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PubMed code 25996309

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094772
PNG
(CHEMBL3589796)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1
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 23n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094772
PNG
(CHEMBL3589796)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1
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 32n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094764
PNG
(CHEMBL3589705)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1CCc1ccccc1 |r,c:29,32|
Show InChI InChI=1S/C23H19N5O2/c24-17-12-16-8-11-28-20(16)18(13-17)19(14-4-2-1-3-5-14)26-21(23(28)30)27-22(29)15-6-9-25-10-7-15/h1-7,9-10,12-13,21H,8,11,24H2,(H,27,29)/t21-/m0/s1
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 37n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094774
PNG
(CHEMBL3589798)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:31,34|
Show InChI InChI=1S/C28H28N6O4/c1-28(2,3)38-27(37)31-21-15-30-11-9-19(21)25(35)33-24-26(36)34-12-10-17-13-18(29)14-20(23(17)34)22(32-24)16-7-5-4-6-8-16/h4-9,11,13-15,24H,10,12,29H2,1-3H3,(H,31,37)(H,33,35)/t24-/m0/s1
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 50n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094763
PNG
(CHEMBL3589704)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1 |r,c:29,32|
Show InChI InChI=1S/C28H25Cl2N5O2/c29-21-13-18(14-22(30)23(21)31)27(36)33-26-28(37)35-11-8-17-12-19(34-9-4-5-10-34)15-20(25(17)35)24(32-26)16-6-2-1-3-7-16/h1-3,6-7,12-15,26H,4-5,8-11,31H2,(H,33,36)/t26-/m0/s1
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 57n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094773
PNG
(CHEMBL3589797)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2)cc1 |r,c:31,34|
Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
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 69n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094766
PNG
(CHEMBL3589707)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:31,34|
Show InChI InChI=1S/C23H16Cl2N4O2/c24-16-11-26-12-17(25)18(16)22(30)28-21-23(31)29-10-9-14-7-4-8-15(20(14)29)19(27-21)13-5-2-1-3-6-13/h1-8,11-12,21H,9-10H2,(H,28,30)/t21-/m0/s1
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 188n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094771
PNG
(CHEMBL3589795)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C27H21N5O2/c28-20-12-18-10-11-32-24(18)21(14-20)23(16-6-2-1-3-7-16)30-25(27(32)34)31-26(33)22-13-17-8-4-5-9-19(17)15-29-22/h1-9,12-15,25H,10-11,28H2,(H,31,33)/t25-/m0/s1
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 209n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094771
PNG
(CHEMBL3589795)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C27H21N5O2/c28-20-12-18-10-11-32-24(18)21(14-20)23(16-6-2-1-3-7-16)30-25(27(32)34)31-26(33)22-13-17-8-4-5-9-19(17)15-29-22/h1-9,12-15,25H,10-11,28H2,(H,31,33)/t25-/m0/s1
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 215n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094776
PNG
(CHEMBL3589800)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:32,35|
Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-12-24-13-10-17)26-21-23(29)27-14-11-16-7-4-8-18(20(16)27)19(25-21)15-5-2-1-3-6-15/h1-10,12-13,21H,11,14H2,(H,26,28)/t21-/m0/s1
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 246n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094775
PNG
(CHEMBL3589799)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2)cc1 |r,c:32,35|
Show InChI InChI=1S/C24H18Cl2N4O2/c1-13-9-15-7-8-30-21(15)16(10-13)20(14-5-3-2-4-6-14)28-22(24(30)32)29-23(31)19-17(25)11-27-12-18(19)26/h2-6,9-12,22H,7-8H2,1H3,(H,29,31)/t22-/m0/s1
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 316n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094765
PNG
