Found 55 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068283
(CHEMBL3403371)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H26N4O2S/c1-4-26-21(28)19-18(24-22(26)23-14(2)3)17(13-29-19)16-10-11-25(12-16)20(27)15-8-6-5-7-9-15/h5-9,13-14,16H,4,10-12H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068285
(CHEMBL3403372)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccn1 Show InChI InChI=1S/C21H25N5O2S/c1-4-26-20(28)18-17(24-21(26)23-13(2)3)15(12-29-18)14-8-10-25(11-14)19(27)16-7-5-6-9-22-16/h5-7,9,12-14H,4,8,10-11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068287
(CHEMBL3403346)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1cccc(C)n1 Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)23-13(2)3)16(12-30-19)15-9-10-26(11-15)20(28)17-8-6-7-14(4)24-17/h6-8,12-13,15H,5,9-11H2,1-4H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068277
(CHEMBL3403358)Show InChI InChI=1S/C16H18N4OS/c1-4-20-15(21)14-13(19-16(20)18-10(2)3)12(9-22-14)11-6-5-7-17-8-11/h5-10H,4H2,1-3H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068261
(CHEMBL3403361)Show InChI InChI=1S/C17H20N4O2S/c1-5-21-16(22)15-14(20-17(21)19-10(2)3)12(9-24-15)11-6-7-18-13(8-11)23-4/h6-10H,5H2,1-4H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068256
(CHEMBL3403367)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCCN(C1)C(C)=O Show InChI InChI=1S/C18H26N4O2S/c1-5-22-17(24)16-15(20-18(22)19-11(2)3)14(10-25-16)13-7-6-8-21(9-13)12(4)23/h10-11,13H,5-9H2,1-4H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068282
(CHEMBL3403360)Show InChI InChI=1S/C16H20N4OS2/c1-6-20-15(21)14-12(19-16(20)17-8(2)3)11(7-22-14)13-9(4)18-10(5)23-13/h7-8H,6H2,1-5H3,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068254
(CHEMBL3403365)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C21H27N5OS/c1-4-26-20(27)19-18(24-21(26)23-14(2)3)16(13-28-19)15-8-11-25(12-9-15)17-7-5-6-10-22-17/h5-7,10,13-15H,4,8-9,11-12H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068262
(CHEMBL3403362)Show InChI InChI=1S/C15H17N5OS/c1-4-20-14(21)13-12(19-15(20)18-9(2)3)11(7-22-13)10-5-16-8-17-6-10/h5-9H,4H2,1-3H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068260
(CHEMBL3403370)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)CC(C)C Show InChI InChI=1S/C20H30N4O2S/c1-6-24-19(26)18-17(22-20(24)21-13(4)5)15(11-27-18)14-7-8-23(10-14)16(25)9-12(2)3/h11-14H,6-10H2,1-5H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068259
(CHEMBL3403369)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)C(C)C Show InChI InChI=1S/C19H28N4O2S/c1-6-23-18(25)16-15(21-19(23)20-12(4)5)14(10-26-16)13-7-8-22(9-13)17(24)11(2)3/h10-13H,6-9H2,1-5H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068281
(CHEMBL3403359)Show InChI InChI=1S/C15H17N3O2S/c1-4-18-14(19)13-12(17-15(18)16-9(2)3)10(8-21-13)11-6-5-7-20-11/h5-9H,4H2,1-3H3,(H,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068257
(CHEMBL3403368)Show InChI InChI=1S/C17H24N4O2S/c1-5-21-16(23)15-14(19-17(21)18-10(2)3)13(9-24-15)12-6-7-20(8-12)11(4)22/h9-10,12H,5-8H2,1-4H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068255
(CHEMBL3403366)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C18H26N4O2S/c1-5-22-17(24)16-15(20-18(22)19-11(2)3)14(10-25-16)13-6-8-21(9-7-13)12(4)23/h10-11,13H,5-9H2,1-4H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068287
