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PubMed code 27007611

Compile data set for download or QSAR
Found 115 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170164
PNG
(IMBUTAMINE | Imbutamine)
Show SMILES NCCCCc1c[nH]cn1
Show InChI InChI=1S/C7H13N3/c8-4-2-1-3-7-5-9-6-10-7/h5-6H,1-4,8H2,(H,9,10)
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4.30n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells incubated for 40 mins


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170164
PNG
(IMBUTAMINE | Imbutamine)
Show SMILES NCCCCc1c[nH]cn1
Show InChI InChI=1S/C7H13N3/c8-4-2-1-3-7-5-9-6-10-7/h5-6H,1-4,8H2,(H,9,10)
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13n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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13n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170165
PNG
(IODOPHENPROPIT | Iodophenpropit)
Show SMILES N\C(SCCCc1cnc[nH]1)=N\CCc1ccc(I)cc1
Show InChI InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20)
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16n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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22n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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69n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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98n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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99n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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120n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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125n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170163
PNG
(CHEMBL321860)
Show SMILES C\N=C(\NC[C@H]1CC[C@@H](O1)c1c[nH]cn1)NC#N
Show InChI InChI=1S/C11H16N6O/c1-13-11(16-6-12)15-4-8-2-3-10(18-8)9-5-14-7-17-9/h5,7-8,10H,2-4H2,1H3,(H,14,17)(H2,13,15,16)/t8-,10-/m1/s1
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125n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid scintillation...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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155n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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178n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 cells co-expressing mammalian Galphai2 and Gbeta1gamma2


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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180n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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240n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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250n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170160
PNG
(CHEMBL3805431)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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290n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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480n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170155
PNG
(CHEMBL3805220)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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590n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170160
PNG
(CHEMBL3805431)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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745n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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830n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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860n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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870n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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870n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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958n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170155
PNG
(CHEMBL3805220)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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1.05E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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1.23E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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1.35E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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2.13E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170163
PNG
(CHEMBL321860)
Show SMILES C\N=C(\NC[C@H]1CC[C@@H](O1)c1c[nH]cn1)NC#N
Show InChI InChI=1S/C11H16N6O/c1-13-11(16-6-12)15-4-8-2-3-10(18-8)9-5-14-7-17-9/h5,7-8,10H,2-4H2,1H3,(H,14,17)(H2,13,15,16)/t8-,10-/m1/s1
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2.20E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cell membrane incubated for 60 mins by liquid...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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3.05E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170154
PNG
(CHEMBL3806162)
