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PubMed code 26526744

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129948
PNG
(CHEMBL3627997)
Show SMILES O=Cc1cn2CCCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C20H18N2O/c23-13-14-12-21-10-4-1-5-11-22-18-7-3-2-6-16(18)17-9-8-15(14)19(21)20(17)22/h2-3,6-9,12-13H,1,4-5,10-11H2
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n/an/a 9n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of Pim-1 (unknown origin)

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129948
PNG
(CHEMBL3627997)
Show SMILES O=Cc1cn2CCCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C20H18N2O/c23-13-14-12-21-10-4-1-5-11-22-18-7-3-2-6-16(18)17-9-8-15(14)19(21)20(17)22/h2-3,6-9,12-13H,1,4-5,10-11H2
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n/an/a 26n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of Pim-3 (unknown origin)

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129947
PNG
(CHEMBL3627996)
Show SMILES O=Cc1cn2CCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C18H14N2O/c21-11-12-10-19-8-3-9-20-16-5-2-1-4-14(16)15-7-6-13(12)17(19)18(15)20/h1-2,4-7,10-11H,3,8-9H2
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n/an/a 42n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of Pim-1 (unknown origin)

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129947
PNG
(CHEMBL3627996)
Show SMILES O=Cc1cn2CCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C18H14N2O/c21-11-12-10-19-8-3-9-20-16-5-2-1-4-14(16)15-7-6-13(12)17(19)18(15)20/h1-2,4-7,10-11H,3,8-9H2
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n/an/a 50n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of Pim-3 (unknown origin)

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129862
PNG
(CHEMBL3629383)
Show SMILES O=Cc1cn2CC(Cn3c4ccccc4c4ccc1c2c34)OCC#N
Show InChI InChI=1S/C20H15N3O2/c21-7-8-25-14-10-22-9-13(12-24)15-5-6-17-16-3-1-2-4-18(16)23(11-14)20(17)19(15)22/h1-6,9,12,14H,8,10-11H2
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n/an/a 190n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-3 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129864
PNG
(CHEMBL3629391)
Show SMILES BrCCCOC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C21H19BrN2O2/c22-8-3-9-26-15-11-23-10-14(13-25)16-6-7-18-17-4-1-2-5-19(17)24(12-15)21(18)20(16)23/h1-2,4-7,10,13,15H,3,8-9,11-12H2
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n/an/a 340n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-3 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129860
PNG
(CHEMBL3629381)
Show SMILES OC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C18H14N2O2/c21-10-11-7-19-8-12(22)9-20-16-4-2-1-3-14(16)15-6-5-13(11)17(19)18(15)20/h1-7,10,12,22H,8-9H2
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n/an/a 380n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-3 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129862
PNG
(CHEMBL3629383)
Show SMILES O=Cc1cn2CC(Cn3c4ccccc4c4ccc1c2c34)OCC#N
Show InChI InChI=1S/C20H15N3O2/c21-7-8-25-14-10-22-9-13(12-24)15-5-6-17-16-3-1-2-4-18(16)23(11-14)20(17)19(15)22/h1-6,9,12,14H,8,10-11H2
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n/an/a 390n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129861
PNG
(CHEMBL3629382)
Show SMILES CS(=O)(=O)OC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C19H16N2O4S/c1-26(23,24)25-13-9-20-8-12(11-22)14-6-7-16-15-4-2-3-5-17(15)21(10-13)19(16)18(14)20/h2-8,11,13H,9-10H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-3 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50129863
PNG
(CHEMBL3629384)
Show SMILES OCCOC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C20H18N2O3/c23-7-8-25-14-10-21-9-13(12-24)15-5-6-17-16-3-1-2-4-18(16)22(11-14)20(17)19(15)21/h1-6,9,12,14,23H,7-8,10-11H2
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n/an/a 700n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-3 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129864
PNG
(CHEMBL3629391)
Show SMILES BrCCCOC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C21H19BrN2O2/c22-8-3-9-26-15-11-23-10-14(13-25)16-6-7-18-17-4-1-2-5-19(17)24(12-15)21(18)20(16)23/h1-2,4-7,10,13,15H,3,8-9,11-12H2
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n/an/a 740n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129863
PNG
(CHEMBL3629384)
Show SMILES OCCOC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C20H18N2O3/c23-7-8-25-14-10-21-9-13(12-24)15-5-6-17-16-3-1-2-4-18(16)22(11-14)20(17)19(15)21/h1-6,9,12,14,23H,7-8,10-11H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129860
PNG
(CHEMBL3629381)
Show SMILES OC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C18H14N2O2/c21-10-11-7-19-8-12(22)9-20-16-4-2-1-3-14(16)15-6-5-13(11)17(19)18(15)20/h1-7,10,12,22H,8-9H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50129861
PNG
(CHEMBL3629382)
Show SMILES CS(=O)(=O)OC1Cn2cc(C=O)c3ccc4c5ccccc5n(C1)c4c23
Show InChI InChI=1S/C19H16N2O4S/c1-26(23,24)25-13-9-20-8-12(11-22)14-6-7-16-15-4-2-3-5-17(15)21(10-13)19(16)18(14)20/h2-8,11,13H,9-10H2,1H3
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n/an/a 1.56E+3n/an/an/an/an/an/a



Universit£ Clermont Auvergne

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using RSRHSSYPAGT as substrate measured for 30 mins in presence of [gamma-33P]-ATP

Bioorg Med Chem 23: 7313-23 (2015)


Article DOI: 10.1016/j.bmc.2015.10.031
BindingDB Entry DOI: 10.7270/Q23F4RHC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%