(CHEMBL3403346)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1cccc(C)n1 Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)23-13(2)3)16(12-30-19)15-9-10-26(11-15)20(28)17-8-6-7-14(4)24-17/h6-8,12-13,15H,5,9-11H2,1-4H3,(H,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068253
(CHEMBL3403364)Show InChI InChI=1S/C19H30N4OS/c1-6-23-18(24)17-16(21-19(23)20-12(2)3)15(11-25-17)14-7-9-22(10-8-14)13(4)5/h11-14H,6-10H2,1-5H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068263
(CHEMBL3403363)Show InChI InChI=1S/C16H24N4OS/c1-4-20-15(21)14-13(19-16(20)18-10(2)3)12(9-22-14)11-5-7-17-8-6-11/h9-11,17H,4-8H2,1-3H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068282
(CHEMBL3403360)Show InChI InChI=1S/C16H20N4OS2/c1-6-20-15(21)14-12(19-16(20)17-8(2)3)11(7-22-14)13-9(4)18-10(5)23-13/h7-8H,6H2,1-5H3,(H,17,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068285
(CHEMBL3403372)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccn1 Show InChI InChI=1S/C21H25N5O2S/c1-4-26-20(28)18-17(24-21(26)23-13(2)3)15(12-29-18)14-8-10-25(11-14)19(27)16-7-5-6-9-22-16/h5-7,9,12-14H,4,8,10-11H2,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068272
(CHEMBL3403353)Show InChI InChI=1S/C12H15N3OS/c1-2-15-11(16)10-9(6-7-17-10)14-12(15)13-8-4-3-5-8/h6-8H,2-5H2,1H3,(H,13,14) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068266
(CHEMBL3403349)Show InChI InChI=1S/C11H15N3OS/c1-4-14-10(15)9-8(5-6-16-9)13-11(14)12-7(2)3/h5-7H,4H2,1-3H3,(H,12,13) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068283
(CHEMBL3403371)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H26N4O2S/c1-4-26-21(28)19-18(24-22(26)23-14(2)3)17(13-29-19)16-10-11-25(12-16)20(27)15-8-6-5-7-9-15/h5-9,13-14,16H,4,10-12H2,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068261
(CHEMBL3403361)Show InChI InChI=1S/C17H20N4O2S/c1-5-21-16(22)15-14(20-17(21)19-10(2)3)12(9-24-15)11-6-7-18-13(8-11)23-4/h6-10H,5H2,1-4H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068273
(CHEMBL3403354)Show InChI InChI=1S/C13H17N3O2S/c1-2-16-12(17)11-10(5-8-19-11)15-13(16)14-9-3-6-18-7-4-9/h5,8-9H,2-4,6-7H2,1H3,(H,14,15) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068254
(CHEMBL3403365)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C21H27N5OS/c1-4-26-20(27)19-18(24-21(26)23-14(2)3)16(13-28-19)15-8-11-25(12-9-15)17-7-5-6-10-22-17/h5-7,10,13-15H,4,8-9,11-12H2,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068277
(CHEMBL3403358)Show InChI InChI=1S/C16H18N4OS/c1-4-20-15(21)14-13(19-16(20)18-10(2)3)12(9-22-14)11-6-5-7-17-8-11/h5-10H,4H2,1-3H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068281
(CHEMBL3403359)Show InChI InChI=1S/C15H17N3O2S/c1-4-18-14(19)13-12(17-15(18)16-9(2)3)10(8-21-13)11-6-5-7-20-11/h5-9H,4H2,1-3H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068256
(CHEMBL3403367)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCCN(C1)C(C)=O Show InChI InChI=1S/C18H26N4O2S/c1-5-22-17(24)16-15(20-18(22)19-11(2)3)14(10-25-16)13-7-6-8-21(9-13)12(4)23/h10-11,13H,5-9H2,1-4H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068262
(CHEMBL3403362)Show InChI InChI=1S/C15H17N5OS/c1-4-20-14(21)13-12(19-15(20)18-9(2)3)11(7-22-13)10-5-16-8-17-6-10/h5-9H,4H2,1-3H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068276
