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PubMed code 25699149

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081023
PNG
(CHEMBL3421699)
Show SMILES CCCCCn1cc2c(nn(CC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:19:14:21:18.20.17,19:18:21:13.14.15,THB:17:16:13:19.18.20,17:18:13:21.15.16|
Show InChI InChI=1S/C26H33N3O/c1-2-3-6-9-28-16-22-24(21-7-4-5-8-23(21)28)27-29(25(22)30)17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3
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0.390n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081021
PNG
(CHEMBL3421697)
Show SMILES CCCCCn1cc2c(nn(CC3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H29N3O/c1-2-3-9-14-24-16-19-21(18-12-7-8-13-20(18)24)23-25(22(19)26)15-17-10-5-4-6-11-17/h7-8,12-13,16-17H,2-6,9-11,14-15H2,1H3
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0.620n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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3.10n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081031
PNG
(CHEMBL3421694)
Show SMILES CCCCCn1nc2c(cn(CCCCC)c3ccccc23)c1=O
Show InChI InChI=1S/C20H27N3O/c1-3-5-9-13-22-15-17-19(16-11-7-8-12-18(16)22)21-23(20(17)24)14-10-6-4-2/h7-8,11-12,15H,3-6,9-10,13-14H2,1-2H3
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4.30n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081029
PNG
(CHEMBL3421695)
Show SMILES CCCCCCn1nc2c(cn(CCCCC)c3ccccc23)c1=O
Show InChI InChI=1S/C21H29N3O/c1-3-5-7-11-15-24-21(25)18-16-23(14-10-6-4-2)19-13-9-8-12-17(19)20(18)22-24/h8-9,12-13,16H,3-7,10-11,14-15H2,1-2H3
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7.70n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081022
PNG
(CHEMBL3421698)
Show SMILES CCCCCn1cc2c(nn(CCC3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C23H31N3O/c1-2-3-9-15-25-17-20-22(19-12-7-8-13-21(19)25)24-26(23(20)27)16-14-18-10-5-4-6-11-18/h7-8,12-13,17-18H,2-6,9-11,14-16H2,1H3
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8n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081015
PNG
(CHEMBL3421696)
Show SMILES CCCCCn1cc2c(nn(CC3CC3)c2=O)c2ccccc12
Show InChI InChI=1S/C19H23N3O/c1-2-3-6-11-21-13-16-18(15-7-4-5-8-17(15)21)20-22(19(16)23)12-14-9-10-14/h4-5,7-8,13-14H,2-3,6,9-12H2,1H3
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10n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081028
PNG
(CHEMBL3421689)
Show SMILES CCCCCn1cc2c(nn(C3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C21H27N3O/c1-2-3-9-14-23-15-18-20(17-12-7-8-13-19(17)23)22-24(21(18)25)16-10-5-4-6-11-16/h7-8,12-13,15-16H,2-6,9-11,14H2,1H3
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19n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50224062
PNG
(CHEMBL235487 | N3-((1-adamantyl)methyl)-4-oxo-1-pe...)
Show SMILES CCCCCn1cc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c(=O)c2ccccc12 |TLB:11:12:15:19.17.18,THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18|
Show InChI InChI=1S/C26H34N2O2/c1-2-3-6-9-28-16-22(24(29)21-7-4-5-8-23(21)28)25(30)27-17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3,(H,27,30)
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22n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081024
PNG
(CHEMBL3421700)
Show SMILES CCCCCn1cc2c(nn(CCC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:20:15:22:19.21.18,20:19:22:14.15.16,THB:18:17:14:20.19.21,18:19:14:22.16.17|
Show InChI InChI=1S/C27H35N3O/c1-2-3-6-10-29-18-23-25(22-7-4-5-8-24(22)29)28-30(26(23)31)11-9-27-15-19-12-20(16-27)14-21(13-19)17-27/h4-5,7-8,18-21H,2-3,6,9-17H2,1H3
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26n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081041
PNG
(CHEMBL3421688)
Show SMILES CCCCCn1cc2c(nn(-c3cccc(c3)C(F)(F)F)c2=O)c2ccccc12
