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PubMed code 26988302

Compile data set for download or QSAR
Found 104 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 (unknown origin)


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 (unknown origin)


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 (unknown origin)


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of CYP34A (unknown origin)


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159567
PNG
(CHEMBL3786928)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(NC(=O)c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H15ClN2O3/c1-12-9-10-25-17(12)19(24)21-14-7-8-16(15(20)11-14)22-18(23)13-5-3-2-4-6-13/h2-11H,1H3,(H,21,24)(H,22,23)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159690
PNG
(CHEMBL3787309)
Show SMILES Clc1cccc2CN(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H12Cl3N3O2/c21-13-4-1-3-11-10-26(20(28)17(11)13)16-7-6-12(9-15(16)23)25-19(27)18-14(22)5-2-8-24-18/h1-9H,10H2,(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159559
PNG
(CHEMBL3787296)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2N3O2S/c1-10-17(22-9-27-10)18(25)23-12-5-6-15(14(21)7-12)24-8-11-3-2-4-13(20)16(11)19(24)26/h2-7,9H,8H2,1H3,(H,23,25)
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n/an/an/an/a 4.79E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159563
PNG
(CHEMBL3785267)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)CCc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C21H17ClN2O3/c1-13-10-11-27-20(13)21(26)23-15-7-8-18(16(22)12-15)24-17-5-3-2-4-14(17)6-9-19(24)25/h2-5,7-8,10-12H,6,9H2,1H3,(H,23,26)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159574
PNG
(CHEMBL3785850)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCOc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C20H17ClN2O3/c1-13-8-10-26-19(13)20(24)22-14-6-7-16(15(21)12-14)23-9-11-25-18-5-3-2-4-17(18)23/h2-8,10,12H,9,11H2,1H3,(H,22,24)
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n/an/an/an/a 3.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159574
PNG
(CHEMBL3785850)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCOc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C20H17ClN2O3/c1-13-8-10-26-19(13)20(24)22-14-6-7-16(15(21)12-14)23-9-11-25-18-5-3-2-4-17(18)23/h2-8,10,12H,9,11H2,1H3,(H,22,24)
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n/an/an/an/a 3.62E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159577
PNG
(CHEMBL3786032)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2)c(Cl)c1
Show InChI InChI=1S/C21H19ClN2O2/c1-14-9-11-26-20(14)21(25)23-17-6-7-19(18(22)12-17)24-10-8-15-4-2-3-5-16(15)13-24/h2-7,9,11-12H,8,10,13H2,1H3,(H,23,25)
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n/an/an/an/a 2.47E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159594
PNG
(CHEMBL3785400)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1Cc2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H15ClN2O3/c1-12-9-10-26-18(12)19(24)22-14-5-7-15(8-6-14)23-11-13-3-2-4-16(21)17(13)20(23)25/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a 353n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159560
PNG
(CHEMBL3785245)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-12-8-9-28-19(12)20(26)23-14-6-7-17(16(22)11-14)24-18(25)10-13-4-2-3-5-15(13)21(24)27/h2-9,11H,10H2,1H3,(H,23,26)
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n/an/an/an/a 242n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159579
PNG
(CHEMBL3787241)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cc(Cl)ccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-6-7-27-18(11)19(25)23-14-3-5-17(16(22)9-14)24-10-12-8-13(21)2-4-15(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159576
PNG
(CHEMBL3785252)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN2O3/c1-13-9-11-27-19(13)20(25)23-15-6-7-18(17(22)12-15)24-10-8-14-4-2-3-5-16(14)21(24)26/h2-7,9,11-12H,8,10H2,1H3,(H,23,25)
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n/an/an/an/a 776n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159600
PNG
(CHEMBL3785775)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1Cc2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H14ClFN2O3/c1-11-7-8-27-18(11)19(25)23-16-6-5-13(9-15(16)22)24-10-12-3-2-4-14(21)17(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159593
