI=1/C27H51N7O10/c1-14(2)9-18(31-26(42)20(12-36)33-22(38)16(29)11-35)24(40)34-21(13-37)25(41)30-17(7-5-6-8-28)23(39)32-19(27(43)44)10-15(3)4/h14-21,35-37H,5-13,28-29H2,1-4H3,(H,30,41)(H,31,42)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t16-,17-,18-,19-,20-,21-/s2
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PubMed
n/an/an/an/a 7.50E+3n/an/an/an/a



Sorbonne Universit£s

Curated by ChEMBL


Assay Description
Induction of calcium release in human FPR2 receptor-expressed HEK cell by cytosolic-free calcium assay


J Med Chem 58: 1089-99 (2015)


Article DOI: 10.1021/jm501018q
BindingDB Entry DOI: 10.7270/Q2CN75KX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%