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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM206291 (4-((2-((3-(Tert-butyl)phenyl)amino)quinolin-5-yl)o...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.26E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Korea Institute of Science and Technology | Assay Description Reaction Biology Corporation Kinase HotSpotSM service: In a final reactionvolume of 25 μL, kinase (5-10 mU) is incubated with 25 mM Tris pH 7.5,... | Chem Biol Drug Des 89: 98-113 (2017) Article DOI: 10.1111/cbdd.12836 BindingDB Entry DOI: 10.7270/Q2NZ86GZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM206292 (4-((2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)q...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Korea Institute of Science and Technology | Assay Description Reaction Biology Corporation Kinase HotSpotSM service: In a final reactionvolume of 25 μL, kinase (5-10 mU) is incubated with 25 mM Tris pH 7.5,... | Chem Biol Drug Des 89: 98-113 (2017) Article DOI: 10.1111/cbdd.12836 BindingDB Entry DOI: 10.7270/Q2NZ86GZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM206291 (4-((2-((3-(Tert-butyl)phenyl)amino)quinolin-5-yl)o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Korea Institute of Science and Technology | Assay Description Reaction Biology Corporation Kinase HotSpotSM service: In a final reactionvolume of 25 μL, kinase (5-10 mU) is incubated with 25 mM Tris pH 7.5,... | Chem Biol Drug Des 89: 98-113 (2017) Article DOI: 10.1111/cbdd.12836 BindingDB Entry DOI: 10.7270/Q2NZ86GZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM206292 (4-((2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)q...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Korea Institute of Science and Technology | Assay Description Reaction Biology Corporation Kinase HotSpotSM service: In a final reactionvolume of 25 μL, kinase (5-10 mU) is incubated with 25 mM Tris pH 7.5,... | Chem Biol Drug Des 89: 98-113 (2017) Article DOI: 10.1111/cbdd.12836 BindingDB Entry DOI: 10.7270/Q2NZ86GZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
