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PubMed code 26248802

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115286
PNG
(CHEMBL3609016)
Show SMILES OB(O)c1ccc(CN(Cc2ccco2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C23H20BFN4O4/c25-18-5-8-19(9-6-18)28-23(30)16-3-10-22(27-12-16)29(15-21-2-1-11-33-21)14-20-7-4-17(13-26-20)24(31)32/h1-13,31-32H,14-15H2,(H,28,30)
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n/an/a 3.30n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115227
PNG
(CHEMBL3609018)
Show SMILES OB(O)c1ccc(CN(Cc2ccccc2)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C24H21BFN5O3/c26-20-7-10-21(11-8-20)30-23(32)18-12-28-24(29-13-18)31(15-17-4-2-1-3-5-17)16-22-9-6-19(14-27-22)25(33)34/h1-14,33-34H,15-16H2,(H,30,32)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115227
PNG
(CHEMBL3609018)
Show SMILES OB(O)c1ccc(CN(Cc2ccccc2)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C24H21BFN5O3/c26-20-7-10-21(11-8-20)30-23(32)18-12-28-24(29-13-18)31(15-17-4-2-1-3-5-17)16-22-9-6-19(14-27-22)25(33)34/h1-14,33-34H,15-16H2,(H,30,32)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115286
PNG
(CHEMBL3609016)
Show SMILES OB(O)c1ccc(CN(Cc2ccco2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C23H20BFN4O4/c25-18-5-8-19(9-6-18)28-23(30)16-3-10-22(27-12-16)29(15-21-2-1-11-33-21)14-20-7-4-17(13-26-20)24(31)32/h1-13,31-32H,14-15H2,(H,28,30)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150812
PNG
(US8981106, 2 (SX-576))
Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM150812
PNG
(US8981106, 2 (SX-576))
Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115215
PNG
(CHEMBL3609006)
Show SMILES CN(Cc1ccc(cn1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-17-6-3-14(11-22-17)20(27)28)18-9-2-13(10-23-18)19(26)24-16-7-4-15(21)5-8-16/h2-11,27-28H,12H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115210
PNG
(CHEMBL3609011)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-2-4-15(5-3-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-8-6-16(21)7-9-17/h2-11,27-28H,12H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115368
PNG
(CHEMBL3609013)
Show SMILES OB(O)c1ccc(CN(Cc2ccccc2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C25H22BFN4O3/c27-21-8-11-22(12-9-21)30-25(32)19-6-13-24(29-14-19)31(16-18-4-2-1-3-5-18)17-23-10-7-20(15-28-23)26(33)34/h1-15,33-34H,16-17H2,(H,30,32)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115368
PNG
(CHEMBL3609013)
Show SMILES OB(O)c1ccc(CN(Cc2ccccc2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C25H22BFN4O3/c27-21-8-11-22(12-9-21)30-25(32)19-6-13-24(29-14-19)31(16-18-4-2-1-3-5-18)17-23-10-7-20(15-28-23)26(33)34/h1-15,33-34H,16-17H2,(H,30,32)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115219
PNG
(CHEMBL3609003)
Show SMILES CN(Cc1cccc(c1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H19BFN3O3/c1-25(13-14-3-2-4-16(11-14)21(27)28)19-10-5-15(12-23-19)20(26)24-18-8-6-17(22)7-9-18/h2-12,27-28H,13H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115224
PNG
(CHEMBL3609021)
Show SMILES OB(O)c1ccc(CN(Cc2ccco2)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C22H19BFN5O4/c24-17-4-7-18(8-5-17)28-21(30)15-10-26-22(27-11-15)29(14-20-2-1-9-33-20)13-19-6-3-16(12-25-19)23(31)32/h1-12,31-32H,13-14H2,(H,28,30)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115220
PNG
