Found 67 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167428
(CHEMBL3797264)Show SMILES COc1cccc(Oc2cccc(N3CCCCC3)c2CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1 |r| Show InChI InChI=1S/C30H35N5O5/c1-39-22-7-5-8-23(18-22)40-27-10-6-9-26(35-15-3-2-4-16-35)24(27)19-33-30(32)34-28(36)21-13-11-20(12-14-21)17-25(31)29(37)38/h5-14,18,25H,2-4,15-17,19,31H2,1H3,(H,37,38)(H3,32,33,34,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167427
(CHEMBL3800397)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2cccc(Cl)c2)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C29H32ClN5O4/c30-21-6-4-7-22(17-21)39-26-9-5-8-25(35-14-2-1-3-15-35)23(26)18-33-29(32)34-27(36)20-12-10-19(11-13-20)16-24(31)28(37)38/h4-13,17,24H,1-3,14-16,18,31H2,(H,37,38)(H3,32,33,34,36)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167429
(CHEMBL3799301)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2ccc(cc2)C(F)(F)F)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C30H32F3N5O4/c31-30(32,33)21-11-13-22(14-12-21)42-26-6-4-5-25(38-15-2-1-3-16-38)23(26)18-36-29(35)37-27(39)20-9-7-19(8-10-20)17-24(34)28(40)41/h4-14,24H,1-3,15-18,34H2,(H,40,41)(H3,35,36,37,39)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167538
(CHEMBL3799331)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1cc(ccc1N1CCCCC1)-c1nccs1)C(O)=O |r| Show InChI InChI=1S/C26H30N6O3S/c27-21(25(34)35)14-17-4-6-18(7-5-17)23(33)31-26(28)30-16-20-15-19(24-29-10-13-36-24)8-9-22(20)32-11-2-1-3-12-32/h4-10,13,15,21H,1-3,11-12,14,16,27H2,(H,34,35)(H3,28,30,31,33)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167426
(CHEMBL3798045)Show SMILES Cc1cccc(Oc2cccc(N3CCCCC3)c2CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1 |r| Show InChI InChI=1S/C30H35N5O4/c1-20-7-5-8-23(17-20)39-27-10-6-9-26(35-15-3-2-4-16-35)24(27)19-33-30(32)34-28(36)22-13-11-21(12-14-22)18-25(31)29(37)38/h5-14,17,25H,2-4,15-16,18-19,31H2,1H3,(H,37,38)(H3,32,33,34,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167424
(CHEMBL3799287)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2ccccc2C(F)(F)F)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C30H32F3N5O4/c31-30(32,33)22-7-2-3-9-26(22)42-25-10-6-8-24(38-15-4-1-5-16-38)21(25)18-36-29(35)37-27(39)20-13-11-19(12-14-20)17-23(34)28(40)41/h2-3,6-14,23H,1,4-5,15-18,34H2,(H,40,41)(H3,35,36,37,39)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167425
(CHEMBL3799810)Show SMILES COc1ccccc1Oc1cccc(N2CCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C30H35N5O5/c1-39-26-9-3-4-10-27(26)40-25-11-7-8-24(35-16-5-2-6-17-35)22(25)19-33-30(32)34-28(36)21-14-12-20(13-15-21)18-23(31)29(37)38/h3-4,7-15,23H,2,5-6,16-19,31H2,1H3,(H,37,38)(H3,32,33,34,36)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167399
(CHEMBL3800151)Show SMILES Cc1ccccc1Oc1cccc(N2CCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C30H35N5O4/c1-20-8-3-4-10-26(20)39-27-11-7-9-25(35-16-5-2-6-17-35)23(27)19-33-30(32)34-28(36)22-14-12-21(13-15-22)18-24(31)29(37)38/h3-4,7-15,24H,2,5-6,16-19,31H2,1H3,(H,37,38)(H3,32,33,34,36)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167398
(CHEMBL3798880)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2ccc(Cl)cc2)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C29H32ClN5O4/c30-21-11-13-22(14-12-21)39-26-6-4-5-25(35-15-2-1-3-16-35)23(26)18-33-29(32)34-27(36)20-9-7-19(8-10-20)17-24(31)28(37)38/h4-14,24H,1-3,15-18,31H2,(H,37,38)(H3,32,33,34,36)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167537
