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PubMed code 27184766

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50174569
PNG
(CHEMBL3809634)
Show SMILES COc1ccc2c(OCc3nnc4nnc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C20H15N7O2/c1-28-14-7-8-15-16(11-14)21-10-9-17(15)29-12-18-22-24-20-25-23-19(26-27(18)20)13-5-3-2-4-6-13/h2-11H,12H2,1H3
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Taizhou Vocational& Technical College

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using poly(Glu-Tyr) substrate incubated for 60 mins by ELISA


Bioorg Med Chem Lett 26: 3042-7 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.007
BindingDB Entry DOI: 10.7270/Q2T155JJ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Taizhou Vocational& Technical College

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using TK substrate-biotin as substrate preincubated with compound followed by substrate addition for 40 mins meas...


Bioorg Med Chem Lett 26: 3042-7 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.007
BindingDB Entry DOI: 10.7270/Q2T155JJ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50174568
PNG
(CHEMBL3810279)
Show SMILES O=C(C1CCCCC1)N1CCN(CC1)c1nnc2nncn2n1
Show InChI InChI=1S/C14H20N8O/c23-12(11-4-2-1-3-5-11)20-6-8-21(9-7-20)14-18-17-13-16-15-10-22(13)19-14/h10-11H,1-9H2
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Article
PubMed
n/an/a 7.90E+3n/an/an/an/an/an/a



Taizhou Vocational& Technical College

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using TK substrate-biotin as substrate preincubated with compound followed by substrate addition for 40 mins meas...


Bioorg Med Chem Lett 26: 3042-7 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.007
BindingDB Entry DOI: 10.7270/Q2T155JJ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50174566
PNG
(CHEMBL3809108)
Show SMILES C1CN(CCO1)c1nnc2nncn2n1
Show InChI InChI=1S/C7H9N7O/c1-3-15-4-2-13(1)7-11-10-6-9-8-5-14(6)12-7/h5H,1-4H2
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Article
PubMed
n/an/a 1.18E+4n/an/an/an/an/an/a



Taizhou Vocational& Technical College

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using TK substrate-biotin as substrate preincubated with compound followed by substrate addition for 40 mins meas...


Bioorg Med Chem Lett 26: 3042-7 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.007
BindingDB Entry DOI: 10.7270/Q2T155JJ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50174567
PNG
(CHEMBL3810244)
Show SMILES CC(C)C(=O)N1CCN(CC1)c1nnc2nncn2n1
Show InChI InChI=1S/C11H16N8O/c1-8(2)9(20)17-3-5-18(6-4-17)11-15-14-10-13-12-7-19(10)16-11/h7-8H,3-6H2,1-2H3
PDB
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KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a 2.37E+4n/an/an/an/an/an/a



Taizhou Vocational& Technical College

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using TK substrate-biotin as substrate preincubated with compound followed by substrate addition for 40 mins meas...


Bioorg Med Chem Lett 26: 3042-7 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.007
BindingDB Entry DOI: 10.7270/Q2T155JJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%