PNG
(CHEMBL3786739)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1Cc2c(cccc2Cl)C1=O
Show InChI InChI=1S/C20H15ClN2O3/c1-12-9-10-26-18(12)19(24)22-13-5-7-14(8-6-13)23-11-16-15(20(23)25)3-2-4-17(16)21/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a 245n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159593
PNG
(CHEMBL3786739)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1Cc2c(cccc2Cl)C1=O
Show InChI InChI=1S/C20H15ClN2O3/c1-12-9-10-26-18(12)19(24)22-13-5-7-14(8-6-13)23-11-16-15(20(23)25)3-2-4-17(16)21/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a 245n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159585
PNG
(CHEMBL3785990)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H14ClF3N2O3/c1-11-7-8-30-18(11)19(28)26-12-5-6-17(16(22)9-12)27-10-14-13(20(27)29)3-2-4-15(14)21(23,24)25/h2-9H,10H2,1H3,(H,26,28)
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n/an/an/an/a 1.13E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159569
PNG
(CHEMBL3787619)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H15ClN2O3/c1-12-8-9-26-18(12)19(24)22-14-6-7-17(16(21)10-14)23-11-13-4-2-3-5-15(13)20(23)25/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a 3.72E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50128021
PNG
(CHEMBL3628116)
Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu4 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159560
PNG
(CHEMBL3785245)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-12-8-9-28-19(12)20(26)23-14-6-7-17(16(22)11-14)24-18(25)10-13-4-2-3-5-15(13)21(24)27/h2-9,11H,10H2,1H3,(H,23,26)
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n/an/an/an/a 224n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159571
PNG
(CHEMBL3785813)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C20H15ClN2O3/c1-12-8-9-26-19(12)20(25)22-14-6-7-17(15(21)11-14)23-16-5-3-2-4-13(16)10-18(23)24/h2-9,11H,10H2,1H3,(H,22,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159571
PNG
(CHEMBL3785813)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C20H15ClN2O3/c1-12-8-9-26-19(12)20(25)22-14-6-7-17(15(21)11-14)23-16-5-3-2-4-13(16)10-18(23)24/h2-9,11H,10H2,1H3,(H,22,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159582
PNG
(CHEMBL3786160)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3F)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14ClFN2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(15(21)9-12)24-10-14-13(20(24)26)3-2-4-16(14)22/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 891n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159595
PNG
(CHEMBL3786584)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1Cl
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-8-9-27-18(11)19(25)23-14-6-7-15(17(22)16(14)21)24-10-12-4-2-3-5-13(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159687
PNG
(CHEMBL3787159)
Show SMILES Cc1cccnc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15Cl2N3O2/c1-12-4-3-9-24-19(12)20(27)25-14-7-8-17(16(23)10-14)26-11-13-5-2-6-15(22)18(13)21(26)28/h2-10H,11H2,1H3,(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159692
PNG
(CHEMBL3785499)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2N3O2S/c1-10-17(22-9-27-10)18(25)23-11-5-6-16(15(21)7-11)24-8-13-12(19(24)26)3-2-4-14(13)20/h2-7,9H,8H2,1H3,(H,23,25)
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n/an/an/an/a 955n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159559
PNG
(CHEMBL3787296)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2N3O2S/c1-10-17(22-9-27-10)18(25)23-12-5-6-15(14(21)7-12)24-8-11-3-2-4-13(20)16(11)19(24)26/h2-7,9H,8H2,1H3,(H,23,25)
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n/an/an/an/a 4.69E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159561
PNG
(CHEMBL3785247)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3CC2=O)c(Cl)c1
Show InChI InChI=1S/C22H17ClN2O4/c1-13-8-9-29-21(13)22(28)24-16-6-7-18(17(23)12-16)25-19(26)10-14-4-2-3-5-15(14)11-20(25)27/h2-9,12H,10-11H2,1H3,(H,24,28)
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n/an/an/an/a 3.50E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159563
PNG
