Affinity Data by PubMed id=26850006

PubMed code 26850006

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM23926 ((E)-resveratrol \| 5-[(E)-2-(4-hydroxyphenyl)etheny...) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition inc...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM23926 ((E)-resveratrol \| 5-[(E)-2-(4-hydroxyphenyl)etheny...) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	996	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate ...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50147005 (CHEMBL3765737) Show SMILES COC(=O)c1cc(\C=C\c2cc(O)cc(O)c2)ccc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate ...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM23928 (1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...) Show SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition inc...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM23928 (1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...) Show SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate ...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50147006 (CHEMBL3763742) Show SMILES OC(=O)c1cc(\C=C\c2cc(O)cc(O)c2)ccc1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition inc...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50147005 (CHEMBL3765737) Show SMILES COC(=O)c1cc(\C=C\c2cc(O)cc(O)c2)ccc1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition inc...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50147006 (CHEMBL3763742) Show SMILES OC(=O)c1cc(\C=C\c2cc(O)cc(O)c2)ccc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate ...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50147007 (CHEMBL1095380) Show SMILES OC(=O)c1cc(\C=C\c2ccc(O)cc2)ccc1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.21E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition inc...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50147007 (CHEMBL1095380) Show SMILES OC(=O)c1cc(\C=C\c2ccc(O)cc2)ccc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate ...				Bioorg Med Chem Lett 26: 1411-5 (2016) Article DOI: 10.1016/j.bmcl.2016.01.069 BindingDB Entry DOI: 10.7270/Q2X92D52
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%