(CHEMBL3589706)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2)cc1 |r,c:31,34|
Show InChI InChI=1S/C23H19N5O2/c24-18-13-25-11-9-16(18)22(29)27-21-23(30)28-12-10-15-7-4-8-17(20(15)28)19(26-21)14-5-2-1-3-6-14/h1-9,11,13,21H,10,12,24H2,(H,27,29)/t21-/m0/s1
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 338n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094776
PNG
(CHEMBL3589800)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:32,35|
Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-12-24-13-10-17)26-21-23(29)27-14-11-16-7-4-8-18(20(16)27)19(25-21)15-5-2-1-3-6-15/h1-10,12-13,21H,11,14H2,(H,26,28)/t21-/m0/s1
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 392n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094774
PNG
(CHEMBL3589798)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:31,34|
Show InChI InChI=1S/C28H28N6O4/c1-28(2,3)38-27(37)31-21-15-30-11-9-19(21)25(35)33-24-26(36)34-12-10-17-13-18(29)14-20(23(17)34)22(32-24)16-7-5-4-6-8-16/h4-9,11,13-15,24H,10,12,29H2,1-3H3,(H,31,37)(H,33,35)/t24-/m0/s1
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 393n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094775
PNG
(CHEMBL3589799)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2)cc1 |r,c:32,35|
Show InChI InChI=1S/C24H18Cl2N4O2/c1-13-9-15-7-8-30-21(15)16(10-13)20(14-5-3-2-4-6-14)28-22(24(30)32)29-23(31)19-17(25)11-27-12-18(19)26/h2-6,9-12,22H,7-8H2,1H3,(H,29,31)/t22-/m0/s1
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 552n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094761
PNG
(CHEMBL3589702)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2)cc1 |r,c:30,33|
Show InChI InChI=1S/C30H32N4O/c35-28-13-11-24(12-14-28)15-25-20-33-27(17-23-9-5-2-6-10-23)21-34-26(16-22-7-3-1-4-8-22)19-31-29(34)18-30(33)32-25/h1-14,18,25-27,32,35H,15-17,19-21H2/t25-,26-,27-/m0/s1
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 566n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094773
PNG
(CHEMBL3589797)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2)cc1 |r,c:31,34|
Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
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 605n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094764
PNG
(CHEMBL3589705)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1CCc1ccccc1 |r,c:29,32|
Show InChI InChI=1S/C23H19N5O2/c24-17-12-16-8-11-28-20(16)18(13-17)19(14-4-2-1-3-5-14)26-21(23(28)30)27-22(29)15-6-9-25-10-7-15/h1-7,9-10,12-13,21H,8,11,24H2,(H,27,29)/t21-/m0/s1
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 642n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094772
PNG
(CHEMBL3589796)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1
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 721n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094774
PNG
(CHEMBL3589798)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:31,34|
Show InChI InChI=1S/C28H28N6O4/c1-28(2,3)38-27(37)31-21-15-30-11-9-19(21)25(35)33-24-26(36)34-12-10-17-13-18(29)14-20(23(17)34)22(32-24)16-7-5-4-6-8-16/h4-9,11,13-15,24H,10,12,29H2,1-3H3,(H,31,37)(H,33,35)/t24-/m0/s1
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 767n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094766
PNG
(CHEMBL3589707)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:31,34|
Show InChI InChI=1S/C23H16Cl2N4O2/c24-16-11-26-12-17(25)18(16)22(30)28-21-23(31)29-10-9-14-7-4-8-15(20(14)29)19(27-21)13-5-2-1-3-6-13/h1-8,11-12,21H,9-10H2,(H,28,30)/t21-/m0/s1
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 878n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094764
PNG
(CHEMBL3589705)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1CCc1ccccc1 |r,c:29,32|
Show InChI InChI=1S/C23H19N5O2/c24-17-12-16-8-11-28-20(16)18(13-17)19(14-4-2-1-3-5-14)26-21(23(28)30)27-22(29)15-6-9-25-10-7-15/h1-7,9-10,12-13,21H,8,11,24H2,(H,27,29)/t21-/m0/s1
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 949n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094768
