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PubMed code 26923692

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154813
PNG
(CHEMBL3774451)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-12-1-4-14(5-2-12)34-20(23(26,27)28)19(32-33-34)22(35)31-13-3-6-18(16(25)11-13)36-17-8-10-30-21-15(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 1.70n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 1.90n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50154813
PNG
(CHEMBL3774451)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-12-1-4-14(5-2-12)34-20(23(26,27)28)19(32-33-34)22(35)31-13-3-6-18(16(25)11-13)36-17-8-10-30-21-15(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 2.10n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50154813
PNG
(CHEMBL3774451)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-12-1-4-14(5-2-12)34-20(23(26,27)28)19(32-33-34)22(35)31-13-3-6-18(16(25)11-13)36-17-8-10-30-21-15(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 4.60n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154823
PNG
(CHEMBL3774498)
Show SMILES Fc1cc(NC(=O)c2nnn(c2C(F)(F)F)-c2ccccc2F)ccc1Oc1ccnc2[nH]ccc12
Show InChI InChI=1S/C23H13F5N6O2/c24-14-3-1-2-4-16(14)34-20(23(26,27)28)19(32-33-34)22(35)31-12-5-6-18(15(25)11-12)36-17-8-10-30-21-13(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 5.20n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154816
PNG
(CHEMBL3774862)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H14F4N6O2/c24-13-1-5-15(6-2-13)33-20(23(25,26)27)19(31-32-33)22(34)30-14-3-7-16(8-4-14)35-18-10-12-29-21-17(18)9-11-28-21/h1-12H,(H,28,29)(H,30,34)
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n/an/a 6.40n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154824
PNG
(CHEMBL3774954)
Show SMILES Fc1cc(NC(=O)c2nnn(c2C(F)(F)F)-c2ccccc2)ccc1Oc1ccnc2[nH]ccc12
Show InChI InChI=1S/C23H14F4N6O2/c24-16-12-13(6-7-18(16)35-17-9-11-29-21-15(17)8-10-28-21)30-22(34)19-20(23(25,26)27)33(32-31-19)14-4-2-1-3-5-14/h1-12H,(H,28,29)(H,30,34)
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n/an/a 7.30n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154821
PNG
(CHEMBL3775126)
Show SMILES Fc1ccc(cc1F)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H12F6N6O2/c24-14-3-2-12(10-15(14)25)35-20(23(27,28)29)19(33-34-35)22(36)32-11-1-4-18(16(26)9-11)37-17-6-8-31-21-13(17)5-7-30-21/h1-10H,(H,30,31)(H,32,36)
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n/an/a 11n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154817
PNG
(CHEMBL3774870)
Show SMILES Fc1ccccc1-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H14F4N6O2/c24-16-3-1-2-4-17(16)33-20(23(25,26)27)19(31-32-33)22(34)30-13-5-7-14(8-6-13)35-18-10-12-29-21-15(18)9-11-28-21/h1-12H,(H,28,29)(H,30,34)
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n/an/a 11n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154818
PNG
(CHEMBL3775026)
Show SMILES FC(F)(F)c1c(nnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H15F3N6O2/c24-23(25,26)20-19(30-31-32(20)15-4-2-1-3-5-15)22(33)29-14-6-8-16(9-7-14)34-18-11-13-28-21-17(18)10-12-27-21/h1-13H,(H,27,28)(H,29,33)
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n/an/a 11n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154836
PNG
(CHEMBL3774523)
Show SMILES Cc1c(nnn1-c1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C23H16F2N6O2/c1-13-21(29-30-31(13)16-5-2-14(24)3-6-16)23(32)28-15-4-7-20(18(25)12-15)33-19-9-11-27-22-17(19)8-10-26-22/h2-12H,1H3,(H,26,27)(H,28,32)
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n/an/a 13n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154822
PNG
(CHEMBL3774984)
Show SMILES COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C24H16F4N6O3/c1-36-15-5-3-14(4-6-15)34-21(24(26,27)28)20(32-33-34)23(35)31-13-2-7-19(17(25)12-13)37-18-9-11-30-22-16(18)8-10-29-22/h2-12H,1H3,(H,29,30)(H,31,35)
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n/an/a 13n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154837
PNG
(CHEMBL3775013)
Show SMILES Cc1c(nnn1-c1ccccc1F)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C23H16F2N6O2/c1-13-21(29-30-31(13)18-5-3-2-4-16(18)24)23(32)28-14-6-7-20(17(25)12-14)33-19-9-11-27-22-15(19)8-10-26-22/h2-12H,1H3,(H,26,27)(H,28,32)