Show SMILES CN\C(NC[C@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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3.50E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incuba...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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3.80E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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5.68E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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6.08E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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6.52E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170160
PNG
(CHEMBL3805431)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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6.78E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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7.25E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170160
PNG
(CHEMBL3805431)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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7.36E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170155
PNG
(CHEMBL3805220)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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7.91E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170123
PNG
(CHEMBL3805003)
Show SMILES CC(C)CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N |r|
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13+/s2
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8.35E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170122
PNG
(CHEMBL3806255)
Show SMILES CC(C)CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N |r|
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13-/s2
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8.75E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170125
PNG
(CHEMBL3805663)
Show SMILES N#C\N=C(\NCCCc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C20H26N6/c21-14-25-20(23-10-4-7-16-5-2-1-3-6-16)24-12-17-8-9-18(11-17)19-13-22-15-26-19/h1-3,5-6,13,15,17-18H,4,7-12H2,(H,22,26)(H2,23,24,25)/t17-,18+/s2
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9.35E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170154
PNG
(CHEMBL3806162)
Show SMILES CN\C(NC[C@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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9.50E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbet...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170155
PNG
(CHEMBL3805220)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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9.82E+3n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170151
PNG
(CHEMBL3805264)
Show SMILES N#C\N=C(\NCCNc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H25N7/c20-13-25-19(23-9-8-22-17-4-2-1-3-5-17)24-11-15-6-7-16(10-15)18-12-21-14-26-18/h1-5,12,14-16,22H,6-11H2,(H,21,26)(H2,23,24,25)/t15-,16-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170116
PNG
(CHEMBL3805813)
Show SMILES NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C9H15N3/c10-4-7-1-2-8(3-7)9-5-11-6-12-9/h5-8H,1-4,10H2,(H,11,12)/t7-,8-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170124
PNG
(CHEMBL3806098)
Show SMILES N#C\N=C(\NCCCc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C20H26N6/c21-14-25-20(23-10-4-7-16-5-2-1-3-6-16)24-12-17-8-9-18(11-17)19-13-22-15-26-19/h1-3,5-6,13,15,17-18H,4,7-12H2,(H,22,26)(H2,23,24,25)/t17-,18-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170154
PNG
(CHEMBL3806162)
Show SMILES CN\C(NC[C@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170120
PNG
(CHEMBL3804837)
Show SMILES N#C\N=C(/NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)NC1CC1 |r|
Show InChI InChI=1/C14H20N6/c15-8-18-14(20-12-3-4-12)17-6-10-1-2-11(5-10)13-7-16-9-19-13/h7,9-12H,1-6H2,(H,16,19)(H2,17,18,20)/t10-,11-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170152
PNG
(CHEMBL3805178)
Show SMILES N#C\N=C(\NCCNc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H25N7/c20-13-25-19(23-9-8-22-17-4-2-1-3-5-17)24-11-15-6-7-16(10-15)18-12-21-14-26-18/h1-5,12,14-16,22H,6-11H2,(H,21,26)(H2,23,24,25)/t15-,16+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170117
PNG
(CHEMBL3805995)
Show SMILES NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C9H15N3/c10-4-7-1-2-8(3-7)9-5-11-6-12-9/h5-8H,1-4,10H2,(H,11,12)/t7-,8+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170121
PNG
(CHEMBL3806146)
Show SMILES N#C\N=C(/NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)NC1CC1 |r|
Show InChI InChI=1/C14H20N6/c15-8-18-14(20-12-3-4-12)17-6-10-1-2-11(5-10)13-7-16-9-19-13/h7,9-12H,1-6H2,(H,16,19)(H2,17,18,20)/t10-,11+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170147
PNG
(CHEMBL3804862)
Show SMILES N#C\N=C(\NCCOc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6O/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170150
PNG
(CHEMBL3806015)
Show SMILES N#C\N=C(\NCCOc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6O/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50170154
PNG
(CHEMBL3806162)
Show SMILES CN\C(NC[C@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 incubated for 60 mins by liquid sci...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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1.03E+4n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 60 mins by liquid ...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 63n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170154
PNG
(CHEMBL3806162)