Show InChI InChI=1S/C22H20F3N3O/c1-2-3-6-12-27-14-18-20(17-10-4-5-11-19(17)27)26-28(21(18)29)16-9-7-8-15(13-16)22(23,24)25/h4-5,7-11,13-14H,2-3,6,12H2,1H3
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29n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50397385
PNG
(CHEMBL2170529)
Show SMILES CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c(-c2ccncc2)c1C |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11|
Show InChI InChI=1S/C27H35N3O2/c1-3-4-5-10-30-17-23(25(31)24(18(30)2)22-6-8-28-9-7-22)26(32)29-27-14-19-11-20(15-27)13-21(12-19)16-27/h6-9,17,19-21H,3-5,10-16H2,1-2H3,(H,29,32)
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37n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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52n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50397385
PNG
(CHEMBL2170529)
Show SMILES CCCCCn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(=O)c(-c2ccncc2)c1C |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11|
Show InChI InChI=1S/C27H35N3O2/c1-3-4-5-10-30-17-23(25(31)24(18(30)2)22-6-8-28-9-7-22)26(32)29-27-14-19-11-20(15-27)13-21(12-19)16-27/h6-9,17,19-21H,3-5,10-16H2,1-2H3,(H,29,32)
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081045
PNG
(CHEMBL3421686)
Show SMILES CCCCCn1cc2c(nn(-c3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C21H21N3O/c1-2-3-9-14-23-15-18-20(17-12-7-8-13-19(17)23)22-24(21(18)25)16-10-5-4-6-11-16/h4-8,10-13,15H,2-3,9,14H2,1H3
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1.37E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50224062
PNG
(CHEMBL235487 | N3-((1-adamantyl)methyl)-4-oxo-1-pe...)
Show SMILES CCCCCn1cc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c(=O)c2ccccc12 |TLB:11:12:15:19.17.18,THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18|
Show InChI InChI=1S/C26H34N2O2/c1-2-3-6-9-28-16-22(24(29)21-7-4-5-8-23(21)28)25(30)27-17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3,(H,27,30)
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081032
PNG
(CHEMBL3421693)
Show SMILES CCCCCn1cc2c(nn(CCCc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C24H27N3O/c1-2-3-9-16-26-18-21-23(20-14-7-8-15-22(20)26)25-27(24(21)28)17-10-13-19-11-5-4-6-12-19/h4-8,11-12,14-15,18H,2-3,9-10,13,16-17H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081036
PNG
(CHEMBL3421691)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(CCCc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C30H31N3O/c1-2-3-12-21-32-26-20-11-10-19-25(26)28-27(29(32)24-17-8-5-9-18-24)30(34)33(31-28)22-13-16-23-14-6-4-7-15-23/h4-11,14-15,17-20H,2-3,12-13,16,21-22H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081045
PNG
(CHEMBL3421686)
Show SMILES CCCCCn1cc2c(nn(-c3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C21H21N3O/c1-2-3-9-14-23-15-18-20(17-12-7-8-13-19(17)23)22-24(21(18)25)16-10-5-4-6-11-16/h4-8,10-13,15H,2-3,9,14H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081046
PNG
(CHEMBL3421685)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(-c3cccc(c3)C(F)(F)F)c2=O)c2ccccc12
Show InChI InChI=1S/C28H24F3N3O/c1-2-3-9-17-33-23-16-8-7-15-22(23)25-24(26(33)19-11-5-4-6-12-19)27(35)34(32-25)21-14-10-13-20(18-21)28(29,30)31/h4-8,10-16,18H,2-3,9,17H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081043
PNG
(CHEMBL3421687)
Show SMILES CCCCCn1cc2c(nn(-c3ccc(OC)cc3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-3-4-7-14-24-15-19-21(18-8-5-6-9-20(18)24)23-25(22(19)26)16-10-12-17(27-2)13-11-16/h5-6,8-13,15H,3-4,7,14H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081021
PNG
(CHEMBL3421697)
Show SMILES CCCCCn1cc2c(nn(CC3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H29N3O/c1-2-3-9-14-24-16-19-21(18-12-7-8-13-20(18)24)23-25(22(19)26)15-17-10-5-4-6-11-17/h7-8,12-13,16-17H,2-6,9-11,14-15H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081022
