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PubMed code 26430878

Compile data set for download or QSAR
Found 102 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128270
PNG
(CHEMBL3628719)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-21-28(23-10-13-33-14-11-23)31(35-36)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)34-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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PubMed
n/an/a 0.240n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128274
PNG
(CHEMBL3628723)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2nc3ccccc3cc2OCCF)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-23(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-25-26(33-15-12-28)16-21-4-2-3-5-24(21)30-25/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 0.260n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128269
PNG
(CHEMBL3628718)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-19-26(21-10-13-31-14-11-21)29(33-34)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)32-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 0.270n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128275
PNG
(CHEMBL3628724)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-23(17-10-12-27-13-11-17)25(29-30)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)28-21/h2-15H,16H2,1H3
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n/an/a 0.290n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128239
PNG
(CHEMBL3628998)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-33(30(23-36-38)25-10-13-35-14-11-25)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)37-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128293
PNG
(CHEMBL3628716)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-24(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)30-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 0.320n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128271
PNG
(CHEMBL3628720)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-23-30(25-10-13-35-14-11-25)33(37-38)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)36-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 0.330n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128237
PNG
(CHEMBL3628996)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-29(26(19-32-34)21-10-13-31-14-11-21)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)33-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 0.360n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128259
PNG
(CHEMBL3628999)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-27(24(17-31-33)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)32-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,32)
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n/an/a 0.370n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128238
PNG
(CHEMBL3628997)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-31(28(21-34-36)23-10-13-33-14-11-23)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)35-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 0.470n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128272
PNG
(CHEMBL3628721)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-17-24(19-10-13-29-14-11-19)27(32-33)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,31)
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n/an/a 0.520n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128268
PNG
(CHEMBL3628717)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-17-26(20-10-13-30-14-11-20)28(32-33)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)31-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 0.650n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128279
PNG
(CHEMBL3628714)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(18-10-12-28-13-11-18)26(30-31)19-6-8-22(9-7-19)32-17-21-14-20(15-27)23-4-2-3-5-25(23)29-21/h2-14,16H,15,17H2,1H3
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n/an/a 0.680n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128291
PNG
(CHEMBL3628713)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(F)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-22(17-10-12-27-13-11-17)25(29-30)18-6-8-20(9-7-18)31-16-19-14-23(26)21-4-2-3-5-24(21)28-19/h2-15H,16H2,1H3
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n/an/a 0.710n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128266
PNG
(CHEMBL3629001)
Show SMILES Cn1ncc(c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-25(23(15-28-30)17-10-12-27-13-11-17)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)29-21/h2-15H,16H2,1H3
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n/an/a 0.760n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128236
PNG
(CHEMBL3628995)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-28(26(17-31-33)20-10-13-30-14-11-20)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)32-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128278
PNG
(CHEMBL3628994)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-27(24(17-30-32)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.20n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128292
PNG
(CHEMBL3628715)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O/c1-33-18-26(20-12-15-30-16-13-20)28(32-33)21-8-10-24(11-9-21)34-19-23-17-22(5-4-14-29)25-6-2-3-7-27(25)31-23/h2-3,6-13,15-18H,4-5,14,19H2,1H3
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n/an/a 1.80n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128273
PNG
(CHEMBL3628722)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-18-26(20-11-14-31-15-12-20)29(34-36)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)32-23)37-17-22(10-13-30)33-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 3.10n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128265
PNG
(CHEMBL3629000)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-29(26(17-32-36)20-11-14-31-15-12-20)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)33-23)37-18-22(10-13-30)34-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128277
PNG
(CHEMBL3628726)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(OCCF)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-25(19-10-13-29-14-11-19)27(31-32)20-3-6-23(7-4-20)34-18-22-5-2-21-16-24(33-15-12-28)8-9-26(21)30-22/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50128276
