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PubMed code 25797163

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066836
PNG
(CHEMBL3401617)
Show SMILES CCN(CC)c1ccc(CCNC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C21H24ClN3O/c1-3-25(4-2)18-8-5-15(6-9-18)11-12-23-21(26)20-14-16-13-17(22)7-10-19(16)24-20/h5-10,13-14,24H,3-4,11-12H2,1-2H3,(H,23,26)
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n/an/a 79n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066834
PNG
(CHEMBL3401615)
Show SMILES CCN(CC)c1ccc(CCNC(=O)c2[nH]c3ccc(F)cc3c2C)cc1
Show InChI InChI=1S/C22H26FN3O/c1-4-26(5-2)18-9-6-16(7-10-18)12-13-24-22(27)21-15(3)19-14-17(23)8-11-20(19)25-21/h6-11,14,25H,4-5,12-13H2,1-3H3,(H,24,27)
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n/an/a 151n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066832
PNG
(CHEMBL3401613)
Show SMILES CCc1c([nH]c2ccc(F)cc12)C(=O)NCCc1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H24FN3O/c1-4-17-18-13-15(22)7-10-19(18)24-20(17)21(26)23-12-11-14-5-8-16(9-6-14)25(2)3/h5-10,13,24H,4,11-12H2,1-3H3,(H,23,26)
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n/an/a 205n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50389935
PNG
(CHEMBL2071071)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NCCc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C22H24ClN3O/c23-18-6-9-20-17(14-18)15-21(25-20)22(27)24-11-10-16-4-7-19(8-5-16)26-12-2-1-3-13-26/h4-9,14-15,25H,1-3,10-13H2,(H,24,27)
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n/an/a 212n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066838
PNG
(CHEMBL3401619)
Show SMILES Cc1c([nH]c2ccc(F)cc12)C(=O)NCCc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C23H26FN3O/c1-16-20-15-18(24)7-10-21(20)26-22(16)23(28)25-12-11-17-5-8-19(9-6-17)27-13-3-2-4-14-27/h5-10,15,26H,2-4,11-14H2,1H3,(H,25,28)
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n/an/a 279n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066835
PNG
(CHEMBL3401616)
Show SMILES CCN(CC)c1ccc(CCNC(=O)c2cc3cc(F)ccc3[nH]2)cc1
Show InChI InChI=1S/C21H24FN3O/c1-3-25(4-2)18-8-5-15(6-9-18)11-12-23-21(26)20-14-16-13-17(22)7-10-19(16)24-20/h5-10,13-14,24H,3-4,11-12H2,1-2H3,(H,23,26)
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n/an/a 318n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066839
PNG
(CHEMBL3401620)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C22H24FN3O/c23-18-6-9-20-17(14-18)15-21(25-20)22(27)24-11-10-16-4-7-19(8-5-16)26-12-2-1-3-13-26/h4-9,14-15,25H,1-3,10-13H2,(H,24,27)
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n/an/a 319n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066833
PNG
(CHEMBL3401614)
Show SMILES CCN(CC)c1ccc(CCNC(=O)c2[nH]c3ccc(F)cc3c2CC)cc1
Show InChI InChI=1S/C23H28FN3O/c1-4-19-20-15-17(24)9-12-21(20)26-22(19)23(28)25-14-13-16-7-10-18(11-8-16)27(5-2)6-3/h7-12,15,26H,4-6,13-14H2,1-3H3,(H,25,28)
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n/an/a 361n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066793
PNG
(CHEMBL3400533)
Show SMILES CCN(CC)c1ccc(CCNC(=O)c2[nH]c3ccc(Cl)cc3c2CC)cc1
Show InChI InChI=1S/C23H28ClN3O/c1-4-19-20-15-17(24)9-12-21(20)26-22(19)23(28)25-14-13-16-7-10-18(11-8-16)27(5-2)6-3/h7-12,15,26H,4-6,13-14H2,1-3H3,(H,25,28)
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n/an/a 483n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066837
PNG
(CHEMBL3401618)
Show SMILES CCc1c([nH]c2ccc(F)cc12)C(=O)NCCc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C24H28FN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
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n/an/a 605n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50389928
PNG
