Found 40 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127711
(CHEMBL3629719)Show SMILES C[C@@H]1N(CCC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OCC(C)(C)C |r| Show InChI InChI=1S/C24H34N4O3/c1-16-12-18(13-19-14-25-26-20(16)19)21(29)27-9-6-24(7-10-27)8-11-28(17(24)2)22(30)31-15-23(3,4)5/h12-14,17H,6-11,15H2,1-5H3,(H,25,26)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127710
(CHEMBL3629720)Show SMILES C[C@H]1N(CCC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OCC(C)(C)C |r| Show InChI InChI=1S/C24H34N4O3/c1-16-12-18(13-19-14-25-26-20(16)19)21(29)27-9-6-24(7-10-27)8-11-28(17(24)2)22(30)31-15-23(3,4)5/h12-14,17H,6-11,15H2,1-5H3,(H,25,26)/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127718
(CHEMBL3629713)Show SMILES C[C@@H](OC(=O)N1CCC2(C1)CCN(CC2)C(=O)c1cc(C)c2[nH]ncc2c1)c1ccccc1 |r| Show InChI InChI=1S/C26H30N4O3/c1-18-14-21(15-22-16-27-28-23(18)22)24(31)29-11-8-26(9-12-29)10-13-30(17-26)25(32)33-19(2)20-6-4-3-5-7-20/h3-7,14-16,19H,8-13,17H2,1-2H3,(H,27,28)/t19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127711
(CHEMBL3629719)Show SMILES C[C@@H]1N(CCC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OCC(C)(C)C |r| Show InChI InChI=1S/C24H34N4O3/c1-16-12-18(13-19-14-25-26-20(16)19)21(29)27-9-6-24(7-10-27)8-11-28(17(24)2)22(30)31-15-23(3,4)5/h12-14,17H,6-11,15H2,1-5H3,(H,25,26)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127712
(CHEMBL3629718)Show SMILES C[C@@H]1CC2(CN1C(=O)OCC(C)(C)C)CCN(C(C)C2)C(=O)c1cc(C)c2[nH]ncc2c1 |r| Show InChI InChI=1S/C25H36N4O3/c1-16-9-19(10-20-13-26-27-21(16)20)22(30)28-8-7-25(11-17(28)2)12-18(3)29(14-25)23(31)32-15-24(4,5)6/h9-10,13,17-18H,7-8,11-12,14-15H2,1-6H3,(H,26,27)/t17?,18-,25?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127710
(CHEMBL3629720)Show SMILES C[C@H]1N(CCC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OCC(C)(C)C |r| Show InChI InChI=1S/C24H34N4O3/c1-16-12-18(13-19-14-25-26-20(16)19)21(29)27-9-6-24(7-10-27)8-11-28(17(24)2)22(30)31-15-23(3,4)5/h12-14,17H,6-11,15H2,1-5H3,(H,25,26)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127720
(CHEMBL3629711)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OCC(C)(C)C)CC1 Show InChI InChI=1S/C23H32N4O3/c1-16-11-17(12-18-13-24-25-19(16)18)20(28)26-8-5-23(6-9-26)7-10-27(14-23)21(29)30-15-22(2,3)4/h11-13H,5-10,14-15H2,1-4H3,(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127716
(CHEMBL3629715)Show SMILES CC1N(CC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H30N4O3/c1-14-10-16(11-17-12-23-24-18(14)17)19(27)25-8-6-22(7-9-25)13-26(15(22)2)20(28)29-21(3,4)5/h10-12,15H,6-9,13H2,1-5H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127718
(CHEMBL3629713)Show SMILES C[C@@H](OC(=O)N1CCC2(C1)CCN(CC2)C(=O)c1cc(C)c2[nH]ncc2c1)c1ccccc1 |r| Show InChI InChI=1S/C26H30N4O3/c1-18-14-21(15-22-16-27-28-23(18)22)24(31)29-11-8-26(9-12-29)10-13-30(17-26)25(32)33-19(2)20-6-4-3-5-7-20/h3-7,14-16,19H,8-13,17H2,1-2H3,(H,27,28)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127722
(CHEMBL3629709)Show SMILES C[C@@H](OC(=O)N1CC2(C1)CCN(CC2)C(=O)c1cc(C)c2[nH]ncc2c1)c1ccccc1 |r| Show InChI InChI=1S/C25H28N4O3/c1-17-12-20(13-21-14-26-27-22(17)21)23(30)28-10-8-25(9-11-28)15-29(16-25)24(31)32-18(2)19-6-4-3-5-7-19/h3-7,12-14,18H,8-11,15-16H2,1-2H3,(H,26,27)/t18-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127723
(CHEMBL3629708)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CN(C2)C(=O)OCC(C)(C)C)CC1 Show InChI InChI=1S/C22H30N4O3/c1-15-9-16(10-17-11-23-24-18(15)17)19(27)25-7-5-22(6-8-25)12-26(13-22)20(28)29-14-21(2,3)4/h9-11H,5-8,12-14H2,1-4H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127750
(CHEMBL3629705)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CN(C2)C(=O)OC(C)(C)C)CC1 Show InChI InChI=1S/C21H28N4O3/c1-14-9-15(10-16-11-22-23-17(14)16)18(26)24-7-5-21(6-8-24)12-25(13-21)19(27)28-20(2,3)4/h9-11H,5-8,12-13H2,1-4H3,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127752
(CHEMBL3629703)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OC(C)(C)C)CC1 Show InChI InChI=1S/C22H30N4O3/c1-15-11-16(12-17-13-23-24-18(15)17)19(27)25-8-5-22(6-9-25)7-10-26(14-22)20(28)29-21(2,3)4/h11-13H,5-10,14H2,1-4H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127750
(CHEMBL3629705)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CN(C2)C(=O)OC(C)(C)C)CC1 Show InChI InChI=1S/C21H28N4O3/c1-14-9-15(10-16-11-22-23-17(14)16)18(26)24-7-5-21(6-8-24)12-25(13-21)19(27)28-20(2,3)4/h9-11H,5-8,12-13H2,1-4H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127720
(CHEMBL3629711)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OCC(C)(C)C)CC1 Show InChI InChI=1S/C23H32N4O3/c1-16-11-17(12-18-13-24-25-19(16)18)20(28)26-8-5-23(6-9-26)7-10-27(14-23)21(29)30-15-22(2,3)4/h11-13H,5-10,14-15H2,1-4H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127751
(CHEMBL3629704)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CC2(C1)CCN(CC2)C(=O)OC(C)(C)C Show InChI InChI=1S/C21H28N4O3/c1-14-9-15(10-16-11-22-23-17(14)16)18(26)25-12-21(13-25)5-7-24(8-6-21)19(27)28-20(2,3)4/h9-11H,5-8,12-13H2,1-4H3,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127722
(CHEMBL3629709)Show SMILES C[C@@H](OC(=O)N1CC2(C1)CCN(CC2)C(=O)c1cc(C)c2[nH]ncc2c1)c1ccccc1 |r| Show InChI InChI=1S/C25H28N4O3/c1-17-12-20(13-21-14-26-27-22(17)21)23(30)28-10-8-25(9-11-28)15-29(16-25)24(31)32-18(2)19-6-4-3-5-7-19/h3-7,12-14,18H,8-11,15-16H2,1-2H3,(H,26,27)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127716
(CHEMBL3629715)Show SMILES CC1N(CC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H30N4O3/c1-14-10-16(11-17-12-23-24-18(14)17)19(27)25-8-6-22(7-9-25)13-26(15(22)2)20(28)29-21(3,4)5/h10-12,15H,6-9,13H2,1-5H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127752
(CHEMBL3629703)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OC(C)(C)C)CC1 Show InChI InChI=1S/C22H30N4O3/c1-15-11-16(12-17-13-23-24-18(15)17)19(27)25-8-5-22(6-9-25)7-10-26(14-22)20(28)29-21(2,3)4/h11-13H,5-10,14H2,1-4H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127753
(CHEMBL3629702)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(C1)CCN(CC2)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H30N4O3/c1-15-11-16(12-17-13-23-24-18(15)17)19(27)26-10-7-22(14-26)5-8-25(9-6-22)20(28)29-21(2,3)4/h11-13H,5-10,14H2,1-4H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127712