(CHEMBL3785267)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)CCc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C21H17ClN2O3/c1-13-10-11-27-20(13)21(26)23-15-7-8-18(16(22)12-15)24-17-5-3-2-4-14(17)6-9-19(24)25/h2-5,7-8,10-12H,6,9H2,1H3,(H,23,26)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159570
PNG
(CHEMBL3786060)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ccccc3C2)c(Cl)c1
Show InChI InChI=1S/C20H17ClN2O2/c1-13-8-9-25-19(13)20(24)22-16-6-7-18(17(21)10-16)23-11-14-4-2-3-5-15(14)12-23/h2-10H,11-12H2,1H3,(H,22,24)
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n/an/an/an/a 1.78E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159595
PNG
(CHEMBL3786584)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1Cl
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-8-9-27-18(11)19(25)23-14-6-7-15(17(22)16(14)21)24-10-12-4-2-3-5-13(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159577
PNG
(CHEMBL3786032)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2)c(Cl)c1
Show InChI InChI=1S/C21H19ClN2O2/c1-14-9-11-26-20(14)21(25)23-17-6-7-19(18(22)12-17)24-10-8-15-4-2-3-5-16(15)13-24/h2-7,9,11-12H,8,10,13H2,1H3,(H,23,25)
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n/an/an/an/a 2.47E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159587
PNG
(CHEMBL3787140)
Show SMILES COc1cccc2C(=O)N(Cc12)c1ccc(NC(=O)c2occc2C)cc1Cl
Show InChI InChI=1S/C21H17ClN2O4/c1-12-8-9-28-19(12)20(25)23-13-6-7-17(16(22)10-13)24-11-15-14(21(24)26)4-3-5-18(15)27-2/h3-10H,11H2,1-2H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159588
PNG
(CHEMBL3785911)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN3O3/c1-11-6-8-26-17(11)18(24)22-12-4-5-16(14(20)9-12)23-10-15-13(19(23)25)3-2-7-21-15/h2-9H,10H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159588
PNG
(CHEMBL3785911)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN3O3/c1-11-6-8-26-17(11)18(24)22-12-4-5-16(14(20)9-12)23-10-15-13(19(23)25)3-2-7-21-15/h2-9H,10H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159591
PNG
(CHEMBL3786977)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2(C)C)c(Cl)c1
Show InChI InChI=1S/C22H19ClN2O3/c1-13-10-11-28-19(13)20(26)24-14-8-9-18(17(23)12-14)25-21(27)15-6-4-5-7-16(15)22(25,2)3/h4-12H,1-3H3,(H,24,26)
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n/an/an/an/a 7.08E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159691
PNG
(CHEMBL3786982)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN3O2S/c1-11-17(21-10-26-11)18(24)22-13-6-7-16(15(20)8-13)23-9-12-4-2-3-5-14(12)19(23)25/h2-8,10H,9H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159570
PNG
(CHEMBL3786060)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ccccc3C2)c(Cl)c1
Show InChI InChI=1S/C20H17ClN2O2/c1-13-8-9-25-19(13)20(24)22-16-6-7-18(17(21)10-16)23-11-14-4-2-3-5-15(14)12-23/h2-10H,11-12H2,1H3,(H,22,24)
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n/an/an/an/a 1.76E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159692
PNG
(CHEMBL3785499)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2N3O2S/c1-10-17(22-9-27-10)18(25)23-11-5-6-16(15(21)7-11)24-8-13-12(19(24)26)3-2-4-14(13)20/h2-7,9H,8H2,1H3,(H,23,25)
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n/an/an/an/a 954n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159567
PNG
(CHEMBL3786928)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(NC(=O)c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H15ClN2O3/c1-12-9-10-25-17(12)19(24)21-14-7-8-16(15(20)11-14)22-18(23)13-5-3-2-4-6-13/h2-11H,1H3,(H,21,24)(H,22,23)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159592
PNG
(CHEMBL3786494)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1Cc2ccccc2C1=O
Show InChI InChI=1S/C20H16N2O3/c1-13-10-11-25-18(13)19(23)21-15-6-8-16(9-7-15)22-12-14-4-2-3-5-17(14)20(22)24/h2-11H,12H2,1H3,(H,21,23)
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n/an/an/an/a 1.55E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159594
PNG
(CHEMBL3785400)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1Cc2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H15ClN2O3/c1-12-9-10-26-18(12)19(24)22-14-5-7-15(8-6-14)23-11-13-3-2-4-16(21)17(13)20(23)25/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a 355n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159601