PNG
(CHEMBL3421698)
Show SMILES CCCCCn1cc2c(nn(CCC3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C23H31N3O/c1-2-3-9-15-25-17-20-22(19-12-7-8-13-21(19)25)24-26(23(20)27)16-14-18-10-5-4-6-11-18/h7-8,12-13,17-18H,2-6,9-11,14-16H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081039
PNG
(CHEMBL3421690)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(Cc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C28H27N3O/c1-2-3-12-19-30-24-18-11-10-17-23(24)26-25(27(30)22-15-8-5-9-16-22)28(32)31(29-26)20-21-13-6-4-7-14-21/h4-11,13-18H,2-3,12,19-20H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081028
PNG
(CHEMBL3421689)
Show SMILES CCCCCn1cc2c(nn(C3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C21H27N3O/c1-2-3-9-14-23-15-18-20(17-12-7-8-13-19(17)23)22-24(21(18)25)16-10-5-4-6-11-16/h7-8,12-13,15-16H,2-6,9-11,14H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081041
PNG
(CHEMBL3421688)
Show SMILES CCCCCn1cc2c(nn(-c3cccc(c3)C(F)(F)F)c2=O)c2ccccc12
Show InChI InChI=1S/C22H20F3N3O/c1-2-3-6-12-27-14-18-20(17-10-4-5-11-19(17)27)26-28(21(18)29)16-9-7-8-15(13-16)22(23,24)25/h4-5,7-11,13-14H,2-3,6,12H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081043
PNG
(CHEMBL3421687)
Show SMILES CCCCCn1cc2c(nn(-c3ccc(OC)cc3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H23N3O2/c1-3-4-7-14-24-15-19-21(18-8-5-6-9-20(18)24)23-25(22(19)26)16-10-12-17(27-2)13-11-16/h5-6,8-13,15H,3-4,7,14H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081039
PNG
(CHEMBL3421690)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(Cc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C28H27N3O/c1-2-3-12-19-30-24-18-11-10-17-23(24)26-25(27(30)22-15-8-5-9-16-22)28(32)31(29-26)20-21-13-6-4-7-14-21/h4-11,13-18H,2-3,12,19-20H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081036
PNG
(CHEMBL3421691)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(CCCc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C30H31N3O/c1-2-3-12-21-32-26-20-11-10-19-25(26)28-27(29(32)24-17-8-5-9-18-24)30(34)33(31-28)22-13-16-23-14-6-4-7-15-23/h4-11,14-15,17-20H,2-3,12-13,16,21-22H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081033
PNG
(CHEMBL3421692)
Show SMILES CCCCCn1cc2c(nn(Cc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H23N3O/c1-2-3-9-14-24-16-19-21(18-12-7-8-13-20(18)24)23-25(22(19)26)15-17-10-5-4-6-11-17/h4-8,10-13,16H,2-3,9,14-15H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081024
PNG
(CHEMBL3421700)
Show SMILES CCCCCn1cc2c(nn(CCC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:20:15:22:19.21.18,20:19:22:14.15.16,THB:18:17:14:20.19.21,18:19:14:22.16.17|
Show InChI InChI=1S/C27H35N3O/c1-2-3-6-10-29-18-23-25(22-7-4-5-8-24(22)29)28-30(26(23)31)11-9-27-15-19-12-20(16-27)14-21(13-19)17-27/h4-5,7-8,18-21H,2-3,6,9-17H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50080944
PNG
(CHEMBL3421684)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(-c3ccc(OC)cc3)c2=O)c2ccccc12
Show InChI InChI=1S/C28H27N3O2/c1-3-4-10-19-30-24-14-9-8-13-23(24)26-25(27(30)20-11-6-5-7-12-20)28(32)31(29-26)21-15-17-22(33-2)18-16-21/h5-9,11-18H,3-4,10,19H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081014
PNG
(CHEMBL3421681)
Show SMILES CCCCCn1cc2c(n[nH]c2=O)c2ccccc12
Show InChI InChI=1S/C15H17N3O/c1-2-3-6-9-18-10-12-14(16-17-15(12)19)11-7-4-5-8-13(11)18/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,17,19)
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081000
PNG
(CHEMBL3421682)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(n[nH]c2=O)c2ccccc12
Show InChI InChI=1S/C21H21N3O/c1-2-3-9-14-24-17-13-8-7-12-16(17)19-18(21(25)23-22-19)20(24)15-10-5-4-6-11-15/h4-8,10-13H,2-3,9,14H2,1H3,(H,23,25)
