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PubMed code 26483200

Compile data set for download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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 0.310n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50285668
PNG
(2-(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-prop...)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
Show InChI InChI=1S/C27H30N4O2/c1-32-26-10-5-4-9-25(26)31-18-16-30(17-19-31)15-6-20-33-22-13-11-21(12-14-22)27-28-23-7-2-3-8-24(23)29-27/h2-5,7-14H,6,15-20H2,1H3,(H,28,29)
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 1.70n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to dopaminergic D3 receptor (unknown origin)

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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 2.70n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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 3.20n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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 3.60n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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 8.30n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50285668
PNG
(2-(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-prop...)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
Show InChI InChI=1S/C27H30N4O2/c1-32-26-10-5-4-9-25(26)31-18-16-30(17-19-31)15-6-20-33-22-13-11-21(12-14-22)27-28-23-7-2-3-8-24(23)29-27/h2-5,7-14H,6,15-20H2,1H3,(H,28,29)
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 8.80n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to dopaminergic D2 receptor (unknown origin)

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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 11n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 12n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 15n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50285668
PNG
(2-(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-prop...)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
Show InChI InChI=1S/C27H30N4O2/c1-32-26-10-5-4-9-25(26)31-18-16-30(17-19-31)15-6-20-33-22-13-11-21(12-14-22)27-28-23-7-2-3-8-24(23)29-27/h2-5,7-14H,6,15-20H2,1H3,(H,28,29)
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 16n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133179
PNG
(CHEMBL3634814)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C27H26N4O2S/c1-4-9-25-22(6-1)26(29-34-25)31-17-15-30(16-18-31)14-5-19-32-21-12-10-20(11-13-21)27-28-23-7-2-3-8-24(23)33-27/h1-4,6-13H,5,14-19H2
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 17n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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 19n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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 21n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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 22n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133169
PNG
(CHEMBL3634819)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(-c3nc4ccccc4o3)c(F)c2)CC1
Show InChI InChI=1S/C28H25F2N3O3/c29-19-6-8-22-26(16-19)36-32-27(22)18-10-13-33(14-11-18)12-3-15-34-20-7-9-21(23(30)17-20)28-31-24-4-1-2-5-25(24)35-28/h1-2,4-9,16-18H,3,10-15H2
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 24n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133203
PNG
(CHEMBL3634810)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C27H29N3O3/c1-31-26-10-5-3-8-24(26)30-18-16-29(17-19-30)15-6-20-32-22-13-11-21(12-14-22)27-28-23-7-2-4-9-25(23)33-27/h2-5,7-14H,6,15-20H2,1H3
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 29n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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 30n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5-HT2C receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133174
PNG
(CHEMBL3634824)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(CCc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C30H30FN3O3/c31-23-9-12-25-28(20-23)37-33-30(25)22-14-17-34(18-15-22)16-3-19-35-24-10-6-21(7-11-24)8-13-29-32-26-4-1-2-5-27(26)36-29/h1-2,4-7,9-12,20,22H,3,8,13-19H2
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 31n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133175