(CHEMBL2071063)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H24ClN3O/c1-4-17-18-13-15(22)7-10-19(18)24-20(17)21(26)23-12-11-14-5-8-16(9-6-14)25(2)3/h5-10,13,24H,4,11-12H2,1-3H3,(H,23,26)
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n/an/a 787n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066804
PNG
(CHEMBL3401603)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1cccc(Cl)c1
Show InChI InChI=1S/C19H18Cl2N2O/c1-2-15-16-11-14(21)6-7-17(16)23-18(15)19(24)22-9-8-12-4-3-5-13(20)10-12/h3-7,10-11,23H,2,8-9H2,1H3,(H,22,24)
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n/an/a 831n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50389939
PNG
(CHEMBL1553629)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
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n/an/a 853n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066794
PNG
(CHEMBL3400534)
Show SMILES CCCN(CCC)c1ccc(CCNC(=O)c2[nH]c3ccc(Cl)cc3c2CC)cc1
Show InChI InChI=1S/C25H32ClN3O/c1-4-15-29(16-5-2)20-10-7-18(8-11-20)13-14-27-25(30)24-21(6-3)22-17-19(26)9-12-23(22)28-24/h7-12,17,28H,4-6,13-16H2,1-3H3,(H,27,30)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066805
PNG
(CHEMBL3401604)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1cccc(OC)c1
Show InChI InChI=1S/C20H21ClN2O2/c1-3-16-17-12-14(21)7-8-18(17)23-19(16)20(24)22-10-9-13-5-4-6-15(11-13)25-2/h4-8,11-12,23H,3,9-10H2,1-2H3,(H,22,24)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066808
PNG
(CHEMBL3401607)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H17Cl3N2O/c1-2-13-14-10-12(20)4-6-17(14)24-18(13)19(25)23-8-7-11-3-5-15(21)16(22)9-11/h3-6,9-10,24H,2,7-8H2,1H3,(H,23,25)
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n/an/a 2.17E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066802
PNG
(CHEMBL3400542)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C23H27ClN2O/c1-5-18-19-14-17(24)10-11-20(19)26-21(18)22(27)25-13-12-15-6-8-16(9-7-15)23(2,3)4/h6-11,14,26H,5,12-13H2,1-4H3,(H,25,27)
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n/an/a 2.43E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50389930
PNG
(CHEMBL2071065)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H18Cl2N2O/c1-2-15-16-11-14(21)7-8-17(16)23-18(15)19(24)22-10-9-12-3-5-13(20)6-4-12/h3-8,11,23H,2,9-10H2,1H3,(H,22,24)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066801
PNG
(CHEMBL3400541)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(OC)cc1
Show InChI InChI=1S/C20H21ClN2O2/c1-3-16-17-12-14(21)6-9-18(17)23-19(16)20(24)22-11-10-13-4-7-15(25-2)8-5-13/h4-9,12,23H,3,10-11H2,1-2H3,(H,22,24)
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n/an/a 2.56E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066800
PNG
(CHEMBL3400540)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C19H19ClN2O/c1-2-15-16-12-14(20)8-9-17(16)22-18(15)19(23)21-11-10-13-6-4-3-5-7-13/h3-9,12,22H,2,10-11H2,1H3,(H,21,23)
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n/an/a 3.15E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066795
PNG
(CHEMBL3400535)
Show SMILES CCCCCCNc1ccc(CCNC(=O)c2[nH]c3ccc(Cl)cc3c2CC)cc1
Show InChI InChI=1S/C25H32ClN3O/c1-3-5-6-7-15-27-20-11-8-18(9-12-20)14-16-28-25(30)24-21(4-2)22-17-19(26)10-13-23(22)29-24/h8-13,17,27,29H,3-7,14-16H2,1-2H3,(H,28,30)
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n/an/a 3.62E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066815
PNG
(CHEMBL3401608)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc2OCOc2c1
Show InChI InChI=1S/C20H19ClN2O3/c1-2-14-15-10-13(21)4-5-16(15)23-19(14)20(24)22-8-7-12-3-6-17-18(9-12)26-11-25-17/h3-6,9-10,23H,2,7-8,11H2,1H3,(H,22,24)
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n/an/a 4.32E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066828
PNG
(CHEMBL3401609)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NC1CCN(Cc2ccccc2)C1
