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PubMed code 27409517

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198194
PNG
(CHEMBL3978947)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@@]1([#6])[#6@H](-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]-[#6@@H](-[#8])-[#6](-[#6])=[#6])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,t:28,TLB:49:48:20.8.6:29.27.40|
Show InChI InChI=1S/C43H58O7/c1-26(2)12-11-21-41(10)32(16-13-30(9)14-17-33(44)29(7)8)25-42(22-19-27(3)4)38(48)36(37(47)31-15-18-34(45)35(46)24-31)39(49)43(41,40(42)50)23-20-28(5)6/h12-13,15,18-20,24,32-33,44-46,48H,7,11,14,16-17,21-23,25H2,1-6,8-10H3/b30-13+/t32-,33-,41+,42+,43-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50190131
PNG
(Oblongifolin C)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6@@H]1-[#6][C@@]2([#6]\[#6]=[#6](\[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]([#6]\[#6]=[#6](\[#6])-[#6])([#6]2=O)[C@@]1([#6])[#6]-[#6]\[#6]=[#6](\[#6])-[#6] |r,t:19,THB:40:39:20.18.31:41.11.10|
Show InChI InChI=1S/C43H58O6/c1-27(2)13-11-15-31(9)16-18-33-26-42(23-20-29(5)6)38(47)36(37(46)32-17-19-34(44)35(45)25-32)39(48)43(40(42)49,24-21-30(7)8)41(33,10)22-12-14-28(3)4/h13-14,16-17,19-21,25,33,44-45,47H,11-12,15,18,22-24,26H2,1-10H3/b31-16+/t33-,41+,42+,43-/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50448068
PNG
(Guttiferone K)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6][C@@]1([#6])[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](\[#6])-[#6])[#6]2=O |r,TLB:43:42:23.21.34:6.14.8|
Show InChI InChI=1S/C38H50O6/c1-23(2)11-10-18-36(9)28(14-12-24(3)4)22-37(19-16-25(5)6)33(42)31(32(41)27-13-15-29(39)30(40)21-27)34(43)38(36,35(37)44)20-17-26(7)8/h11-13,15-17,21,28,31,39-40H,10,14,18-20,22H2,1-9H3/t28-,31?,36+,37+,38-/m1/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198198
PNG
(CHEMBL3889506)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@@]1([#6])[#6@H](-[#6]\[#6]=[#6](/[#6])-[#6]\[#6]=[#6]\C([#6])([#6])[#8])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,t:28,TLB:49:48:20.8.6:29.27.40|
Show InChI InChI=1S/C43H58O7/c1-27(2)13-11-22-41(10)32(17-15-30(7)14-12-21-40(8,9)50)26-42(23-19-28(3)4)37(47)35(36(46)31-16-18-33(44)34(45)25-31)38(48)43(41,39(42)49)24-20-29(5)6/h12-13,15-16,18-21,25,32,44-45,47,50H,11,14,17,22-24,26H2,1-10H3/b21-12+,30-15+/t32-,41+,42+,43-/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198200
PNG
(CHEMBL3976184)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@@]1([#6])[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3cccc(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,t:22,TLB:42:41:14.8.6:23.21.33|
Show InChI InChI=1S/C38H50O5/c1-24(2)12-11-19-36(9)29(16-15-25(3)4)23-37(20-17-26(5)6)33(41)31(32(40)28-13-10-14-30(39)22-28)34(42)38(36,35(37)43)21-18-27(7)8/h10,12-15,17-18,22,29,39,41H,11,16,19-21,23H2,1-9H3/t29-,36+,37+,38-/m1/s1
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n/an/a 5.70E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198195
PNG
(CHEMBL3917534)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@@]1([#6])[#6@H](-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]-[#6@H](-[#8])-[#6](-[#6])=[#6])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,t:28,TLB:49:48:20.8.6:29.27.40|
Show InChI InChI=1S/C43H58O7/c1-26(2)12-11-21-41(10)32(16-13-30(9)14-17-33(44)29(7)8)25-42(22-19-27(3)4)38(48)36(37(47)31-15-18-34(45)35(46)24-31)39(49)43(41,40(42)50)23-20-28(5)6/h12-13,15,18-20,24,32-33,44-46,48H,7,11,14,16-17,21-23,25H2,1-6,8-10H3/b30-13+/t32-,33+,41+,42+,43-/m1/s1