PNG
(CHEMBL3634825)
Show SMILES CC(c1nc2ccccc2o1)c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C30H30FN3O3/c1-20(30-32-26-5-2-3-6-27(26)36-30)21-7-10-24(11-8-21)35-18-4-15-34-16-13-22(14-17-34)29-25-12-9-23(31)19-28(25)37-33-29/h2-3,5-12,19-20,22H,4,13-18H2,1H3
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 31n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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 38n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133174
PNG
(CHEMBL3634824)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(CCc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C30H30FN3O3/c31-23-9-12-25-28(20-23)37-33-30(25)22-14-17-34(18-15-22)16-3-19-35-24-10-6-21(7-11-24)8-13-29-32-26-4-1-2-5-27(26)36-29/h1-2,4-7,9-12,20,22H,3,8,13-19H2
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 38n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133183
PNG
(CHEMBL3634811)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H25N5O2/c1-2-6-22-21(5-1)27-23(31-22)19-7-9-20(10-8-19)30-18-4-13-28-14-16-29(17-15-28)24-25-11-3-12-26-24/h1-3,5-12H,4,13-18H2
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 39n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133177
PNG
(CHEMBL3634817)
Show SMILES Cc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)-c1nc2ccccc2o1
Show InChI InChI=1S/C29H28FN3O3/c1-19-17-21(29-31-24-5-2-3-6-26(24)35-29)7-10-25(19)34-16-4-13-33-14-11-20(12-15-33)28-23-9-8-22(30)18-27(23)36-32-28/h2-3,5-10,17-18,20H,4,11-16H2,1H3
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 41n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 42n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5-HT2C receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133203
PNG
(CHEMBL3634810)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C27H29N3O3/c1-31-26-10-5-3-8-24(26)30-18-16-29(17-19-30)15-6-20-32-22-13-11-21(12-14-22)27-28-23-7-2-4-9-25(23)33-27/h2-5,7-14H,6,15-20H2,1H3
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 47n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133174
PNG
(CHEMBL3634824)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(CCc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C30H30FN3O3/c31-23-9-12-25-28(20-23)37-33-30(25)22-14-17-34(18-15-22)16-3-19-35-24-10-6-21(7-11-24)8-13-29-32-26-4-1-2-5-27(26)36-29/h1-2,4-7,9-12,20,22H,3,8,13-19H2
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 53n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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 54n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133183
PNG
(CHEMBL3634811)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H25N5O2/c1-2-6-22-21(5-1)27-23(31-22)19-7-9-20(10-8-19)30-18-4-13-28-14-16-29(17-15-28)24-25-11-3-12-26-24/h1-3,5-12H,4,13-18H2
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 56n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133175
PNG
(CHEMBL3634825)
Show SMILES CC(c1nc2ccccc2o1)c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C30H30FN3O3/c1-20(30-32-26-5-2-3-6-27(26)36-30)21-7-10-24(11-8-21)35-18-4-15-34-16-13-22(14-17-34)29-25-12-9-23(31)19-28(25)37-33-29/h2-3,5-12,19-20,22H,4,13-18H2,1H3
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 60n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 63n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133176
PNG
(CHEMBL3634818)
Show SMILES COc1cc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)ccc1-c1nc2ccccc2o1
Show InChI InChI=1S/C29H28FN3O4/c1-34-26-18-21(8-10-23(26)29-31-24-5-2-3-6-25(24)36-29)35-16-4-13-33-14-11-19(12-15-33)28-22-9-7-20(30)17-27(22)37-32-28/h2-3,5-10,17-19H,4,11-16H2,1H3
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 72n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133180
PNG
(CHEMBL3634815)
Show SMILES Cc1ccc2oc(nc2c1)-c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C29H28FN3O3/c1-19-3-10-26-25(17-19)31-29(35-26)21-4-7-23(8-5-21)34-16-2-13-33-14-11-20(12-15-33)28-24-9-6-22(30)18-27(24)36-32-28/h3-10,17-18,20H,2,11-16H2,1H3
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 76n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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 84n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133175
PNG
(CHEMBL3634825)