(CHEMBL3799498)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(cccc1C(F)(F)F)N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C24H28F3N5O3/c25-24(26,27)18-5-4-6-20(32-11-2-1-3-12-32)17(18)14-30-23(29)31-21(33)16-9-7-15(8-10-16)13-19(28)22(34)35/h4-10,19H,1-3,11-14,28H2,(H,34,35)(H3,29,30,31,33)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167820
(CHEMBL3797282)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CC2CCC1C2)C(O)=O |r| Show InChI InChI=1S/C24H29N5O3/c25-20(23(31)32)12-15-5-8-17(9-6-15)22(30)28-24(26)27-13-18-3-1-2-4-21(18)29-14-16-7-10-19(29)11-16/h1-6,8-9,16,19-20H,7,10-14,25H2,(H,31,32)(H3,26,27,28,30)/t16?,19?,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167536
(CHEMBL3799767)Show SMILES Cc1cccc(N2CCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-6-5-7-21(29-12-3-2-4-13-29)19(16)15-27-24(26)28-22(30)18-10-8-17(9-11-18)14-20(25)23(31)32/h5-11,20H,2-4,12-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167757
(CHEMBL3797766)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2ccccc2)cccc1N1CCCCCC1)C(O)=O |r| Show InChI InChI=1S/C30H35N5O4/c31-25(29(37)38)19-21-13-15-22(16-14-21)28(36)34-30(32)33-20-24-26(35-17-6-1-2-7-18-35)11-8-12-27(24)39-23-9-4-3-5-10-23/h3-5,8-16,25H,1-2,6-7,17-20,31H2,(H,37,38)(H3,32,33,34,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167397
(CHEMBL3799918)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2cccc(c2)C(F)(F)F)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C30H32F3N5O4/c31-30(32,33)21-6-4-7-22(17-21)42-26-9-5-8-25(38-14-2-1-3-15-38)23(26)18-36-29(35)37-27(39)20-12-10-19(11-13-20)16-24(34)28(40)41/h4-13,17,24H,1-3,14-16,18,34H2,(H,40,41)(H3,35,36,37,39)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167509
(CHEMBL3797417)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1cc(ccc1N1CCCCC1)-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C29H33N5O3/c30-25(28(36)37)17-20-9-11-22(12-10-20)27(35)33-29(31)32-19-24-18-23(21-7-3-1-4-8-21)13-14-26(24)34-15-5-2-6-16-34/h1,3-4,7-14,18,25H,2,5-6,15-17,19,30H2,(H,36,37)(H3,31,32,33,35)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167396
(CHEMBL3799711)Show SMILES Cc1ccc(Oc2cccc(N3CCCCC3)c2CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)cc1 |r| Show InChI InChI=1S/C30H35N5O4/c1-20-8-14-23(15-9-20)39-27-7-5-6-26(35-16-3-2-4-17-35)24(27)19-33-30(32)34-28(36)22-12-10-21(11-13-22)18-25(31)29(37)38/h5-15,25H,2-4,16-19,31H2,1H3,(H,37,38)(H3,32,33,34,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167821
(CHEMBL3797220)Show SMILES CC1CCCCN1c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-6-4-5-13-29(16)21-8-3-2-7-19(21)15-27-24(26)28-22(30)18-11-9-17(10-12-18)14-20(25)23(31)32/h2-3,7-12,16,20H,4-6,13-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t16?,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167395
(CHEMBL3799737)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2ccccc2Cl)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C29H32ClN5O4/c30-22-7-2-3-9-26(22)39-25-10-6-8-24(35-15-4-1-5-16-35)21(25)18-33-29(32)34-27(36)20-13-11-19(12-14-20)17-23(31)28(37)38/h2-3,6-14,23H,1,4-5,15-18,31H2,(H,37,38)(H3,32,33,34,36)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167508
