Found 51 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095314
(CHEMBL3589893)Show InChI InChI=1S/C13H10Cl3N3O/c1-6(20)18-11-3-2-8(13(17)19-11)9-4-7(14)5-10(15)12(9)16/h2-5H,1H3,(H3,17,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095311
(CHEMBL3589904)Show InChI InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8/beta1 expressed in HEK293 cells by manual patch clamp electrophysiology |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8/beta1 expressed in HEK293 cells by manual patch clamp electrophysiology |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8/beta1 expressed in HEK293 cells by manual patch clamp electrophysiology |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095331
(CHEMBL3589903)Show InChI InChI=1S/C17H15ClN4O3/c1-9-13(8-25-22-9)17(23)21-15-6-4-11(16(19)20-15)12-7-10(24-2)3-5-14(12)18/h3-8H,1-2H3,(H3,19,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095329
(CHEMBL3589901)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl Show InChI InChI=1S/C16H11Cl3N4O2/c1-7-11(6-25-23-7)16(24)22-13-3-2-9(15(20)21-13)10-4-8(17)5-12(18)14(10)19/h2-6H,1H3,(H3,20,21,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095311
(CHEMBL3589904)Show InChI InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095328
(CHEMBL3589900)Show SMILES Cn1nccc1C(=O)Nc1ccc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl Show InChI InChI=1S/C16H12Cl3N5O/c1-24-12(4-5-21-24)16(25)23-13-3-2-9(15(20)22-13)10-6-8(17)7-11(18)14(10)19/h2-7H,1H3,(H3,20,22,23,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095330
(CHEMBL3589902)Show InChI InChI=1S/C16H13Cl2N5O/c1-23-13(6-7-20-23)16(24)22-14-5-3-10(15(19)21-14)11-8-9(17)2-4-12(11)18/h2-8H,1H3,(H3,19,21,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095343
(CHEMBL3589908)Show SMILES Cn1nccc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F3N5O2/c1-25-12(8-9-22-25)16(26)24-14-7-6-11(15(21)23-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-9H,1H3,(H3,21,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095345
(CHEMBL3589910)Show SMILES Nc1nc(NC(=O)c2ccccc2)ccc1-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C19H14F3N3O2/c20-19(21,22)27-15-9-5-4-8-13(15)14-10-11-16(24-17(14)23)25-18(26)12-6-2-1-3-7-12/h1-11H,(H3,23,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50095314
(CHEMBL3589893)Show InChI InChI=1S/C13H10Cl3N3O/c1-6(20)18-11-3-2-8(13(17)19-11)9-4-7(14)5-10(15)12(9)16/h2-5H,1H3,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50095314
(CHEMBL3589893)Show InChI InChI=1S/C13H10Cl3N3O/c1-6(20)18-11-3-2-8(13(17)19-11)9-4-7(14)5-10(15)12(9)16/h2-5H,1H3,(H3,17,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 3 subunit alpha
(Homo sapiens (Human)) | BDBM50095314
(CHEMBL3589893)Show InChI InChI=1S/C13H10Cl3N3O/c1-6(20)18-11-3-2-8(13(17)19-11)9-4-7(14)5-10(15)12(9)16/h2-5H,1H3,(H3,17,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095334
(CHEMBL3589907)Show InChI InChI=1S/C16H18ClN3O2/c1-9(2)16(21)20-14-7-5-11(15(18)19-14)12-8-10(22-3)4-6-13(12)17/h4-9H,1-3H3,(H3,18,19,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095333
(CHEMBL3589906)Show InChI InChI=1S/C16H14ClN5O/c1-22-13(8-9-19-22)16(23)21-14-7-6-11(15(18)20-14)10-4-2-3-5-12(10)17/h2-9H,1H3,(H3,18,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50095313
(CHEMBL3589892)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)6-2-9(12(17)19-5-6)8-3-7(14)4-10(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 3 subunit alpha
(Homo sapiens (Human)) | BDBM50095313
(CHEMBL3589892)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)6-2-9(12(17)19-5-6)8-3-7(14)4-10(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50095313
(CHEMBL3589892)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)6-2-9(12(17)19-5-6)8-3-7(14)4-10(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095344
(CHEMBL3589909)Show SMILES Cn1nncc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C16H13F3N6O2/c1-25-11(8-21-24-25)15(26)23-13-7-6-10(14(20)22-13)9-4-2-3-5-12(9)27-16(17,18)19/h2-8H,1H3,(H3,20,22,23,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095332
(CHEMBL3589905)Show InChI InChI=1S/C17H16ClN5O2/c1-23-13(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(18)3-5-14(12)25-2/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
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| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in SHSY5Y cells by FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
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Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.2 expressed in SHSY5Y cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 3 subunit alpha
