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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C-X-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50112266 (CHEMBL3608763) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of CXCR4 in human Jurkat cells assessed as reduction in HIV-Nef-M1-induced mitochondrial membrane depolarization at 0.01 to 100 uM by JC1 ... | ACS Med Chem Lett 6: 753-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00036 BindingDB Entry DOI: 10.7270/Q2K64KVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| C-X-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50112266 (CHEMBL3608763) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Antagonist activity against CXCR4 (unknown origin) by Ca2+ flux GPCR signaling assay | ACS Med Chem Lett 6: 753-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00036 BindingDB Entry DOI: 10.7270/Q2K64KVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| C-C chemokine receptor type 5 (Homo sapiens (Human)) | BDBM50112266 (CHEMBL3608763) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of CCR5 assessed as reduction in fusion of effector cells expressing JRFL envelope (CCR5-tropic/CD4-dependent) with human HeLa-C14 target ... | ACS Med Chem Lett 6: 753-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00036 BindingDB Entry DOI: 10.7270/Q2K64KVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| C-C chemokine receptor type 5 (Homo sapiens (Human)) | BDBM50112267 (CHEMBL3608771) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [125I]-MIP-1beta form CCR5 (unknown origin) | ACS Med Chem Lett 6: 753-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00036 BindingDB Entry DOI: 10.7270/Q2K64KVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| C-X-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50112266 (CHEMBL3608763) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.20E+4 | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of CXCR4 assessed as reduction in fusion of human ACTOne-X4 cells as target cells expressing only CXCR4) with effector cells expressing HI... | ACS Med Chem Lett 6: 753-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00036 BindingDB Entry DOI: 10.7270/Q2K64KVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| C-X-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50112266 (CHEMBL3608763) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of CXCR4 assessed as reduction in fusion of human HeLa/67 as target cells expressing CD4, CCR5, and CXCR4) and Lai envelope-expressing eff... | ACS Med Chem Lett 6: 753-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00036 BindingDB Entry DOI: 10.7270/Q2K64KVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
