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PubMed code 26483198

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133162
PNG
(CHEMBL3634799)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H17FN8/c1-14-18(24)6-7-19(29-14)23-22(16-5-8-21-27-13-28-32(21)12-16)30-20(31-23)11-26-17-4-2-3-15(9-17)10-25/h2-9,12-13,26H,11H2,1H3,(H,30,31)
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n/an/a 7.70n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133164
PNG
(CHEMBL3634711)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-17(23)8-9-18(27-14)22-21(15-7-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-16-5-3-2-4-6-16/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 9.20n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133157
PNG
(CHEMBL3634706)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H17FN8/c1-14-5-7-18(24)22(29-14)23-21(16-6-8-20-27-13-28-32(20)12-16)30-19(31-23)11-26-17-4-2-3-15(9-17)10-25/h2-9,12-13,26H,11H2,1H3,(H,30,31)
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n/an/a 9.20n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50015639
PNG
(CHEMBL3260567 | USRE47141, Example 2)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 9.70n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133159
PNG
(CHEMBL3634704)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-7-9-17(23)21(27-14)22-20(15-8-10-19-25-13-26-30(19)12-15)28-18(29-22)11-24-16-5-3-2-4-6-16/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 9.80n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133167
PNG
(CHEMBL3634708)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2cccc(C=C)c2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20FN7/c1-3-16-5-4-6-18(11-16)26-12-20-30-22(17-8-10-21-27-14-28-32(21)13-17)24(31-20)23-19(25)9-7-15(2)29-23/h3-11,13-14,26H,1,12H2,2H3,(H,30,31)
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n/an/a 9.80n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133161
PNG
(CHEMBL3634800)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19FN8O/c1-13-17(24)6-7-18(29-13)22-21(15-5-8-20-27-12-28-32(20)11-15)30-19(31-22)10-26-16-4-2-3-14(9-16)23(25)33/h2-9,11-12,26H,10H2,1H3,(H2,25,33)(H,30,31)
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n/an/a 11n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133168
PNG
(CHEMBL3634707)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19FN8O/c1-13-5-7-17(24)21(29-13)22-20(15-6-8-19-27-12-28-32(19)11-15)30-18(31-22)10-26-16-4-2-3-14(9-16)23(25)33/h2-9,11-12,26H,10H2,1H3,(H2,25,33)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133158
PNG
(CHEMBL3634705)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H17F2N7/c1-13-6-8-16(24)21(28-13)22-20(14-7-9-19-26-12-27-31(19)11-14)29-18(30-22)10-25-17-5-3-2-4-15(17)23/h2-9,11-12,25H,10H2,1H3,(H,29,30)
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n/an/a 12n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133163
PNG
(CHEMBL3634712)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H17F2N7/c1-13-15(23)7-8-18(28-13)22-21(14-6-9-20-26-12-27-31(20)11-14)29-19(30-22)10-25-17-5-3-2-4-16(17)24/h2-9,11-12,25H,10H2,1H3,(H,29,30)
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n/an/a 13n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133160
PNG
(CHEMBL3634801)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2cccc(C=C)c2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20FN7/c1-3-16-5-4-6-18(11-16)26-12-21-30-23(17-7-10-22-27-14-28-32(22)13-17)24(31-21)20-9-8-19(25)15(2)29-20/h3-11,13-14,26H,1,12H2,2H3,(H,30,31)
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n/an/a 14n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50298220
PNG
(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Show SMILES Cc1cccc(n1)-c1nc([nH]c1-c1ccc2OCOc2c1)C(C)(C)C
Show InChI InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
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n/an/a 35n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133165
PNG
(CHEMBL3634710)
Show SMILES Cc1cc(F)cc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H17F2N7/c1-13-8-15(23)9-18(28-13)22-21(14-6-7-20-26-12-27-31(20)11-14)29-19(30-22)10-25-17-5-3-2-4-16(17)24/h2-9,11-12,25H,10H2,1H3,(H,29,30)
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n/an/a 42n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50015640
PNG
(GALUNISERTIB | LY-2157299)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O |(13.61,.14,;12.84,-1.19,;13.61,-2.53,;12.84,-3.86,;11.3,-3.86,;10.53,-2.53,;11.3,-1.19,;8.99,-2.53,;8.08,-1.28,;6.62,-1.76,;5.15,-1.28,;4.25,-2.53,;5.15,-3.77,;6.62,-3.3,;8.08,-3.77,;8.56,-5.24,;10.06,-5.56,;10.54,-7.02,;9.51,-8.17,;8,-7.85,;6.97,-8.99,;5.47,-8.67,;4.99,-7.21,;6.02,-6.06,;7.53,-6.38,;3.48,-6.89,;3.01,-5.42,;2.45,-8.03,)|
Show InChI InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)
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n/an/a 69n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133166
PNG
(CHEMBL3634709)
Show SMILES Cc1cc(F)cc(n1)-c1[nH]c(CNc2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-9-16(23)10-18(27-14)22-21(15-7-8-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-5-3-2-4-6-17/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 73n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133167