PNG
(CHEMBL3785372)
Show SMILES Cc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H16ClN3O2/c1-13-5-4-10-23-19(13)20(26)24-15-8-9-18(17(22)11-15)25-12-14-6-2-3-7-16(14)21(25)27/h2-11H,12H2,1H3,(H,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159572
PNG
(CHEMBL3785210)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C20H17ClN2O2/c1-13-9-11-25-19(13)20(24)22-15-6-7-18(16(21)12-15)23-10-8-14-4-2-3-5-17(14)23/h2-7,9,11-12H,8,10H2,1H3,(H,22,24)
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n/an/an/an/a 5.75E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159597
PNG
(CHEMBL3787654)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1Cl
Show InChI InChI=1S/C20H13Cl3N2O3/c1-10-7-8-28-18(10)19(26)24-13-5-6-14(17(23)16(13)22)25-9-11-3-2-4-12(21)15(11)20(25)27/h2-8H,9H2,1H3,(H,24,26)
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n/an/an/an/a 6.52E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159589
PNG
(CHEMBL3787366)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccnc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN3O3/c1-11-6-8-26-17(11)18(24)22-13-4-5-15(14(20)9-13)23-10-12-3-2-7-21-16(12)19(23)25/h2-9H,10H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159565
PNG
(CHEMBL3786488)
Show SMILES [H][C@@]12CCCC[C@@]1([H])C(=O)N(C2=O)c1ccc(NC(=O)c2occc2C)cc1Cl |r|
Show InChI InChI=1S/C20H19ClN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h6-10,13-14H,2-5H2,1H3,(H,22,24)/t13-,14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159566
PNG
(CHEMBL3786597)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(NC(=O)c2ccccc2C(O)=O)c(Cl)c1
Show InChI InChI=1S/C20H15ClN2O5/c1-11-8-9-28-17(11)19(25)22-12-6-7-16(15(21)10-12)23-18(24)13-4-2-3-5-14(13)20(26)27/h2-10H,1H3,(H,22,25)(H,23,24)(H,26,27)
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n/an/an/an/a 930n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159581
PNG
(CHEMBL3785852)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3C)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN2O3/c1-12-4-3-5-15-16(12)11-24(21(15)26)18-7-6-14(10-17(18)22)23-20(25)19-13(2)8-9-27-19/h3-10H,11H2,1-2H3,(H,23,25)
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n/an/an/an/a 1.07E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159575
PNG
(CHEMBL3786721)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCOc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C19H16ClN3O3/c1-12-6-9-25-17(12)18(24)22-13-4-5-15(14(20)11-13)23-8-10-26-19-16(23)3-2-7-21-19/h2-7,9,11H,8,10H2,1H3,(H,22,24)
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n/an/an/an/a 2.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159579
PNG
(CHEMBL3787241)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cc(Cl)ccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-6-7-27-18(11)19(25)23-14-3-5-17(16(22)9-14)24-10-12-8-13(21)2-4-15(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159581
PNG
(CHEMBL3785852)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3C)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN2O3/c1-12-4-3-5-15-16(12)11-24(21(15)26)18-7-6-14(10-17(18)22)23-20(25)19-13(2)8-9-27-19/h3-10H,11H2,1-2H3,(H,23,25)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159585
PNG
(CHEMBL3785990)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H14ClF3N2O3/c1-11-7-8-30-18(11)19(28)26-12-5-6-17(16(22)9-12)27-10-14-13(20(27)29)3-2-4-15(14)21(23,24)25/h2-9H,10H2,1H3,(H,26,28)
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n/an/an/an/a 1.15E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159587
PNG
(CHEMBL3787140)
Show SMILES COc1cccc2C(=O)N(Cc12)c1ccc(NC(=O)c2occc2C)cc1Cl
Show InChI InChI=1S/C21H17ClN2O4/c1-12-8-9-28-19(12)20(25)23-13-6-7-17(16(22)10-13)24-11-15-14(21(24)26)4-3-5-18(15)27-2/h3-10H,11H2,1-2H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159576
PNG
(CHEMBL3785252)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN2O3/c1-13-9-11-27-19(13)20(25)23-15-6-7-18(17(22)12-15)24-10-8-14-4-2-3-5-16(14)21(24)26/h2-7,9,11-12H,8,10H2,1H3,(H,23,25)
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n/an/an/an/a 781n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159598
PNG
(CHEMBL3786287)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1Cc2ccccc2C1=O