PNG
(CHEMBL3589709)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccccc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:20,23|
Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-5-12-24-14-17)26-21-23(29)27-13-11-16-8-4-10-18(20(16)27)19(25-21)15-6-2-1-3-7-15/h1-10,12,14,21H,11,13H2,(H,26,28)/t21-/m0/s1
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 1.02E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094767
PNG
(CHEMBL3589708)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccccc3)CN3[C@H](CN=C3C=C2N1)C(C)C |r,c:20,23|
Show InChI InChI=1S/C23H34N4/c1-16(2)10-19-14-26-20(11-18-8-6-5-7-9-18)15-27-21(17(3)4)13-24-22(27)12-23(26)25-19/h5-9,12,16-17,19-21,25H,10-11,13-15H2,1-4H3/t19-,20-,21+/m0/s1
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PubMed
 1.08E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094770
PNG
(CHEMBL3589794)
Show SMILES CC(C)[C@H]1CN=C2C=C3N(CCc4ccccc4)[C@@H](Cc4ccc(O)cc4)CN3[C@@H](Cc3ccccc3)CN12 |r,t:5,7|
Show InChI InChI=1S/C25H22N8O2/c1-13-10-19-29-30-20(14(2)33(19)31-13)24(34)28-23-25(35)32-9-8-16-11-17(26)12-18(22(16)32)21(27-23)15-6-4-3-5-7-15/h3-7,10-12,23H,8-9,26H2,1-2H3,(H,28,34)/t23-/m0/s1
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 1.11E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094765
PNG
(CHEMBL3589706)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2)cc1 |r,c:31,34|
Show InChI InChI=1S/C23H19N5O2/c24-18-13-25-11-9-16(18)22(29)27-21-23(30)28-12-10-15-7-4-8-17(20(15)28)19(26-21)14-5-2-1-3-6-14/h1-9,11,13,21H,10,12,24H2,(H,27,29)/t21-/m0/s1
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 1.18E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094771
PNG
(CHEMBL3589795)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C27H21N5O2/c28-20-12-18-10-11-32-24(18)21(14-20)23(16-6-2-1-3-7-16)30-25(27(32)34)31-26(33)22-13-17-8-4-5-9-19(17)15-29-22/h1-9,12-15,25H,10-11,28H2,(H,31,33)/t25-/m0/s1
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PubMed
 1.19E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094762
PNG
(CHEMBL3589703)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:30,33|
Show InChI InChI=1S/C38H40N4O/c43-36-18-16-32(17-19-36)24-34-28-42-35(23-31-14-8-3-9-15-31)27-41-33(22-30-12-6-2-7-13-30)26-39-37(41)25-38(42)40(34)21-20-29-10-4-1-5-11-29/h1-19,25,33-35,43H,20-24,26-28H2/t33-,34-,35-/m0/s1
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 1.29E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094766
PNG
(CHEMBL3589707)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:31,34|
Show InChI InChI=1S/C23H16Cl2N4O2/c24-16-11-26-12-17(25)18(16)22(30)28-21-23(31)29-10-9-14-7-4-8-15(20(14)29)19(27-21)13-5-2-1-3-6-13/h1-8,11-12,21H,9-10H2,(H,28,30)/t21-/m0/s1
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 1.31E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094763
PNG
(CHEMBL3589704)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1 |r,c:29,32|
Show InChI InChI=1S/C28H25Cl2N5O2/c29-21-13-18(14-22(30)23(21)31)27(36)33-26-28(37)35-11-8-17-12-19(34-9-4-5-10-34)15-20(25(17)35)24(32-26)16-6-2-1-3-7-16/h1-3,6-7,12-15,26H,4-5,8-11,31H2,(H,33,36)/t26-/m0/s1
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 1.33E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094770
PNG
(CHEMBL3589794)
Show SMILES CC(C)[C@H]1CN=C2C=C3N(CCc4ccccc4)[C@@H](Cc4ccc(O)cc4)CN3[C@@H](Cc3ccccc3)CN12 |r,t:5,7|
Show InChI InChI=1S/C25H22N8O2/c1-13-10-19-29-30-20(14(2)33(19)31-13)24(34)28-23-25(35)32-9-8-16-11-17(26)12-18(22(16)32)21(27-23)15-6-4-3-5-7-15/h3-7,10-12,23H,8-9,26H2,1-2H3,(H,28,34)/t23-/m0/s1
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 1.38E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094768
PNG
(CHEMBL3589709)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccccc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:20,23|
Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-5-12-24-14-17)26-21-23(29)27-13-11-16-8-4-10-18(20(16)27)19(25-21)15-6-2-1-3-7-15/h1-10,12,14,21H,11,13H2,(H,26,28)/t21-/m0/s1
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 1.40E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094776
PNG
(CHEMBL3589800)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:32,35|
Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-12-24-13-10-17)26-21-23(29)27-14-11-16-7-4-8-18(20(16)27)19(25-21)15-5-2-1-3-6-15/h1-10,12-13,21H,11,14H2,(H,26,28)/t21-/m0/s1
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 1.55E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094770
PNG
(CHEMBL3589794)
Show SMILES CC(C)[C@H]1CN=C2C=C3N(CCc4ccccc4)[C@@H](Cc4ccc(O)cc4)CN3[C@@H](Cc3ccccc3)CN12 |r,t:5,7|
Show InChI InChI=1S/C25H22N8O2/c1-13-10-19-29-30-20(14(2)33(19)31-13)24(34)28-23-25(35)32-9-8-16-11-17(26)12-18(22(16)32)21(27-23)15-6-4-3-5-7-15/h3-7,10-12,23H,8-9,26H2,1-2H3,(H,28,34)/t23-/m0/s1
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 1.90E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094769
PNG
(CHEMBL3589710)
Show SMILES CC(C)[C@H]1CN=C2C=C3N[C@@H](Cc4ccc(O)cc4)CN3[C@@H](Cc3ccccc3)CN12 |r,t:5,7|
Show InChI InChI=1S/C27H19N5O4/c33-26(22-13-17-8-4-5-9-19(17)15-28-22)30-25-27(34)31-11-10-18-12-20(32(35)36)14-21(24(18)31)23(29-25)16-6-2-1-3-7-16/h1-9,12-15,25H,10-11H2,(H,30,33)/t25-/m0/s1
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 1.95E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094761
PNG
(CHEMBL3589702)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2)cc1 |r,c:30,33|
Show InChI InChI=1S/C30H32N4O/c35-28-13-11-24(12-14-28)15-25-20-33-27(17-23-9-5-2-6-10-23)21-34-26(16-22-7-3-1-4-8-22)19-31-29(34)18-30(33)32-25/h1-14,18,25-27,32,35H,15-17,19-21H2/t25-,26-,27-/m0/s1
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 2.09E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094773
PNG
(CHEMBL3589797)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2)cc1 |r,c:31,34|
Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
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 2.37E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094768
PNG
(CHEMBL3589709)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccccc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:20,23|
Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-5-12-24-14-17)26-21-23(29)27-13-11-16-8-4-10-18(20(16)27)19(25-21)15-6-2-1-3-7-15/h1-10,12,14,21H,11,13H2,(H,26,28)/t21-/m0/s1
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 2.75E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094762
PNG
(CHEMBL3589703)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:30,33|
Show InChI InChI=1S/C38H40N4O/c43-36-18-16-32(17-19-36)24-34-28-42-35(23-31-14-8-3-9-15-31)27-41-33(22-30-12-6-2-7-13-30)26-39-37(41)25-38(42)40(34)21-20-29-10-4-1-5-11-29/h1-19,25,33-35,43H,20-24,26-28H2/t33-,34-,35-/m0/s1
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 3.16E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094763
PNG
(CHEMBL3589704)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1 |r,c:29,32|
Show InChI InChI=1S/C28H25Cl2N5O2/c29-21-13-18(14-22(30)23(21)31)27(36)33-26-28(37)35-11-8-17-12-19(34-9-4-5-10-34)15-20(25(17)35)24(32-26)16-6-2-1-3-7-16/h1-3,6-7,12-15,26H,4-5,8-11,31H2,(H,33,36)/t26-/m0/s1
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 3.44E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094775
PNG
(CHEMBL3589799)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccc(O)cc5)CN=C4C=C3N2)cc1 |r,c:32,35|
Show InChI InChI=1S/C24H18Cl2N4O2/c1-13-9-15-7-8-30-21(15)16(10-13)20(14-5-3-2-4-6-14)28-22(24(30)32)29-23(31)19-17(25)11-27-12-18(19)26/h2-6,9-12,22H,7-8H2,1H3,(H,29,31)/t22-/m0/s1
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 3.76E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094765
PNG
