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PubMed code 26820900

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50158080
PNG
(CHEMBL3779935)
Show SMILES CC1(C)CCC(C)(C)c2cc3c(OC4CCCC34c3ccc(cc3)C(O)=O)cc12
Show InChI InChI=1/C26H30O3/c1-24(2)12-13-25(3,4)19-15-21-20(14-18(19)24)26(11-5-6-22(26)29-21)17-9-7-16(8-10-17)23(27)28/h7-10,14-15,22H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 25n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50158083
PNG
(CHEMBL3780004)
Show SMILES CC1(C)CCC(C)(C)c2cc3c(OC4CCCCC34c3ccc(cc3)C(O)=O)cc12
Show InChI InChI=1/C27H32O3/c1-25(2)13-14-26(3,4)20-16-22-21(15-19(20)25)27(12-6-5-7-23(27)30-22)18-10-8-17(9-11-18)24(28)29/h8-11,15-16,23H,5-7,12-14H2,1-4H3,(H,28,29)
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n/an/an/an/a 50n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 32n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50032675
PNG
(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Show SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
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n/an/an/an/a 32n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50157944
PNG
(CHEMBL3780806)
Show SMILES [H][C@]12CCC[C@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C26H30O3/c1-24(2)12-13-25(3,4)19-15-21-20(14-18(19)24)26(11-5-6-22(26)29-21)17-9-7-16(8-10-17)23(27)28/h7-10,14-15,22H,5-6,11-13H2,1-4H3,(H,27,28)/t22-,26+/s2
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50157943
PNG
(CHEMBL3780763)
Show SMILES [H][C@@]12CCCC[C@@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C27H32O3/c1-25(2)13-14-26(3,4)20-16-22-21(15-19(20)25)27(12-6-5-7-23(27)30-22)18-10-8-17(9-11-18)24(28)29/h8-11,15-16,23H,5-7,12-14H2,1-4H3,(H,28,29)/t23-,27+/s2
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n/an/an/an/a 20n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50157942
PNG
(CHEMBL3781132)
Show SMILES [H][C@@]12CCC[C@@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C26H30O3/c1-24(2)12-13-25(3,4)19-15-21-20(14-18(19)24)26(11-5-6-22(26)29-21)17-9-7-16(8-10-17)23(27)28/h7-10,14-15,22H,5-6,11-13H2,1-4H3,(H,27,28)/t22-,26+/s2
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n/an/an/an/a 6.30n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50158082
PNG
(CHEMBL3781998)
Show SMILES CC1(C)CCC(C)(C)c2cc3c(OC4CCCCC34c3ccc(C(O)=O)c(F)c3)cc12
Show InChI InChI=1/C27H31FO3/c1-25(2)11-12-26(3,4)19-15-22-20(14-18(19)25)27(10-6-5-7-23(27)31-22)16-8-9-17(24(29)30)21(28)13-16/h8-9,13-15,23H,5-7,10-12H2,1-4H3,(H,29,30)
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n/an/an/an/a 50n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50158079
PNG
(CHEMBL3781771)
Show SMILES [H][C@]12CCCCC[C@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C28H34O3/c1-26(2)14-15-27(3,4)21-17-23-22(16-20(21)26)28(13-7-5-6-8-24(28)31-23)19-11-9-18(10-12-19)25(29)30/h9-12,16-17,24H,5-8,13-15H2,1-4H3,(H,29,30)/t24-,28+/s2
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n/an/an/an/a 126n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50157943
PNG
(CHEMBL3780763)
Show SMILES [H][C@@]12CCCC[C@@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C27H32O3/c1-25(2)13-14-26(3,4)20-16-22-21(15-19(20)25)27(12-6-5-7-23(27)30-22)18-10-8-17(9-11-18)24(28)29/h8-11,15-16,23H,5-7,12-14H2,1-4H3,(H,28,29)/t23-,27+/s2
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n/an/an/an/a 16n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50157942
PNG
(CHEMBL3781132)
Show SMILES [H][C@@]12CCC[C@@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C26H30O3/c1-24(2)12-13-25(3,4)19-15-21-20(14-18(19)24)26(11-5-6-22(26)29-21)17-9-7-16(8-10-17)23(27)28/h7-10,14-15,22H,5-6,11-13H2,1-4H3,(H,27,28)/t22-,26+/s2
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n/an/an/an/a 25n/an/an/an/a



University of Gothenburg

Curated by ChEMBL


Assay Description
Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay


J Med Chem 59: 1232-8 (2016)


BindingDB Entry DOI: 10.7270/Q2X63PT7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
* indicates data uncertainty>20%