Show SMILES CC(c1nc2ccccc2o1)c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C30H30FN3O3/c1-20(30-32-26-5-2-3-6-27(26)36-30)21-7-10-24(11-8-21)35-18-4-15-34-16-13-22(14-17-34)29-25-12-9-23(31)19-28(25)37-33-29/h2-3,5-12,19-20,22H,4,13-18H2,1H3
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 90n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50285668
PNG
(2-(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-prop...)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
Show InChI InChI=1S/C27H30N4O2/c1-32-26-10-5-4-9-25(26)31-18-16-30(17-19-31)15-6-20-33-22-13-11-21(12-14-22)27-28-23-7-2-3-8-24(23)29-27/h2-5,7-14H,6,15-20H2,1H3,(H,28,29)
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 109n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133182
PNG
(CHEMBL3634812)
Show SMILES Fc1ccc(C(=O)C2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c(F)c1
Show InChI InChI=1S/C28H26F2N2O3/c29-21-8-11-23(24(30)18-21)27(33)19-12-15-32(16-13-19)14-3-17-34-22-9-6-20(7-10-22)28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,18-19H,3,12-17H2
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 114n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133178
PNG
(CHEMBL3634816)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3cc(Cl)ccc3o2)CC1
Show InChI InChI=1S/C28H25ClFN3O3/c29-20-4-9-25-24(16-20)31-28(35-25)19-2-6-22(7-3-19)34-15-1-12-33-13-10-18(11-14-33)27-23-8-5-21(30)17-26(23)36-32-27/h2-9,16-18H,1,10-15H2
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 135n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133169
PNG
(CHEMBL3634819)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(-c3nc4ccccc4o3)c(F)c2)CC1
Show InChI InChI=1S/C28H25F2N3O3/c29-19-6-8-22-26(16-19)36-32-27(22)18-10-13-33(14-11-18)12-3-15-34-20-7-9-21(23(30)17-20)28-31-24-4-1-2-5-25(24)35-28/h1-2,4-9,16-18H,3,10-15H2
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 143n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133208
PNG
(CHEMBL3634809)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCC(CC1)c1nc2ccccc2s1
Show InChI InChI=1S/C28H27N3O2S/c1-3-8-25-23(6-1)29-27(33-25)20-10-12-22(13-11-20)32-19-5-16-31-17-14-21(15-18-31)28-30-24-7-2-4-9-26(24)34-28/h1-4,6-13,21H,5,14-19H2
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 146n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 155n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 161n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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 186n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5-HT2C receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133183
PNG
(CHEMBL3634811)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H25N5O2/c1-2-6-22-21(5-1)27-23(31-22)19-7-9-20(10-8-19)30-18-4-13-28-14-16-29(17-15-28)24-25-11-3-12-26-24/h1-3,5-12H,4,13-18H2
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 198n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133182
PNG
(CHEMBL3634812)
Show SMILES Fc1ccc(C(=O)C2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c(F)c1
Show InChI InChI=1S/C28H26F2N2O3/c29-21-8-11-23(24(30)18-21)27(33)19-12-15-32(16-13-19)14-3-17-34-22-9-6-20(7-10-22)28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,18-19H,3,12-17H2
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 199n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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 211n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133169
PNG
(CHEMBL3634819)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(-c3nc4ccccc4o3)c(F)c2)CC1
Show InChI InChI=1S/C28H25F2N3O3/c29-19-6-8-22-26(16-19)36-32-27(22)18-10-13-33(14-11-18)12-3-15-34-20-7-9-21(23(30)17-20)28-31-24-4-1-2-5-25(24)35-28/h1-2,4-9,16-18H,3,10-15H2
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 232n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133209
PNG
(CHEMBL3634808)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCC(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C28H27N3O3/c1-3-8-25-23(6-1)29-27(33-25)20-10-12-22(13-11-20)32-19-5-16-31-17-14-21(15-18-31)28-30-24-7-2-4-9-26(24)34-28/h1-4,6-13,21H,5,14-19H2
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 243n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50285668
PNG
(2-(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-prop...)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