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n/an/a 14n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154829
PNG
(CHEMBL3775300)
Show SMILES Cc1c(nnn1-c1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H17FN6O2/c1-14-21(28-29-30(14)17-6-2-15(24)3-7-17)23(31)27-16-4-8-18(9-5-16)32-20-11-13-26-22-19(20)10-12-25-22/h2-13H,1H3,(H,25,26)(H,27,31)
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n/an/a 15n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154830
PNG
(CHEMBL3775137)
Show SMILES Cc1c(nnn1-c1ccccc1F)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H17FN6O2/c1-14-21(28-29-30(14)19-5-3-2-4-18(19)24)23(31)27-15-6-8-16(9-7-15)32-20-11-13-26-22-17(20)10-12-25-22/h2-13H,1H3,(H,25,26)(H,27,31)
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n/an/a 16n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154815
PNG
(CHEMBL3774679)
Show SMILES COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C24H17F3N6O3/c1-35-16-8-4-15(5-9-16)33-21(24(25,26)27)20(31-32-33)23(34)30-14-2-6-17(7-3-14)36-19-11-13-29-22-18(19)10-12-28-22/h2-13H,1H3,(H,28,29)(H,30,34)
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n/an/a 16n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154820
PNG
(CHEMBL3775343)
Show SMILES Fc1ccc(cc1Cl)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H12ClF5N6O2/c24-14-10-12(2-3-15(14)25)35-20(23(27,28)29)19(33-34-35)22(36)32-11-1-4-18(16(26)9-11)37-17-6-8-31-21-13(17)5-7-30-21/h1-10H,(H,30,31)(H,32,36)
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n/an/a 16n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154838
PNG
(CHEMBL3774790)
Show SMILES Cc1c(nnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C23H17FN6O2/c1-14-21(28-29-30(14)16-5-3-2-4-6-16)23(31)27-15-7-8-20(18(24)13-15)32-19-10-12-26-22-17(19)9-11-25-22/h2-13H,1H3,(H,25,26)(H,27,31)
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n/an/a 17n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154819
PNG
(CHEMBL3775721)
Show SMILES Fc1cc(NC(=O)c2nnn(c2C(F)(F)F)-c2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc2[nH]ccc12
Show InChI InChI=1S/C24H12ClF7N6O2/c25-15-3-2-12(10-14(15)23(27,28)29)38-20(24(30,31)32)19(36-37-38)22(39)35-11-1-4-18(16(26)9-11)40-17-6-8-34-21-13(17)5-7-33-21/h1-10H,(H,33,34)(H,35,39)
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n/an/a 18n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154831
PNG
(CHEMBL3775550)
Show SMILES Cc1c(nnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H18N6O2/c1-15-21(27-28-29(15)17-5-3-2-4-6-17)23(30)26-16-7-9-18(10-8-16)31-20-12-14-25-22-19(20)11-13-24-22/h2-14H,1H3,(H,24,25)(H,26,30)
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n/an/a 19n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154839
PNG
(CHEMBL3775327)
Show SMILES Fc1ccc(cc1Cl)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H13ClF4N6O2/c24-16-11-13(3-6-17(16)25)34-20(23(26,27)28)19(32-33-34)22(35)31-12-1-4-14(5-2-12)36-18-8-10-30-21-15(18)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 19n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154840
PNG
(CHEMBL3774694)
Show SMILES FC(F)(F)c1c(nnn1-c1ccc(Cl)c(c1)C(F)(F)F)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C24H13ClF6N6O2/c25-17-6-3-13(11-16(17)23(26,27)28)37-20(24(29,30)31)19(35-36-37)22(38)34-12-1-4-14(5-2-12)39-18-8-10-33-21-15(18)7-9-32-21/h1-11H,(H,32,33)(H,34,38)
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n/an/a 21n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154814
PNG
(CHEMBL3775648)
Show SMILES Fc1ccc(cc1F)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-16-6-3-13(11-17(16)25)34-20(23(26,27)28)19(32-33-34)22(35)31-12-1-4-14(5-2-12)36-18-8-10-30-21-15(18)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 21n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154827
PNG
(CHEMBL3775764)
Show SMILES Cc1c(nnn1-c1ccc(F)c(F)c1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H16F2N6O2/c1-13-21(29-30-31(13)15-4-7-18(24)19(25)12-15)23(32)28-14-2-5-16(6-3-14)33-20-9-11-27-22-17(20)8-10-26-22/h2-12H,1H3,(H,26,27)(H,28,32)
