Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transthyretin (Homo sapiens (Human)) | BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM7458 (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50240510 (CHEMBL898 | DIFLUNISAL) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | DrugBank PDB Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM35905 (Tolfenamic acid | cid_610479 | flufenamic acid ana...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM22971 (2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM85507 (CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM13066 (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50109016 (Aceclofenac | CHEBI:31159) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50110590 (2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo... | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM35905 (Tolfenamic acid | cid_610479 | flufenamic acid ana...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM13066 (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM85507 (CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50109016 (Aceclofenac | CHEBI:31159) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50110590 (2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM7458 (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM22971 (2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM50240510 (CHEMBL898 | DIFLUNISAL) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | DrugBank PDB Article PubMed | n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a |
Ume£ University Curated by ChEMBL | Assay Description Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis | J Med Chem 58: 6507-15 (2015) Article DOI: 10.1021/acs.jmedchem.5b00544 BindingDB Entry DOI: 10.7270/Q2P84DP1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |