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PubMed code 26481659

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50005711
PNG
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C |r|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50354086
PNG
(FK-228 | Istodax | ROMIDEPSIN)
Show SMILES C\C=C1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C |r|
Show InChI InChI=1S/C25H39N3O6S2/c1-6-19-23(31)28-21(15(4)5)25(33)34-17(9-7-8-10-35)11-16(29)12-18(14(2)3)22(30)27-20(13-36)24(32)26-19/h6-7,9,14-15,17-18,20-21,35-36H,8,10-13H2,1-5H3,(H,26,32)(H,27,30)(H,28,31)/b9-7+,19-6-/t17-,18-,20-,21+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50354086
PNG
(FK-228 | Istodax | ROMIDEPSIN)
Show SMILES C\C=C1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C |r|
Show InChI InChI=1S/C25H39N3O6S2/c1-6-19-23(31)28-21(15(4)5)25(33)34-17(9-7-8-10-35)11-16(29)12-18(14(2)3)22(30)27-20(13-36)24(32)26-19/h6-7,9,14-15,17-18,20-21,35-36H,8,10-13H2,1-5H3,(H,26,32)(H,27,30)(H,28,31)/b9-7+,19-6-/t17-,18-,20-,21+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM50005711
PNG
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C |r|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
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n/an/a 65n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50005711
PNG
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C |r|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Histone deacetylase 6


(Homo sapiens (Human))		BDBM50354086
PNG
(FK-228 | Istodax | ROMIDEPSIN)
Show SMILES C\C=C1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C |r|
Show InChI InChI=1S/C25H39N3O6S2/c1-6-19-23(31)28-21(15(4)5)25(33)34-17(9-7-8-10-35)11-16(29)12-18(14(2)3)22(30)27-20(13-36)24(32)26-19/h6-7,9,14-15,17-18,20-21,35-36H,8,10-13H2,1-5H3,(H,26,32)(H,27,30)(H,28,31)/b9-7+,19-6-/t17-,18-,20-,21+/m1/s1
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n/an/a 281n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50129133
PNG
(CHEMBL3628320)
Show SMILES CCCCCCCCSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1 |r|
Show InChI InChI=1S/C30H52N4O6S2/c1-7-8-9-10-11-13-16-41-42-17-14-12-15-23-18-24(35)33-27(21(4)5)30(39)32-22(6)28(37)34-26(20(2)3)29(38)31-19-25(36)40-23/h12,15,20-23,26-27H,7-11,13-14,16-19H2,1-6H3,(H,31,38)(H,32,39)(H,33,35)(H,34,37)/b15-12+/t22-,23-,26-,27-/m1/s1
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n/an/a 820n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50129135
PNG
(CHEMBL3628323)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cn(C)cn2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H42N8O6S/c1-17(2)26-23-14-37(35-34-23)15-25(40)43-21(9-7-8-10-44-19(5)38)12-24(39)32-27(18(3)4)29(42)31-22(28(41)33-26)11-20-13-36(6)16-30-20/h7,9,13-14,16-18,21-22,26-27H,8,10-12,15H2,1-6H3,(H,31,42)(H,32,39)(H,33,41)/b9-7+/t21-,22-,26-,27-/m1/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50129134
PNG
(CHEMBL3628322)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r|
Show InChI InChI=1S/C31H42N6O6S/c1-19(2)28-25-17-37(36-35-25)18-27(40)43-23(13-9-10-14-44-21(5)38)16-26(39)33-29(20(3)4)31(42)32-24(30(41)34-28)15-22-11-7-6-8-12-22/h6-9,11-13,17,19-20,23-24,28-29H,10,14-16,18H2,1-5H3,(H,32,42)(H,33,39)(H,34,41)/b13-9+/t23-,24-,28-,29-/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50129132
PNG
(CHEMBL3628319)
Show SMILES CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1 |r|
Show InChI InChI=1S/C30H50N4O7S/c1-7-8-9-10-11-15-25(37)42-16-13-12-14-22-17-23(35)33-27(20(4)5)30(40)32-21(6)28(38)34-26(19(2)3)29(39)31-18-24(36)41-22/h12,14,19-22,26-27H,7-11,13,15-18H2,1-6H3,(H,31,39)(H,32,40)(H,33,35)(H,34,38)/b14-12+/t21-,22-,26-,27-/m1/s1
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n/an/a 1.27E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50129135
PNG
(CHEMBL3628323)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cn(C)cn2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H42N8O6S/c1-17(2)26-23-14-37(35-34-23)15-25(40)43-21(9-7-8-10-44-19(5)38)12-24(39)32-27(18(3)4)29(42)31-22(28(41)33-26)11-20-13-36(6)16-30-20/h7,9,13-14,16-18,21-22,26-27H,8,10-12,15H2,1-6H3,(H,31,42)(H,32,39)(H,33,41)/b9-7+/t21-,22-,26-,27-/m1/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50129134
PNG
(CHEMBL3628322)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r|
Show InChI InChI=1S/C31H42N6O6S/c1-19(2)28-25-17-37(36-35-25)18-27(40)43-23(13-9-10-14-44-21(5)38)16-26(39)33-29(20(3)4)31(42)32-24(30(41)34-28)15-22-11-7-6-8-12-22/h6-9,11-13,17,19-20,23-24,28-29H,10,14-16,18H2,1-5H3,(H,32,42)(H,33,39)(H,34,41)/b13-9+/t23-,24-,28-,29-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50129133
PNG
(CHEMBL3628320)
Show SMILES CCCCCCCCSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1 |r|
Show InChI InChI=1S/C30H52N4O6S2/c1-7-8-9-10-11-13-16-41-42-17-14-12-15-23-18-24(35)33-27(21(4)5)30(39)32-22(6)28(37)34-26(20(2)3)29(38)31-19-25(36)40-23/h12,15,20-23,26-27H,7-11,13-14,16-19H2,1-6H3,(H,31,38)(H,32,39)(H,33,35)(H,34,37)/b15-12+/t22-,23-,26-,27-/m1/s1
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n/an/a 8.01E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM50129134
PNG
(CHEMBL3628322)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r|
Show InChI InChI=1S/C31H42N6O6S/c1-19(2)28-25-17-37(36-35-25)18-27(40)43-23(13-9-10-14-44-21(5)38)16-26(39)33-29(20(3)4)31(42)32-24(30(41)34-28)15-22-11-7-6-8-12-22/h6-9,11-13,17,19-20,23-24,28-29H,10,14-16,18H2,1-5H3,(H,32,42)(H,33,39)(H,34,41)/b13-9+/t23-,24-,28-,29-/m1/s1
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n/an/a 8.67E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM50129133
PNG
(CHEMBL3628320)
Show SMILES CCCCCCCCSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1 |r|
Show InChI InChI=1S/C30H52N4O6S2/c1-7-8-9-10-11-13-16-41-42-17-14-12-15-23-18-24(35)33-27(21(4)5)30(39)32-22(6)28(37)34-26(20(2)3)29(38)31-19-25(36)40-23/h12,15,20-23,26-27H,7-11,13-14,16-19H2,1-6H3,(H,31,38)(H,32,39)(H,33,35)(H,34,37)/b15-12+/t22-,23-,26-,27-/m1/s1
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n/an/a 8.90E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM50129135
PNG
(CHEMBL3628323)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cn(C)cn2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r|
Show InChI InChI=1S/C29H42N8O6S/c1-17(2)26-23-14-37(35-34-23)15-25(40)43-21(9-7-8-10-44-19(5)38)12-24(39)32-27(18(3)4)29(42)31-22(28(41)33-26)11-20-13-36(6)16-30-20/h7,9,13-14,16-18,21-22,26-27H,8,10-12,15H2,1-6H3,(H,31,42)(H,32,39)(H,33,41)/b9-7+/t21-,22-,26-,27-/m1/s1
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n/an/a 9.89E+3n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50129132
PNG
(CHEMBL3628319)
Show SMILES CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1 |r|
Show InChI InChI=1S/C30H50N4O7S/c1-7-8-9-10-11-15-25(37)42-16-13-12-14-22-17-23(35)33-27(20(4)5)30(40)32-21(6)28(38)34-26(19(2)3)29(39)31-18-24(36)41-22/h12,14,19-22,26-27H,7-11,13,15-18H2,1-6H3,(H,31,39)(H,32,40)(H,33,35)(H,34,38)/b14-12+/t21-,22-,26-,27-/m1/s1
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Article
PubMed
n/an/a 1.43E+4n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))		BDBM50129132
PNG
(CHEMBL3628319)
Show SMILES CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)O1 |r|
Show InChI InChI=1S/C30H50N4O7S/c1-7-8-9-10-11-15-25(37)42-16-13-12-14-22-17-23(35)33-27(20(4)5)30(40)32-21(6)28(38)34-26(19(2)3)29(39)31-18-24(36)41-22/h12,14,19-22,26-27H,7-11,13,15-18H2,1-6H3,(H,31,39)(H,32,40)(H,33,35)(H,34,38)/b14-12+/t21-,22-,26-,27-/m1/s1
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PubMed
n/an/a 1.83E+4n/an/an/an/an/an/a



Ronzoni Institute for Chemical and Biochem. Research

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method

Bioorg Med Chem 23: 6785-93 (2015)


Article DOI: 10.1016/j.bmc.2015.10.004
BindingDB Entry DOI: 10.7270/Q21N82XF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%