Show SMILES CN\C(NC[C@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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n/an/an/an/a 2.68E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 370n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 14n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 9.20E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170155
PNG
(CHEMBL3805220)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 500n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170163
PNG
(CHEMBL321860)
Show SMILES C\N=C(\NC[C@H]1CC[C@@H](O1)c1c[nH]cn1)NC#N
Show InChI InChI=1S/C11H16N6O/c1-13-11(16-6-12)15-4-8-2-3-10(18-8)9-5-14-7-17-9/h5,7-8,10H,2-4H2,1H3,(H,14,17)(H2,13,15,16)/t8-,10-/m1/s1
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n/an/an/an/a 78n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP production incub...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170117
PNG
(CHEMBL3805995)
Show SMILES NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C9H15N3/c10-4-7-1-2-8(3-7)9-5-11-6-12-9/h5-8H,1-4,10H2,(H,11,12)/t7-,8+/s2
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n/an/an/an/a 150n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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n/an/an/an/a 111n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170120
PNG
(CHEMBL3804837)
Show SMILES N#C\N=C(/NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)NC1CC1 |r|
Show InChI InChI=1/C14H20N6/c15-8-18-14(20-12-3-4-12)17-6-10-1-2-11(5-10)13-7-16-9-19-13/h7,9-12H,1-6H2,(H,16,19)(H2,17,18,20)/t10-,11-/s2
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n/an/an/an/a 230n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50415643
PNG
(CHEMBL1078642 | UR-PI376)
Show SMILES N#CNC(NCCSc1ccccc1)=NCCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C17H22N6S/c18-13-22-17(20-9-5-4-6-15-12-19-14-23-15)21-10-11-24-16-7-2-1-3-8-16/h1-3,7-8,12,14H,4-6,9-11H2,(H,19,23)(H2,20,21,22)
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n/an/an/an/a 720n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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n/an/an/an/a 547n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170120
PNG
(CHEMBL3804837)
Show SMILES N#C\N=C(/NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)NC1CC1 |r|
Show InChI InChI=1/C14H20N6/c15-8-18-14(20-12-3-4-12)17-6-10-1-2-11(5-10)13-7-16-9-19-13/h7,9-12H,1-6H2,(H,16,19)(H2,17,18,20)/t10-,11-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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n/an/an/an/a 212n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 25n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 538n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 3.63E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50415643
PNG
(CHEMBL1078642 | UR-PI376)
Show SMILES N#CNC(NCCSc1ccccc1)=NCCCCc1cnc[nH]1 |w:14.15|
Show InChI InChI=1S/C17H22N6S/c18-13-22-17(20-9-5-4-6-15-12-19-14-23-15)21-10-11-24-16-7-2-1-3-8-16/h1-3,7-8,12,14H,4-6,9-11H2,(H,19,23)(H2,20,21,22)
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n/an/an/an/a 37n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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n/an/an/an/a 129n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170162
PNG
(CHEMBL3805514)
Show SMILES CC(=N)SCCNC(N)=N
Show InChI InChI=1S/C5H12N4S/c1-4(6)10-3-2-9-5(7)8/h6H,2-3H2,1H3,(H4,7,8,9)
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n/an/an/an/a 44n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170123
PNG
(CHEMBL3805003)
Show SMILES CC(C)CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N |r|
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13+/s2
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n/an/an/an/a 858n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 994n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170122
PNG
(CHEMBL3806255)
Show SMILES CC(C)CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N |r|
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13-/s2
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n/an/an/an/a 15n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170124
PNG
(CHEMBL3806098)
Show SMILES N#C\N=C(\NCCCc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C20H26N6/c21-14-25-20(23-10-4-7-16-5-2-1-3-6-16)24-12-17-8-9-18(11-17)19-13-22-15-26-19/h1-3,5-6,13,15,17-18H,4,7-12H2,(H,22,26)(H2,23,24,25)/t17-,18-/s2
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n/an/an/an/a 125n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170119
PNG
(CHEMBL3806206)
Show SMILES CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10+/s2
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n/an/an/an/a 119n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50170155
PNG
(CHEMBL3805220)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 589n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170116
PNG
(CHEMBL3805813)
Show SMILES NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C9H15N3/c10-4-7-1-2-8(3-7)9-5-11-6-12-9/h5-8H,1-4,10H2,(H,11,12)/t7-,8-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 90 mins by [35S]GTPgammaS binding...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170116
PNG
(CHEMBL3805813)
Show SMILES NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C9H15N3/c10-4-7-1-2-8(3-7)9-5-11-6-12-9/h5-8H,1-4,10H2,(H,11,12)/t7-,8-/s2
