Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50117753
(CHEMBL3613806)Show SMILES COc1cc(CNCc2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1OC Show InChI InChI=1S/C21H22ClNO4/c1-24-19-10-14(11-20(25-2)21(19)26-3)12-23-13-17-8-9-18(27-17)15-4-6-16(22)7-5-15/h4-11,23H,12-13H2,1-3H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav3.1 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50117754
(CHEMBL3613808)Show SMILES COc1ccc(cc1Cl)-c1ccc(CNCc2cc(OC)c(OC)c(OC)c2)o1 Show InChI InChI=1S/C22H24ClNO5/c1-25-19-7-5-15(11-17(19)23)18-8-6-16(29-18)13-24-12-14-9-20(26-2)22(28-4)21(10-14)27-3/h5-11,24H,12-13H2,1-4H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav3.1 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50117752
(CHEMBL3613804)Show SMILES COc1cc(CNCc2ccc(o2)-c2cccc(c2)C(F)(F)F)cc(OC)c1OC Show InChI InChI=1S/C22H22F3NO4/c1-27-19-9-14(10-20(28-2)21(19)29-3)12-26-13-17-7-8-18(30-17)15-5-4-6-16(11-15)22(23,24)25/h4-11,26H,12-13H2,1-3H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav3.1 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM50117753
(CHEMBL3613806)Show SMILES COc1cc(CNCc2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1OC Show InChI InChI=1S/C21H22ClNO4/c1-24-19-10-14(11-20(25-2)21(19)26-3)12-23-13-17-8-9-18(27-17)15-4-6-16(22)7-5-15/h4-11,23H,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav2.2 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50117756
(CHEMBL3613811)Show InChI InChI=1S/C19H21ClN2O3/c1-23-17-6-12(7-18(24-2)19(17)25-3)9-21-10-13-11-22-16-5-4-14(20)8-15(13)16/h4-8,11,21-22H,9-10H2,1-3H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav3.1 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM50117754
(CHEMBL3613808)Show SMILES COc1ccc(cc1Cl)-c1ccc(CNCc2cc(OC)c(OC)c(OC)c2)o1 Show InChI InChI=1S/C22H24ClNO5/c1-25-19-7-5-15(11-17(19)23)18-8-6-16(29-18)13-24-12-14-9-20(26-2)22(28-4)21(10-14)27-3/h5-11,24H,12-13H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav2.2 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50117755
(CHEMBL3613810)Show SMILES COc1cc(CNCc2ccc(Oc3ccc(cc3)C#N)cc2)cc(OC)c1OC Show InChI InChI=1S/C24H24N2O4/c1-27-22-12-19(13-23(28-2)24(22)29-3)16-26-15-18-6-10-21(11-7-18)30-20-8-4-17(14-25)5-9-20/h4-13,26H,15-16H2,1-3H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav3.1 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM50117752
(CHEMBL3613804)Show SMILES COc1cc(CNCc2ccc(o2)-c2cccc(c2)C(F)(F)F)cc(OC)c1OC Show InChI InChI=1S/C22H22F3NO4/c1-27-19-9-14(10-20(28-2)21(19)29-3)12-26-13-17-7-8-18(30-17)15-5-4-6-16(11-15)22(23,24)25/h4-11,26H,12-13H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav2.2 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50117751
(CHEMBL3613802)Show SMILES NC(=O)c1cccc(NCc2ccc(o2)-c2ccc(Oc3ccc(cc3)C#N)cc2)c1 Show InChI InChI=1S/C25H19N3O3/c26-15-17-4-8-21(9-5-17)30-22-10-6-18(7-11-22)24-13-12-23(31-24)16-28-20-3-1-2-19(14-20)25(27)29/h1-14,28H,16H2,(H2,27,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav3.1 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM50117755
(CHEMBL3613810)Show SMILES COc1cc(CNCc2ccc(Oc3ccc(cc3)C#N)cc2)cc(OC)c1OC Show InChI InChI=1S/C24H24N2O4/c1-27-22-12-19(13-23(28-2)24(22)29-3)16-26-15-18-6-10-21(11-7-18)30-20-8-4-17(14-25)5-9-20/h4-13,26H,15-16H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav2.2 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM50117756
(CHEMBL3613811)Show InChI InChI=1S/C19H21ClN2O3/c1-23-17-6-12(7-18(24-2)19(17)25-3)9-21-10-13-11-22-16-5-4-14(20)8-15(13)16/h4-8,11,21-22H,9-10H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description
Inhibition of Cav2.2 channel (unknown origin) assessed as reduction in peak currents by whole cell patch-clamp method |
Bioorg Med Chem 23: 6166-72 (2015)
Article DOI: 10.1016/j.bmc.2015.07.067
BindingDB Entry DOI: 10.7270/Q21R6S9B |
More data for this
Ligand-Target Pair | |
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