(CHEMBL3609002)
Show SMILES OB(O)c1cccc(CNc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17BFN3O3/c21-16-5-7-17(8-6-16)24-19(25)14-4-9-18(23-12-14)22-11-13-2-1-3-15(10-13)20(26)27/h1-10,12,26-27H,11H2,(H,22,23)(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115224
PNG
(CHEMBL3609021)
Show SMILES OB(O)c1ccc(CN(Cc2ccco2)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C22H19BFN5O4/c24-17-4-7-18(8-5-17)28-21(30)15-10-26-22(27-11-15)29(14-20-2-1-9-33-20)13-19-6-3-16(12-25-19)23(31)32/h1-12,31-32H,13-14H2,(H,28,30)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115210
PNG
(CHEMBL3609011)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-2-4-15(5-3-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-8-6-16(21)7-9-17/h2-11,27-28H,12H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115220
PNG
(CHEMBL3609002)
Show SMILES OB(O)c1cccc(CNc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17BFN3O3/c21-16-5-7-17(8-6-16)24-19(25)14-4-9-18(23-12-14)22-11-13-2-1-3-15(10-13)20(26)27/h1-10,12,26-27H,11H2,(H,22,23)(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115213
PNG
(CHEMBL3609008)
Show SMILES OB(O)c1cccc(CNc2ncc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C18H16BFN4O3/c20-15-4-6-16(7-5-15)24-17(25)13-10-22-18(23-11-13)21-9-12-2-1-3-14(8-12)19(26)27/h1-8,10-11,26-27H,9H2,(H,24,25)(H,21,22,23)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115371
PNG
(CHEMBL3609012)
Show SMILES CN(Cc1ccc(cn1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C18H17BFN5O3/c1-25(11-16-5-2-13(10-21-16)19(27)28)18-22-8-12(9-23-18)17(26)24-15-6-3-14(20)4-7-15/h2-10,27-28H,11H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115217
PNG
(CHEMBL3609005)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H19BFN3O3/c1-25(13-14-2-5-16(6-3-14)21(27)28)19-11-4-15(12-23-19)20(26)24-18-9-7-17(22)8-10-18/h2-12,27-28H,13H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115213
PNG
(CHEMBL3609008)
Show SMILES OB(O)c1cccc(CNc2ncc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C18H16BFN4O3/c20-15-4-6-16(7-5-15)24-17(25)13-10-22-18(23-11-13)21-9-12-2-1-3-14(8-12)19(26)27/h1-8,10-11,26-27H,9H2,(H,24,25)(H,21,22,23)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115217
PNG
(CHEMBL3609005)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H19BFN3O3/c1-25(13-14-2-5-16(6-3-14)21(27)28)19-11-4-15(12-23-19)20(26)24-18-9-7-17(22)8-10-18/h2-12,27-28H,13H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115371
PNG
(CHEMBL3609012)
Show SMILES CN(Cc1ccc(cn1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C18H17BFN5O3/c1-25(11-16-5-2-13(10-21-16)19(27)28)18-22-8-12(9-23-18)17(26)24-15-6-3-14(20)4-7-15/h2-10,27-28H,11H2,1H3,(H,24,26)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115215
PNG
(CHEMBL3609006)
Show SMILES CN(Cc1ccc(cn1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-17-6-3-14(11-22-17)20(27)28)18-9-2-13(10-23-18)19(26)24-16-7-4-15(21)5-8-16/h2-11,27-28H,12H2,1H3,(H,24,26)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115211
PNG
(CHEMBL3609010)
Show SMILES OB(O)c1ccc(CNc2ncc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H16BFN4O3/c20-15-5-7-16(8-6-15)24-17(25)13-10-22-18(23-11-13)21-9-12-1-3-14(4-2-12)19(26)27/h1-8,10-11,26-27H,9H2,(H,24,25)(H,21,22,23)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115226
PNG
(CHEMBL3609019)