PNG
(CHEMBL3628725)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(CF)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(19-10-12-28-13-11-19)26(30-31)20-4-7-23(8-5-20)32-17-22-6-3-21-14-18(15-27)2-9-25(21)29-22/h2-14,16H,15,17H2,1H3
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n/an/a>76n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128292
PNG
(CHEMBL3628715)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O/c1-33-18-26(20-12-15-30-16-13-20)28(32-33)21-8-10-24(11-9-21)34-19-23-17-22(5-4-14-29)25-6-2-3-7-27(25)31-23/h2-3,6-13,15-18H,4-5,14,19H2,1H3
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n/an/a 380n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128292
PNG
(CHEMBL3628715)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O/c1-33-18-26(20-12-15-30-16-13-20)28(32-33)21-8-10-24(11-9-21)34-19-23-17-22(5-4-14-29)25-6-2-3-7-27(25)31-23/h2-3,6-13,15-18H,4-5,14,19H2,1H3
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n/an/a 460n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128266
PNG
(CHEMBL3629001)
Show SMILES Cn1ncc(c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-25(23(15-28-30)17-10-12-27-13-11-17)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)29-21/h2-15H,16H2,1H3
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n/an/a 760n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128265
PNG
(CHEMBL3629000)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-29(26(17-32-36)20-11-14-31-15-12-20)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)33-23)37-18-22(10-13-30)34-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 810n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128265
PNG
(CHEMBL3629000)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-29(26(17-32-36)20-11-14-31-15-12-20)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)33-23)37-18-22(10-13-30)34-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128269
PNG
(CHEMBL3628718)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-19-26(21-10-13-31-14-11-21)29(33-34)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)32-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128293
PNG
(CHEMBL3628716)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-24(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)30-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128278
PNG
(CHEMBL3628994)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-27(24(17-30-32)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.02E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128274
PNG
(CHEMBL3628723)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2nc3ccccc3cc2OCCF)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-23(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-25-26(33-15-12-28)16-21-4-2-3-5-24(21)30-25/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128269
PNG
(CHEMBL3628718)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-19-26(21-10-13-31-14-11-21)29(33-34)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)32-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 1.44E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128273
PNG
(CHEMBL3628722)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-18-26(20-11-14-31-15-12-20)29(34-36)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)32-23)37-17-22(10-13-30)33-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 1.57E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128270
PNG
(CHEMBL3628719)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-21-28(23-10-13-33-14-11-23)31(35-36)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)34-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 1.57E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128270
PNG
(CHEMBL3628719)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-21-28(23-10-13-33-14-11-23)31(35-36)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)34-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 1.58E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128259
PNG
(CHEMBL3628999)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-27(24(17-31-33)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)32-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,32)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128239
PNG
(CHEMBL3628998)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-33(30(23-36-38)25-10-13-35-14-11-25)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)37-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 1.73E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128274
PNG
(CHEMBL3628723)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2nc3ccccc3cc2OCCF)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-23(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-25-26(33-15-12-28)16-21-4-2-3-5-24(21)30-25/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.76E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128268
PNG
(CHEMBL3628717)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-17-26(20-10-13-30-14-11-20)28(32-33)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)31-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 1.77E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128293
PNG
(CHEMBL3628716)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-24(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)30-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.77E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128265
PNG
(CHEMBL3629000)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-29(26(17-32-36)20-11-14-31-15-12-20)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)33-23)37-18-22(10-13-30)34-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 1.86E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128268
PNG
(CHEMBL3628717)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-17-26(20-10-13-30-14-11-20)28(32-33)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)31-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 2.22E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128275
PNG