Show InChI InChI=1S/C27H30N4O2/c1-32-26-10-5-4-9-25(26)31-18-16-30(17-19-31)15-6-20-33-22-13-11-21(12-14-22)27-28-23-7-2-3-8-24(23)29-27/h2-5,7-14H,6,15-20H2,1H3,(H,28,29)
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 258n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133208
PNG
(CHEMBL3634809)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCC(CC1)c1nc2ccccc2s1
Show InChI InChI=1S/C28H27N3O2S/c1-3-8-25-23(6-1)29-27(33-25)20-10-12-22(13-11-20)32-19-5-16-31-17-14-21(15-18-31)28-30-24-7-2-4-9-26(24)34-28/h1-4,6-13,21H,5,14-19H2
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 281n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133182
PNG
(CHEMBL3634812)
Show SMILES Fc1ccc(C(=O)C2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c(F)c1
Show InChI InChI=1S/C28H26F2N2O3/c29-21-8-11-23(24(30)18-21)27(33)19-12-15-32(16-13-19)14-3-17-34-22-9-6-20(7-10-22)28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,18-19H,3,12-17H2
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 408n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133203
PNG
(CHEMBL3634810)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C27H29N3O3/c1-31-26-10-5-3-8-24(26)30-18-16-29(17-19-30)15-6-20-32-22-13-11-21(12-14-22)27-28-23-7-2-4-9-25(23)33-27/h2-5,7-14H,6,15-20H2,1H3
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 467n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133209
PNG
(CHEMBL3634808)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCC(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C28H27N3O3/c1-3-8-25-23(6-1)29-27(33-25)20-10-12-22(13-11-20)32-19-5-16-31-17-14-21(15-18-31)28-30-24-7-2-4-9-26(24)34-28/h1-4,6-13,21H,5,14-19H2
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 568n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133178
PNG
(CHEMBL3634816)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3cc(Cl)ccc3o2)CC1
Show InChI InChI=1S/C28H25ClFN3O3/c29-20-4-9-25-24(16-20)31-28(35-25)19-2-6-22(7-3-19)34-15-1-12-33-13-10-18(11-14-33)27-23-8-5-21(30)17-26(23)36-32-27/h2-9,16-18H,1,10-15H2
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 660n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133172
PNG
(CHEMBL3634822)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-9-12-24-27(19-22)36-32-28(24)20-13-16-33(17-14-20)15-3-4-18-34-23-10-7-21(8-11-23)29-31-25-5-1-2-6-26(25)35-29/h1-2,5-12,19-20H,3-4,13-18H2
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 729n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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 765n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133179
PNG
(CHEMBL3634814)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C27H26N4O2S/c1-4-9-25-22(6-1)26(29-34-25)31-17-15-30(16-18-31)14-5-19-32-21-12-10-20(11-13-21)27-28-23-7-2-3-8-24(23)33-27/h1-4,6-13H,5,14-19H2
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 879n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133179
PNG
(CHEMBL3634814)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C27H26N4O2S/c1-4-9-25-22(6-1)26(29-34-25)31-17-15-30(16-18-31)14-5-19-32-21-12-10-20(11-13-21)27-28-23-7-2-3-8-24(23)33-27/h1-4,6-13H,5,14-19H2
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 970n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133172
PNG
(CHEMBL3634822)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-9-12-24-27(19-22)36-32-28(24)20-13-16-33(17-14-20)15-3-4-18-34-23-10-7-21(8-11-23)29-31-25-5-1-2-6-26(25)35-29/h1-2,5-12,19-20H,3-4,13-18H2
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 996n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133176
PNG
(CHEMBL3634818)
Show SMILES COc1cc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)ccc1-c1nc2ccccc2o1
Show InChI InChI=1S/C29H28FN3O4/c1-34-26-18-21(8-10-23(26)29-31-24-5-2-3-6-25(24)36-29)35-16-4-13-33-14-11-19(12-15-33)28-22-9-7-20(30)17-27(22)37-32-28/h2-3,5-10,17-19H,4,11-16H2,1H3
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 1.19E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133173
PNG
(CHEMBL3634823)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3s2)CC1
Show InChI InChI=1S/C28H26FN3O2S/c29-21-8-11-23-25(18-21)34-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-26(24)35-28/h1-2,4-11,18-19H,3,12-17H2
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 1.27E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133210