Show SMILES OB(O)c1ccc(CN(Cc2ccccn2)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C23H20BFN6O3/c25-18-5-8-19(9-6-18)30-22(32)16-11-28-23(29-12-16)31(14-20-3-1-2-10-26-20)15-21-7-4-17(13-27-21)24(33)34/h1-13,33-34H,14-15H2,(H,30,32)
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n/an/a 2.05E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115218
PNG
(CHEMBL3609004)
Show SMILES OB(O)c1ccc(CNc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H17BFN3O3/c21-16-6-8-17(9-7-16)24-19(25)14-3-10-18(23-12-14)22-11-13-1-4-15(5-2-13)20(26)27/h1-10,12,26-27H,11H2,(H,22,23)(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115287
PNG
(CHEMBL3609015)
Show SMILES OB(O)c1ccc(CN(CC2CCOCC2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C24H26BFN4O4/c26-20-3-6-21(7-4-20)29-24(31)18-1-8-23(28-13-18)30(15-17-9-11-34-12-10-17)16-22-5-2-19(14-27-22)25(32)33/h1-8,13-14,17,32-33H,9-12,15-16H2,(H,29,31)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115212
PNG
(CHEMBL3609009)
Show SMILES CN(Cc1cccc(c1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-3-2-4-15(9-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-7-5-16(21)6-8-17/h2-11,27-28H,12H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115212
PNG
(CHEMBL3609009)
Show SMILES CN(Cc1cccc(c1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-3-2-4-15(9-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-7-5-16(21)6-8-17/h2-11,27-28H,12H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115211
PNG
(CHEMBL3609010)
Show SMILES OB(O)c1ccc(CNc2ncc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H16BFN4O3/c20-15-5-7-16(8-6-15)24-17(25)13-10-22-18(23-11-13)21-9-12-1-3-14(4-2-12)19(26)27/h1-8,10-11,26-27H,9H2,(H,24,25)(H,21,22,23)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115219
PNG
(CHEMBL3609003)
Show SMILES CN(Cc1cccc(c1)B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H19BFN3O3/c1-25(13-14-3-2-4-16(11-14)21(27)28)19-10-5-15(12-23-19)20(26)24-18-8-6-17(22)7-9-18/h2-12,27-28H,13H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115218
PNG
(CHEMBL3609004)
Show SMILES OB(O)c1ccc(CNc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H17BFN3O3/c21-16-6-8-17(9-7-16)24-19(25)14-3-10-18(23-12-14)22-11-13-1-4-15(5-2-13)20(26)27/h1-10,12,26-27H,11H2,(H,22,23)(H,24,25)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115226
PNG
(CHEMBL3609019)
Show SMILES OB(O)c1ccc(CN(Cc2ccccn2)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C23H20BFN6O3/c25-18-5-8-19(9-6-18)30-22(32)16-11-28-23(29-12-16)31(14-20-3-1-2-10-26-20)15-21-7-4-17(13-27-21)24(33)34/h1-13,33-34H,14-15H2,(H,30,32)
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n/an/a 4.31E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115288
PNG
(CHEMBL3609014)
Show SMILES OB(O)c1ccc(CN(Cc2ccccn2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C24H21BFN5O3/c26-19-6-9-20(10-7-19)30-24(32)17-4-11-23(29-13-17)31(15-21-3-1-2-12-27-21)16-22-8-5-18(14-28-22)25(33)34/h1-14,33-34H,15-16H2,(H,30,32)
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n/an/a 4.85E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115285
PNG
(CHEMBL3609017)
Show SMILES OB(O)c1ccc(CN(CC(O)=O)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C19H17BFN5O5/c21-14-2-5-15(6-3-14)25-18(29)12-7-23-19(24-8-12)26(11-17(27)28)10-16-4-1-13(9-22-16)20(30)31/h1-9,30-31H,10-11H2,(H,25,29)(H,27,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115222
