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PubMed code 26494260

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129249
PNG
(CHEMBL3629534)
Show SMILES COc1ccc(CCC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H29NO3/c1-24-16-14-23(15-17-24,20-6-4-3-5-7-20)18-27-22(25)13-10-19-8-11-21(26-2)12-9-19/h3-9,11-12H,10,13-18H2,1-2H3
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 370n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129249
PNG
(CHEMBL3629534)
Show SMILES COc1ccc(CCC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H29NO3/c1-24-16-14-23(15-17-24,20-6-4-3-5-7-20)18-27-22(25)13-10-19-8-11-21(26-2)12-9-19/h3-9,11-12H,10,13-18H2,1-2H3
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 380n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129179
PNG
(CHEMBL3629530)
Show SMILES COc1ccc(CCOC(=O)C2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H27NO3/c1-23-15-13-22(14-16-23,19-6-4-3-5-7-19)21(24)26-17-12-18-8-10-20(25-2)11-9-18/h3-11H,12-17H2,1-2H3
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 640n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129249
PNG
(CHEMBL3629534)
Show SMILES COc1ccc(CCC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H29NO3/c1-24-16-14-23(15-17-24,20-6-4-3-5-7-20)18-27-22(25)13-10-19-8-11-21(26-2)12-9-19/h3-9,11-12H,10,13-18H2,1-2H3
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 670n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129179
PNG
(CHEMBL3629530)
Show SMILES COc1ccc(CCOC(=O)C2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H27NO3/c1-23-15-13-22(14-16-23,19-6-4-3-5-7-19)21(24)26-17-12-18-8-10-20(25-2)11-9-18/h3-11H,12-17H2,1-2H3
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 870n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129179
PNG
(CHEMBL3629530)
Show SMILES COc1ccc(CCOC(=O)C2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H27NO3/c1-23-15-13-22(14-16-23,19-6-4-3-5-7-19)21(24)26-17-12-18-8-10-20(25-2)11-9-18/h3-11H,12-17H2,1-2H3
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 1.20E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129251
PNG
(CHEMBL3627739)
Show SMILES COc1ccc(CCC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O2/c1-25-16-14-23(15-17-25,20-6-4-3-5-7-20)18-24-22(26)13-10-19-8-11-21(27-2)12-9-19/h3-9,11-12H,10,13-18H2,1-2H3,(H,24,26)
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 1.54E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129251
PNG
(CHEMBL3627739)
Show SMILES COc1ccc(CCC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O2/c1-25-16-14-23(15-17-25,20-6-4-3-5-7-20)18-24-22(26)13-10-19-8-11-21(27-2)12-9-19/h3-9,11-12H,10,13-18H2,1-2H3,(H,24,26)
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 1.81E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129257
PNG
(CHEMBL3629537)
Show SMILES COc1ccc(CCOC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O3/c1-25-15-13-23(14-16-25,20-6-4-3-5-7-20)18-24-22(26)28-17-12-19-8-10-21(27-2)11-9-19/h3-11H,12-18H2,1-2H3,(H,24,26)
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 2.05E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129248
PNG
(CHEMBL3629533)
Show SMILES COc1ccc(CCC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H31NO4/c1-25-15-13-24(14-16-25,20-7-5-4-6-8-20)18-29-23(26)12-10-19-9-11-21(27-2)22(17-19)28-3/h4-9,11,17H,10,12-16,18H2,1-3H3
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 2.14E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129257
PNG
(CHEMBL3629537)
Show SMILES COc1ccc(CCOC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O3/c1-25-15-13-23(14-16-25,20-6-4-3-5-7-20)18-24-22(26)28-17-12-19-8-10-21(27-2)11-9-19/h3-11H,12-18H2,1-2H3,(H,24,26)
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 2.30E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129257
PNG
(CHEMBL3629537)
Show SMILES COc1ccc(CCOC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O3/c1-25-15-13-23(14-16-25,20-6-4-3-5-7-20)18-24-22(26)28-17-12-19-8-10-21(27-2)11-9-19/h3-11H,12-18H2,1-2H3,(H,24,26)
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 2.91E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129247