PNG
(CHEMBL3634708)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2cccc(C=C)c2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20FN7/c1-3-16-5-4-6-18(11-16)26-12-20-30-22(17-8-10-21-27-14-28-32(21)13-17)24(31-20)23-19(25)9-7-15(2)29-23/h3-11,13-14,26H,1,12H2,2H3,(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133157
PNG
(CHEMBL3634706)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H17FN8/c1-14-5-7-18(24)22(29-14)23-21(16-6-8-20-27-13-28-32(20)12-16)30-19(31-23)11-26-17-4-2-3-15(9-17)10-25/h2-9,12-13,26H,11H2,1H3,(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133168
PNG
(CHEMBL3634707)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19FN8O/c1-13-5-7-17(24)21(29-13)22-20(15-6-8-19-27-12-28-32(19)11-15)30-18(31-22)10-26-16-4-2-3-14(9-16)23(25)33/h2-9,11-12,26H,10H2,1H3,(H2,25,33)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133159
PNG
(CHEMBL3634704)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-7-9-17(23)21(27-14)22-20(15-8-10-19-25-13-26-30(19)12-15)28-18(29-22)11-24-16-5-3-2-4-6-16/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 399n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50015640
PNG
(GALUNISERTIB | LY-2157299)
Show SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O |(13.61,.14,;12.84,-1.19,;13.61,-2.53,;12.84,-3.86,;11.3,-3.86,;10.53,-2.53,;11.3,-1.19,;8.99,-2.53,;8.08,-1.28,;6.62,-1.76,;5.15,-1.28,;4.25,-2.53,;5.15,-3.77,;6.62,-3.3,;8.08,-3.77,;8.56,-5.24,;10.06,-5.56,;10.54,-7.02,;9.51,-8.17,;8,-7.85,;6.97,-8.99,;5.47,-8.67,;4.99,-7.21,;6.02,-6.06,;7.53,-6.38,;3.48,-6.89,;3.01,-5.42,;2.45,-8.03,)|
Show InChI InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)
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n/an/a 405n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50298220
PNG
(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Show SMILES Cc1cccc(n1)-c1nc([nH]c1-c1ccc2OCOc2c1)C(C)(C)C
Show InChI InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
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n/an/a 668n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133158
PNG
(CHEMBL3634705)
Show SMILES Cc1ccc(F)c(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H17F2N7/c1-13-6-8-16(24)21(28-13)22-20(14-7-9-19-26-12-27-31(19)11-14)29-18(30-22)10-25-17-5-3-2-4-15(17)23/h2-9,11-12,25H,10H2,1H3,(H,29,30)
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n/an/a 766n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133162
PNG
(CHEMBL3634799)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H17FN8/c1-14-18(24)6-7-19(29-14)23-22(16-5-8-21-27-13-28-32(21)12-16)30-20(31-23)11-26-17-4-2-3-15(9-17)10-25/h2-9,12-13,26H,11H2,1H3,(H,30,31)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133161
PNG
(CHEMBL3634800)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19FN8O/c1-13-17(24)6-7-18(29-13)22-21(15-5-8-20-27-12-28-32(20)11-15)30-19(31-22)10-26-16-4-2-3-14(9-16)23(25)33/h2-9,11-12,26H,10H2,1H3,(H2,25,33)(H,30,31)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133160
PNG
(CHEMBL3634801)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2cccc(C=C)c2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20FN7/c1-3-16-5-4-6-18(11-16)26-12-21-30-23(17-7-10-22-27-14-28-32(22)13-17)24(31-21)20-9-8-19(25)15(2)29-20/h3-11,13-14,26H,1,12H2,2H3,(H,30,31)
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n/an/a 1.81E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133164
PNG
(CHEMBL3634711)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-17(23)8-9-18(27-14)22-21(15-7-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-16-5-3-2-4-6-16/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 2.04E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50015639
PNG
(CHEMBL3260567 | USRE47141, Example 2)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a 2.18E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133163
PNG
(CHEMBL3634712)
Show SMILES Cc1nc(ccc1F)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H17F2N7/c1-13-15(23)7-8-18(28-13)22-21(14-6-9-20-26-12-27-31(20)11-14)29-19(30-22)10-25-17-5-3-2-4-16(17)24/h2-9,11-12,25H,10H2,1H3,(H,29,30)
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n/an/a 3.37E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133165
PNG
(CHEMBL3634710)
Show SMILES Cc1cc(F)cc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H17F2N7/c1-13-8-15(23)9-18(28-13)22-21(14-6-7-20-26-12-27-31(20)11-14)29-19(30-22)10-25-17-5-3-2-4-16(17)24/h2-9,11-12,25H,10H2,1H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50133166
PNG
(CHEMBL3634709)
Show SMILES Cc1cc(F)cc(n1)-c1[nH]c(CNc2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H18FN7/c1-14-9-16(23)10-18(27-14)22-21(15-7-8-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-5-3-2-4-6-17/h2-10,12-13,24H,11H2,1H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay

Bioorg Med Chem Lett 25: 5228-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.058
BindingDB Entry DOI: 10.7270/Q2BP04MB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%