PNG
(CHEMBL3609000)
Show SMILES OB(O)c1ccccc1CNc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H17BFN3O3/c21-15-6-8-16(9-7-15)24-19(25)14-5-10-18(23-12-14)22-11-13-3-1-2-4-17(13)20(26)27/h1-10,12,26-27H,11H2,(H,22,23)(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115287
PNG
(CHEMBL3609015)
Show SMILES OB(O)c1ccc(CN(CC2CCOCC2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C24H26BFN4O4/c26-20-3-6-21(7-4-20)29-24(31)18-1-8-23(28-13-18)30(15-17-9-11-34-12-10-17)16-22-5-2-19(14-27-22)25(32)33/h1-8,13-14,17,32-33H,9-12,15-16H2,(H,29,31)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115225
PNG
(CHEMBL3609020)
Show SMILES NCCN(Cc1ccc(cn1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H20BFN6O3/c21-15-2-5-16(6-3-15)26-18(28)13-9-24-19(25-10-13)27(8-7-22)12-17-4-1-14(11-23-17)20(29)30/h1-6,9-11,29-30H,7-8,12,22H2,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115222
PNG
(CHEMBL3609000)
Show SMILES OB(O)c1ccccc1CNc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H17BFN3O3/c21-15-6-8-16(9-7-15)24-19(25)14-5-10-18(23-12-14)22-11-13-3-1-2-4-17(13)20(26)27/h1-10,12,26-27H,11H2,(H,22,23)(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115221
PNG
(CHEMBL3609001)
Show SMILES CN(Cc1ccccc1B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H19BFN3O3/c1-25(13-15-4-2-3-5-18(15)21(27)28)19-11-6-14(12-23-19)20(26)24-17-9-7-16(22)8-10-17/h2-12,27-28H,13H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115288
PNG
(CHEMBL3609014)
Show SMILES OB(O)c1ccc(CN(Cc2ccccn2)c2ccc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C24H21BFN5O3/c26-19-6-9-20(10-7-19)30-24(32)17-4-11-23(29-13-17)31(15-21-3-1-2-12-27-21)16-22-8-5-18(14-28-22)25(33)34/h1-14,33-34H,15-16H2,(H,30,32)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115214
PNG
(CHEMBL3609007)
Show SMILES CN(Cc1ccccc1B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-4-2-3-5-17(13)20(27)28)19-22-10-14(11-23-19)18(26)24-16-8-6-15(21)7-9-16/h2-11,27-28H,12H2,1H3,(H,24,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115225
PNG
(CHEMBL3609020)
Show SMILES NCCN(Cc1ccc(cn1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H20BFN6O3/c21-15-2-5-16(6-3-15)26-18(28)13-9-24-19(25-10-13)27(8-7-22)12-17-4-1-14(11-23-17)20(29)30/h1-6,9-11,29-30H,7-8,12,22H2,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115221
PNG
(CHEMBL3609001)
Show SMILES CN(Cc1ccccc1B(O)O)c1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H19BFN3O3/c1-25(13-15-4-2-3-5-18(15)21(27)28)19-11-6-14(12-23-19)20(26)24-17-9-7-16(22)8-10-17/h2-12,27-28H,13H2,1H3,(H,24,26)
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50115214
PNG
(CHEMBL3609007)
Show SMILES CN(Cc1ccccc1B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-4-2-3-5-17(13)20(27)28)19-22-10-14(11-23-19)18(26)24-16-8-6-15(21)7-9-16/h2-11,27-28H,12H2,1H3,(H,24,26)
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50115285
PNG
(CHEMBL3609017)
Show SMILES OB(O)c1ccc(CN(CC(O)=O)c2ncc(cn2)C(=O)Nc2ccc(F)cc2)nc1
Show InChI InChI=1S/C19H17BFN5O5/c21-14-2-5-15(6-3-14)25-18(29)12-7-23-19(24-8-12)26(11-17(27)28)10-16-4-1-13(9-22-16)20(30)31/h1-9,30-31H,10-11H2,(H,25,29)(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...


Bioorg Med Chem Lett 25: 3793-7 (2015)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%