Affinity Data by PubMed id=26700575

PubMed code 26700575

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10877 (4-(2-hydroxyethyl)benzene-1-sulfonamide \| CHEMBL67...) Show SMILES NS(=O)(=O)c1ccc(CCO)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	3.92E+5	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM4703 (4-carboxybenzenesulfonamide 1 \| 4-sulfamoylbenzoic...) Show SMILES NS(=O)(=O)c1ccc(cc1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50415863 (CHEMBL358263) Show SMILES CCc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as steady state dissociation co...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50423787 (4-Propyl-Benzenesulfonamide \| 4-Propylbenzenesulfo...) Show SMILES CCCc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	6.06E+4	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as steady state dissociation co...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50423787 (4-Propyl-Benzenesulfonamide \| 4-Propylbenzenesulfo...) Show SMILES CCCc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	5.78E+4	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50415863 (CHEMBL358263) Show SMILES CCc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	9.83E+4	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10859 (4-methylbenzene-1-sulfonamide \| CHEMBL574 \| aromat...) Show SMILES Cc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	3.32E+5	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as steady state dissociation co...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Carbonic anhydrase 2 (Bos taurus)	BDBM10857 (4-aminobenzene-1-sulfonamide \| CHEMBL21 \| Sulfanil...) Show SMILES Nc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.88E+3	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to bovine carbonic anhydrase-2 assessed as dissociation constant by SPR method				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10877 (4-(2-hydroxyethyl)benzene-1-sulfonamide \| CHEMBL67...) Show SMILES NS(=O)(=O)c1ccc(CCO)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	4.29E+5	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as steady state dissociation co...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Carbonic anhydrase 2 (Bos taurus)	BDBM4703 (4-carboxybenzenesulfonamide 1 \| 4-sulfamoylbenzoic...) Show SMILES NS(=O)(=O)c1ccc(cc1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to bovine carbonic anhydrase-2 assessed as dissociation constant by SPR method				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10859 (4-methylbenzene-1-sulfonamide \| CHEMBL574 \| aromat...) Show SMILES Cc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.93E+5	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10857 (4-aminobenzene-1-sulfonamide \| CHEMBL21 \| Sulfanil...) Show SMILES Nc1ccc(cc1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.55E+3	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM12414 (CHEMBL27601 \| benzenesulfonamide \| hCA inhibitor, ...) Show SMILES NS(=O)(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	1.14E+6	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as steady state dissociation co...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM12414 (CHEMBL27601 \| benzenesulfonamide \| hCA inhibitor, ...) Show SMILES NS(=O)(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	1.15E+6	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...				J Med Chem 59: 4245-56 (2016) Article DOI: 10.1021/acs.jmedchem.5b01643 BindingDB Entry DOI: 10.7270/Q2PV6NB2
Istituto Italiano di Tecnologia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%