(CHEMBL3628724)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-23(17-10-12-27-13-11-17)25(29-30)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)28-21/h2-15H,16H2,1H3
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n/an/a 2.33E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128275
PNG
(CHEMBL3628724)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-23(17-10-12-27-13-11-17)25(29-30)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)28-21/h2-15H,16H2,1H3
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n/an/a 2.55E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128272
PNG
(CHEMBL3628721)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-17-24(19-10-13-29-14-11-19)27(32-33)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,31)
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n/an/a 3.48E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128273
PNG
(CHEMBL3628722)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-18-26(20-11-14-31-15-12-20)29(34-36)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)32-23)37-17-22(10-13-30)33-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 3.56E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128278
PNG
(CHEMBL3628994)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-27(24(17-30-32)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 3.72E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128272
PNG
(CHEMBL3628721)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-17-24(19-10-13-29-14-11-19)27(32-33)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,31)
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n/an/a 3.74E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128278
PNG
(CHEMBL3628994)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-27(24(17-30-32)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 3.77E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128279
PNG
(CHEMBL3628714)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(18-10-12-28-13-11-18)26(30-31)19-6-8-22(9-7-19)32-17-21-14-20(15-27)23-4-2-3-5-25(23)29-21/h2-14,16H,15,17H2,1H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128268
PNG
(CHEMBL3628717)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-17-26(20-10-13-30-14-11-20)28(32-33)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)31-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 4.07E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128279
PNG
(CHEMBL3628714)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(18-10-12-28-13-11-18)26(30-31)19-6-8-22(9-7-19)32-17-21-14-20(15-27)23-4-2-3-5-25(23)29-21/h2-14,16H,15,17H2,1H3
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n/an/a 4.09E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128236
PNG
(CHEMBL3628995)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-28(26(17-31-33)20-10-13-30-14-11-20)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)32-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 4.24E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128273
PNG
(CHEMBL3628722)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-18-26(20-11-14-31-15-12-20)29(34-36)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)32-23)37-17-22(10-13-30)33-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 4.51E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128268
PNG
(CHEMBL3628717)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-17-26(20-10-13-30-14-11-20)28(32-33)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)31-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 4.55E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128236
PNG
(CHEMBL3628995)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-28(26(17-31-33)20-10-13-30-14-11-20)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)32-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 4.77E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128272
PNG
(CHEMBL3628721)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-17-24(19-10-13-29-14-11-19)27(32-33)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,31)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128278
PNG
(CHEMBL3628994)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-27(24(17-30-32)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 5.61E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128279
PNG
(CHEMBL3628714)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(18-10-12-28-13-11-18)26(30-31)19-6-8-22(9-7-19)32-17-21-14-20(15-27)23-4-2-3-5-25(23)29-21/h2-14,16H,15,17H2,1H3
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n/an/a 5.68E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128272
PNG
(CHEMBL3628721)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-17-24(19-10-13-29-14-11-19)27(32-33)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)31-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,31)
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n/an/a 5.97E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128291
PNG
(CHEMBL3628713)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(F)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-22(17-10-12-27-13-11-17)25(29-30)18-6-8-20(9-7-18)31-16-19-14-23(26)21-4-2-3-5-24(21)28-19/h2-15H,16H2,1H3
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n/an/a 6.42E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128238
PNG
(CHEMBL3628997)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-31(28(21-34-36)23-10-13-33-14-11-23)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)35-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 7.31E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128279
PNG
(CHEMBL3628714)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C26H21FN4O/c1-31-16-24(18-10-12-28-13-11-18)26(30-31)19-6-8-22(9-7-19)32-17-21-14-20(15-27)23-4-2-3-5-25(23)29-21/h2-14,16H,15,17H2,1H3
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n/an/a 7.71E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128293
PNG
(CHEMBL3628716)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-24(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)30-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 7.76E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128291
PNG