Show InChI InChI=1S/C20H15FN2O3/c1-12-8-9-26-18(12)19(24)22-17-7-6-14(10-16(17)21)23-11-13-4-2-3-5-15(13)20(23)25/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu4 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159580
PNG
(CHEMBL3786400)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-13-5-6-16(15(22)9-13)24-10-12-3-2-4-14(21)17(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 484n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159598
PNG
(CHEMBL3786287)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1Cc2ccccc2C1=O
Show InChI InChI=1S/C20H15FN2O3/c1-12-8-9-26-18(12)19(24)22-17-7-6-14(10-16(17)21)23-11-13-4-2-3-5-15(13)20(23)25/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159590
PNG
(CHEMBL3786738)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3nccnc3C2=O)c(Cl)c1
Show InChI InChI=1S/C18H13ClN4O3/c1-10-4-7-26-16(10)17(24)22-11-2-3-14(12(19)8-11)23-9-13-15(18(23)25)21-6-5-20-13/h2-8H,9H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159592
PNG
(CHEMBL3786494)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1Cc2ccccc2C1=O
Show InChI InChI=1S/C20H16N2O3/c1-13-10-11-25-18(13)19(23)21-15-6-8-16(9-7-15)22-12-14-4-2-3-5-17(14)20(22)24/h2-11H,12H2,1H3,(H,21,23)
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n/an/an/an/a 1.56E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159573
PNG
(CHEMBL3785114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccnc3C2)c(Cl)c1
Show InChI InChI=1S/C19H16ClN3O2/c1-12-6-8-25-18(12)19(24)22-14-4-5-17(15(20)9-14)23-10-13-3-2-7-21-16(13)11-23/h2-9H,10-11H2,1H3,(H,22,24)
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n/an/an/an/a 9.55E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159575
PNG
(CHEMBL3786721)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCOc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C19H16ClN3O3/c1-12-6-9-25-17(12)18(24)22-13-4-5-15(14(20)11-13)23-8-10-26-19-16(23)3-2-7-21-19/h2-7,9,11H,8,10H2,1H3,(H,22,24)
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n/an/an/an/a 2.61E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159687
PNG
(CHEMBL3787159)
Show SMILES Cc1cccnc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15Cl2N3O2/c1-12-4-3-9-24-19(12)20(27)25-14-7-8-17(16(23)10-14)26-11-13-5-2-6-15(22)18(13)21(26)28/h2-10H,11H2,1H3,(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159690
PNG
(CHEMBL3787309)
Show SMILES Clc1cccc2CN(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H12Cl3N3O2/c21-13-4-1-3-11-10-26(20(28)17(11)13)16-7-6-12(9-15(16)23)25-19(27)18-14(22)5-2-8-24-18/h1-9H,10H2,(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159564
PNG
(CHEMBL3787043)
Show SMILES [H][C@@]12CCCC[C@]1([H])C(=O)N(C2=O)c1ccc(NC(=O)c2occc2C)cc1Cl |r|
Show InChI InChI=1S/C20H19ClN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h6-10,13-14H,2-5H2,1H3,(H,22,24)/t13-,14+
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159566
PNG
(CHEMBL3786597)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(NC(=O)c2ccccc2C(O)=O)c(Cl)c1
Show InChI InChI=1S/C20H15ClN2O5/c1-11-8-9-28-17(11)19(25)22-12-6-7-16(15(21)10-12)23-18(24)13-4-2-3-5-14(13)20(26)27/h2-10H,1H3,(H,22,25)(H,23,24)(H,26,27)
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n/an/an/an/a 933n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159569
PNG
(CHEMBL3787619)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H15ClN2O3/c1-12-8-9-26-18(12)19(24)22-14-6-7-17(16(21)10-14)23-11-13-4-2-3-5-15(13)20(23)25/h2-10H,11H2,1H3,(H,22,24)
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n/an/an/an/a 3.72E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159596
PNG
(CHEMBL3787498)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1Cl
Show InChI InChI=1S/C20H13Cl3N2O3/c1-10-7-8-28-18(10)19(26)24-14-5-6-15(17(23)16(14)22)25-9-12-11(20(25)27)3-2-4-13(12)21/h2-8H,9H2,1H3,(H,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159590
PNG
(CHEMBL3786738)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3nccnc3C2=O)c(Cl)c1
Show InChI InChI=1S/C18H13ClN4O3/c1-10-4-7-26-16(10)17(24)22-11-2-3-14(12(19)8-11)23-9-13-15(18(23)25)21-6-5-20-13/h2-8H,9H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159689
PNG
(CHEMBL3785119)
