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PubMed code 26897090

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 1.20n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 1.5n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147911
PNG
(CHEMBL3764158)
Show SMILES COc1cc2c(Oc3ccc(NC(=S)N\N=C\c4ccccc4)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H34FN5O3S/c1-39-30-20-25-27(21-31(30)40-18-8-17-38-15-6-3-7-16-38)34-14-13-28(25)41-29-12-11-24(19-26(29)33)36-32(42)37-35-22-23-9-4-2-5-10-23/h2,4-5,9-14,19-22H,3,6-8,15-18H2,1H3,(H2,36,37,42)/b35-22+
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n/an/a 8.90n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147892
PNG
(CHEMBL3764241)
Show SMILES COc1ccc(\C=N\NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)cc1
Show InChI InChI=1S/C33H36FN5O5/c1-41-25-10-7-23(8-11-25)22-36-38-33(40)37-24-9-12-30(27(34)19-24)44-29-13-14-35-28-21-32(31(42-2)20-26(28)29)43-18-6-17-39-15-4-3-5-16-39/h7-14,19-22H,3-6,15-18H2,1-2H3,(H2,37,38,40)/b36-22+
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n/an/a 14n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 15n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Ron (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147899
PNG
(CHEMBL3765572)
Show SMILES COc1ccc(\C=N\NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCC(C)CC5)c(OC)cc34)c(F)c2)cc1
Show InChI InChI=1S/C34H38FN5O5/c1-23-12-16-40(17-13-23)15-4-18-44-33-21-29-27(20-32(33)43-3)30(11-14-36-29)45-31-10-7-25(19-28(31)35)38-34(41)39-37-22-24-5-8-26(42-2)9-6-24/h5-11,14,19-23H,4,12-13,15-18H2,1-3H3,(H2,38,39,41)/b37-22+
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n/an/a 16n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147914
PNG
(CHEMBL3764060)
Show SMILES COc1cc2c(Oc3ccc(NC(=S)N\N=C\c4ccc(F)cc4Cl)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H32ClF2N5O3S/c1-41-30-18-24-27(19-31(30)42-15-5-14-40-12-3-2-4-13-40)36-11-10-28(24)43-29-9-8-23(17-26(29)35)38-32(44)39-37-20-21-6-7-22(34)16-25(21)33/h6-11,16-20H,2-5,12-15H2,1H3,(H2,38,39,44)/b37-20+
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n/an/a 17n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147903
PNG
(CHEMBL3763886)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4ccc(F)cc4Cl)cc3F)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C33H34ClF2N5O4/c1-21-9-13-41(14-10-21)12-3-15-44-32-19-28-25(18-31(32)43-2)29(8-11-37-28)45-30-7-6-24(17-27(30)36)39-33(42)40-38-20-22-4-5-23(35)16-26(22)34/h4-8,11,16-21H,3,9-10,12-15H2,1-2H3,(H2,39,40,42)/b38-20+
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n/an/a 26n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147895
PNG
(CHEMBL3765124)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccs4)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C30H32FN5O4S/c1-38-28-18-23-25(19-29(28)39-15-6-14-36-12-3-2-4-13-36)32-11-10-26(23)40-27-9-8-21(17-24(27)31)34-30(37)35-33-20-22-7-5-16-41-22/h5,7-11,16-20H,2-4,6,12-15H2,1H3,(H2,34,35,37)/b33-20+
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n/an/a 54n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147888
PNG
(CHEMBL3764184)
Show SMILES COc1ccc(\C=N\NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCOCC5)c(OC)cc34)c(F)c2)cc1
Show InChI InChI=1S/C32H34FN5O6/c1-40-24-7-4-22(5-8-24)21-35-37-32(39)36-23-6-9-29(26(33)18-23)44-28-10-11-34-27-20-31(30(41-2)19-25(27)28)43-15-3-12-38-13-16-42-17-14-38/h4-11,18-21H,3,12-17H2,1-2H3,(H2,36,37,39)/b35-21+
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n/an/a 56n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147919
PNG
(CHEMBL3765283)
Show SMILES COc1cc2c(Oc3ccc(\C=N\NC(=O)Nc4ccccc4)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H34FN5O4/c1-40-30-20-25-27(21-31(30)41-18-8-17-38-15-6-3-7-16-38)34-14-13-28(25)42-29-12-11-23(19-26(29)33)22-35-37-32(39)36-24-9-4-2-5-10-24/h2,4-5,9-14,19-22H,3,6-8,15-18H2,1H3,(H2,36,37,39)/b35-22+
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n/an/a 63n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147891
PNG
(CHEMBL3764320)
Show SMILES COc1ccc(\C=N\NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCC5)c(OC)cc34)c(F)c2)cc1
Show InChI InChI=1S/C32H34FN5O5/c1-40-24-9-6-22(7-10-24)21-35-37-32(39)36-23-8-11-29(26(33)18-23)43-28-12-13-34-27-20-31(30(41-2)19-25(27)28)42-17-5-16-38-14-3-4-15-38/h6-13,18-21H,3-5,14-17H2,1-2H3,(H2,36,37,39)/b35-21+
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n/an/a 72n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50147922
PNG
(CHEMBL3763970)
Show SMILES COc1cc2c(Oc3ccc(\C=N\NC(=O)Nc4ccc(F)cc4Br)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C32H32BrF2N5O4/c1-42-30-18-23-27(19-31(30)43-15-5-14-40-12-3-2-4-13-40)36-11-10-28(23)44-29-9-6-21(16-25(29)35)20-37-39-32(41)38-26-8-7-22(34)17-24(26)33/h6-11,16-20H,2-5,12-15H2,1H3,(H2,38,39,41)/b37-20+
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n/an/a 121n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 163n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 210n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 212n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-alpha (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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n/an/a 367n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Flt-3 (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50147893
PNG
(CHEMBL3764279)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)N\N=C\c4cccc(CC=C)c4O)cc3F)ccnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C35H38FN5O5/c1-3-9-24-10-7-11-25(34(24)42)23-38-40-35(43)39-26-12-13-31(28(36)20-26)46-30-14-15-37-29-22-33(32(44-2)21-27(29)30)45-19-8-18-41-16-5-4-6-17-41/h3,7,10-15,20-23,42H,1,4-6,8-9,16-19H2,2H3,(H2,39,40,43)/b38-23+
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of EGFR (unknown origin) using poly(glu,Tyr)4:1 as substrate incubated for 30 mins by homogeneous time-resolved fluorescence assay

Bioorg Med Chem 24: 1331-45 (2016)


Article DOI: 10.1016/j.bmc.2016.02.003
BindingDB Entry DOI: 10.7270/Q2V989XB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%