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PubMed code 27096050

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174162
PNG
(CHEMBL3808669)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r|
Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174153
PNG
(CHEMBL3808887)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)\C=C\C2)nc13 |r,t:25|
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3+/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174168
PNG
(CHEMBL3810121)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C/C2)nc13 |r,c:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m0/s1
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n/an/a 0.0600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174162
PNG
(CHEMBL3808669)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r|
Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m0/s1
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n/an/a 0.0700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174168
PNG
(CHEMBL3810121)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C/C2)nc13 |r,c:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174149
PNG
(CHEMBL3808662)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C(C)=C\C2)nc13 |r,t:25|
Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6+/t13-/m0/s1
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n/an/a 0.0800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174133
PNG
(CHEMBL3810095)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)CCC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h4,7-9,11,13,25H,3,5-6,10H2,1-2H3,(H,22,27)(H,23,26)/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174149
PNG
(CHEMBL3808662)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C(C)=C\C2)nc13 |r,t:25|
Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6+/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174157
PNG
(CHEMBL3808942)
Show SMILES [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r|
Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174140
PNG
(CHEMBL3809940)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C(C)=C/C2)nc13 |r,c:25|
Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6-/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174133
PNG
(CHEMBL3810095)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)CCC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h4,7-9,11,13,25H,3,5-6,10H2,1-2H3,(H,22,27)(H,23,26)/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174146
PNG
(CHEMBL3809691)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)\C=C/C2)nc13 |r,c:25|
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3-/t11-,13+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174153
PNG
(CHEMBL3808887)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)\C=C\C2)nc13 |r,t:25|
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3+/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174150
PNG
(CHEMBL3809986)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@@H](C)\C=C\C2)nc13 |r,t:25|
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3+/t11-,13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174113
PNG
(CHEMBL3809565)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC[C@@H](C)CC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-5,8,11,13,25H,6-7,9-10H2,1-2H3,(H,22,26)(H,23,27)/t11-,13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174113
PNG
(CHEMBL3809565)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC[C@@H](C)CC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-5,8,11,13,25H,6-7,9-10H2,1-2H3,(H,22,26)(H,23,27)/t11-,13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174112
PNG
(CHEMBL3809377)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC[C@H](C)CC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-5,8,11,13,25H,6-7,9-10H2,1-2H3,(H,22,26)(H,23,27)/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174140
PNG
(CHEMBL3809940)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C(C)=C/C2)nc13 |r,c:25|
Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6-/t13-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174132
PNG
(CHEMBL3809127)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@@H](C)CCC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h4,7-9,11,13,25H,3,5-6,10H2,1-2H3,(H,22,27)(H,23,26)/t11-,13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174157
PNG
(CHEMBL3808942)
Show SMILES [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r|
Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174146
PNG
(CHEMBL3809691)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)\C=C/C2)nc13 |r,c:25|
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3-/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174112
PNG
(CHEMBL3809377)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC[C@H](C)CC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-5,8,11,13,25H,6-7,9-10H2,1-2H3,(H,22,26)(H,23,27)/t11-,13+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174171
PNG
(CHEMBL3809463)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C\C2)nc13 |r,t:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2+/t12-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174150
PNG
(CHEMBL3809986)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@@H](C)\C=C\C2)nc13 |r,t:25|
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3+/t11-,13-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174169
PNG
(CHEMBL3809044)
Show SMILES [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C\C2)nc13 |r,t:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2+/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174171
PNG
(CHEMBL3809463)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C\C2)nc13 |r,t:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2+/t12-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174169
PNG
(CHEMBL3809044)
Show SMILES [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C\C2)nc13 |r,t:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2+/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50174167
PNG
(CHEMBL3808445)
Show SMILES [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C/C2)nc13 |r,c:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174132
PNG
(CHEMBL3809127)
Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@@H](C)CCC2)nc13 |r|
Show InChI InChI=1S/C21H23N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h4,7-9,11,13,25H,3,5-6,10H2,1-2H3,(H,22,27)(H,23,26)/t11-,13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM238545
PNG
(US9394297, 191)
Show SMILES CCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C19H21N5O/c1-3-8-20-18-11(2)22-15-6-4-5-12(17(15)24-18)16-10-13-14(23-16)7-9-21-19(13)25/h4-6,10,23H,3,7-9H2,1-2H3,(H,20,24)(H,21,25)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM238525
PNG
(US9394297, 159)
Show SMILES CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C20H23N5O/c1-3-4-9-21-19-12(2)23-16-7-5-6-13(18(16)25-19)17-11-14-15(24-17)8-10-22-20(14)26/h5-7,11,24H,3-4,8-10H2,1-2H3,(H,21,25)(H,22,26)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50174167
PNG
(CHEMBL3808445)
Show SMILES [H][C@@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C/C2)nc13 |r,c:24|
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM238539
PNG
(US9394297, 183)
Show SMILES Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1Nc1ccccc1
Show InChI InChI=1S/C22H19N5O/c1-13-21(25-14-6-3-2-4-7-14)27-20-15(8-5-9-18(20)24-13)19-12-16-17(26-19)10-11-23-22(16)28/h2-9,12,26H,10-11H2,1H3,(H,23,28)(H,25,27)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM238525
PNG
(US9394297, 159)
Show SMILES CCCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C20H23N5O/c1-3-4-9-21-19-12(2)23-16-7-5-6-13(18(16)25-19)17-11-14-15(24-17)8-10-22-20(14)26/h5-7,11,24H,3-4,8-10H2,1-2H3,(H,21,25)(H,22,26)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM238539
PNG
(US9394297, 183)
Show SMILES Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1Nc1ccccc1
Show InChI InChI=1S/C22H19N5O/c1-13-21(25-14-6-3-2-4-7-14)27-20-15(8-5-9-18(20)24-13)19-12-16-17(26-19)10-11-23-22(16)28/h2-9,12,26H,10-11H2,1H3,(H,23,28)(H,25,27)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM238545
PNG
(US9394297, 191)
Show SMILES CCCNc1nc2c(cccc2nc1C)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C19H21N5O/c1-3-8-20-18-11(2)22-15-6-4-5-12(17(15)24-18)16-10-13-14(23-16)7-9-21-19(13)25/h4-6,10,23H,3,7-9H2,1-2H3,(H,20,24)(H,21,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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UniChem
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PubMed
n/an/a 5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo...

ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%