(CHEMBL3629718)Show SMILES C[C@@H]1CC2(CN1C(=O)OCC(C)(C)C)CCN(C(C)C2)C(=O)c1cc(C)c2[nH]ncc2c1 |r| Show InChI InChI=1S/C25H36N4O3/c1-16-9-19(10-20-13-26-27-21(16)20)22(30)28-8-7-25(11-17(28)2)12-18(3)29(14-25)23(31)32-15-24(4,5)6/h9-10,13,17-18H,7-8,11-12,14-15H2,1-6H3,(H,26,27)/t17?,18-,25?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127723
(CHEMBL3629708)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CN(C2)C(=O)OCC(C)(C)C)CC1 Show InChI InChI=1S/C22H30N4O3/c1-15-9-16(10-17-11-23-24-18(15)17)19(27)25-7-5-22(6-8-25)12-26(13-22)20(28)29-14-21(2,3)4/h9-11H,5-8,12-14H2,1-4H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127721
(CHEMBL3629710)Show SMILES CC(C)OC(=O)N1CCC2(C1)CCN(CC2)C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C21H28N4O3/c1-14(2)28-20(27)25-9-6-21(13-25)4-7-24(8-5-21)19(26)16-10-15(3)18-17(11-16)12-22-23-18/h10-12,14H,4-9,13H2,1-3H3,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127719
(CHEMBL3629712)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OCc2ccccc2)CC1 Show InChI InChI=1S/C25H28N4O3/c1-18-13-20(14-21-15-26-27-22(18)21)23(30)28-10-7-25(8-11-28)9-12-29(17-25)24(31)32-16-19-5-3-2-4-6-19/h2-6,13-15H,7-12,16-17H2,1H3,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127753
(CHEMBL3629702)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(C1)CCN(CC2)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H30N4O3/c1-15-11-16(12-17-13-23-24-18(15)17)19(27)26-10-7-22(14-26)5-8-25(9-6-22)20(28)29-21(2,3)4/h11-13H,5-10,14H2,1-4H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127713
(CHEMBL3629717)Show SMILES C[C@H]1CC2(CN1C(=O)OCC(C)(C)C)CCN(C(C)C2)C(=O)c1cc(C)c2[nH]ncc2c1 |r| Show InChI InChI=1S/C25H36N4O3/c1-16-9-19(10-20-13-26-27-21(16)20)22(30)28-8-7-25(11-17(28)2)12-18(3)29(14-25)23(31)32-15-24(4,5)6/h9-10,13,17-18H,7-8,11-12,14-15H2,1-6H3,(H,26,27)/t17?,18-,25?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127751
(CHEMBL3629704)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CC2(C1)CCN(CC2)C(=O)OC(C)(C)C Show InChI InChI=1S/C21H28N4O3/c1-14-9-15(10-16-11-22-23-17(14)16)18(26)25-12-21(13-25)5-7-24(8-6-21)19(27)28-20(2,3)4/h9-11H,5-8,12-13H2,1-4H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127719
(CHEMBL3629712)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OCc2ccccc2)CC1 Show InChI InChI=1S/C25H28N4O3/c1-18-13-20(14-21-15-26-27-22(18)21)23(30)28-10-7-25(8-11-28)9-12-29(17-25)24(31)32-16-19-5-3-2-4-6-19/h2-6,13-15H,7-12,16-17H2,1H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127721
(CHEMBL3629710)Show SMILES CC(C)OC(=O)N1CCC2(C1)CCN(CC2)C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C21H28N4O3/c1-14(2)28-20(27)25-9-6-21(13-25)4-7-24(8-5-21)19(26)16-10-15(3)18-17(11-16)12-22-23-18/h10-12,14H,4-9,13H2,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127717
(CHEMBL3629714)Show SMILES CC1CC2(CN(C2)C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C22H30N4O3/c1-14-8-16(9-17-11-23-24-18(14)17)19(27)26-7-6-22(10-15(26)2)12-25(13-22)20(28)29-21(3,4)5/h8-9,11,15H,6-7,10,12-13H2,1-5H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127713
