Found 16 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069090
(CHEMBL3403506)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1cccc2ccccc12 |(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.39,-5.37,;2.8,-7.74,;3.73,-8.94,;3.11,-10.35,;1.58,-10.52,;.67,-9.28,;1.29,-7.87,;4.33,-7.57,;5.06,-8.57,;4.83,-6.44,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;2.66,-.77,;1.33,-1.54,;,-.77,)| Show InChI InChI=1S/C29H29N3O5/c1-36-23-14-9-15-24(37-2)26(23)22-18-25(30-27(33)29(28(34)35)16-6-3-7-17-29)31-32(22)21-13-8-11-19-10-4-5-12-20(19)21/h4-5,8-15,18H,3,6-7,16-17H2,1-2H3,(H,34,35)(H,30,31,33) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 128 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069089
(CHEMBL3403505)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12 |(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.39,-5.37,;2.8,-7.74,;3.73,-8.94,;3.11,-10.35,;1.58,-10.52,;.67,-9.28,;1.29,-7.87,;4.33,-7.57,;5.06,-8.57,;4.83,-6.44,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.73,1.38,;2.66,-.77,;1.33,-1.54,;,-.77,)| Show InChI InChI=1S/C28H27ClN4O5/c1-37-22-7-6-8-23(38-2)25(22)21-16-24(31-26(34)28(27(35)36)12-4-3-5-13-28)32-33(21)20-11-14-30-19-15-17(29)9-10-18(19)20/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,35,36)(H,31,32,34) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50019412
(CHEMBL3290096)Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)NC1(CCCCC1)C(O)=O |(21.2,-17.42,;21.67,-15.96,;23.18,-15.64,;24.21,-16.78,;25.72,-16.46,;26.19,-15,;25.16,-13.85,;25.64,-12.39,;27.14,-12.07,;23.66,-14.17,;22.32,-12.69,;22.64,-11.18,;21.3,-10.41,;20.16,-11.44,;20.79,-12.85,;19.78,-14.58,;20.55,-15.92,;19.78,-17.25,;18.24,-17.25,;17.47,-15.92,;15.93,-15.92,;15.16,-14.58,;13.62,-14.58,;15.93,-13.25,;17.47,-13.25,;18.24,-14.58,;21.14,-8.88,;22.39,-7.97,;19.74,-8.25,;19.57,-6.72,;21.11,-6.83,;21.97,-5.55,;21.3,-4.17,;19.76,-4.06,;18.9,-5.34,;18.08,-7.16,;17,-6.07,;17.72,-8.64,)| Show InChI InChI=1S/C28H27ClN4O5/c1-37-23-7-6-8-24(38-2)25(23)22-16-20(26(34)31-28(27(35)36)12-4-3-5-13-28)32-33(22)21-11-14-30-19-15-17(29)9-10-18(19)21/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,31,34)(H,35,36) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 177 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069091
(CHEMBL3403507)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1 |(2.94,7.42,;3.73,6.48,;5.25,6.75,;5.77,8.2,;7.28,8.47,;8.28,7.3,;7.76,5.85,;8.75,4.67,;9.97,4.89,;6.25,5.58,;5.62,4.17,;4.11,3.85,;3.97,2.33,;2.63,1.56,;2.63,.02,;3.7,-.59,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;1.3,-2.29,;.23,-2.91,;2.36,-2.91,;5.35,1.69,;6.38,2.84,;7.92,2.67,;8.91,3.84,;10.43,3.56,;10.94,2.11,;12.15,1.89,;9.94,.94,;8.43,1.22,)| Show InChI InChI=1S/C25H26FN3O5/c1-33-19-7-6-8-20(34-2)22(19)18-15-21(28-29(18)17-11-9-16(26)10-12-17)27-23(30)25(24(31)32)13-4-3-5-14-25/h6-12,15H,3-5,13-14H2,1-2H3,(H,31,32)(H,27,28,30) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 271 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50019417