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50080946
PNG
(CHEMBL3421683)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(-c3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C27H25N3O/c1-2-3-12-19-29-23-18-11-10-17-22(23)25-24(26(29)20-13-6-4-7-14-20)27(31)30(28-25)21-15-8-5-9-16-21/h4-11,13-18H,2-3,12,19H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081014
PNG
(CHEMBL3421681)
Show SMILES CCCCCn1cc2c(n[nH]c2=O)c2ccccc12
Show InChI InChI=1S/C15H17N3O/c1-2-3-6-9-18-10-12-14(16-17-15(12)19)11-7-4-5-8-13(11)18/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,17,19)
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081000
PNG
(CHEMBL3421682)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(n[nH]c2=O)c2ccccc12
Show InChI InChI=1S/C21H21N3O/c1-2-3-9-14-24-17-13-8-7-12-16(17)19-18(21(25)23-22-19)20(24)15-10-5-4-6-11-15/h4-8,10-13H,2-3,9,14H2,1H3,(H,23,25)
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081032
PNG
(CHEMBL3421693)
Show SMILES CCCCCn1cc2c(nn(CCCc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C24H27N3O/c1-2-3-9-16-26-18-21-23(20-14-7-8-15-22(20)26)25-27(24(21)28)17-10-13-19-11-5-4-6-12-19/h4-8,11-12,14-15,18H,2-3,9-10,13,16-17H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081033
PNG
(CHEMBL3421692)
Show SMILES CCCCCn1cc2c(nn(Cc3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H23N3O/c1-2-3-9-14-24-16-19-21(18-12-7-8-13-20(18)24)23-25(22(19)26)15-17-10-5-4-6-11-17/h4-8,10-13,16H,2-3,9,14-15H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50080944
PNG
(CHEMBL3421684)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(-c3ccc(OC)cc3)c2=O)c2ccccc12
Show InChI InChI=1S/C28H27N3O2/c1-3-4-10-19-30-24-14-9-8-13-23(24)26-25(27(30)20-11-6-5-7-12-20)28(32)31(29-26)21-15-17-22(33-2)18-16-21/h5-9,11-18H,3-4,10,19H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081046
PNG
(CHEMBL3421685)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(-c3cccc(c3)C(F)(F)F)c2=O)c2ccccc12
Show InChI InChI=1S/C28H24F3N3O/c1-2-3-9-17-33-23-16-8-7-15-22(23)25-24(26(33)19-11-5-4-6-12-19)27(35)34(32-25)21-14-10-13-20(18-21)28(29,30)31/h4-8,10-16,18H,2-3,9,17H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081031
PNG
(CHEMBL3421694)
Show SMILES CCCCCn1nc2c(cn(CCCCC)c3ccccc23)c1=O
Show InChI InChI=1S/C20H27N3O/c1-3-5-9-13-22-15-17-19(16-11-7-8-12-18(16)22)21-23(20(17)24)14-10-6-4-2/h7-8,11-12,15H,3-6,9-10,13-14H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081023
PNG
(CHEMBL3421699)
Show SMILES CCCCCn1cc2c(nn(CC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:19:14:21:18.20.17,19:18:21:13.14.15,THB:17:16:13:19.18.20,17:18:13:21.15.16|
Show InChI InChI=1S/C26H33N3O/c1-2-3-6-9-28-16-22-24(21-7-4-5-8-23(21)28)27-29(25(22)30)17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081015
PNG
(CHEMBL3421696)
Show SMILES CCCCCn1cc2c(nn(CC3CC3)c2=O)c2ccccc12
Show InChI InChI=1S/C19H23N3O/c1-2-3-6-11-21-13-16-18(15-7-4-5-8-17(15)21)20-22(19(16)23)12-14-9-10-14/h4-5,7-8,13-14H,2-3,6,9-12H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50080946
PNG
(CHEMBL3421683)
Show SMILES CCCCCn1c(-c2ccccc2)c2c(nn(-c3ccccc3)c2=O)c2ccccc12
Show InChI InChI=1S/C27H25N3O/c1-2-3-12-19-29-23-18-11-10-17-22(23)25-24(26(29)20-13-6-4-7-14-20)27(31)30(28-25)21-15-8-5-9-16-21/h4-11,13-18H,2-3,12,19H2,1H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB2 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50081029
PNG
(CHEMBL3421695)
Show SMILES CCCCCCn1nc2c(cn(CCCCC)c3ccccc23)c1=O
Show InChI InChI=1S/C21H29N3O/c1-3-5-7-11-15-24-21(25)18-16-23(14-10-6-4-2)19-13-9-8-12-17(19)20(18)22-24/h8-9,12-13,16H,3-7,10-11,14-15H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55940 from human CB1 receptor after 1 hr by scintillation counting analysis