(CHEMBL3797520)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1cc(Cl)ccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C23H28ClN5O3/c24-18-8-9-20(29-10-2-1-3-11-29)17(13-18)14-27-23(26)28-21(30)16-6-4-15(5-7-16)12-19(25)22(31)32/h4-9,13,19H,1-3,10-12,14,25H2,(H,31,32)(H3,26,27,28,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50145648
(LP-778902 | LX1032 | LX1606 | Telotristat | Xermel...)Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)-c1ccc(C[C@H](N)C(O)=O)cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H22ClF3N6O3/c1-13-8-9-35(34-13)20-11-16(26)6-7-17(20)22(25(27,28)29)38-21-12-19(32-24(31)33-21)15-4-2-14(3-5-15)10-18(30)23(36)37/h2-9,11-12,18,22H,10,30H2,1H3,(H,36,37)(H2,31,32,33)/t18-,22+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167826
(CHEMBL3798995)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCCCCC1)C(O)=O |r| Show InChI InChI=1S/C24H31N5O3/c25-20(23(31)32)15-17-9-11-18(12-10-17)22(30)28-24(26)27-16-19-7-3-4-8-21(19)29-13-5-1-2-6-14-29/h3-4,7-12,20H,1-2,5-6,13-16,25H2,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167394
(CHEMBL3798405)Show SMILES COc1ccc(Oc2cccc(N3CCCCC3)c2CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)cc1 |r| Show InChI InChI=1S/C30H35N5O5/c1-39-22-12-14-23(15-13-22)40-27-7-5-6-26(35-16-3-2-4-17-35)24(27)19-33-30(32)34-28(36)21-10-8-20(9-11-21)18-25(31)29(37)38/h5-15,25H,2-4,16-19,31H2,1H3,(H,37,38)(H3,32,33,34,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167507
(CHEMBL3799404)Show SMILES COc1cccc(N2CCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C24H31N5O4/c1-33-21-7-5-6-20(29-12-3-2-4-13-29)18(21)15-27-24(26)28-22(30)17-10-8-16(9-11-17)14-19(25)23(31)32/h5-11,19H,2-4,12-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167801
(CHEMBL3799259)Show SMILES Cc1cccc(N2CCCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C25H33N5O3/c1-17-7-6-8-22(30-13-4-2-3-5-14-30)20(17)16-28-25(27)29-23(31)19-11-9-18(10-12-19)15-21(26)24(32)33/h6-12,21H,2-5,13-16,26H2,1H3,(H,32,33)(H3,27,28,29,31)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167547
(CHEMBL3800237)Show SMILES CC1CCCN(C1)c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-5-4-12-29(15-16)21-7-3-2-6-19(21)14-27-24(26)28-22(30)18-10-8-17(9-11-18)13-20(25)23(31)32/h2-3,6-11,16,20H,4-5,12-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t16?,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167822
(CHEMBL3800114)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C23H29N5O3/c24-19(22(30)31)14-16-8-10-17(11-9-16)21(29)27-23(25)26-15-18-6-2-3-7-20(18)28-12-4-1-5-13-28/h2-3,6-11,19H,1,4-5,12-15,24H2,(H,30,31)(H3,25,26,27,29)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167506
(CHEMBL3799132)Show SMILES COc1ccc(N2CCCCC2)c(CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1 |r| Show InChI InChI=1S/C24H31N5O4/c1-33-19-9-10-21(29-11-3-2-4-12-29)18(14-19)15-27-24(26)28-22(30)17-7-5-16(6-8-17)13-20(25)23(31)32/h5-10,14,20H,2-4,11-13,15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167505
(CHEMBL3799920)Show SMILES Cc1ccc(N2CCCCC2)c(CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-5-10-21(29-11-3-2-4-12-29)19(13-16)15-27-24(26)28-22(30)18-8-6-17(7-9-18)14-20(25)23(31)32/h5-10,13,20H,2-4,11-12,14-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167546