PNG
(CHEMBL3634807)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC2COc3ccccc3O2)CC1
Show InChI InChI=1S/C29H31N3O4/c1-2-7-26-25(6-1)30-29(36-26)22-10-12-23(13-11-22)33-19-5-14-31-15-17-32(18-16-31)20-24-21-34-27-8-3-4-9-28(27)35-24/h1-4,6-13,24H,5,14-21H2
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 1.42E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133176
PNG
(CHEMBL3634818)
Show SMILES COc1cc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)ccc1-c1nc2ccccc2o1
Show InChI InChI=1S/C29H28FN3O4/c1-34-26-18-21(8-10-23(26)29-31-24-5-2-3-6-25(24)36-29)35-16-4-13-33-14-11-19(12-15-33)28-22-9-7-20(30)17-27(22)37-32-28/h2-3,5-10,17-19H,4,11-16H2,1H3
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 1.56E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133177
PNG
(CHEMBL3634817)
Show SMILES Cc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)-c1nc2ccccc2o1
Show InChI InChI=1S/C29H28FN3O3/c1-19-17-21(29-31-24-5-2-3-6-26(24)35-29)7-10-25(19)34-16-4-13-33-14-11-20(12-15-33)28-23-9-8-22(30)18-27(23)36-32-28/h2-3,5-10,17-18,20H,4,11-16H2,1H3
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 1.59E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133173
PNG
(CHEMBL3634823)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3s2)CC1
Show InChI InChI=1S/C28H26FN3O2S/c29-21-8-11-23-25(18-21)34-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-26(24)35-28/h1-2,4-11,18-19H,3,12-17H2
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 1.76E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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 1.99E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5-HT2C receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133211
PNG
(CHEMBL3634806)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C25H26N4O2/c1-2-7-23-22(6-1)27-25(31-23)20-9-11-21(12-10-20)30-19-5-14-28-15-17-29(18-16-28)24-8-3-4-13-26-24/h1-4,6-13H,5,14-19H2
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 1.99E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133212
PNG
(CHEMBL3634805)
Show SMILES Cc1cccc(N2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c1C
Show InChI InChI=1S/C28H31N3O2/c1-21-7-5-9-26(22(21)2)31-18-16-30(17-19-31)15-6-20-32-24-13-11-23(12-14-24)28-29-25-8-3-4-10-27(25)33-28/h3-5,7-14H,6,15-20H2,1-2H3
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 2.14E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133177
PNG
(CHEMBL3634817)
Show SMILES Cc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)-c1nc2ccccc2o1
Show InChI InChI=1S/C29H28FN3O3/c1-19-17-21(29-31-24-5-2-3-6-26(24)35-29)7-10-25(19)34-16-4-13-33-14-11-20(12-15-33)28-23-9-8-22(30)18-27(23)36-32-28/h2-3,5-10,17-18,20H,4,11-16H2,1H3
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 2.14E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133172
PNG
(CHEMBL3634822)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-9-12-24-27(19-22)36-32-28(24)20-13-16-33(17-14-20)15-3-4-18-34-23-10-7-21(8-11-23)29-31-25-5-1-2-6-26(25)35-29/h1-2,5-12,19-20H,3-4,13-18H2
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 2.20E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133211
PNG
(CHEMBL3634806)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C25H26N4O2/c1-2-7-23-22(6-1)27-25(31-23)20-9-11-21(12-10-20)30-19-5-14-28-15-17-29(18-16-28)24-8-3-4-13-26-24/h1-4,6-13H,5,14-19H2
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 2.34E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133214
PNG
(CHEMBL3634803)
Show SMILES Clc1cccc(N2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c1Cl
Show InChI InChI=1S/C26H25Cl2N3O2/c27-21-5-3-7-23(25(21)28)31-16-14-30(15-17-31)13-4-18-32-20-11-9-19(10-12-20)26-29-22-6-1-2-8-24(22)33-26/h1-3,5-12H,4,13-18H2
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 2.89E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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 3.15E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133213
PNG
(CHEMBL3634804)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C27H26F3N3O2/c28-27(29,30)21-5-3-6-22(19-21)33-16-14-32(15-17-33)13-4-18-34-23-11-9-20(10-12-23)26-31-24-7-1-2-8-25(24)35-26/h1-3,5-12,19H,4,13-18H2
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 4.48E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133215