(CHEMBL3290101)Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1cccc2ccccc12)C(=O)NC1(CCCCC1)C(O)=O |(20.81,-16.86,;21.28,-15.39,;22.79,-15.07,;23.82,-16.21,;25.33,-15.89,;25.8,-14.43,;24.77,-13.29,;25.25,-11.82,;26.75,-11.5,;23.27,-13.61,;21.93,-12.12,;22.25,-10.61,;20.91,-9.84,;19.77,-10.87,;20.39,-12.28,;19.39,-14.01,;20.16,-15.35,;19.39,-16.68,;17.85,-16.68,;17.08,-15.35,;15.54,-15.35,;14.77,-14.01,;15.54,-12.68,;17.08,-12.68,;17.85,-14.01,;20.75,-8.31,;22,-7.41,;19.34,-7.68,;19.18,-6.15,;20.72,-6.26,;21.58,-4.98,;20.91,-3.6,;19.37,-3.49,;18.51,-4.77,;17.69,-6.59,;17.33,-8.07,;16.6,-5.5,)| Show InChI InChI=1S/C29H29N3O5/c1-36-24-14-9-15-25(37-2)26(24)23-18-21(27(33)30-29(28(34)35)16-6-3-7-17-29)31-32(23)22-13-8-11-19-10-4-5-12-20(19)22/h4-5,8-15,18H,3,6-7,16-17H2,1-2H3,(H,30,33)(H,34,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50019423
(CHEMBL3290105)Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccc(F)cc1)C(=O)NC1(CCCCC1)C(O)=O |(18.77,-17.38,;19.54,-16.04,;21.08,-16.04,;21.85,-17.38,;23.39,-17.38,;24.16,-16.04,;23.39,-14.71,;24.16,-13.38,;25.7,-13.38,;21.85,-14.71,;20.85,-12.98,;21.48,-11.57,;20.33,-10.54,;19,-11.31,;19.32,-12.81,;18.29,-13.96,;18.76,-15.42,;17.73,-16.57,;16.23,-16.25,;15.2,-17.39,;15.75,-14.78,;16.78,-13.64,;20.49,-9.01,;21.9,-8.38,;19.25,-8.1,;19.41,-6.57,;20.9,-7,;21.99,-5.92,;21.62,-4.43,;20.13,-4,;19.04,-5.09,;17.87,-6.68,;17.01,-5.4,;17.2,-8.06,)| Show InChI InChI=1S/C25H26FN3O5/c1-33-20-7-6-8-21(34-2)22(20)19-15-18(28-29(19)17-11-9-16(26)10-12-17)23(30)27-25(24(31)32)13-4-3-5-14-25/h6-12,15H,3-5,13-14H2,1-2H3,(H,27,30)(H,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069092
(CHEMBL3403508)Show SMILES COc1ccccc1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C24H24FN3O4/c1-32-20-8-4-3-7-18(20)19-15-21(27-28(19)17-11-9-16(25)10-12-17)26-22(29)24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,30,31)(H,26,27,29) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50069089
(CHEMBL3403505)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12 |(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.39,-5.37,;2.8,-7.74,;3.73,-8.94,;3.11,-10.35,;1.58,-10.52,;.67,-9.28,;1.29,-7.87,;4.33,-7.57,;5.06,-8.57,;4.83,-6.44,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.73,1.38,;2.66,-.77,;1.33,-1.54,;,-.77,)| Show InChI InChI=1S/C28H27ClN4O5/c1-37-22-7-6-8-23(38-2)25(22)21-16-24(31-26(34)28(27(35)36)12-4-3-5-13-28)32-33(21)20-11-14-30-19-15-17(29)9-10-18(19)20/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,35,36)(H,31,32,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069088
(CHEMBL3403504)Show SMILES COc1cccc(OC)c1-c1cc(CN[C@@H](C2CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12 |r,wU:15.16,(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.8,-7.74,;4.33,-7.57,;5.25,-8.81,;6.78,-8.64,;7.4,-7.23,;6.48,-5.99,;4.95,-6.16,;2.18,-9.15,;.96,-9.29,;2.91,-10.14,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.73,1.38,;2.66,-.77,;1.33,-1.54,;,-.77,)| Show InChI InChI=1S/C29H31ClN4O4/c1-37-25-9-6-10-26(38-2)27(25)24-16-20(17-32-28(29(35)36)18-7-4-3-5-8-18)33-34(24)23-13-14-31-22-15-19(30)11-12-21(22)23/h6,9-16,18,28,32H,3-5,7-8,17H2,1-2H3,(H,35,36)/t28-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS2 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50069088
(CHEMBL3403504)Show SMILES COc1cccc(OC)c1-c1cc(CN[C@@H](C2CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12 |r,wU:15.16,(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.8,-7.74,;4.33,-7.57,;5.25,-8.81,;6.78,-8.64,;7.4,-7.23,;6.48,-5.99,;4.95,-6.16,;2.18,-9.15,;.96,-9.29,;2.91,-10.14,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.73,1.38,;2.66,-.77,;1.33,-1.54,;,-.77,)| Show InChI InChI=1S/C29H31ClN4O4/c1-37-25-9-6-10-26(38-2)27(25)24-16-20(17-32-28(29(35)36)18-7-4-3-5-8-18)33-34(24)23-13-14-31-22-15-19(30)11-12-21(22)23/h6,9-16,18,28,32H,3-5,7-8,17H2,1-2H3,(H,35,36)/t28-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50069090