(CHEMBL3798902)Show SMILES CC1CC(C)CN(C1)c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C25H33N5O3/c1-16-11-17(2)15-30(14-16)22-6-4-3-5-20(22)13-28-25(27)29-23(31)19-9-7-18(8-10-19)12-21(26)24(32)33/h3-10,16-17,21H,11-15,26H2,1-2H3,(H,32,33)(H3,27,28,29,31)/t16?,17?,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167393
(CHEMBL3799306)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2ccccc2)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C29H33N5O4/c30-24(28(36)37)18-20-12-14-21(15-13-20)27(35)33-29(31)32-19-23-25(34-16-5-2-6-17-34)10-7-11-26(23)38-22-8-3-1-4-9-22/h1,3-4,7-15,24H,2,5-6,16-19,30H2,(H,36,37)(H3,31,32,33,35)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167392
(CHEMBL3798665)Show SMILES CC(C)Oc1cccc(N2CCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C26H35N5O4/c1-17(2)35-23-8-6-7-22(31-13-4-3-5-14-31)20(23)16-29-26(28)30-24(32)19-11-9-18(10-12-19)15-21(27)25(33)34/h6-12,17,21H,3-5,13-16,27H2,1-2H3,(H,33,34)(H3,28,29,30,32)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167391
(CHEMBL3799607)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(OC2CCCCC2)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C29H39N5O4/c30-24(28(36)37)18-20-12-14-21(15-13-20)27(35)33-29(31)32-19-23-25(34-16-5-2-6-17-34)10-7-11-26(23)38-22-8-3-1-4-9-22/h7,10-15,22,24H,1-6,8-9,16-19,30H2,(H,36,37)(H3,31,32,33,35)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167823
(CHEMBL3798411)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCCC1)C(O)=O |r| Show InChI InChI=1S/C22H27N5O3/c23-18(21(29)30)13-15-7-9-16(10-8-15)20(28)26-22(24)25-14-17-5-1-2-6-19(17)27-11-3-4-12-27/h1-2,5-10,18H,3-4,11-14,23H2,(H,29,30)(H3,24,25,26,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167545
(CHEMBL3800634)Show SMILES COC1CCN(CC1)c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C24H31N5O4/c1-33-19-10-12-29(13-11-19)21-5-3-2-4-18(21)15-27-24(26)28-22(30)17-8-6-16(7-9-17)14-20(25)23(31)32/h2-9,19-20H,10-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167504
(CHEMBL3798319)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Cl)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C23H28ClN5O3/c24-18-5-4-6-20(29-11-2-1-3-12-29)17(18)14-27-23(26)28-21(30)16-9-7-15(8-10-16)13-19(25)22(31)32/h4-10,19H,1-3,11-14,25H2,(H,31,32)(H3,26,27,28,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167503
(CHEMBL3799154)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(cccc1-c1ccccc1)N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C29H33N5O3/c30-25(28(36)37)18-20-12-14-22(15-13-20)27(35)33-29(31)32-19-24-23(21-8-3-1-4-9-21)10-7-11-26(24)34-16-5-2-6-17-34/h1,3-4,7-15,25H,2,5-6,16-19,30H2,(H,36,37)(H3,31,32,33,35)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167502
(CHEMBL3797373)Show SMILES COc1cccc(CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1N1CCCCC1 |r| Show InChI InChI=1S/C24H31N5O4/c1-33-20-7-5-6-18(21(20)29-12-3-2-4-13-29)15-27-24(26)28-22(30)17-10-8-16(9-11-17)14-19(25)23(31)32/h5-11,19H,2-4,12-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167544
(CHEMBL3800064)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCC(Cc2ccccc2)CC1)C(O)=O |r| Show InChI InChI=1S/C30H35N5O3/c31-26(29(37)38)19-22-10-12-24(13-11-22)28(36)34-30(32)33-20-25-8-4-5-9-27(25)35-16-14-23(15-17-35)18-21-6-2-1-3-7-21/h1-13,23,26H,14-20,31H2,(H,37,38)(H3,32,33,34,36)/t26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167827