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n/an/a 21n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154826
PNG
(CHEMBL3774740)
Show SMILES Cc1c(nnn1-c1ccc(F)c(Cl)c1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C23H16ClFN6O2/c1-13-21(29-30-31(13)15-4-7-19(25)18(24)12-15)23(32)28-14-2-5-16(6-3-14)33-20-9-11-27-22-17(20)8-10-26-22/h2-12H,1H3,(H,26,27)(H,28,32)
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n/an/a 22n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154834
PNG
(CHEMBL3775756)
Show SMILES Cc1c(nnn1-c1ccc(F)c(F)c1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C23H15F3N6O2/c1-12-21(30-31-32(12)14-3-4-16(24)17(25)11-14)23(33)29-13-2-5-20(18(26)10-13)34-19-7-9-28-22-15(19)6-8-27-22/h2-11H,1H3,(H,27,28)(H,29,33)
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n/an/a 22n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154835
PNG
(CHEMBL3775092)
Show SMILES COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C
Show InChI InChI=1S/C24H19FN6O3/c1-14-22(29-30-31(14)16-4-6-17(33-2)7-5-16)24(32)28-15-3-8-21(19(25)13-15)34-20-10-12-27-23-18(20)9-11-26-23/h3-13H,1-2H3,(H,26,27)(H,28,32)
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n/an/a 24n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154828
PNG
(CHEMBL3775275)
Show SMILES COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)cc2)c1C
Show InChI InChI=1S/C24H20N6O3/c1-15-22(28-29-30(15)17-5-9-18(32-2)10-6-17)24(31)27-16-3-7-19(8-4-16)33-21-12-14-26-23-20(21)11-13-25-23/h3-14H,1-2H3,(H,25,26)(H,27,31)
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n/an/a 25n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154833
PNG
(CHEMBL3774854)
Show SMILES Cc1c(nnn1-c1ccc(F)c(Cl)c1)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C23H15ClF2N6O2/c1-12-21(30-31-32(12)14-3-4-17(25)16(24)11-14)23(33)29-13-2-5-20(18(26)10-13)34-19-7-9-28-22-15(19)6-8-27-22/h2-11H,1H3,(H,27,28)(H,29,33)
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n/an/a 29n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154832
PNG
(CHEMBL3775150)
Show SMILES Cc1c(nnn1-c1ccc(Cl)c(c1)C(F)(F)F)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C24H15ClF4N6O2/c1-12-21(33-34-35(12)14-3-4-17(25)16(11-14)24(27,28)29)23(36)32-13-2-5-20(18(26)10-13)37-19-7-9-31-22-15(19)6-8-30-22/h2-11H,1H3,(H,30,31)(H,32,36)
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n/an/a 38n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50154825
PNG
(CHEMBL3775785)
Show SMILES Cc1c(nnn1-c1ccc(Cl)c(c1)C(F)(F)F)C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)cc1
Show InChI InChI=1S/C24H16ClF3N6O2/c1-13-21(32-33-34(13)15-4-7-19(25)18(12-15)24(26,27)28)23(35)31-14-2-5-16(6-3-14)36-20-9-11-30-22-17(20)8-10-29-22/h2-12H,1H3,(H,29,30)(H,31,35)
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n/an/a 43n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cMet (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50154813
PNG
(CHEMBL3774451)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-12-1-4-14(5-2-12)34-20(23(26,27)28)19(32-33-34)22(35)31-13-3-6-18(16(25)11-13)36-17-8-10-30-21-15(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 86n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50154813
PNG
(CHEMBL3774451)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-12-1-4-14(5-2-12)34-20(23(26,27)28)19(32-33-34)22(35)31-13-3-6-18(16(25)11-13)36-17-8-10-30-21-15(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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n/an/a 325n/an/an/an/an/an/a



Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of cKit (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50154813
PNG
(CHEMBL3774451)
Show SMILES Fc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1C(F)(F)F
Show InChI InChI=1S/C23H13F5N6O2/c24-12-1-4-14(5-2-12)34-20(23(26,27)28)19(32-33-34)22(35)31-13-3-6-18(16(25)11-13)36-17-8-10-30-21-15(17)7-9-29-21/h1-11H,(H,29,30)(H,31,35)
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Jiangxi Science and Technology Normal University

Curated by ChEMBL


Assay Description
Inhibition of EGFR (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay


Bioorg Med Chem Lett 26: 1680-4 (2016)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%