(CHEMBL3403357)Show SMILES CCn1c(N[C@H]2CC[C@@H](CC2)C(O)=O)nc2ccsc2c1=O |r,wU:5.4,wD:8.11,(-3.72,-2.76,;-3.72,-1.53,;-2.38,-.77,;-2.38,.77,;-3.72,1.53,;-3.72,3.07,;-5.06,3.84,;-5.06,5.38,;-3.73,6.15,;-2.4,5.39,;-2.39,3.85,;-3.74,7.69,;-4.8,8.31,;-2.67,8.31,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.03,-2.79,)| Show InChI InChI=1S/C15H19N3O3S/c1-2-18-13(19)12-11(7-8-22-12)17-15(18)16-10-5-3-9(4-6-10)14(20)21/h7-10H,2-6H2,1H3,(H,16,17)(H,20,21)/t9-,10- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068265
(CHEMBL3403348)Show InChI InChI=1S/C11H15N3OS/c1-3-6-12-11-13-8-5-7-16-9(8)10(15)14(11)4-2/h5,7H,3-4,6H2,1-2H3,(H,12,13) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068259
(CHEMBL3403369)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)C(C)C Show InChI InChI=1S/C19H28N4O2S/c1-6-23-18(25)16-15(21-19(23)20-12(4)5)14(10-26-16)13-7-8-22(9-13)17(24)11(2)3/h10-13H,6-9H2,1-5H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068269
(CHEMBL3403351)Show InChI InChI=1S/C12H17N3OS/c1-5-15-10(16)9-8(6-7-17-9)13-11(15)14-12(2,3)4/h6-7H,5H2,1-4H3,(H,13,14) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068255
(CHEMBL3403366)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C18H26N4O2S/c1-5-22-17(24)16-15(20-18(22)19-11(2)3)14(10-25-16)13-6-8-21(9-7-13)12(4)23/h10-11,13H,5-9H2,1-4H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50068287
(CHEMBL3403346)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1cccc(C)n1 Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)23-13(2)3)16(12-30-19)15-9-10-26(11-15)20(28)17-8-6-7-14(4)24-17/h6-8,12-13,15H,5,9-11H2,1-4H3,(H,23,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068257
(CHEMBL3403368)Show InChI InChI=1S/C17H24N4O2S/c1-5-21-16(23)15-14(19-17(21)18-10(2)3)13(9-24-15)12-6-7-20(8-12)11(4)22/h9-10,12H,5-8H2,1-4H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068275
(CHEMBL3403356)Show SMILES CCn1c(N[C@H]2CC[C@@H](CC2)C(=O)OC)nc2ccsc2c1=O |r,wU:5.4,wD:8.11,(-3.72,-2.76,;-3.72,-1.53,;-2.38,-.77,;-2.38,.77,;-3.72,1.53,;-3.72,3.07,;-5.06,3.84,;-5.06,5.38,;-3.73,6.15,;-2.4,5.39,;-2.39,3.85,;-3.74,7.69,;-4.8,8.31,;-2.4,8.47,;-2.4,9.7,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.03,-2.79,)| Show InChI InChI=1S/C16H21N3O3S/c1-3-19-14(20)13-12(8-9-23-13)18-16(19)17-11-6-4-10(5-7-11)15(21)22-2/h8-11H,3-7H2,1-2H3,(H,17,18)/t10-,11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50068287
(CHEMBL3403346)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1cccc(C)n1 Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)23-13(2)3)16(12-30-19)15-9-10-26(11-15)20(28)17-8-6-7-14(4)24-17/h6-8,12-13,15H,5,9-11H2,1-4H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE5A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068260
(CHEMBL3403370)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)CC(C)C Show InChI InChI=1S/C20H30N4O2S/c1-6-24-19(26)18-17(22-20(24)21-13(4)5)15(11-27-18)14-7-8-23(10-14)16(25)9-12(2)3/h11-14H,6-10H2,1-5H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068274
(CHEMBL3403355)Show SMILES CCn1c(N[C@H]2CC[C@H](O)CC2)nc2ccsc2c1=O |r,wU:5.4,wD:8.8,(-3.72,-2.76,;-3.72,-1.53,;-2.38,-.77,;-2.38,.77,;-3.72,1.53,;-3.72,3.07,;-5.06,3.84,;-5.06,5.38,;-3.73,6.15,;-3.74,7.38,;-2.4,5.39,;-2.39,3.85,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.03,-2.79,)| Show InChI InChI=1S/C14H19N3O2S/c1-2-17-13(19)12-11(7-8-20-12)16-14(17)15-9-3-5-10(18)6-4-9/h7-10,18H,2-6H2,1H3,(H,15,16)/t9-,10- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068271