(CHEMBL3629717)Show SMILES C[C@H]1CC2(CN1C(=O)OCC(C)(C)C)CCN(C(C)C2)C(=O)c1cc(C)c2[nH]ncc2c1 |r| Show InChI InChI=1S/C25H36N4O3/c1-16-9-19(10-20-13-26-27-21(16)20)22(30)28-8-7-25(11-17(28)2)12-18(3)29(14-25)23(31)32-15-24(4,5)6/h9-10,13,17-18H,7-8,11-12,14-15H2,1-6H3,(H,26,27)/t17?,18-,25?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127717
(CHEMBL3629714)Show SMILES CC1CC2(CN(C2)C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C22H30N4O3/c1-14-8-16(9-17-11-23-24-18(14)17)19(27)26-7-6-22(10-15(26)2)12-25(13-22)20(28)29-21(3,4)5/h8-9,11,15H,6-7,10,12-13H2,1-5H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127714
(CHEMBL3629716)Show SMILES CC1CC2(CCN(C2)C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C23H32N4O3/c1-15-10-17(11-18-13-24-25-19(15)18)20(28)27-9-7-23(12-16(27)2)6-8-26(14-23)21(29)30-22(3,4)5/h10-11,13,16H,6-9,12,14H2,1-5H3,(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127714
(CHEMBL3629716)Show SMILES CC1CC2(CCN(C2)C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C23H32N4O3/c1-15-10-17(11-18-13-24-25-19(15)18)20(28)27-9-7-23(12-16(27)2)6-8-26(14-23)21(29)30-22(3,4)5/h10-11,13,16H,6-9,12,14H2,1-5H3,(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127724
(CHEMBL3629707)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CC2(CN(C2)C(=O)OC(C)(C)C)C1 Show InChI InChI=1S/C19H24N4O3/c1-12-5-13(6-14-7-20-21-15(12)14)16(24)22-8-19(9-22)10-23(11-19)17(25)26-18(2,3)4/h5-7H,8-11H2,1-4H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127725
(CHEMBL3629706)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OC(C)(C)C)C1 Show InChI InChI=1S/C21H28N4O3/c1-14-9-15(10-16-11-22-23-17(14)16)18(26)24-7-5-21(12-24)6-8-25(13-21)19(27)28-20(2,3)4/h9-11H,5-8,12-13H2,1-4H3,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127714
(CHEMBL3629716)Show SMILES CC1CC2(CCN(C2)C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C23H32N4O3/c1-15-10-17(11-18-13-24-25-19(15)18)20(28)27-9-7-23(12-16(27)2)6-8-26(14-23)21(29)30-22(3,4)5/h10-11,13,16H,6-9,12,14H2,1-5H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127714
(CHEMBL3629716)Show SMILES CC1CC2(CCN(C2)C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)c2[nH]ncc2c1 Show InChI InChI=1S/C23H32N4O3/c1-15-10-17(11-18-13-24-25-19(15)18)20(28)27-9-7-23(12-16(27)2)6-8-26(14-23)21(29)30-22(3,4)5/h10-11,13,16H,6-9,12,14H2,1-5H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50127725
(CHEMBL3629706)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CCN(C2)C(=O)OC(C)(C)C)C1 Show InChI InChI=1S/C21H28N4O3/c1-14-9-15(10-16-11-22-23-17(14)16)18(26)24-7-5-21(12-24)6-8-25(13-21)19(27)28-20(2,3)4/h9-11H,5-8,12-13H2,1-4H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 1
(Rattus norvegicus (Rat)) | BDBM50127724
(CHEMBL3629707)Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CC2(CN(C2)C(=O)OC(C)(C)C)C1 Show InChI InChI=1S/C19H24N4O3/c1-12-5-13(6-14-7-20-21-15(12)14)16(24)22-8-19(9-22)10-23(11-19)17(25)26-18(2,3)4/h5-7H,8-11H2,1-4H3,(H,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
Curated by ChEMBL
| Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil... |
Bioorg Med Chem Lett 25: 5352-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.035
BindingDB Entry DOI: 10.7270/Q2W37Z4R |
More data for this
Ligand-Target Pair | |
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