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PubMed code 27238842

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176799
PNG
(CHEMBL3808617)
Show SMILES COc1ccc(Nc2nc(NCCCO)c3ccccc3n2)cc1
Show InChI InChI=1S/C18H20N4O2/c1-24-14-9-7-13(8-10-14)20-18-21-16-6-3-2-5-15(16)17(22-18)19-11-4-12-23/h2-3,5-10,23H,4,11-12H2,1H3,(H2,19,20,21,22)
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n/an/a 680n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176800
PNG
(CHEMBL3809956)
Show SMILES COc1ccc(Nc2nc(NC3CCCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C20H22N4O/c1-25-16-12-10-15(11-13-16)22-20-23-18-9-5-4-8-17(18)19(24-20)21-14-6-2-3-7-14/h4-5,8-14H,2-3,6-7H2,1H3,(H2,21,22,23,24)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176760
PNG
(CHEMBL3809304)
Show SMILES COc1ccc(cc1)N(C)c1nc(NC2CCCC2)c2ccccc2n1
Show InChI InChI=1S/C21H24N4O/c1-25(16-11-13-17(26-2)14-12-16)21-23-19-10-6-5-9-18(19)20(24-21)22-15-7-3-4-8-15/h5-6,9-15H,3-4,7-8H2,1-2H3,(H,22,23,24)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176787
PNG
(CHEMBL3808937)
Show SMILES Oc1ccc(Nc2nc(NC3CCCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C19H20N4O/c24-15-11-9-14(10-12-15)21-19-22-17-8-4-3-7-16(17)18(23-19)20-13-5-1-2-6-13/h3-4,7-13,24H,1-2,5-6H2,(H2,20,21,22,23)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176789
PNG
(CHEMBL3809769)
Show SMILES OCCCNc1nc(Nc2ccc(cc2)C#N)nc2ccccc12
Show InChI InChI=1S/C18H17N5O/c19-12-13-6-8-14(9-7-13)21-18-22-16-5-2-1-4-15(16)17(23-18)20-10-3-11-24/h1-2,4-9,24H,3,10-11H2,(H2,20,21,22,23)
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n/an/a 1.72E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176780
PNG
(CHEMBL3808931)
Show SMILES CCCNc1nc(nc2ccccc12)N(C)c1ccc(OC)cc1
Show InChI InChI=1S/C19H22N4O/c1-4-13-20-18-16-7-5-6-8-17(16)21-19(22-18)23(2)14-9-11-15(24-3)12-10-14/h5-12H,4,13H2,1-3H3,(H,20,21,22)
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n/an/a 1.84E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176779
PNG
(CHEMBL3809339)
Show SMILES COc1ccc(cc1)N(C)c1nc(NCCCO)c2ccccc2n1
Show InChI InChI=1S/C19H22N4O2/c1-23(14-8-10-15(25-2)11-9-14)19-21-17-7-4-3-6-16(17)18(22-19)20-12-5-13-24/h3-4,6-11,24H,5,12-13H2,1-2H3,(H,20,21,22)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176796
PNG
(CHEMBL3808513)
Show SMILES COc1ccc(Nc2nc(N3CCOCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C19H20N4O2/c1-24-15-8-6-14(7-9-15)20-19-21-17-5-3-2-4-16(17)18(22-19)23-10-12-25-13-11-23/h2-9H,10-13H2,1H3,(H,20,21,22)
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n/an/a 2.06E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176797
PNG
(CHEMBL3809699)
Show SMILES CNc1nc(Nc2ccc(OC)cc2)nc2ccccc12
Show InChI InChI=1S/C16H16N4O/c1-17-15-13-5-3-4-6-14(13)19-16(20-15)18-11-7-9-12(21-2)10-8-11/h3-10H,1-2H3,(H2,17,18,19,20)
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n/an/a 2.25E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176788
PNG
(CHEMBL3809150)
Show SMILES OC(=O)c1ccc(Nc2nc(NC3CCCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C20H20N4O2/c25-19(26)13-9-11-15(12-10-13)22-20-23-17-8-4-3-7-16(17)18(24-20)21-14-5-1-2-6-14/h3-4,7-12,14H,1-2,5-6H2,(H,25,26)(H2,21,22,23,24)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176798
PNG
(CHEMBL3810139)
Show SMILES CCCNc1nc(Nc2ccc(OC)cc2)nc2ccccc12