(CHEMBL3403352)Show InChI InChI=1S/C11H13N3OS/c1-2-14-10(15)9-8(5-6-16-9)13-11(14)12-7-3-4-7/h5-7H,2-4H2,1H3,(H,12,13) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068264
(CHEMBL3403347)Show InChI InChI=1S/C10H13N3OS/c1-3-11-10-12-7-5-6-15-8(7)9(14)13(10)4-2/h5-6H,3-4H2,1-2H3,(H,11,12) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50068285
(CHEMBL3403372)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccn1 Show InChI InChI=1S/C21H25N5O2S/c1-4-26-20(28)18-17(24-21(26)23-13(2)3)15(12-29-18)14-8-10-25(11-14)19(27)16-7-5-6-9-22-16/h5-7,9,12-14H,4,8,10-11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE5A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50068286
(CHEMBL3403373)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C Show InChI InChI=1S/C22H27N5O2S/c1-5-27-21(29)19-18(25-22(27)24-13(2)3)16(12-30-19)15-8-10-26(11-15)20(28)17-14(4)7-6-9-23-17/h6-7,9,12-13,15H,5,8,10-11H2,1-4H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE5A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50068285
(CHEMBL3403372)Show SMILES CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ccccn1 Show InChI InChI=1S/C21H25N5O2S/c1-4-26-20(28)18-17(24-21(26)23-13(2)3)15(12-29-18)14-8-10-25(11-14)19(27)16-7-5-6-9-22-16/h5-7,9,12-14H,4,8,10-11H2,1-3H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50068268
(CHEMBL3403350)Show InChI InChI=1S/C12H16N2OS/c1-4-14-10(7-8(2)3)13-9-5-6-16-11(9)12(14)15/h5-6,8H,4,7H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068272
(CHEMBL3403353)Show InChI InChI=1S/C12H15N3OS/c1-2-15-11(16)10-9(6-7-17-10)14-12(15)13-8-4-3-5-8/h6-8H,2-5H2,1H3,(H,13,14) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068266
(CHEMBL3403349)Show InChI InChI=1S/C11H15N3OS/c1-4-14-10(15)9-8(5-6-16-9)13-11(14)12-7(2)3/h5-7H,4H2,1-3H3,(H,12,13) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068273
(CHEMBL3403354)Show InChI InChI=1S/C13H17N3O2S/c1-2-16-12(17)11-10(5-8-19-11)15-13(16)14-9-3-6-18-7-4-9/h5,8-9H,2-4,6-7H2,1H3,(H,14,15) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068263
(CHEMBL3403363)Show InChI InChI=1S/C16H24N4OS/c1-4-20-15(21)14-13(19-16(20)18-10(2)3)12(9-22-14)11-5-7-17-8-6-11/h9-11,17H,4-8H2,1-3H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068274
(CHEMBL3403355)Show SMILES CCn1c(N[C@H]2CC[C@H](O)CC2)nc2ccsc2c1=O |r,wU:5.4,wD:8.8,(-3.72,-2.76,;-3.72,-1.53,;-2.38,-.77,;-2.38,.77,;-3.72,1.53,;-3.72,3.07,;-5.06,3.84,;-5.06,5.38,;-3.73,6.15,;-3.74,7.38,;-2.4,5.39,;-2.39,3.85,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.03,-2.79,)| Show InChI InChI=1S/C14H19N3O2S/c1-2-17-13(19)12-11(7-8-20-12)16-14(17)15-9-3-5-10(18)6-4-9/h7-10,18H,2-6H2,1H3,(H,15,16)/t9-,10- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50068253
(CHEMBL3403364)Show InChI InChI=1S/C19H30N4OS/c1-6-23-18(24)17-16(21-19(23)20-12(2)3)15(11-25-17)14-7-9-22(10-8-14)13(4)5/h11-14H,6-10H2,1-5H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation counting |
Bioorg Med Chem Lett 25: 1910-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.031
BindingDB Entry DOI: 10.7270/Q2NC62VM |
More data for this
Ligand-Target Pair | |
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