PNG
(CHEMBL3629532)
Show SMILES COc1ccc(CCNC(=O)C2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O2/c1-24-16-13-22(14-17-24,19-6-4-3-5-7-19)21(25)23-15-12-18-8-10-20(26-2)11-9-18/h3-11H,12-17H2,1-2H3,(H,23,25)
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 3.29E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129251
PNG
(CHEMBL3627739)
Show SMILES COc1ccc(CCC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H30N2O2/c1-25-16-14-23(15-17-25,20-6-4-3-5-7-20)18-24-22(26)13-10-19-8-11-21(27-2)12-9-19/h3-9,11-12H,10,13-18H2,1-2H3,(H,24,26)
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 3.44E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129259
PNG
(CHEMBL3629539)
Show SMILES COc1ccc(CCNC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-26-16-13-23(14-17-26,20-6-4-3-5-7-20)18-25-22(27)24-15-12-19-8-10-21(28-2)11-9-19/h3-11H,12-18H2,1-2H3,(H2,24,25,27)
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 3.55E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129248
PNG
(CHEMBL3629533)
Show SMILES COc1ccc(CCC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H31NO4/c1-25-15-13-24(14-16-25,20-7-5-4-6-8-20)18-29-23(26)12-10-19-9-11-21(27-2)22(17-19)28-3/h4-9,11,17H,10,12-16,18H2,1-3H3
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 3.63E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129252
PNG
(CHEMBL3629536)
Show SMILES COc1ccc(CCNC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H32N2O4/c1-26-15-12-24(13-16-26,20-7-5-4-6-8-20)18-30-23(27)25-14-11-19-9-10-21(28-2)22(17-19)29-3/h4-10,17H,11-16,18H2,1-3H3,(H,25,27)
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 4.03E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129259
PNG
(CHEMBL3629539)
Show SMILES COc1ccc(CCNC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-26-16-13-23(14-17-26,20-6-4-3-5-7-20)18-25-22(27)24-15-12-19-8-10-21(28-2)11-9-19/h3-11H,12-18H2,1-2H3,(H2,24,25,27)
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 4.30E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129248
PNG
(CHEMBL3629533)
Show SMILES COc1ccc(CCC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H31NO4/c1-25-15-13-24(14-16-25,20-7-5-4-6-8-20)18-29-23(26)12-10-19-9-11-21(27-2)22(17-19)28-3/h4-9,11,17H,10,12-16,18H2,1-3H3
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 4.60E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129252
PNG
(CHEMBL3629536)
Show SMILES COc1ccc(CCNC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H32N2O4/c1-26-15-12-24(13-16-26,20-7-5-4-6-8-20)18-30-23(27)25-14-11-19-9-10-21(28-2)22(17-19)29-3/h4-10,17H,11-16,18H2,1-3H3,(H,25,27)
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 5.09E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129143
PNG
(CHEMBL3629529)
Show SMILES COc1ccc(CCOC(=O)C2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H29NO4/c1-24-14-12-23(13-15-24,19-7-5-4-6-8-19)22(25)28-16-11-18-9-10-20(26-2)21(17-18)27-3/h4-10,17H,11-16H2,1-3H3
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 5.26E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129259
PNG
(CHEMBL3629539)
Show SMILES COc1ccc(CCNC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-26-16-13-23(14-17-26,20-6-4-3-5-7-20)18-25-22(27)24-15-12-19-8-10-21(28-2)11-9-19/h3-11H,12-18H2,1-2H3,(H2,24,25,27)
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 5.40E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129252
PNG
(CHEMBL3629536)
Show SMILES COc1ccc(CCNC(=O)OCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H32N2O4/c1-26-15-12-24(13-16-26,20-7-5-4-6-8-20)18-30-23(27)25-14-11-19-9-10-21(28-2)22(17-19)29-3/h4-10,17H,11-16,18H2,1-3H3,(H,25,27)
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 5.41E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129143
PNG
(CHEMBL3629529)
Show SMILES COc1ccc(CCOC(=O)C2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H29NO4/c1-24-14-12-23(13-15-24,19-7-5-4-6-8-19)22(25)28-16-11-18-9-10-20(26-2)21(17-18)27-3/h4-10,17H,11-16H2,1-3H3
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 6.95E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129247