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081022
PNG
(CHEMBL3421698)
Show SMILES CCCCCn1cc2c(nn(CCC3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C23H31N3O/c1-2-3-9-15-25-17-20-22(19-12-7-8-13-21(19)25)24-26(23(20)27)16-14-18-10-5-4-6-11-18/h7-8,12-13,17-18H,2-6,9-11,14-16H2,1H3
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n/an/an/an/a 5.40n/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assay


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081021
PNG
(CHEMBL3421697)
Show SMILES CCCCCn1cc2c(nn(CC3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C22H29N3O/c1-2-3-9-14-24-16-19-21(18-12-7-8-13-20(18)24)23-25(22(19)26)15-17-10-5-4-6-11-17/h7-8,12-13,16-17H,2-6,9-11,14-15H2,1H3
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n/an/an/an/a 14n/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assay


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081023
PNG
(CHEMBL3421699)
Show SMILES CCCCCn1cc2c(nn(CC34CC5CC(CC(C5)C3)C4)c2=O)c2ccccc12 |TLB:19:14:21:18.20.17,19:18:21:13.14.15,THB:17:16:13:19.18.20,17:18:13:21.15.16|
Show InChI InChI=1S/C26H33N3O/c1-2-3-6-9-28-16-22-24(21-7-4-5-8-23(21)28)27-29(25(22)30)17-26-13-18-10-19(14-26)12-20(11-18)15-26/h4-5,7-8,16,18-20H,2-3,6,9-15,17H2,1H3
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n/an/an/an/a 64n/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assay


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50081028
PNG
(CHEMBL3421689)
Show SMILES CCCCCn1cc2c(nn(C3CCCCC3)c2=O)c2ccccc12
Show InChI InChI=1S/C21H27N3O/c1-2-3-9-14-23-15-18-20(17-12-7-8-13-19(17)23)22-24(21(18)25)16-10-5-4-6-11-16/h7-8,12-13,15-16H,2-6,9-11,14H2,1H3
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n/an/an/an/a 204n/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assay


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assay


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50180022
PNG
(5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1...)
Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2C3(C)CCC(C3)C2(C)C)cc1 |THB:21:22:26.25:28|
Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)
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n/an/an/an/a 1.80n/an/an/an/a



Universit£ de Lille Nord de France

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor after 1 hr by [35S]-GTPgammaS binding assay


ACS Med Chem Lett 6: 198-203 (2015)


Article DOI: 10.1021/ml500439x
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%