(CHEMBL3628713)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(F)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-22(17-10-12-27-13-11-17)25(29-30)18-6-8-20(9-7-18)31-16-19-14-23(26)21-4-2-3-5-24(21)28-19/h2-15H,16H2,1H3
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n/an/a 8.35E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128238
PNG
(CHEMBL3628997)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-31(28(21-34-36)23-10-13-33-14-11-23)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)35-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 8.36E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128266
PNG
(CHEMBL3629001)
Show SMILES Cn1ncc(c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-25(23(15-28-30)17-10-12-27-13-11-17)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)29-21/h2-15H,16H2,1H3
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n/an/a 9.73E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128271
PNG
(CHEMBL3628720)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-23-30(25-10-13-35-14-11-25)33(37-38)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)36-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 9.89E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128271
PNG
(CHEMBL3628720)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-23-30(25-10-13-35-14-11-25)33(37-38)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)36-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 1.03E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128237
PNG
(CHEMBL3628996)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-29(26(19-32-34)21-10-13-31-14-11-21)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)33-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 1.16E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128237
PNG
(CHEMBL3628996)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-29(26(19-32-34)21-10-13-31-14-11-21)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)33-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 1.23E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128259
PNG
(CHEMBL3628999)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-27(24(17-31-33)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)32-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,32)
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n/an/a 1.24E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50128239
PNG
(CHEMBL3628998)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-33(30(23-36-38)25-10-13-35-14-11-25)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)37-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128265
PNG
(CHEMBL3629000)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-29(26(17-32-36)20-11-14-31-15-12-20)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)33-23)37-18-22(10-13-30)34-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 1.62E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128269
PNG
(CHEMBL3628718)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-19-26(21-10-13-31-14-11-21)29(33-34)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)32-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 1.62E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50128273
PNG
(CHEMBL3628722)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H24FN7O/c1-36-18-26(20-11-14-31-15-12-20)29(34-36)21-6-8-24(9-7-21)38-19-23-16-28(25-4-2-3-5-27(25)32-23)37-17-22(10-13-30)33-35-37/h2-9,11-12,14-18H,10,13,19H2,1H3
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n/an/a 1.83E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128292
PNG
(CHEMBL3628715)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O/c1-33-18-26(20-12-15-30-16-13-20)28(32-33)21-8-10-24(11-9-21)34-19-23-17-22(5-4-14-29)25-6-2-3-7-27(25)31-23/h2-3,6-13,15-18H,4-5,14,19H2,1H3
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n/an/a 1.91E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128274
PNG
(CHEMBL3628723)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2nc3ccccc3cc2OCCF)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-23(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-25-26(33-15-12-28)16-21-4-2-3-5-24(21)30-25/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 1.99E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128292
PNG
(CHEMBL3628715)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(CCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O/c1-33-18-26(20-12-15-30-16-13-20)28(32-33)21-8-10-24(11-9-21)34-19-23-17-22(5-4-14-29)25-6-2-3-7-27(25)31-23/h2-3,6-13,15-18H,4-5,14,19H2,1H3
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n/an/a 2.19E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128269
PNG
(CHEMBL3628718)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-19-26(21-10-13-31-14-11-21)29(33-34)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)32-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 2.29E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128275
PNG
(CHEMBL3628724)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-23(17-10-12-27-13-11-17)25(29-30)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)28-21/h2-15H,16H2,1H3
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n/an/a 2.39E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128274
PNG
(CHEMBL3628723)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2nc3ccccc3cc2OCCF)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-23(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-25-26(33-15-12-28)16-21-4-2-3-5-24(21)30-25/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 2.59E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128239
PNG
(CHEMBL3628998)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-33(30(23-36-38)25-10-13-35-14-11-25)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)37-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 2.81E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128293
PNG
(CHEMBL3628716)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H23FN4O2/c1-32-17-24(19-10-13-29-14-11-19)27(31-32)20-6-8-22(9-7-20)34-18-21-16-26(33-15-12-28)23-4-2-3-5-25(23)30-21/h2-11,13-14,16-17H,12,15,18H2,1H3