PNG
(CHEMBL3634802)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H27N3O2/c1-2-7-22(8-3-1)29-18-16-28(17-19-29)15-6-20-30-23-13-11-21(12-14-23)26-27-24-9-4-5-10-25(24)31-26/h1-5,7-14H,6,15-20H2
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 4.68E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133212
PNG
(CHEMBL3634805)
Show SMILES Cc1cccc(N2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c1C
Show InChI InChI=1S/C28H31N3O2/c1-21-7-5-9-26(22(21)2)31-18-16-30(17-19-31)15-6-20-32-24-13-11-23(12-14-24)28-29-25-8-3-4-10-27(25)33-28/h3-5,7-14H,6,15-20H2,1-2H3
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 4.69E+3n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133180
PNG
(CHEMBL3634815)
Show SMILES Cc1ccc2oc(nc2c1)-c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C29H28FN3O3/c1-19-3-10-26-25(17-19)31-29(35-26)21-4-7-23(8-5-21)34-16-2-13-33-14-11-20(12-15-33)28-24-9-6-22(30)18-27(24)36-32-28/h3-10,17-18,20H,2,11-16H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133208
PNG
(CHEMBL3634809)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCC(CC1)c1nc2ccccc2s1
Show InChI InChI=1S/C28H27N3O2S/c1-3-8-25-23(6-1)29-27(33-25)20-10-12-22(13-11-20)32-19-5-16-31-17-14-21(15-18-31)28-30-24-7-2-4-9-26(24)34-28/h1-4,6-13,21H,5,14-19H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133180
PNG
(CHEMBL3634815)
Show SMILES Cc1ccc2oc(nc2c1)-c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C29H28FN3O3/c1-19-3-10-26-25(17-19)31-29(35-26)21-4-7-23(8-5-21)34-16-2-13-33-14-11-20(12-15-33)28-24-9-6-22(30)18-27(24)36-32-28/h3-10,17-18,20H,2,11-16H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133213
PNG
(CHEMBL3634804)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C27H26F3N3O2/c28-27(29,30)21-5-3-6-22(19-21)33-16-14-32(15-17-33)13-4-18-34-23-11-9-20(10-12-23)26-31-24-7-1-2-8-25(24)35-26/h1-3,5-12,19H,4,13-18H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133173
PNG
(CHEMBL3634823)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3s2)CC1
Show InChI InChI=1S/C28H26FN3O2S/c29-21-8-11-23-25(18-21)34-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-26(24)35-28/h1-2,4-11,18-19H,3,12-17H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133178
PNG
(CHEMBL3634816)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3cc(Cl)ccc3o2)CC1
Show InChI InChI=1S/C28H25ClFN3O3/c29-20-4-9-25-24(16-20)31-28(35-25)19-2-6-22(7-3-19)34-15-1-12-33-13-10-18(11-14-33)27-23-8-5-21(30)17-26(23)36-32-27/h2-9,16-18H,1,10-15H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133211
PNG
(CHEMBL3634806)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C25H26N4O2/c1-2-7-23-22(6-1)27-25(31-23)20-9-11-21(12-10-20)30-19-5-14-28-15-17-29(18-16-28)24-8-3-4-13-26-24/h1-4,6-13H,5,14-19H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133214
PNG
(CHEMBL3634803)
Show SMILES Clc1cccc(N2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c1Cl
Show InChI InChI=1S/C26H25Cl2N3O2/c27-21-5-3-7-23(25(21)28)31-16-14-30(15-17-31)13-4-18-32-20-11-9-19(10-12-20)26-29-22-6-1-2-8-24(22)33-26/h1-3,5-12H,4,13-18H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133215
PNG
(CHEMBL3634802)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H27N3O2/c1-2-7-22(8-3-1)29-18-16-28(17-19-29)15-6-20-30-23-13-11-21(12-14-23)26-27-24-9-4-5-10-25(24)31-26/h1-5,7-14H,6,15-20H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133209
PNG
(CHEMBL3634808)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCC(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C28H27N3O3/c1-3-8-25-23(6-1)29-27(33-25)20-10-12-22(13-11-20)32-19-5-16-31-17-14-21(15-18-31)28-30-24-7-2-4-9-26(24)34-28/h1-4,6-13,21H,5,14-19H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133212
PNG
(CHEMBL3634805)
Show SMILES Cc1cccc(N2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c1C
Show InChI InChI=1S/C28H31N3O2/c1-21-7-5-9-26(22(21)2)31-18-16-30(17-19-31)15-6-20-32-24-13-11-23(12-14-24)28-29-25-8-3-4-10-27(25)33-28/h3-5,7-14H,6,15-20H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133213
PNG
(CHEMBL3634804)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C27H26F3N3O2/c28-27(29,30)21-5-3-6-22(19-21)33-16-14-32(15-17-33)13-4-18-34-23-11-9-20(10-12-23)26-31-24-7-1-2-8-25(24)35-26/h1-3,5-12,19H,4,13-18H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133210
