Affinity Data by PubMed id=27667561

PubMed code 27667561

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein mono-ADP-ribosyltransferase PARP15 [460-656,Y598L] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein mono-ADP-ribosyltransferase PARP10 [809-1017] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	329	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,R931A] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	597	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 [1535-1801,Y1660L] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,S927A] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP10 [809-1017,L926Y] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP16 [1-280] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP15 [460-656] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein mono-ADP-ribosyltransferase PARP4 [250-565] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 [1535-1801] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 [873-1161] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP12 [489-701] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 [1030-1317] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 [R100H] (Homo sapiens (Human))	BDBM199181 (4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...) Show SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oulu					Assay Description This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...				Cell Chem Biol 23: 1251-1260 (2016) Article DOI: 10.1016/j.chembiol.2016.08.012 BindingDB Entry DOI: 10.7270/Q2B56HJ3
University of Oulu					More data for this Ligand-Target Pair

* indicates data uncertainty>20%