(CHEMBL3797788)Show SMILES CCOc1cccc(N2CCCCC2)c1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C25H33N5O4/c1-2-34-22-8-6-7-21(30-13-4-3-5-14-30)19(22)16-28-25(27)29-23(31)18-11-9-17(10-12-18)15-20(26)24(32)33/h6-12,20H,2-5,13-16,26H2,1H3,(H,32,33)(H3,27,28,29,31)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167543
(CHEMBL3800552)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CC2CC2C1)C(O)=O |r| Show InChI InChI=1S/C23H27N5O3/c24-19(22(30)31)9-14-5-7-15(8-6-14)21(29)27-23(25)26-11-16-3-1-2-4-20(16)28-12-17-10-18(17)13-28/h1-8,17-19H,9-13,24H2,(H,30,31)(H3,25,26,27,29)/t17?,18?,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167470
(CHEMBL3798304)Show SMILES Cc1cccc(CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1N1CCCCC1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-6-5-7-19(21(16)29-12-3-2-4-13-29)15-27-24(26)28-22(30)18-10-8-17(9-11-18)14-20(25)23(31)32/h5-11,20H,2-4,12-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167701
(CHEMBL3799421)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(OC2CCC2)cccc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C27H35N5O4/c28-22(26(34)35)16-18-10-12-19(13-11-18)25(33)31-27(29)30-17-21-23(32-14-2-1-3-15-32)8-5-9-24(21)36-20-6-4-7-20/h5,8-13,20,22H,1-4,6-7,14-17,28H2,(H,34,35)(H3,29,30,31,33)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167542
(CHEMBL3800563)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCC(CC1)c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C29H33N5O3/c30-25(28(36)37)18-20-10-12-23(13-11-20)27(35)33-29(31)32-19-24-8-4-5-9-26(24)34-16-14-22(15-17-34)21-6-2-1-3-7-21/h1-13,22,25H,14-19,30H2,(H,36,37)(H3,31,32,33,35)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167541
(CHEMBL3798838)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCSCC1)C(O)=O |r| Show InChI InChI=1S/C22H27N5O3S/c23-18(21(29)30)13-15-5-7-16(8-6-15)20(28)26-22(24)25-14-17-3-1-2-4-19(17)27-9-11-31-12-10-27/h1-8,18H,9-14,23H2,(H,29,30)(H3,24,25,26,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167458
(CHEMBL3799910)Show SMILES COc1ccc(CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c(c1)N1CCCCC1 |r| Show InChI InChI=1S/C24H31N5O4/c1-33-19-10-9-18(21(14-19)29-11-3-2-4-12-29)15-27-24(26)28-22(30)17-7-5-16(6-8-17)13-20(25)23(31)32/h5-10,14,20H,2-4,11-13,15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167385
(CHEMBL3797985)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCCc1ccccc1-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C25H26N4O3/c26-22(24(31)32)16-17-10-12-20(13-11-17)23(30)29-25(27)28-15-14-19-8-4-5-9-21(19)18-6-2-1-3-7-18/h1-13,22H,14-16,26H2,(H,31,32)(H3,27,28,29,30)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167432
(CHEMBL3797505)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1cccc(Cl)c1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C23H28ClN5O3/c24-18-6-4-5-17(20(18)29-11-2-1-3-12-29)14-27-23(26)28-21(30)16-9-7-15(8-10-16)13-19(25)22(31)32/h4-10,19H,1-3,11-14,25H2,(H,31,32)(H3,26,27,28,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167431
(CHEMBL3797367)Show SMILES Cc1ccc(CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c(c1)N1CCCCC1 |r| Show InChI InChI=1S/C24H31N5O3/c1-16-5-8-19(21(13-16)29-11-3-2-4-12-29)15-27-24(26)28-22(30)18-9-6-17(7-10-18)14-20(25)23(31)32/h5-10,13,20H,2-4,11-12,14-15,25H2,1H3,(H,31,32)(H3,26,27,28,30)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167430
