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PubMed code 26526740

Compile data set for download or QSAR
Found 111 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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n/an/a 1n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129828
PNG
(CHEMBL3628796)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H20BrN5O3/c1-31-20-11-18-19(12-21(20)32-2)25-13-26-22(18)27-15-6-8-16(9-7-15)28-23(30)29-17-5-3-4-14(24)10-17/h3-13H,1-2H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50380487
PNG
(CHEMBL2018884)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H21BrN4O4/c1-14-9-17(7-8-19(14)29-24(30)28-16-6-4-5-15(25)10-16)33-23-18-11-21(31-2)22(32-3)12-20(18)26-13-27-23/h4-13H,1-3H3,(H2,28,29,30)
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n/an/a 4n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a 5n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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n/an/a 6n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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n/an/a 7n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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n/an/a 8n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129845
PNG
(CHEMBL3628806)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C23H18BrClN4O4/c1-31-20-10-16-19(11-21(20)32-2)26-12-27-22(16)33-15-6-7-18(17(25)9-15)29-23(30)28-14-5-3-4-13(24)8-14/h3-12H,1-2H3,(H2,28,29,30)
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n/an/a 8n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129843
PNG
(CHEMBL3628810)
Show SMILES Clc1cc(Oc2ncnc3sccc23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C19H12BrClN4O2S/c20-11-2-1-3-12(8-11)24-19(26)25-16-5-4-13(9-15(16)21)27-17-14-6-7-28-18(14)23-10-22-17/h1-10H,(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129828
PNG
(CHEMBL3628796)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H20BrN5O3/c1-31-20-11-18-19(12-21(20)32-2)25-13-26-22(18)27-15-6-8-16(9-7-15)28-23(30)29-17-5-3-4-14(24)10-17/h3-13H,1-2H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 12n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129841
PNG
(CHEMBL3628907)
Show SMILES Clc1cc(Oc2ncnc3sc4CCCCc4c23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C23H18BrClN4O2S/c24-13-4-3-5-14(10-13)28-23(30)29-18-9-8-15(11-17(18)25)31-21-20-16-6-1-2-7-19(16)32-22(20)27-12-26-21/h3-5,8-12H,1-2,6-7H2,(H2,28,29,30)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129844
PNG
(CHEMBL3628809)
Show SMILES Cc1cc(Oc2ncnc3sccc23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C20H15BrN4O2S/c1-12-9-15(27-18-16-7-8-28-19(16)23-11-22-18)5-6-17(12)25-20(26)24-14-4-2-3-13(21)10-14/h2-11H,1H3,(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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n/an/a 18n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129822
PNG
(CHEMBL1688539)
Show SMILES Fc1ccc(Nc2ncnc3ccccc23)cc1Cl
Show InChI InChI=1S/C14H9ClFN3/c15-11-7-9(5-6-12(11)16)19-14-10-3-1-2-4-13(10)17-8-18-14/h1-8H,(H,17,18,19)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129842
PNG
(CHEMBL3628906)
Show SMILES Cc1cc(Oc2ncnc3sc4CCCCc4c23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C24H21BrN4O2S/c1-14-11-17(9-10-19(14)29-24(30)28-16-6-4-5-15(25)12-16)31-22-21-18-7-2-3-8-20(18)32-23(21)27-13-26-22/h4-6,9-13H,2-3,7-8H2,1H3,(H2,28,29,30)
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n/an/a 34n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a 46n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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n/an/a 47n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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n/an/a 91n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/a 200n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Abl (unknown origin)


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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n/an/a 310n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/a 400n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR (unknown origin)


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/a 400n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin)


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50380446
PNG
(CHEMBL2018756)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C20H22N4O4/c1-5-28-20(25)24-15-7-6-13(8-12(15)2)23-19-14-9-17(26-3)18(27-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 500n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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n/an/a 570n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129832
PNG
(CHEMBL3628800)
Show SMILES Fc1ccc(Oc2ncnc3ccccc23)cc1Cl
Show InChI InChI=1S/C14H8ClFN2O/c15-11-7-9(5-6-12(11)16)19-14-10-3-1-2-4-13(10)17-8-18-14/h1-8H
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129840
PNG
(CHEMBL3628803)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C20H21N3O5/c1-5-27-20(24)23-15-7-6-13(8-12(15)2)28-19-14-9-17(25-3)18(26-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,23,24)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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n/an/a 650n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129836