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n/an/an/an/a 1.71E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170147
PNG
(CHEMBL3804862)
Show SMILES N#C\N=C(\NCCOc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6O/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 524n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 13n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170121
PNG
(CHEMBL3806146)
Show SMILES N#C\N=C(/NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)NC1CC1 |r|
Show InChI InChI=1/C14H20N6/c15-8-18-14(20-12-3-4-12)17-6-10-1-2-11(5-10)13-7-16-9-19-13/h7,9-12H,1-6H2,(H,16,19)(H2,17,18,20)/t10-,11+/s2
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n/an/an/an/a 1.53E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170162
PNG
(CHEMBL3805514)
Show SMILES CC(=N)SCCNC(N)=N
Show InChI InChI=1S/C5H12N4S/c1-4(6)10-3-2-9-5(7)8/h6H,2-3H2,1H3,(H4,7,8,9)
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n/an/an/an/a 170n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 166n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Homo sapiens (Human))
BDBM50170117
PNG
(CHEMBL3805995)
Show SMILES NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C9H15N3/c10-4-7-1-2-8(3-7)9-5-11-6-12-9/h5-8H,1-4,10H2,(H,11,12)/t7-,8+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H2 receptor expressed in sf9 cell membrane co-expressing Gsalphas incubated for 90 mins by [35S]GTPgammaS binding...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170161
PNG
(CHEMBL3805392)
Show SMILES N#C\N=C(\NCCSc1ccccc1)N[C@H]1CC[C@H](CC1)c1c[nH]cn1 |r,wD:15.15,18.22,(-1.6,2.16,;-2.67,1.55,;-4,.78,;-4,-.77,;-5.34,-1.53,;-6.67,-.76,;-8.01,-1.53,;-9.34,-.76,;-10.68,-1.52,;-12.01,-.75,;-13.35,-1.52,;-13.35,-3.06,;-12.01,-3.83,;-10.68,-3.06,;-2.67,-1.54,;-1.33,-.77,;,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;2.67,1.54,;4.05,.9,;5.09,2.04,;4.32,3.38,;2.81,3.06,)|
Show InChI InChI=1/C19H24N6S/c20-13-23-19(22-10-11-26-17-4-2-1-3-5-17)25-16-8-6-15(7-9-16)18-12-21-14-24-18/h1-5,12,14-16H,6-11H2,(H,21,24)(H2,22,23,25)/t15-,16+
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n/an/an/an/a 110n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170153
PNG
(CHEMBL3805437)
Show SMILES CN\C(NC[C@@H]1CC[C@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170160
PNG
(CHEMBL3805431)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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n/an/an/an/a 549n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170127
PNG
(CHEMBL3806079)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16+/s2
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n/an/an/an/a 293n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50170122
PNG
(CHEMBL3806255)
Show SMILES CC(C)CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N |r|
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13-/s2
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n/an/an/an/a 578n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 Receptor


(Mus musculus (mouse))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 94n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 206n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170121
PNG
(CHEMBL3806146)
Show SMILES N#C\N=C(/NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)NC1CC1 |r|
Show InChI InChI=1/C14H20N6/c15-8-18-14(20-12-3-4-12)17-6-10-1-2-11(5-10)13-7-16-9-19-13/h7,9-12H,1-6H2,(H,16,19)(H2,17,18,20)/t10-,11+/s2
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n/an/an/an/a 245n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170125
PNG
(CHEMBL3805663)
Show SMILES N#C\N=C(\NCCCc1ccccc1)NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C20H26N6/c21-14-25-20(23-10-4-7-16-5-2-1-3-6-16)24-12-17-8-9-18(11-17)19-13-22-15-26-19/h1-3,5-6,13,15,17-18H,4,7-12H2,(H,22,26)(H2,23,24,25)/t17-,18+/s2
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n/an/an/an/a 372n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170118
PNG
(CHEMBL3804906)
Show SMILES CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r|
Show InChI InChI=1/C12H18N6/c1-14-12(17-7-13)16-5-9-2-3-10(4-9)11-6-15-8-18-11/h6,8-10H,2-5H2,1H3,(H,15,18)(H2,14,16,17)/t9-,10-/s2
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n/an/an/an/a 100n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1 |r|
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 11n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22880
PNG
(2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine | 4-Met...)
Show SMILES Cc1nc[nH]c1CCN
Show InChI InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
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n/an/an/an/a 1.24E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 190n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubate...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 13n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 11n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50170123
PNG
(CHEMBL3805003)
Show SMILES CC(C)CN\C(NC[C@@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N |r|
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13+/s2
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n/an/an/an/a 202n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


J Med Chem 59: 3452-70 (2016)


BindingDB Entry DOI: 10.7270/Q23T9K42
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%