Show SMILES Clc1cccc2C(=O)N(Cc12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H12Cl3N3O2/c21-14-4-1-3-12-13(14)10-26(20(12)28)17-7-6-11(9-16(17)23)25-19(27)18-15(22)5-2-8-24-18/h1-9H,10H2,(H,25,27)
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n/an/an/an/a 1.27E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159586
PNG
(CHEMBL3785392)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3C#N)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H14ClN3O3/c1-12-7-8-28-19(12)20(26)24-14-5-6-18(17(22)9-14)25-11-16-13(10-23)3-2-4-15(16)21(25)27/h2-9H,11H2,1H3,(H,24,26)
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n/an/an/an/a 2.09E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159584
PNG
(CHEMBL3785382)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Br)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14BrClN2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 389n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159565
PNG
(CHEMBL3786488)
Show SMILES [H][C@@]12CCCC[C@@]1([H])C(=O)N(C2=O)c1ccc(NC(=O)c2occc2C)cc1Cl |r|
Show InChI InChI=1S/C20H19ClN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h6-10,13-14H,2-5H2,1H3,(H,22,24)/t13-,14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159599
PNG
(CHEMBL3786552)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1Cc2c(cccc2Cl)C1=O
Show InChI InChI=1S/C20H14ClFN2O3/c1-11-7-8-27-18(11)19(25)23-17-6-5-12(9-16(17)22)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 1.26E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159564
PNG
(CHEMBL3787043)
Show SMILES [H][C@@]12CCCC[C@]1([H])C(=O)N(C2=O)c1ccc(NC(=O)c2occc2C)cc1Cl |r|
Show InChI InChI=1S/C20H19ClN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h6-10,13-14H,2-5H2,1H3,(H,22,24)/t13-,14+
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159599
PNG
(CHEMBL3786552)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1Cc2c(cccc2Cl)C1=O
Show InChI InChI=1S/C20H14ClFN2O3/c1-11-7-8-27-18(11)19(25)23-17-6-5-12(9-16(17)22)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 1.26E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159561
PNG
(CHEMBL3785247)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)Cc3ccccc3CC2=O)c(Cl)c1
Show InChI InChI=1S/C22H17ClN2O4/c1-13-8-9-29-21(13)22(28)24-16-6-7-18(17(23)12-16)25-19(26)10-14-4-2-3-5-15(14)11-20(25)27/h2-9,12H,10-11H2,1H3,(H,24,28)
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n/an/an/an/a 3.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159573
PNG
(CHEMBL3785114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccnc3C2)c(Cl)c1
Show InChI InChI=1S/C19H16ClN3O2/c1-12-6-8-25-18(12)19(24)22-14-4-5-17(15(20)9-14)23-10-13-3-2-7-21-16(13)11-23/h2-9H,10-11H2,1H3,(H,22,24)
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n/an/an/an/a 9.55E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159572
PNG
(CHEMBL3785210)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C20H17ClN2O2/c1-13-9-11-25-19(13)20(24)22-15-6-7-18(16(21)12-15)23-10-8-14-4-2-3-5-17(14)23/h2-7,9,11-12H,8,10H2,1H3,(H,22,24)
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n/an/an/an/a 5.71E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 211n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159589
PNG
(CHEMBL3787366)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccnc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN3O3/c1-11-6-8-26-17(11)18(24)22-13-4-5-15(14(20)9-13)23-10-12-3-2-7-21-16(12)19(23)25/h2-9H,10H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159600
PNG
(CHEMBL3785775)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1Cc2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H14ClFN2O3/c1-11-7-8-27-18(11)19(25)23-16-6-5-13(9-15(16)22)24-10-12-3-2-4-14(21)17(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159653
PNG
(CHEMBL3785387)
Show SMILES Cc1cccnc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15Cl2N3O2/c1-12-4-3-9-24-19(12)20(27)25-13-7-8-18(17(23)10-13)26-11-15-14(21(26)28)5-2-6-16(15)22/h2-10H,11H2,1H3,(H,25,27)
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n/an/an/an/a 1.45E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159689
PNG
(CHEMBL3785119)