(CHEMBL3589706)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccc(O)cc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2)cc1 |r,c:31,34|
Show InChI InChI=1S/C23H19N5O2/c24-18-13-25-11-9-16(18)22(29)27-21-23(30)28-12-10-15-7-4-8-17(20(15)28)19(26-21)14-5-2-1-3-6-14/h1-9,11,13,21H,10,12,24H2,(H,27,29)/t21-/m0/s1
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 4.14E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094769
PNG
(CHEMBL3589710)
Show SMILES CC(C)[C@H]1CN=C2C=C3N[C@@H](Cc4ccc(O)cc4)CN3[C@@H](Cc3ccccc3)CN12 |r,t:5,7|
Show InChI InChI=1S/C27H19N5O4/c33-26(22-13-17-8-4-5-9-19(17)15-28-22)30-25-27(34)31-11-10-18-12-20(32(35)36)14-21(24(18)31)23(29-25)16-6-2-1-3-7-16/h1-9,12-15,25H,10-11H2,(H,30,33)/t25-/m0/s1
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 5.04E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094761
PNG
(CHEMBL3589702)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2)cc1 |r,c:30,33|
Show InChI InChI=1S/C30H32N4O/c35-28-13-11-24(12-14-28)15-25-20-33-27(17-23-9-5-2-6-10-23)21-34-26(16-22-7-3-1-4-8-22)19-31-29(34)18-30(33)32-25/h1-14,18,25-27,32,35H,15-17,19-21H2/t25-,26-,27-/m0/s1
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 8.39E+3n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50094767
PNG
(CHEMBL3589708)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccccc3)CN3[C@H](CN=C3C=C2N1)C(C)C |r,c:20,23|
Show InChI InChI=1S/C23H34N4/c1-16(2)10-19-14-26-20(11-18-8-6-5-7-9-18)15-27-21(17(3)4)13-24-22(27)12-23(26)25-19/h5-9,12,16-17,19-21,25H,10-11,13-15H2,1-4H3/t19-,20-,21+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor in rat cortices by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50094762
PNG
(CHEMBL3589703)
Show SMILES Oc1ccc(C[C@H]2CN3[C@@H](Cc4ccccc4)CN4[C@@H](Cc5ccccc5)CN=C4C=C3N2CCc2ccccc2)cc1 |r,c:30,33|
Show InChI InChI=1S/C38H40N4O/c43-36-18-16-32(17-19-36)24-34-28-42-35(23-31-14-8-3-9-15-31)27-41-33(22-30-12-6-2-7-13-30)26-39-37(41)25-38(42)40(34)21-20-29-10-4-1-5-11-29/h1-19,25,33-35,43H,20-24,26-28H2/t33-,34-,35-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cortices and cerebella by competition binding assay

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50094764
PNG
(CHEMBL3589705)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1CCc1ccccc1 |r,c:29,32|
Show InChI InChI=1S/C23H19N5O2/c24-17-12-16-8-11-28-20(16)18(13-17)19(14-4-2-1-3-5-14)26-21(23(28)30)27-22(29)15-6-9-25-10-7-15/h1-7,9-10,12-13,21H,8,11,24H2,(H,27,29)/t21-/m0/s1
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n/an/an/an/a 1.64E+3n/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Agonist activity at delta opioid receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by...

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50094772
PNG
(CHEMBL3589796)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@H](CN=C3C=C2N1CCc1ccccc1)C(C)C |r,c:21,24|
Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1
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n/an/an/an/a 366n/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Agonist activity at delta opioid receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by...

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50094763
PNG
(CHEMBL3589704)
Show SMILES CC(C)C[C@H]1CN2[C@@H](Cc3ccc(O)cc3)CN3[C@@H](Cc4ccccc4)CN=C3C=C2N1 |r,c:29,32|
Show InChI InChI=1S/C28H25Cl2N5O2/c29-21-13-18(14-22(30)23(21)31)27(36)33-26-28(37)35-11-8-17-12-19(34-9-4-5-10-34)15-20(25(17)35)24(32-26)16-6-2-1-3-7-16/h1-3,6-7,12-15,26H,4-5,8-11,31H2,(H,33,36)/t26-/m0/s1
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n/an/an/an/a 6.37E+3n/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Agonist activity at delta opioid receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by...

J Med Chem 58: 4905-17 (2015)


Article DOI: 10.1021/jm501637c
BindingDB Entry DOI: 10.7270/Q2TB18NQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%