Found 4 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50061711
(CHEMBL1365395)Show SMILES Cc1ccc2c(C)nc(Nc3nc(O)cc(CSc4nnnn4-c4ccccc4)n3)nc2c1 Show InChI InChI=1S/C22H19N9OS/c1-13-8-9-17-14(2)23-20(25-18(17)10-13)27-21-24-15(11-19(32)26-21)12-33-22-28-29-30-31(22)16-6-4-3-5-7-16/h3-11H,12H2,1-2H3,(H2,23,24,25,26,27,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University
Curated by ChEMBL
| Assay Description
Inhibition of human full length HER1 assessed as phosphorylation state by ELISA assay |
Bioorg Med Chem Lett 25: 758-62 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.095
BindingDB Entry DOI: 10.7270/Q2RX9DR0 |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50061711
(CHEMBL1365395)Show SMILES Cc1ccc2c(C)nc(Nc3nc(O)cc(CSc4nnnn4-c4ccccc4)n3)nc2c1 Show InChI InChI=1S/C22H19N9OS/c1-13-8-9-17-14(2)23-20(25-18(17)10-13)27-21-24-15(11-19(32)26-21)12-33-22-28-29-30-31(22)16-6-4-3-5-7-16/h3-11H,12H2,1-2H3,(H2,23,24,25,26,27,32) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University
Curated by ChEMBL
| Assay Description
Inhibition of human full length HER2 assessed as phosphorylation state by ELISA assay |
Bioorg Med Chem Lett 25: 758-62 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.095
BindingDB Entry DOI: 10.7270/Q2RX9DR0 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50061709
(CHEMBL3393072)Show InChI InChI=1S/C16H14BrN5OS/c17-12-5-3-7-18-15(12)20-16(24)22-21-14(23)8-10-9-19-13-6-2-1-4-11(10)13/h1-7,9,19H,8H2,(H,21,23)(H2,18,20,22,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University
Curated by ChEMBL
| Assay Description
Inhibition of human full length HER1 assessed as phosphorylation state by ELISA assay |
Bioorg Med Chem Lett 25: 758-62 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.095
BindingDB Entry DOI: 10.7270/Q2RX9DR0 |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50061709
(CHEMBL3393072)Show InChI InChI=1S/C16H14BrN5OS/c17-12-5-3-7-18-15(12)20-16(24)22-21-14(23)8-10-9-19-13-6-2-1-4-11(10)13/h1-7,9,19H,8H2,(H,21,23)(H2,18,20,22,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University
Curated by ChEMBL
| Assay Description
Inhibition of human full length HER2 assessed as phosphorylation state by ELISA assay |
Bioorg Med Chem Lett 25: 758-62 (2015)
Article DOI: 10.1016/j.bmcl.2014.12.095
BindingDB Entry DOI: 10.7270/Q2RX9DR0 |
More data for this
Ligand-Target Pair | |
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