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.3 expressed in SHSY5Y cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095324
(CHEMBL3589898)Show InChI InChI=1S/C13H11Cl2N3O/c1-17-13(19)11-5-3-8(12(16)18-11)9-6-7(14)2-4-10(9)15/h2-6H,1H3,(H2,16,18)(H,17,19) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.2 expressed in HEK293 cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 1 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.1 expressed in HEK293 cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 3 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 3 subunit alpha
(Homo sapiens (Human)) | BDBM50031299
(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)Show InChI InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) | PDB
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| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50031299
(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)Show InChI InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) | PDB
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| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50031299
(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)Show InChI InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) | PDB
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| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095313
(CHEMBL3589892)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)6-2-9(12(17)19-5-6)8-3-7(14)4-10(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50095312
(CHEMBL2324355)Show SMILES Cc1nocc1C(=O)Nc1ccc(c(N)n1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H13F3N4O3/c1-9-12(8-26-24-9)16(25)23-14-7-6-11(15(21)22-14)10-4-2-3-5-13(10)27-17(18,19)20/h2-8H,1H3,(H3,21,22,23,25) | PDB
MMDB
Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50095310
(CHEMBL3589894)Show InChI InChI=1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20) | PDB
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| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50095311
(CHEMBL3589904)Show InChI InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095346
(CHEMBL3589911)Show InChI InChI=1S/C16H13ClFN5O/c1-23-13(6-7-20-23)16(24)22-14-5-4-11(15(19)21-14)10-3-2-9(18)8-12(10)17/h2-8H,1H3,(H3,19,21,22,24) | PDB
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| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095315
(CHEMBL3589895)Show InChI InChI=1S/C13H12ClN3O/c1-16-13(18)11-7-6-9(12(15)17-11)8-4-2-3-5-10(8)14/h2-7H,1H3,(H2,15,17)(H,16,18) | PDB
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| n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095318
(CHEMBL3589896)Show InChI InChI=1S/C13H12ClN3O/c1-16-13(18)11-6-5-10(12(15)17-11)8-3-2-4-9(14)7-8/h2-7H,1H3,(H2,15,17)(H,16,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095327
(CHEMBL3589899)Show InChI InChI=1S/C13H11Cl2N3O/c1-17-13(19)11-3-2-10(12(16)18-11)7-4-8(14)6-9(15)5-7/h2-6H,1H3,(H2,16,18)(H,17,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50095323
(CHEMBL3589897)Show InChI InChI=1S/C13H12ClN3O/c1-16-13(18)11-7-6-10(12(15)17-11)8-2-4-9(14)5-3-8/h2-7H,1H3,(H2,15,17)(H,16,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50095311
(CHEMBL3589904)Show InChI InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 1 subunit alpha
(Homo sapiens (Human)) | BDBM50095311
(CHEMBL3589904)Show InChI InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
MCE
PC cid
PC sid
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Similars
| Article
PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.1 expressed in HEK293 cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50095311
(CHEMBL3589904)Show InChI InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks Quattro selectivity assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50031299
(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)Show InChI InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) | PDB
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MCE
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PDB
UniChem
Patents
| Article
PubMed
| n/a | n/a | 9.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.8 expressed in HEK293 cells assessed as reduction in blue fluorescent signal by VSP-FRET assay |
ACS Med Chem Lett 6: 650-4 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00059
BindingDB Entry DOI: 10.7270/Q23R0VMJ |
More data for this
Ligand-Target Pair | |
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