(CHEMBL3799871)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccc(Cl)cc1N1CCCCC1)C(O)=O |r| Show InChI InChI=1S/C23H28ClN5O3/c24-18-9-8-17(20(13-18)29-10-2-1-3-11-29)14-27-23(26)28-21(30)16-6-4-15(5-7-16)12-19(25)22(31)32/h4-9,13,19H,1-3,10-12,14,25H2,(H,31,32)(H3,26,27,28,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167824
(CHEMBL3799590)Show SMILES CCN(CC)c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C22H29N5O3/c1-3-27(4-2)19-8-6-5-7-17(19)14-25-22(24)26-20(28)16-11-9-15(10-12-16)13-18(23)21(29)30/h5-12,18H,3-4,13-14,23H2,1-2H3,(H,29,30)(H3,24,25,26,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167539
(CHEMBL3798002)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCOCC1)C(O)=O |r| Show InChI InChI=1S/C22H27N5O4/c23-18(21(29)30)13-15-5-7-16(8-6-15)20(28)26-22(24)25-14-17-3-1-2-4-19(17)27-9-11-31-12-10-27/h1-8,18H,9-14,23H2,(H,29,30)(H3,24,25,26,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167540
(CHEMBL3799789)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCC(O)CC1)C(O)=O |r| Show InChI InChI=1S/C23H29N5O4/c24-19(22(31)32)13-15-5-7-16(8-6-15)21(30)27-23(25)26-14-17-3-1-2-4-20(17)28-11-9-18(29)10-12-28/h1-8,18-19,29H,9-14,24H2,(H,31,32)(H3,25,26,27,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167825
(CHEMBL3798356)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1N1CCC1)C(O)=O |r| Show InChI InChI=1S/C21H25N5O3/c22-17(20(28)29)12-14-6-8-15(9-7-14)19(27)25-21(23)24-13-16-4-1-2-5-18(16)26-10-3-11-26/h1-2,4-9,17H,3,10-13,22H2,(H,28,29)(H3,23,24,25,27)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167388
(CHEMBL3798415)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C24H24N4O3/c25-21(23(30)31)14-16-10-12-18(13-11-16)22(29)28-24(26)27-15-19-8-4-5-9-20(19)17-6-2-1-3-7-17/h1-13,21H,14-15,25H2,(H,30,31)(H3,26,27,28,29)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167380
(CHEMBL3798951)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1-n1nccn1)C(O)=O |r| Show InChI InChI=1S/C20H21N7O3/c21-16(19(29)30)11-13-5-7-14(8-6-13)18(28)26-20(22)23-12-15-3-1-2-4-17(15)27-24-9-10-25-27/h1-10,16H,11-12,21H2,(H,29,30)(H3,22,23,26,28)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 335 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167387
(CHEMBL3798788)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1cccc(c1)-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C24H24N4O3/c25-21(23(30)31)14-16-9-11-19(12-10-16)22(29)28-24(26)27-15-17-5-4-8-20(13-17)18-6-2-1-3-7-18/h1-13,21H,14-15,25H2,(H,30,31)(H3,26,27,28,29)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 405 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167379
(CHEMBL3797650)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1-n1cccn1)C(O)=O |r| Show InChI InChI=1S/C21H22N6O3/c22-17(20(29)30)12-14-6-8-15(9-7-14)19(28)26-21(23)24-13-16-4-1-2-5-18(16)27-11-3-10-25-27/h1-11,17H,12-13,22H2,(H,29,30)(H3,23,24,26,28)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167384
(CHEMBL3798821)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCCCc1ccccc1-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C26H28N4O3/c27-23(25(32)33)17-18-12-14-21(15-13-18)24(31)30-26(28)29-16-6-10-20-9-4-5-11-22(20)19-7-2-1-3-8-19/h1-5,7-9,11-15,23H,6,10,16-17,27H2,(H,32,33)(H3,28,29,30,31)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 599 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167378
