Found 6 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM150812
(US8981106, 2 (SX-576) | USRE47267, Compound 2)Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1 Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems
Curated by ChEMBL
| Assay Description Inhibition of CXCR2 (unknown origin) transfected with RBL cells |
Bioorg Med Chem Lett 25: 2280-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 1
(Homo sapiens (Human)) | BDBM150812
(US8981106, 2 (SX-576) | USRE47267, Compound 2)Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1 Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems
Curated by ChEMBL
| Assay Description Inhibition of CXCR1 (unknown origin) transfected with RBL cells |
Bioorg Med Chem Lett 25: 2280-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM150812
(US8981106, 2 (SX-576) | USRE47267, Compound 2)Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1 Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems
Curated by ChEMBL
| Assay Description Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assay |
Bioorg Med Chem Lett 25: 2280-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM150811
(US8981106, 1 (SX-517) | USRE47267, Compound 1)Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 356 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems
Curated by ChEMBL
| Assay Description Inhibition of CXCR2 (unknown origin) transfected with RBL cells |
Bioorg Med Chem Lett 25: 2280-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM150811
(US8981106, 1 (SX-517) | USRE47267, Compound 1)Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems
Curated by ChEMBL
| Assay Description Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assay |
Bioorg Med Chem Lett 25: 2280-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 1
(Homo sapiens (Human)) | BDBM150811
(US8981106, 1 (SX-517) | USRE47267, Compound 1)Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 903 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems
Curated by ChEMBL
| Assay Description Inhibition of CXCR1 (unknown origin) transfected with RBL cells |
Bioorg Med Chem Lett 25: 2280-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G |
More data for this Ligand-Target Pair | |