PNG
(CHEMBL3629532)
Show SMILES COc1ccc(CCNC(=O)C2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O2/c1-24-16-13-22(14-17-24,19-6-4-3-5-7-19)21(25)23-15-12-18-8-10-20(26-2)11-9-18/h3-11H,12-17H2,1-2H3,(H,23,25)
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 6.97E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129250
PNG
(CHEMBL3629535)
Show SMILES COc1ccc(CCC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H32N2O3/c1-26-15-13-24(14-16-26,20-7-5-4-6-8-20)18-25-23(27)12-10-19-9-11-21(28-2)22(17-19)29-3/h4-9,11,17H,10,12-16,18H2,1-3H3,(H,25,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129250
PNG
(CHEMBL3629535)
Show SMILES COc1ccc(CCC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H32N2O3/c1-26-15-13-24(14-16-26,20-7-5-4-6-8-20)18-25-23(27)12-10-19-9-11-21(28-2)22(17-19)29-3/h4-9,11,17H,10,12-16,18H2,1-3H3,(H,25,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129258
PNG
(CHEMBL3629538)
Show SMILES COc1ccc(CCNC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H33N3O3/c1-27-15-12-24(13-16-27,20-7-5-4-6-8-20)18-26-23(28)25-14-11-19-9-10-21(29-2)22(17-19)30-3/h4-10,17H,11-16,18H2,1-3H3,(H2,25,26,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129258
PNG
(CHEMBL3629538)
Show SMILES COc1ccc(CCNC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H33N3O3/c1-27-15-12-24(13-16-27,20-7-5-4-6-8-20)18-26-23(28)25-14-11-19-9-10-21(29-2)22(17-19)30-3/h4-10,17H,11-16,18H2,1-3H3,(H2,25,26,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129258
PNG
(CHEMBL3629538)
Show SMILES COc1ccc(CCNC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H33N3O3/c1-27-15-12-24(13-16-27,20-7-5-4-6-8-20)18-26-23(28)25-14-11-19-9-10-21(29-2)22(17-19)30-3/h4-10,17H,11-16,18H2,1-3H3,(H2,25,26,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129247
PNG
(CHEMBL3629532)
Show SMILES COc1ccc(CCNC(=O)C2(CCN(C)CC2)c2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O2/c1-24-16-13-22(14-17-24,19-6-4-3-5-7-19)21(25)23-15-12-18-8-10-20(26-2)11-9-18/h3-11H,12-17H2,1-2H3,(H,23,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129190
PNG
(CHEMBL3629531)
Show SMILES COc1ccc(CCNC(=O)C2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H30N2O3/c1-25-15-12-23(13-16-25,19-7-5-4-6-8-19)22(26)24-14-11-18-9-10-20(27-2)21(17-18)28-3/h4-10,17H,11-16H2,1-3H3,(H,24,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129143
PNG
(CHEMBL3629529)
Show SMILES COc1ccc(CCOC(=O)C2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H29NO4/c1-24-14-12-23(13-15-24,19-7-5-4-6-8-19)22(25)28-16-11-18-9-10-20(26-2)21(17-18)27-3/h4-10,17H,11-16H2,1-3H3
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 1.08E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M5


(Homo sapiens (Human))		BDBM50129190
PNG
(CHEMBL3629531)
Show SMILES COc1ccc(CCNC(=O)C2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H30N2O3/c1-25-15-12-23(13-16-25,19-7-5-4-6-8-19)22(26)24-14-11-18-9-10-20(27-2)21(17-18)28-3/h4-10,17H,11-16H2,1-3H3,(H,24,26)
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>3.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50129190
PNG
(CHEMBL3629531)
Show SMILES COc1ccc(CCNC(=O)C2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H30N2O3/c1-25-15-12-23(13-16-25,19-7-5-4-6-8-19)22(26)24-14-11-18-9-10-20(27-2)21(17-18)28-3/h4-10,17H,11-16H2,1-3H3,(H,24,26)
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>3.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50129250
PNG
(CHEMBL3629535)
Show SMILES COc1ccc(CCC(=O)NCC2(CCN(C)CC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C24H32N2O3/c1-26-15-13-24(14-16-26,20-7-5-4-6-8-20)18-25-23(27)12-10-19-9-11-21(28-2)22(17-19)29-3/h4-9,11,17H,10,12-16,18H2,1-3H3,(H,25,27)
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>3.00E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells after 2 hrs by liquid scintillation spectrometry analysis

Bioorg Med Chem Lett 25: 5032-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.029
BindingDB Entry DOI: 10.7270/Q2S75J4G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%