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Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198197
PNG
(CHEMBL3907489)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]C1([#6]\[#6]=[#6](\[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c2ccc(-[#8])c(-[#8])c2)-[#6](=O)-[#6]-2=[#6]1-[#8]C([#6])([#6])[#6]=[#6]-2 |c:32,39,t:17|
Show InChI InChI=1S/C33H40O6/c1-20(2)9-8-10-22(5)14-18-33(17-13-21(3)4)30(38)27(28(36)23-11-12-25(34)26(35)19-23)29(37)24-15-16-32(6,7)39-31(24)33/h9,11-16,19,34-35,38H,8,10,17-18H2,1-7H3/b22-14+
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n/an/a 6.20E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198196
PNG
(CHEMBL3898463)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6@@H]1-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6]3-[#8]-[#6@H](-[#6]-[#6][C@]1([#6])[C@@]3([#6]\[#6]=[#6](\[#6])-[#6])[#6]2=O)C([#6])([#6])[#8])-[#6](=O)-c1ccc(-[#8])c(-[#8])c1 |r,c:19,THB:35:34:11.10.26:20.18.21|
Show InChI InChI=1S/C43H60O7/c1-26(2)12-11-13-29(7)14-16-31-25-42(22-18-27(3)4)37(47)35(36(46)30-15-17-32(44)33(45)24-30)38-43(39(42)48,23-19-28(5)6)41(31,10)21-20-34(50-38)40(8,9)49/h12,14-15,17-19,24,31,34,38,44-45,47,49H,11,13,16,20-23,25H2,1-10H3/b29-14+/t31-,34-,38?,41+,42+,43-/m1/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198193
PNG
(CHEMBL3926514)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6@@H]1-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6]3-[#8]-[#6@H](-[#6]-[#6][C@]1([#6])[C@@]3([#6]\[#6]=[#6](\[#6])-[#6])[#6]2=O)C([#6])([#6])[#8])-[#6](=O)-c1ccc(-[#8])c(-[#8])c1 |r,c:14,THB:30:29:6.5.21:15.13.16|
Show InChI InChI=1S/C38H52O7/c1-22(2)10-12-26-21-37(18-14-23(3)4)32(42)30(31(41)25-11-13-27(39)28(40)20-25)33-38(34(37)43,19-15-24(5)6)36(26,9)17-16-29(45-33)35(7,8)44/h10-11,13-15,20,26,29,33,39-40,42,44H,12,16-19,21H2,1-9H3/t26-,29-,33?,36+,37+,38-/m1/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50198199
PNG
(CHEMBL3935433)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@@]1([#6])[#6@H](-[#6]-[#6](-[#8])-[#6](-[#6])=[#6])-[#6][C@@]2([#6]\[#6]=[#6](/[#6])-[#6])[#6](-[#8])=[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)[C@]1([#6]\[#6]=[#6](/[#6])-[#6])[#6]2=O |r,t:23,TLB:44:43:15.8.6:24.22.35|
Show InChI InChI=1S/C38H50O7/c1-22(2)11-10-16-36(9)27(20-29(40)25(7)8)21-37(17-14-23(3)4)33(43)31(32(42)26-12-13-28(39)30(41)19-26)34(44)38(36,35(37)45)18-15-24(5)6/h11-15,19,27,29,39-41,43H,7,10,16-18,20-21H2,1-6,8-9H3/t27-,29?,36+,37+,38-/m1/s1
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n/an/a 8.80E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50020676
PNG
(CHEBI:41846 | CHEMBL566812)
Show SMILES Cc1cn([C@H]2CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H17N2O13P3/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t7-,8+/m0/s1
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n/an/a 2.87E+4n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))		BDBM50090910
PNG
(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Show SMILES C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO |r|
Show InChI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...

J Nat Prod 79: 1798-807 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00255
BindingDB Entry DOI: 10.7270/Q2930W5F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%