(CHEMBL3403506)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1cccc2ccccc12 |(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.39,-5.37,;2.8,-7.74,;3.73,-8.94,;3.11,-10.35,;1.58,-10.52,;.67,-9.28,;1.29,-7.87,;4.33,-7.57,;5.06,-8.57,;4.83,-6.44,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;2.66,-.77,;1.33,-1.54,;,-.77,)| Show InChI InChI=1S/C29H29N3O5/c1-36-23-14-9-15-24(37-2)26(23)22-18-25(30-27(33)29(28(34)35)16-6-3-7-17-29)31-32(22)21-13-8-11-19-10-4-5-12-20(19)21/h4-5,8-15,18H,3,6-7,16-17H2,1-2H3,(H,34,35)(H,30,31,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50069092
(CHEMBL3403508)Show SMILES COc1ccccc1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C24H24FN3O4/c1-32-20-8-4-3-7-18(20)19-15-21(27-28(19)17-11-9-16(25)10-12-17)26-22(29)24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,30,31)(H,26,27,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50019424
(CHEMBL3290106)Show SMILES COc1ccccc1-c1cc(nn1-c1ccc(F)cc1)C(=O)NC1(CCCCC1)C(O)=O Show InChI InChI=1S/C24H24FN3O4/c1-32-21-8-4-3-7-18(21)20-15-19(27-28(20)17-11-9-16(25)10-12-17)22(29)26-24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,26,29)(H,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 1
(Rattus norvegicus) | BDBM50069091
(CHEMBL3403507)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1 |(2.94,7.42,;3.73,6.48,;5.25,6.75,;5.77,8.2,;7.28,8.47,;8.28,7.3,;7.76,5.85,;8.75,4.67,;9.97,4.89,;6.25,5.58,;5.62,4.17,;4.11,3.85,;3.97,2.33,;2.63,1.56,;2.63,.02,;3.7,-.59,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;1.3,-2.29,;.23,-2.91,;2.36,-2.91,;5.35,1.69,;6.38,2.84,;7.92,2.67,;8.91,3.84,;10.43,3.56,;10.94,2.11,;12.15,1.89,;9.94,.94,;8.43,1.22,)| Show InChI InChI=1S/C25H26FN3O5/c1-33-19-7-6-8-20(34-2)22(19)18-15-21(28-29(18)17-11-9-16(26)10-12-17)27-23(30)25(24(31)32)13-4-3-5-14-25/h6-12,15H,3-5,13-14H2,1-2H3,(H,31,32)(H,27,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069092
(CHEMBL3403508)Show SMILES COc1ccccc1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1 Show InChI InChI=1S/C24H24FN3O4/c1-32-20-8-4-3-7-18(20)19-15-21(27-28(19)17-11-9-16(25)10-12-17)26-22(29)24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,30,31)(H,26,27,29) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 951 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |
Neurotensin receptor type 2
(Rattus norvegicus) | BDBM50069091
(CHEMBL3403507)Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1 |(2.94,7.42,;3.73,6.48,;5.25,6.75,;5.77,8.2,;7.28,8.47,;8.28,7.3,;7.76,5.85,;8.75,4.67,;9.97,4.89,;6.25,5.58,;5.62,4.17,;4.11,3.85,;3.97,2.33,;2.63,1.56,;2.63,.02,;3.7,-.59,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;1.3,-2.29,;.23,-2.91,;2.36,-2.91,;5.35,1.69,;6.38,2.84,;7.92,2.67,;8.91,3.84,;10.43,3.56,;10.94,2.11,;12.15,1.89,;9.94,.94,;8.43,1.22,)| Show InChI InChI=1S/C25H26FN3O5/c1-33-19-7-6-8-20(34-2)22(19)18-15-21(28-29(18)17-11-9-16(26)10-12-17)27-23(30)25(24(31)32)13-4-3-5-14-25/h6-12,15H,3-5,13-14H2,1-2H3,(H,31,32)(H,27,28,30) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at rat NTS2 overexpressed in CHO-k1 cells assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 25: 2060-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.083 BindingDB Entry DOI: 10.7270/Q2BZ67RD |
More data for this Ligand-Target Pair | |