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PubMed code 26447940

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131062
PNG
(CHEMBL3634184)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15ClN5O12P3S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(26-9)1-25-31(24,32)28-30(22,23)27-29(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,32)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,31?/m1/s1
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n/an/an/an/a 880n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131063
PNG
(CHEMBL3634183)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H14ClN5O9P2S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(24-9)1-23-27(22,28)25-26(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,27?/m1/s1
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n/an/an/an/a 500n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131061
PNG
(CHEMBL3634185)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O9P2S2/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(24-10)2-23-26(19,20)25-27(21,22)28/h3-4,6-7,10,17-18H,2H2,1H3,(H,19,20)(H2,12,14,15)(H2,21,22,28)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 900n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131064
PNG
(CHEMBL3634182)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O9P2S2/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(24-10)2-23-27(22,28)25-26(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-,27?/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-U-69,593 binding to Opioid receptor kappa 1

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131062
PNG
(CHEMBL3634184)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15ClN5O12P3S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(26-9)1-25-31(24,32)28-30(22,23)27-29(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,32)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,31?/m1/s1
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n/an/an/an/a 880n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cathepsin B activity

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131059
PNG
(CHEMBL575257)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-26(21,27)24-25(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,27)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-,26?/m1/s1
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n/an/an/an/a 130n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50118242
PNG
(((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-...)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O10P2S/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131064
PNG
(CHEMBL3634182)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O9P2S2/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(24-10)2-23-27(22,28)25-26(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-,27?/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131063
PNG
(CHEMBL3634183)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H14ClN5O9P2S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(24-9)1-23-27(22,28)25-26(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,27?/m1/s1
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n/an/an/an/a 500n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cathepsin B activity

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50118230
PNG
(5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADEN...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 3.27E+4n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131063
PNG
(CHEMBL3634183)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H14ClN5O9P2S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(24-9)1-23-27(22,28)25-26(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,27?/m1/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131064
PNG
(CHEMBL3634182)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O9P2S2/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(24-10)2-23-27(22,28)25-26(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-,27?/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131059
PNG
(CHEMBL575257)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-26(21,27)24-25(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,27)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-,26?/m1/s1
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n/an/an/an/a 130n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against Cathepsin B activity

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131063
PNG
(CHEMBL3634183)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H14ClN5O9P2S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(24-9)1-23-27(22,28)25-26(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,27?/m1/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131064
PNG
(CHEMBL3634182)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O9P2S2/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(24-10)2-23-27(22,28)25-26(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,28)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-,27?/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131059
PNG
(CHEMBL575257)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-26(21,27)24-25(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,27)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-,26?/m1/s1
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n/an/an/an/a 8.70E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131062
PNG
(CHEMBL3634184)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15ClN5O12P3S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(26-9)1-25-31(24,32)28-30(22,23)27-29(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,32)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,31?/m1/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50368125
PNG
(ADENOSINE DIPHOSPHATE | ADP)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131061
PNG
(CHEMBL3634185)
Show SMILES CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C11H17N5O9P2S2/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(24-10)2-23-26(19,20)25-27(21,22)28/h3-4,6-7,10,17-18H,2H2,1H3,(H,19,20)(H2,12,14,15)(H2,21,22,28)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131059
PNG
(CHEMBL575257)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-26(21,27)24-25(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,27)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-,26?/m1/s1
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n/an/an/an/a 8.70E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50368125
PNG
(ADENOSINE DIPHOSPHATE | ADP)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 24n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50366480
PNG
(ADENOSINE TRIPHOSPHATE | ATP)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 850n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131062
PNG
(CHEMBL3634184)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H15ClN5O12P3S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(26-9)1-25-31(24,32)28-30(22,23)27-29(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,32)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6-,9-,31?/m1/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50366480
PNG
(ADENOSINE TRIPHOSPHATE | ATP)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 6.70E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50131060
PNG
(CHEMBL3634186)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H14ClN5O9P2S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(24-9)1-23-26(19,20)25-27(21,22)28/h2-3,5-6,9,17-18H,1H2,(H,19,20)(H2,12,14,15)(H2,21,22,28)/t3-,5-,6-,9-/m1/s1
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n/an/an/an/a 90n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 11


(Homo sapiens (Human))		BDBM50131060
PNG
(CHEMBL3634186)
Show SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C10H14ClN5O9P2S/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(24-9)1-23-26(19,20)25-27(21,22)28/h2-3,5-6,9,17-18H,1H2,(H,19,20)(H2,12,14,15)(H2,21,22,28)/t3-,5-,6-,9-/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Homo sapiens (Human))		BDBM50118230
PNG
(5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADEN...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(S)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H15N5O9P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 1.27E+3n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...

J Med Chem 58: 8427-43 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00575
BindingDB Entry DOI: 10.7270/Q2736SRG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%