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n/an/a 2.95E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128271
PNG
(CHEMBL3628720)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-23-30(25-10-13-35-14-11-25)33(37-38)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)36-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 2.96E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128259
PNG
(CHEMBL3628999)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-27(24(17-31-33)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)32-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,32)
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n/an/a 3.83E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128275
PNG
(CHEMBL3628724)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-23(17-10-12-27-13-11-17)25(29-30)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)28-21/h2-15H,16H2,1H3
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n/an/a 3.85E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128237
PNG
(CHEMBL3628996)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-29(26(19-32-34)21-10-13-31-14-11-21)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)33-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 5.01E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128238
PNG
(CHEMBL3628997)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-31(28(21-34-36)23-10-13-33-14-11-23)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)35-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 5.18E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128239
PNG
(CHEMBL3628998)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-33(30(23-36-38)25-10-13-35-14-11-25)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)37-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 5.87E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128270
PNG
(CHEMBL3628719)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-21-28(23-10-13-33-14-11-23)31(35-36)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)34-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 6.19E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128238
PNG
(CHEMBL3628997)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-31(28(21-34-36)23-10-13-33-14-11-23)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)35-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 6.22E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128237
PNG
(CHEMBL3628996)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C29H27FN4O3/c1-34-29(26(19-32-34)21-10-13-31-14-11-21)22-6-8-24(9-7-22)37-20-23-18-28(36-17-16-35-15-12-30)25-4-2-3-5-27(25)33-23/h2-11,13-14,18-19H,12,15-17,20H2,1H3
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n/an/a 6.64E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128259
PNG
(CHEMBL3628999)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C27H24FN5O/c1-33-27(24(17-31-33)19-10-13-29-14-11-19)20-6-8-22(9-7-20)34-18-21-16-26(30-15-12-28)23-4-2-3-5-25(23)32-21/h2-11,13-14,16-17H,12,15,18H2,1H3,(H,30,32)
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n/an/a 7.88E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128291
PNG
(CHEMBL3628713)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(F)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-22(17-10-12-27-13-11-17)25(29-30)18-6-8-20(9-7-18)31-16-19-14-23(26)21-4-2-3-5-24(21)28-19/h2-15H,16H2,1H3
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n/an/a 1.03E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128266
PNG
(CHEMBL3629001)
Show SMILES Cn1ncc(c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-25(23(15-28-30)17-10-12-27-13-11-17)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)29-21/h2-15H,16H2,1H3
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n/an/a 1.11E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128270
PNG
(CHEMBL3628719)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C31H31FN4O4/c1-36-21-28(23-10-13-33-14-11-23)31(35-36)24-6-8-26(9-7-24)40-22-25-20-30(27-4-2-3-5-29(27)34-25)39-19-18-38-17-16-37-15-12-32/h2-11,13-14,20-21H,12,15-19,22H2,1H3
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n/an/a 1.16E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128271
PNG
(CHEMBL3628720)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C33H35FN4O5/c1-38-23-30(25-10-13-35-14-11-25)33(37-38)26-6-8-28(9-7-26)43-24-27-22-32(29-4-2-3-5-31(29)36-27)42-21-20-41-19-18-40-17-16-39-15-12-34/h2-11,13-14,22-23H,12,15-21,24H2,1H3
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n/an/a 1.44E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128266
PNG
(CHEMBL3629001)
Show SMILES Cn1ncc(c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-25(23(15-28-30)17-10-12-27-13-11-17)18-3-7-22(8-4-18)31-16-21-6-2-19-14-20(26)5-9-24(19)29-21/h2-15H,16H2,1H3
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n/an/a 1.51E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128291
PNG
(CHEMBL3628713)
Show SMILES Cn1cc(c(n1)-c1ccc(OCc2cc(F)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C25H19FN4O/c1-30-15-22(17-10-12-27-13-11-17)25(29-30)18-6-8-20(9-7-18)31-16-19-14-23(26)21-4-2-3-5-24(21)28-19/h2-15H,16H2,1H3
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n/an/a 1.99E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A


(Homo sapiens (Human))
BDBM50128236
PNG
(CHEMBL3628995)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-28(26(17-31-33)20-10-13-30-14-11-20)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)32-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a 3.06E+5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B


(Homo sapiens (Human))
BDBM50128236
PNG
(CHEMBL3628995)
Show SMILES Cn1ncc(c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1)-c1ccncc1
Show InChI InChI=1S/C28H25FN4O2/c1-33-28(26(17-31-33)20-10-13-30-14-11-20)21-6-8-24(9-7-21)35-19-23-16-22(18-34-15-12-29)25-4-2-3-5-27(25)32-23/h2-11,13-14,16-17H,12,15,18-19H2,1H3
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n/an/a>1.00E+6n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...


J Med Chem 58: 8584-600 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01205
BindingDB Entry DOI: 10.7270/Q2C53NPQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%