Affinity Data by PubMed id=26314339

PubMed code 26314339

Found 2 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-ketoglutarate-dependent dioxygenase FTO (Homo sapiens (Human))	BDBM50117830 (CHEMBL3613953) Show SMILES Oc1cc(O)c(NC(=O)C2(CCC2)c2ccccc2)cc1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.95E+3	n/a	n/a	n/a	n/a	n/a	25
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of FTO (unknown origin) (31 to 505 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in 15-mer ssRNA (5'-CUUG...				J Med Chem 58: 7341-8 (2015) Article DOI: 10.1021/acs.jmedchem.5b00702 BindingDB Entry DOI: 10.7270/Q2X068TB
Zhengzhou University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-ketoglutarate-dependent dioxygenase FTO (Homo sapiens (Human))	BDBM50117830 (CHEMBL3613953) Show SMILES Oc1cc(O)c(NC(=O)C2(CCC2)c2ccccc2)cc1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Binding affinity to FTO (unknown origin) (31 to 505 residues) expressed in Escherichia coli BL21 (DE3) by ITC method				J Med Chem 58: 7341-8 (2015) Article DOI: 10.1021/acs.jmedchem.5b00702 BindingDB Entry DOI: 10.7270/Q2X068TB
Zhengzhou University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%