Show InChI InChI=1S/C18H20N4O/c1-3-12-19-17-15-6-4-5-7-16(15)21-18(22-17)20-13-8-10-14(23-2)11-9-13/h4-11H,3,12H2,1-2H3,(H2,19,20,21,22)
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n/an/a 3.43E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176795
PNG
(CHEMBL3809606)
Show SMILES COc1ccc(Nc2nc(NC3CC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C18H18N4O/c1-23-14-10-8-13(9-11-14)20-18-21-16-5-3-2-4-15(16)17(22-18)19-12-6-7-12/h2-5,8-12H,6-7H2,1H3,(H2,19,20,21,22)
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n/an/a 3.56E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176786
PNG
(CHEMBL3808518)
Show SMILES Fc1ccc(Nc2nc(NC3CCCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C19H19FN4/c20-13-9-11-15(12-10-13)22-19-23-17-8-4-3-7-16(17)18(24-19)21-14-5-1-2-6-14/h3-4,7-12,14H,1-2,5-6H2,(H2,21,22,23,24)
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n/an/a 4.17E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50001839
PNG
(CHEMBL428647 | PACLITAXEL | taxol)
Show SMILES CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1 |r,wU:4.3,28.30,26.26,10.10,22.23,30.33,wD:23.37,8.45,44.49,46.51,12.12,c:5,(23.85,-5.1,;25.19,-4.32,;25.18,-2.78,;26.52,-5.08,;26.53,-6.61,;23.91,-8.14,;22.57,-8.89,;21.25,-8.11,;22.55,-10.43,;23.89,-11.22,;25.21,-10.45,;25.2,-11.99,;26.54,-11.23,;26.53,-12.77,;25.19,-13.53,;23.87,-12.75,;25.19,-15.05,;23.85,-15.82,;23.84,-17.36,;25.17,-18.14,;26.51,-17.37,;26.52,-15.82,;27.88,-10.47,;29.2,-11.23,;29.96,-12.57,;31.31,-11.81,;30.55,-10.47,;30.55,-8.91,;29.2,-8.13,;30.52,-7.35,;27.88,-8.91,;26.78,-10,;27.87,-7.37,;29.19,-6.59,;28.1,-12.3,;28.1,-13.84,;29.43,-14.62,;26.76,-14.61,;25.23,-8.91,;25.98,-7.57,;26.76,-8.91,;21.21,-11.18,;19.89,-10.4,;19.91,-8.87,;18.55,-11.16,;18.54,-12.7,;17.22,-10.38,;17.24,-8.84,;15.92,-8.06,;14.57,-8.82,;15.93,-6.52,;17.27,-5.78,;17.28,-4.24,;15.95,-3.46,;14.61,-4.23,;14.6,-5.76,;15.89,-11.14,;14.57,-10.36,;13.23,-11.11,;13.21,-12.65,;14.56,-13.43,;15.89,-12.67,)|
Show InChI InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176785
PNG
(CHEMBL3809070)
Show SMILES Nc1ccc(Nc2nc(NC3CCCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C19H21N5/c20-13-9-11-15(12-10-13)22-19-23-17-8-4-3-7-16(17)18(24-19)21-14-5-1-2-6-14/h3-4,7-12,14H,1-2,5-6,20H2,(H2,21,22,23,24)
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n/an/a 7.27E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176792
PNG
(CHEMBL3808665)
Show SMILES CCCNc1nc(Nc2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C17H17FN4/c1-2-11-19-16-14-5-3-4-6-15(14)21-17(22-16)20-13-9-7-12(18)8-10-13/h3-10H,2,11H2,1H3,(H2,19,20,21,22)
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n/an/a 7.84E+3n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176781
PNG
(CHEMBL3810009)
Show SMILES CNc1nc(nc2ccccc12)N(C)c1ccc(OC)cc1
Show InChI InChI=1S/C17H18N4O/c1-18-16-14-6-4-5-7-15(14)19-17(20-16)21(2)12-8-10-13(22-3)11-9-12/h4-11H,1-3H3,(H,18,19,20)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50113707
PNG
(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12
Show InChI InChI=1S/C16H19ClN6O/c1-10(2)23-9-19-13-14(20-12-5-3-4-11(17)8-12)21-16(18-6-7-24)22-15(13)23/h3-5,8-10,24H,6-7H2,1-2H3,(H2,18,20,21,22)
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n/an/a 1.13E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Mer kinase (588 to 855 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells measured every mi...

