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PubMed code 27077705

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50173334
PNG
(CHEMBL3809935)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1OC1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C26H24F3N3O3/c1-17-5-6-21(31-24(33)19-3-2-4-20(15-19)26(27,28)29)16-23(17)35-22-9-13-32(14-10-22)25(34)18-7-11-30-12-8-18/h2-8,11-12,15-16,22H,9-10,13-14H2,1H3,(H,31,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 99n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human recombinant cKIT expressed in baculovirus using Tyr 06 peptide as substrate after 1 hr by Z-lyte assay


J Med Chem 59: 3964-79 (2016)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50173334
PNG
(CHEMBL3809935)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1OC1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C26H24F3N3O3/c1-17-5-6-21(31-24(33)19-3-2-4-20(15-19)26(27,28)29)16-23(17)35-22-9-13-32(14-10-22)25(34)18-7-11-30-12-8-18/h2-8,11-12,15-16,22H,9-10,13-14H2,1H3,(H,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 120n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human PDGFRbeta (amino acids 557-end) expressed in baculovirus infected insect Sf9 cells using Poly(4...


J Med Chem 59: 3964-79 (2016)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM50173334
PNG
(CHEMBL3809935)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1OC1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C26H24F3N3O3/c1-17-5-6-21(31-24(33)19-3-2-4-20(15-19)26(27,28)29)16-23(17)35-22-9-13-32(14-10-22)25(34)18-7-11-30-12-8-18/h2-8,11-12,15-16,22H,9-10,13-14H2,1H3,(H,31,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 126n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human DDR1 expressed in baculovirus after 1 hr by Z-lyte assay


J Med Chem 59: 3964-79 (2016)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50173334
PNG
(CHEMBL3809935)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1OC1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C26H24F3N3O3/c1-17-5-6-21(31-24(33)19-3-2-4-20(15-19)26(27,28)29)16-23(17)35-22-9-13-32(14-10-22)25(34)18-7-11-30-12-8-18/h2-8,11-12,15-16,22H,9-10,13-14H2,1H3,(H,31,33)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 133n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of His-tagged recombinant human CSF1R expressed in baculovirus expression system after 1 hr by Z-lyte assay


J Med Chem 59: 3964-79 (2016)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%