Affinity Data by PubMed id=26778612

PubMed code 26778612

Found 25 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140929 (CHEMBL3754608) Show SMILES COc1ccc2[nH]cc(\C(=C\c3cccnc3)C#N)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140923 (CHEMBL3753955) Show SMILES N#C\C(=C/c1cccnc1)c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140929 (CHEMBL3754608) Show SMILES COc1ccc2[nH]cc(\C(=C\c3cccnc3)C#N)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140935 (CHEMBL3753380) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140923 (CHEMBL3753955) Show SMILES N#C\C(=C/c1cccnc1)c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140931 (CHEMBL3753782) Show SMILES COc1cccc2[nH]cc(\C(=C\c3cccnc3)C#N)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140927 (CHEMBL3752100) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140931 (CHEMBL3753782) Show SMILES COc1cccc2[nH]cc(\C(=C\c3cccnc3)C#N)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140928 (CHEMBL3752687) Show SMILES N#C\C(=C/c1ccc2OCOc2c1)c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140930 (CHEMBL3753970) Show SMILES COc1ccc2c(c[nH]c2c1)C(=C\c1cccnc1)\C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140930 (CHEMBL3753970) Show SMILES COc1ccc2c(c[nH]c2c1)C(=C\c1cccnc1)\C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140926 (CHEMBL3752869) Show SMILES Clc1ccc(\C=C(/C#N)c2c[nH]c3ccccc23)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140927 (CHEMBL3752100) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140926 (CHEMBL3752869) Show SMILES Clc1ccc(\C=C(/C#N)c2c[nH]c3ccccc23)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140932 (CHEMBL3753668) Show SMILES N#C\C(=C/c1cccnc1)c1c[nH]c2ncccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140932 (CHEMBL3753668) Show SMILES N#C\C(=C/c1cccnc1)c1c[nH]c2ncccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140928 (CHEMBL3752687) Show SMILES N#C\C(=C/c1ccc2OCOc2c1)c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140936 (CHEMBL3752183) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140924 (CHEMBL3752271) Show SMILES Clc1cccc(\C=C(/C#N)c2c[nH]c3ccccc23)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140925 (CHEMBL3754386) Show SMILES Fc1ccc(\C=C(/C#N)c2c[nH]c3ccccc23)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140934 (CHEMBL3754004) Show SMILES N#CC(Cc1cccnc1)c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140933 (CHEMBL3753648) Show SMILES N#C\C(=C/c1c[nH]c2ccccc12)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140925 (CHEMBL3754386) Show SMILES Fc1ccc(\C=C(/C#N)c2c[nH]c3ccccc23)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140933 (CHEMBL3753648) Show SMILES N#C\C(=C/c1c[nH]c2ccccc12)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF20A (Homo sapiens (Human))	BDBM50140934 (CHEMBL3754004) Show SMILES N#CC(Cc1cccnc1)c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...				Bioorg Med Chem 24: 721-34 (2016) Article DOI: 10.1016/j.bmc.2015.12.042 BindingDB Entry DOI: 10.7270/Q29025NR
CNRS Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%