Show SMILES Clc1cccc2C(=O)N(Cc12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H12Cl3N3O2/c21-14-4-1-3-12-13(14)10-26(20(12)28)17-7-6-11(9-16(17)23)25-19(27)18-15(22)5-2-8-24-18/h1-9H,10H2,(H,25,27)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128021
PNG
(CHEMBL3628116)
Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
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n/an/an/an/a 390n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159582
PNG
(CHEMBL3786160)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3F)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14ClFN2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(15(21)9-12)24-10-14-13(20(24)26)3-2-4-16(14)22/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 878n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159591
PNG
(CHEMBL3786977)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2(C)C)c(Cl)c1
Show InChI InChI=1S/C22H19ClN2O3/c1-13-10-11-28-19(13)20(26)24-14-8-9-18(17(23)12-14)25-21(27)15-6-4-5-7-16(15)22(25,2)3/h4-12H,1-3H3,(H,24,26)
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n/an/an/an/a 6.93E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159597
PNG
(CHEMBL3787654)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1Cl
Show InChI InChI=1S/C20H13Cl3N2O3/c1-10-7-8-28-18(10)19(26)24-13-5-6-14(17(23)16(13)22)25-9-11-3-2-4-12(21)15(11)20(25)27/h2-8H,9H2,1H3,(H,24,26)
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n/an/an/an/a 6.61E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159580
PNG
(CHEMBL3786400)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-13-5-6-16(15(22)9-13)24-10-12-3-2-4-14(21)17(12)20(24)26/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 490n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159578
PNG
(CHEMBL3785321)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 211n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159688
PNG
(CHEMBL3786967)
Show SMILES Clc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2N3O2/c21-15-6-3-9-23-18(15)19(26)24-13-7-8-17(16(22)10-13)25-11-12-4-1-2-5-14(12)20(25)27/h1-10H,11H2,(H,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159691
PNG
(CHEMBL3786982)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN3O2S/c1-11-17(21-10-26-11)18(24)22-13-6-7-16(15(20)8-13)23-9-12-4-2-3-5-14(12)19(23)25/h2-8,10H,9H2,1H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccc(C)cc2C1=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159601
PNG
(CHEMBL3785372)
Show SMILES Cc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H16ClN3O2/c1-13-5-4-10-23-19(13)20(26)24-15-8-9-18(17(22)11-15)25-12-14-6-2-3-7-16(14)21(25)27/h2-11H,12H2,1H3,(H,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159653
PNG
(CHEMBL3785387)
Show SMILES Cc1cccnc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15Cl2N3O2/c1-12-4-3-9-24-19(12)20(27)25-13-7-8-18(17(23)10-13)26-11-15-14(21(26)28)5-2-6-16(15)22/h2-10H,11H2,1H3,(H,25,27)
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n/an/an/an/a 1.36E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159586
PNG
(CHEMBL3785392)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3C#N)C2=O)c(Cl)c1
Show InChI InChI=1S/C21H14ClN3O3/c1-12-7-8-28-19(12)20(26)24-14-5-6-18(17(22)9-14)25-11-16-13(10-23)3-2-4-15(16)21(25)27/h2-9H,11H2,1H3,(H,24,26)
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n/an/an/an/a 2.14E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159584
PNG
(CHEMBL3785382)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Br)C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14BrClN2O3/c1-11-7-8-27-18(11)19(25)23-12-5-6-17(16(22)9-12)24-10-14-13(20(24)26)3-2-4-15(14)21/h2-9H,10H2,1H3,(H,23,25)
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n/an/an/an/a 391n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159596
PNG
(CHEMBL3787498)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2Cc3c(cccc3Cl)C2=O)c(Cl)c1Cl
Show InChI InChI=1S/C20H13Cl3N2O3/c1-10-7-8-28-18(10)19(26)24-14-5-6-15(17(23)16(14)22)25-9-12-11(20(25)27)3-2-4-13(12)21/h2-8H,9H2,1H3,(H,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50159688
PNG
(CHEMBL3786967)
Show SMILES Clc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2N3O2/c21-15-6-3-9-23-18(15)19(26)24-13-7-8-17(16(22)10-13)25-11-12-4-1-2-5-14(12)20(25)27/h1-10H,11H2,(H,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%