PNG
(CHEMBL3628804)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3ccccc23)cc1C
Show InChI InChI=1S/C18H17N3O3/c1-3-23-18(22)21-15-9-8-13(10-12(15)2)24-17-14-6-4-5-7-16(14)19-11-20-17/h4-11H,3H2,1-2H3,(H,21,22)
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n/an/a 710n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50380446
PNG
(CHEMBL2018756)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C20H22N4O4/c1-5-28-20(25)24-15-7-6-13(8-12(15)2)23-19-14-9-17(26-3)18(27-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,24,25)(H,21,22,23)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129835
PNG
(CHEMBL3628805)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3sccc23)cc1C
Show InChI InChI=1S/C16H15N3O3S/c1-3-21-16(20)19-13-5-4-11(8-10(13)2)22-14-12-6-7-23-15(12)18-9-17-14/h4-9H,3H2,1-2H3,(H,19,20)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129841
PNG
(CHEMBL3628907)
Show SMILES Clc1cc(Oc2ncnc3sc4CCCCc4c23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C23H18BrClN4O2S/c24-13-4-3-5-14(10-13)28-23(30)29-18-9-8-15(11-17(18)25)31-21-20-16-6-1-2-7-19(16)32-22(20)27-12-26-21/h3-5,8-12H,1-2,6-7H2,(H2,28,29,30)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129824
PNG
(CHEMBL3628792)
Show SMILES Fc1ccc(Nc2ncnc3sc4CCCCc4c23)cc1Cl
Show InChI InChI=1S/C16H13ClFN3S/c17-11-7-9(5-6-12(11)18)21-15-14-10-3-1-2-4-13(10)22-16(14)20-8-19-15/h5-8H,1-4H2,(H,19,20,21)
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n/an/a 1.33E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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n/an/a 1.98E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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n/an/a 2.12E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a 2.31E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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n/an/a 2.82E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129823
PNG
(CHEMBL3628791)
Show SMILES Fc1ccc(Nc2ncnc3sccc23)cc1Cl
Show InChI InChI=1S/C12H7ClFN3S/c13-9-5-7(1-2-10(9)14)17-11-8-3-4-18-12(8)16-6-15-11/h1-6H,(H,15,16,17)
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n/an/a 2.98E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129827
PNG
(CHEMBL3628795)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3sc4CCCCc4c23)cc1C
Show InChI InChI=1S/C20H22N4O2S/c1-3-26-20(25)24-15-9-8-13(10-12(15)2)23-18-17-14-6-4-5-7-16(14)27-19(17)22-11-21-18/h8-11H,3-7H2,1-2H3,(H,24,25)(H,21,22,23)
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n/an/a 3.14E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129842
PNG
(CHEMBL3628906)
Show SMILES Cc1cc(Oc2ncnc3sc4CCCCc4c23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C24H21BrN4O2S/c1-14-11-17(9-10-19(14)29-24(30)28-16-6-4-5-15(25)12-16)31-22-21-18-7-2-3-8-20(18)32-23(21)27-13-26-22/h4-6,9-13H,2-3,7-8H2,1H3,(H2,28,29,30)
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n/an/a 3.29E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129834
PNG
(CHEMBL3628802)
Show SMILES Fc1ccc(Oc2ncnc3sc4CCCCc4c23)cc1Cl
Show InChI InChI=1S/C16H12ClFN2OS/c17-11-7-9(5-6-12(11)18)21-15-14-10-3-1-2-4-13(10)22-16(14)20-8-19-15/h5-8H,1-4H2
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n/an/a 3.50E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129825
PNG
(CHEMBL3628793)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3ccccc23)cc1C
Show InChI InChI=1S/C18H18N4O2/c1-3-24-18(23)22-15-9-8-13(10-12(15)2)21-17-14-6-4-5-7-16(14)19-11-20-17/h4-11H,3H2,1-2H3,(H,22,23)(H,19,20,21)
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n/an/a 3.82E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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n/an/a 3.95E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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n/an/a 4.02E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a 5.47E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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n/an/a 5.75E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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n/an/a 5.84E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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n/an/a 6.22E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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n/an/a 7.15E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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n/an/a 7.64E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129828
PNG
(CHEMBL3628796)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H20BrN5O3/c1-31-20-11-18-19(12-21(20)32-2)25-13-26-22(18)27-15-6-8-16(9-7-15)28-23(30)29-17-5-3-4-14(24)10-17/h3-13H,1-2H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 7.71E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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n/an/a 8.46E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50340917
PNG
(4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...)
Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3
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n/an/a 9.50E+3n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129834
PNG
(CHEMBL3628802)
Show SMILES Fc1ccc(Oc2ncnc3sc4CCCCc4c23)cc1Cl
Show InChI InChI=1S/C16H12ClFN2OS/c17-11-7-9(5-6-12(11)18)21-15-14-10-3-1-2-4-13(10)22-16(14)20-8-19-15/h5-8H,1-4H2
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129845
PNG
(CHEMBL3628806)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C23H18BrClN4O4/c1-31-20-10-16-19(11-21(20)32-2)26-12-27-22(16)33-15-6-7-18(17(25)9-15)29-23(30)28-14-5-3-4-13(24)8-14/h3-12H,1-2H3,(H2,28,29,30)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129825
PNG
(CHEMBL3628793)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3ccccc23)cc1C
Show InChI InChI=1S/C18H18N4O2/c1-3-24-18(23)22-15-9-8-13(10-12(15)2)21-17-14-6-4-5-7-16(14)19-11-20-17/h4-11H,3H2,1-2H3,(H,22,23)(H,19,20,21)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129826
PNG
(CHEMBL3628794)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3sccc23)cc1C
Show InChI InChI=1S/C16H16N4O2S/c1-3-22-16(21)20-13-5-4-11(8-10(13)2)19-14-12-6-7-23-15(12)18-9-17-14/h4-9H,3H2,1-2H3,(H,20,21)(H,17,18,19)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129827
PNG
(CHEMBL3628795)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3sc4CCCCc4c23)cc1C
Show InChI InChI=1S/C20H22N4O2S/c1-3-26-20(25)24-15-9-8-13(10-12(15)2)23-18-17-14-6-4-5-7-16(14)27-19(17)22-11-21-18/h8-11H,3-7H2,1-2H3,(H,24,25)(H,21,22,23)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129833
PNG
(CHEMBL3628801)
Show SMILES Fc1ccc(Oc2ncnc3sccc23)cc1Cl
Show InChI InChI=1S/C12H6ClFN2OS/c13-9-5-7(1-2-10(9)14)17-11-8-3-4-18-12(8)16-6-15-11/h1-6H
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50380487
PNG
(CHEMBL2018884)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H21BrN4O4/c1-14-9-17(7-8-19(14)29-24(30)28-16-6-4-5-15(25)10-16)33-23-18-11-21(31-2)22(32-3)12-20(18)26-13-27-23/h4-13H,1-3H3,(H2,28,29,30)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129840
PNG
(CHEMBL3628803)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C20H21N3O5/c1-5-27-20(24)23-15-7-6-13(8-12(15)2)28-19-14-9-17(25-3)18(26-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,23,24)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129844
PNG
(CHEMBL3628809)
Show SMILES Cc1cc(Oc2ncnc3sccc23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C20H15BrN4O2S/c1-12-9-15(27-18-16-7-8-28-19(16)23-11-22-18)5-6-17(12)25-20(26)24-14-4-2-3-13(21)10-14/h2-11H,1H3,(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129823
PNG
(CHEMBL3628791)
Show SMILES Fc1ccc(Nc2ncnc3sccc23)cc1Cl
Show InChI InChI=1S/C12H7ClFN3S/c13-9-5-7(1-2-10(9)14)17-11-8-3-4-18-12(8)16-6-15-11/h1-6H,(H,15,16,17)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129843
PNG
(CHEMBL3628810)
Show SMILES Clc1cc(Oc2ncnc3sccc23)ccc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C19H12BrClN4O2S/c20-11-2-1-3-12(8-11)24-19(26)25-16-5-4-13(9-15(16)21)27-17-14-6-7-28-18(14)23-10-22-17/h1-10H,(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50340917
PNG
(4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...)
Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129835
PNG
(CHEMBL3628805)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3sccc23)cc1C
Show InChI InChI=1S/C16H15N3O3S/c1-3-21-16(20)19-13-5-4-11(8-10(13)2)22-14-12-6-7-23-15(12)18-9-17-14/h4-9H,3H2,1-2H3,(H,19,20)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129836
PNG
(CHEMBL3628804)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3ccccc23)cc1C
Show InChI InChI=1S/C18H17N3O3/c1-3-23-18(22)21-15-9-8-13(10-12(15)2)24-17-14-6-4-5-7-16(14)19-11-20-17/h4-11H,3H2,1-2H3,(H,21,22)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50129838
PNG
(CHEMBL3628807)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H15BrN4O2/c22-14-4-3-5-16(12-14)26-21(27)25-15-8-10-17(11-9-15)28-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H2,25,26,27)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129833
PNG
(CHEMBL3628801)
Show SMILES Fc1ccc(Oc2ncnc3sccc23)cc1Cl
Show InChI InChI=1S/C12H6ClFN2OS/c13-9-5-7(1-2-10(9)14)17-11-8-3-4-18-12(8)16-6-15-11/h1-6H
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129832
PNG
(CHEMBL3628800)
Show SMILES Fc1ccc(Oc2ncnc3ccccc23)cc1Cl
Show InChI InChI=1S/C14H8ClFN2O/c15-11-7-9(5-6-12(11)16)19-14-10-3-1-2-4-13(10)17-8-18-14/h1-8H
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129826
PNG
(CHEMBL3628794)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3sccc23)cc1C
Show InChI InChI=1S/C16H16N4O2S/c1-3-22-16(21)20-13-5-4-11(8-10(13)2)19-14-12-6-7-23-15(12)18-9-17-14/h4-9H,3H2,1-2H3,(H,20,21)(H,17,18,19)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129822
PNG
(CHEMBL1688539)
Show SMILES Fc1ccc(Nc2ncnc3ccccc23)cc1Cl
Show InChI InChI=1S/C14H9ClFN3/c15-11-7-9(5-6-12(11)16)19-14-10-3-1-2-4-13(10)17-8-18-14/h1-8H,(H,17,18,19)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Src (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of Raf (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50129831
PNG
(CHEMBL3628799)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H20BrN5OS/c24-14-4-3-5-17(12-14)29-23(30)28-16-10-8-15(9-11-16)27-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H,25,26,27)(H2,28,29,30)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50129824
PNG
(CHEMBL3628792)
Show SMILES Fc1ccc(Nc2ncnc3sc4CCCCc4c23)cc1Cl
Show InChI InChI=1S/C16H13ClFN3S/c17-11-7-9(5-6-12(11)18)21-15-14-10-3-1-2-4-13(10)22-16(14)20-8-19-15/h5-8H,1-4H2,(H,19,20,21)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50129837
PNG
(CHEMBL3628811)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sc5CCCCc5c34)cc2)c1
Show InChI InChI=1S/C23H19BrN4O2S/c24-14-4-3-5-16(12-14)28-23(29)27-15-8-10-17(11-9-15)30-21-20-18-6-1-2-7-19(18)31-22(20)26-13-25-21/h3-5,8-13H,1-2,6-7H2,(H2,27,28,29)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50129839
PNG
(CHEMBL3628808)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H13BrN4O2S/c20-12-2-1-3-14(10-12)24-19(25)23-13-4-6-15(7-5-13)26-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H2,23,24,25)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%