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176794
PNG
(CHEMBL3810240)
Show SMILES Nc1ccc(Nc2nc(N3CCOCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C18H19N5O/c19-13-5-7-14(8-6-13)20-18-21-16-4-2-1-3-15(16)17(22-18)23-9-11-24-12-10-23/h1-8H,9-12,19H2,(H,20,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176790
PNG
(CHEMBL3809359)
Show SMILES Nc1ccc(Nc2nc(NCCCO)c3ccccc3n2)cc1
Show InChI InChI=1S/C17H19N5O/c18-12-6-8-13(9-7-12)20-17-21-15-5-2-1-4-14(15)16(22-17)19-10-3-11-23/h1-2,4-9,23H,3,10-11,18H2,(H2,19,20,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176784
PNG
(CHEMBL3809906)
Show SMILES N#Cc1ccc(Nc2nc(NC3CCCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C20H19N5/c21-13-14-9-11-16(12-10-14)23-20-24-18-8-4-3-7-17(18)19(25-20)22-15-5-1-2-6-15/h3-4,7-12,15H,1-2,5-6H2,(H2,22,23,24,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176783
PNG
(CHEMBL3809195)
Show SMILES COc1ccc(cc1)N(C)c1nc(NCC2CCOCC2)c2ccccc2n1
Show InChI InChI=1S/C22H26N4O2/c1-26(17-7-9-18(27-2)10-8-17)22-24-20-6-4-3-5-19(20)21(25-22)23-15-16-11-13-28-14-12-16/h3-10,16H,11-15H2,1-2H3,(H,23,24,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176793
PNG
(CHEMBL1623086)
Show SMILES Fc1ccc(Nc2nc(N3CCOCC3)c3ccccc3n2)cc1
Show InChI InChI=1S/C18H17FN4O/c19-13-5-7-14(8-6-13)20-18-21-16-4-2-1-3-15(16)17(22-18)23-9-11-24-12-10-23/h1-8H,9-12H2,(H,20,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176791
PNG
(CHEMBL3810214)
Show SMILES OCCCNc1nc(Nc2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C17H17FN4O/c18-12-6-8-13(9-7-12)20-17-21-15-5-2-1-4-14(15)16(22-17)19-10-3-11-23/h1-2,4-9,23H,3,10-11H2,(H2,19,20,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50176782
PNG
(CHEMBL3808451)
Show SMILES COc1ccc(cc1)N(C)c1nc(N2CCOCC2)c2ccccc2n1
Show InChI InChI=1S/C20H22N4O2/c1-23(15-7-9-16(25-2)10-8-15)20-21-18-6-4-3-5-17(18)19(22-20)24-11-13-26-14-12-24/h3-10H,11-14H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Beijing Institute of Pharmacology& Toxicology

Curated by ChEMBL


Assay Description
Inhibition of MERTK (unknown origin) using EFPIYDFLPAKKK-CONH2 as substrate and ATP after 180 mins by microfluidic capillary electrophoresis method

Bioorg Med Chem 24: 3083-3092 (2016)


Article DOI: 10.1016/j.bmc.2016.05.025
BindingDB Entry DOI: 10.7270/Q23B621J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%