PNG
(CHEMBL3634807)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC2COc3ccccc3O2)CC1
Show InChI InChI=1S/C29H31N3O4/c1-2-7-26-25(6-1)30-29(36-26)22-10-12-23(13-11-22)33-19-5-14-31-15-17-32(18-16-31)20-24-21-34-27-8-3-4-9-28(27)35-24/h1-4,6-13,24H,5,14-21H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133170
PNG
(CHEMBL3634820)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2cccc(c2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-9-10-23-26(18-21)35-31-27(23)19-11-14-32(15-12-19)13-4-16-33-22-6-3-5-20(17-22)28-30-24-7-1-2-8-25(24)34-28/h1-3,5-10,17-19H,4,11-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133215
PNG
(CHEMBL3634802)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H27N3O2/c1-2-7-22(8-3-1)29-18-16-28(17-19-29)15-6-20-30-23-13-11-21(12-14-23)26-27-24-9-4-5-10-25(24)31-26/h1-5,7-14H,6,15-20H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133170
PNG
(CHEMBL3634820)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2cccc(c2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-9-10-23-26(18-21)35-31-27(23)19-11-14-32(15-12-19)13-4-16-33-22-6-3-5-20(17-22)28-30-24-7-1-2-8-25(24)34-28/h1-3,5-10,17-19H,4,11-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50133210
PNG
(CHEMBL3634807)
Show SMILES C(COc1ccc(cc1)-c1nc2ccccc2o1)CN1CCN(CC2COc3ccccc3O2)CC1
Show InChI InChI=1S/C29H31N3O4/c1-2-7-26-25(6-1)30-29(36-26)22-10-12-23(13-11-22)33-19-5-14-31-15-17-32(18-16-31)20-24-21-34-27-8-3-4-9-28(27)35-24/h1-4,6-13,24H,5,14-21H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50133170
PNG
(CHEMBL3634820)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2cccc(c2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-9-10-23-26(18-21)35-31-27(23)19-11-14-32(15-12-19)13-4-16-33-22-6-3-5-20(17-22)28-30-24-7-1-2-8-25(24)34-28/h1-3,5-10,17-19H,4,11-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50133214
PNG
(CHEMBL3634803)
Show SMILES Clc1cccc(N2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c1Cl
Show InChI InChI=1S/C26H25Cl2N3O2/c27-21-5-3-7-23(25(21)28)31-16-14-30(15-17-31)13-4-18-32-20-11-9-19(10-12-20)26-29-22-6-1-2-8-24(22)33-26/h1-3,5-12H,4,13-18H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50133174
PNG
(CHEMBL3634824)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(CCc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C30H30FN3O3/c31-23-9-12-25-28(20-23)37-33-30(25)22-14-17-34(18-15-22)16-3-19-35-24-10-6-21(7-11-24)8-13-29-32-26-4-1-2-5-27(26)36-29/h1-2,4-7,9-12,20,22H,3,8,13-19H2
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n/an/a 630n/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50133182
PNG
(CHEMBL3634812)
Show SMILES Fc1ccc(C(=O)C2CCN(CCCOc3ccc(cc3)-c3nc4ccccc4o3)CC2)c(F)c1
Show InChI InChI=1S/C28H26F2N2O3/c29-21-8-11-23(24(30)18-21)27(33)19-12-15-32(16-13-19)14-3-17-34-22-9-6-20(7-10-22)28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,18-19H,3,12-17H2
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n/an/a 850n/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50133175
PNG
(CHEMBL3634825)
Show SMILES CC(c1nc2ccccc2o1)c1ccc(OCCCN2CCC(CC2)c2noc3cc(F)ccc23)cc1
Show InChI InChI=1S/C30H30FN3O3/c1-20(30-32-26-5-2-3-6-27(26)36-30)21-7-10-24(11-8-21)35-18-4-15-34-16-13-22(14-17-34)29-25-12-9-23(31)19-28(25)37-33-29/h2-3,5-12,19-20,22H,4,13-18H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50133181
PNG
(CHEMBL3634813)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3o2)CC1
Show InChI InChI=1S/C28H26FN3O3/c29-21-8-11-23-26(18-21)35-31-27(23)19-12-15-32(16-13-19)14-3-17-33-22-9-6-20(7-10-22)28-30-24-4-1-2-5-25(24)34-28/h1-2,4-11,18-19H,3,12-17H2
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n/an/a 3.76E+3n/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50133171
PNG
(CHEMBL3634821)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(Cc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C29H28FN3O3/c30-22-8-11-24-27(19-22)36-32-29(24)21-12-15-33(16-13-21)14-3-17-34-23-9-6-20(7-10-23)18-28-31-25-4-1-2-5-26(25)35-28/h1-2,4-11,19,21H,3,12-18H2
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n/an/a 5.98E+3n/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method

Bioorg Med Chem Lett 25: 5299-305 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.045
BindingDB Entry DOI: 10.7270/Q26W9CW2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%