(CHEMBL3800567)Show SMILES Cc1ccn(n1)-c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C22H24N6O3/c1-14-10-11-28(27-14)19-5-3-2-4-17(19)13-25-22(24)26-20(29)16-8-6-15(7-9-16)12-18(23)21(30)31/h2-11,18H,12-13,23H2,1H3,(H,30,31)(H3,24,25,26,29)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 666 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167383
(CHEMBL3800600)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)Nc1ccccc1-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C23H22N4O3/c24-19(22(29)30)14-15-10-12-17(13-11-15)21(28)27-23(25)26-20-9-5-4-8-18(20)16-6-2-1-3-7-16/h1-13,19H,14,24H2,(H,29,30)(H3,25,26,27,28)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 974 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167382
(CHEMBL3800562)Show SMILES CN(Cc1ccccc1-c1ccccc1)C(\N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C25H26N4O3/c1-29(16-20-9-5-6-10-21(20)18-7-3-2-4-8-18)25(27)28-23(30)19-13-11-17(12-14-19)15-22(26)24(31)32/h2-14,22H,15-16,26H2,1H3,(H,31,32)(H2,27,28,30)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167377
(CHEMBL3800077)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1-n1cncn1)C(O)=O |r| Show InChI InChI=1S/C20H21N7O3/c21-16(19(29)30)9-13-5-7-14(8-6-13)18(28)26-20(22)24-10-15-3-1-2-4-17(15)27-12-23-11-25-27/h1-8,11-12,16H,9-10,21H2,(H,29,30)(H3,22,24,26,28)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167381
(CHEMBL3798985)Show SMILES CN\C(NCc1ccccc1-c1ccccc1)=N/C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C25H26N4O3/c1-27-25(28-16-20-9-5-6-10-21(20)18-7-3-2-4-8-18)29-23(30)19-13-11-17(12-14-19)15-22(26)24(31)32/h2-14,22H,15-16,26H2,1H3,(H,31,32)(H2,27,28,29,30)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167386
(CHEMBL3799822)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccc(cc1)-c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C24H24N4O3/c25-21(23(30)31)14-16-6-12-20(13-7-16)22(29)28-24(26)27-15-17-8-10-19(11-9-17)18-4-2-1-3-5-18/h1-13,21H,14-15,25H2,(H,30,31)(H3,26,27,28,29)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167324
(CHEMBL3798055)Show SMILES Cc1cn(cn1)-c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| Show InChI InChI=1S/C22H24N6O3/c1-14-12-28(13-26-14)19-5-3-2-4-17(19)11-25-22(24)27-20(29)16-8-6-15(7-9-16)10-18(23)21(30)31/h2-9,12-13,18H,10-11,23H2,1H3,(H,30,31)(H3,24,25,27,29)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167389
(CHEMBL3798541)Show SMILES N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C18H20N4O3/c19-15(17(24)25)10-12-6-8-14(9-7-12)16(23)22-18(20)21-11-13-4-2-1-3-5-13/h1-9,15H,10-11,19H2,(H,24,25)(H3,20,21,22,23)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
Tryptophan 5-hydroxylase 1
(Homo sapiens (Human)) | BDBM50167390
(CHEMBL3798809)Show SMILES [#7]-[#6@@H](-[#6]-c1ccc(cc1)-[#6](=O)\[#7]=[#6](\[#7])-[#7])-[#6](-[#8])=O |r| Show InChI InChI=1S/C11H14N4O3/c12-8(10(17)18)5-6-1-3-7(4-2-6)9(16)15-11(13)14/h1-4,8H,5,12H2,(H,17,18)(H4,13,14,15,16)/t8-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Karos Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of TPH1 (unknown origin) |
Bioorg Med Chem Lett 26: 2855-2860 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.057
BindingDB Entry DOI: 10.7270/Q2SN0BW3 |
More data for this
Ligand-Target Pair | |
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