Show InChI InChI=1/C22H24ClN3O/c1-2-18-19-12-16(23)8-9-20(19)25-21(18)22(27)24-17-10-11-26(14-17)13-15-6-4-3-5-7-15/h3-9,12,17,25H,2,10-11,13-14H2,1H3,(H,24,27)
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n/an/a 4.76E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50389925
PNG
(CHEMBL2071060)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H18ClN3O3/c1-2-15-16-11-13(20)5-8-17(16)22-18(15)19(24)21-10-9-12-3-6-14(7-4-12)23(25)26/h3-8,11,22H,2,9-10H2,1H3,(H,21,24)
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n/an/a 5.74E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066803
PNG
(CHEMBL3401602)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccccc1Cl
Show InChI InChI=1S/C19H18Cl2N2O/c1-2-14-15-11-13(20)7-8-17(15)23-18(14)19(24)22-10-9-12-5-3-4-6-16(12)21/h3-8,11,23H,2,9-10H2,1H3,(H,22,24)
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n/an/a 5.81E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066829
PNG
(CHEMBL3401610)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)Nc1cccc(c1)-c1cccc(n1)N(C)C
Show InChI InChI=1S/C24H23ClN4O/c1-4-18-19-14-16(25)11-12-21(19)28-23(18)24(30)26-17-8-5-7-15(13-17)20-9-6-10-22(27-20)29(2)3/h5-14,28H,4H2,1-3H3,(H,26,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066807
PNG
(CHEMBL3401606)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(OC)c(O)c1
Show InChI InChI=1S/C20H21ClN2O3/c1-3-14-15-11-13(21)5-6-16(15)23-19(14)20(25)22-9-8-12-4-7-18(26-2)17(24)10-12/h4-7,10-11,23-24H,3,8-9H2,1-2H3,(H,22,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066797
PNG
(CHEMBL3400537)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C21H22ClN3O2/c1-3-17-18-12-15(22)6-9-19(18)25-20(17)21(27)23-11-10-14-4-7-16(8-5-14)24-13(2)26/h4-9,12,25H,3,10-11H2,1-2H3,(H,23,27)(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066796
PNG
(CHEMBL3400536)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1cccc(c1)N(C)C
Show InChI InChI=1S/C21H24ClN3O/c1-4-17-18-13-15(22)8-9-19(18)24-20(17)21(26)23-11-10-14-6-5-7-16(12-14)25(2)3/h5-9,12-13,24H,4,10-11H2,1-3H3,(H,23,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066830
PNG
(CHEMBL3401611)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H22ClN3O/c1-2-17-18-14-15(22)8-9-19(18)23-20(17)21(26)25-12-10-24(11-13-25)16-6-4-3-5-7-16/h3-9,14,23H,2,10-13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066798
PNG
(CHEMBL3400538)
Show SMILES CCCC(=O)Nc1ccc(CCNC(=O)c2[nH]c3ccc(Cl)cc3c2CC)cc1
Show InChI InChI=1S/C23H26ClN3O2/c1-3-5-21(28)26-17-9-6-15(7-10-17)12-13-25-23(29)22-18(4-2)19-14-16(24)8-11-20(19)27-22/h6-11,14,27H,3-5,12-13H2,1-2H3,(H,25,29)(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066831
PNG
(CHEMBL3401612)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)N1CCN(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21Cl2N3O/c1-2-17-18-13-15(23)5-8-19(18)24-20(17)21(27)26-11-9-25(10-12-26)16-6-3-14(22)4-7-16/h3-8,13,24H,2,9-12H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066799
PNG
(CHEMBL3400539)
Show SMILES CCCCCC(=O)Nc1ccc(CCNC(=O)c2[nH]c3ccc(Cl)cc3c2CC)cc1
Show InChI InChI=1S/C25H30ClN3O2/c1-3-5-6-7-23(30)28-19-11-8-17(9-12-19)14-15-27-25(31)24-20(4-2)21-16-18(26)10-13-22(21)29-24/h8-13,16,29H,3-7,14-15H2,1-2H3,(H,27,31)(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50066806
PNG
(CHEMBL3401605)
Show SMILES CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1cccc(O)c1
Show InChI InChI=1S/C19H19ClN2O2/c1-2-15-16-11-13(20)6-7-17(16)22-18(15)19(24)21-9-8-12-4-3-5-14(23)10-12/h3-7,10-11,22-23H,2,8-9H2,1H3,(H,21,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells assessed as inhibition of CP55940-induced calcium mobilization incubated fo...


Bioorg Med Chem 23: 2195-203 (2015)


Article DOI: 10.1016/j.bmc.2015.02.058
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%