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PubMed code 27688180

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210747
PNG
(CHEMBL3968039)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H38ClN7O3/c1-21-6-7-23(16-22(21)2)37-32(41)38-27-9-8-24(17-26(27)33)36-31-25-18-29(42-4)30(19-28(25)34-20-35-31)43-15-5-10-40-13-11-39(3)12-14-40/h6-9,16-20H,5,10-15H2,1-4H3,(H,34,35,36)(H2,37,38,41)
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n/an/a 1n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210697
PNG
(CHEMBL3962233)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H33Cl2N7O3/c1-38-11-13-39(14-12-38)10-3-15-42-28-18-26-23(17-27(28)41-2)29(34-19-33-26)35-22-8-9-25(24(32)16-22)37-30(40)36-21-6-4-20(31)5-7-21/h4-9,16-19H,3,10-15H2,1-2H3,(H,33,34,35)(H2,36,37,40)
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n/an/a 1n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM21
PNG
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 11n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210695
PNG
(CHEMBL3929448)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H32Cl2FN7O3/c1-39-9-11-40(12-10-39)8-3-13-43-28-17-26-21(16-27(28)42-2)29(35-18-34-26)36-19-5-7-25(23(32)15-19)38-30(41)37-20-4-6-24(33)22(31)14-20/h4-7,14-18H,3,8-13H2,1-2H3,(H,34,35,36)(H2,37,38,41)
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n/an/a 14n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210705
PNG
(CHEMBL3979264)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-12-14-38(15-13-37)11-6-16-41-28-19-26-23(18-27(28)40-2)29(33-20-32-26)34-22-9-10-25(24(31)17-22)36-30(39)35-21-7-4-3-5-8-21/h3-5,7-10,17-20H,6,11-16H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 14n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210748
PNG
(CHEMBL3920551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C31H35ClN6O4/c1-20-5-6-22(15-21(20)2)36-31(39)37-26-8-7-23(16-25(26)32)35-30-24-17-28(40-3)29(18-27(24)33-19-34-30)42-12-4-9-38-10-13-41-14-11-38/h5-8,15-19H,4,9-14H2,1-3H3,(H,33,34,35)(H2,36,37,39)
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n/an/a 14n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210752
PNG
(CHEMBL3938494)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H36ClN7O3/c1-21-7-4-5-8-25(21)36-31(40)37-26-10-9-22(17-24(26)32)35-30-23-18-28(41-3)29(19-27(23)33-20-34-30)42-16-6-11-39-14-12-38(2)13-15-39/h4-5,7-10,17-20H,6,11-16H2,1-3H3,(H,33,34,35)(H2,36,37,40)
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n/an/a 15n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM21
PNG
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 15n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210701
PNG
(CHEMBL3957025)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C29H30Cl2N6O4/c1-39-26-16-22-25(17-27(26)41-12-2-9-37-10-13-40-14-11-37)32-18-33-28(22)34-21-7-8-24(23(31)15-21)36-29(38)35-20-5-3-19(30)4-6-20/h3-8,15-18H,2,9-14H2,1H3,(H,32,33,34)(H2,35,36,38)
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n/an/a 17n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210698
PNG
(CHEMBL3939588)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C31H35ClN6O3/c1-20-7-8-22(15-21(20)2)36-31(39)37-26-10-9-23(16-25(26)32)35-30-24-17-28(40-3)29(18-27(24)33-19-34-30)41-14-13-38-11-5-4-6-12-38/h7-10,15-19H,4-6,11-14H2,1-3H3,(H,33,34,35)(H2,36,37,39)
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n/an/a 18n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210748
PNG
(CHEMBL3920551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C31H35ClN6O4/c1-20-5-6-22(15-21(20)2)36-31(39)37-26-8-7-23(16-25(26)32)35-30-24-17-28(40-3)29(18-27(24)33-19-34-30)42-12-4-9-38-10-13-41-14-11-38/h5-8,15-19H,4,9-14H2,1-3H3,(H,33,34,35)(H2,36,37,39)
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n/an/a 51n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210695
PNG
(CHEMBL3929448)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H32Cl2FN7O3/c1-39-9-11-40(12-10-39)8-3-13-43-28-17-26-21(16-27(28)42-2)29(35-18-34-26)36-19-5-7-25(23(32)15-19)38-30(41)37-20-4-6-24(33)22(31)14-20/h4-7,14-18H,3,8-13H2,1-2H3,(H,34,35,36)(H2,37,38,41)
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n/an/a 78n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210747
PNG
(CHEMBL3968039)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H38ClN7O3/c1-21-6-7-23(16-22(21)2)37-32(41)38-27-9-8-24(17-26(27)33)36-31-25-18-29(42-4)30(19-28(25)34-20-35-31)43-15-5-10-40-13-11-39(3)12-14-40/h6-9,16-20H,5,10-15H2,1-4H3,(H,34,35,36)(H2,37,38,41)
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n/an/a 79n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210752
PNG
(CHEMBL3938494)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H36ClN7O3/c1-21-7-4-5-8-25(21)36-31(40)37-26-10-9-22(17-24(26)32)35-30-23-18-28(41-3)29(19-27(23)33-20-34-30)42-16-6-11-39-14-12-38(2)13-15-39/h4-5,7-10,17-20H,6,11-16H2,1-3H3,(H,33,34,35)(H2,36,37,40)
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n/an/a 178n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210707
PNG
(CHEMBL3923551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H35N7O3/c1-36-14-16-37(17-15-36)13-6-18-40-28-20-26-25(19-27(28)39-2)29(32-21-31-26)33-23-9-11-24(12-10-23)35-30(38)34-22-7-4-3-5-8-22/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,31,32,33)(H2,34,35,38)
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n/an/a 194n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210704
PNG
(CHEMBL3948354)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C29H31ClN6O3/c1-38-26-17-22-25(18-27(26)39-15-14-36-12-6-3-7-13-36)31-19-32-28(22)33-21-10-11-24(23(30)16-21)35-29(37)34-20-8-4-2-5-9-20/h2,4-5,8-11,16-19H,3,6-7,12-15H2,1H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 212n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210746
PNG
(CHEMBL3905552)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-22-6-7-26(18-23(22)2)37-32(40)36-25-10-8-24(9-11-25)35-31-27-19-29(41-4)30(20-28(27)33-21-34-31)42-17-5-12-39-15-13-38(3)14-16-39/h6-11,18-21H,5,12-17H2,1-4H3,(H,33,34,35)(H2,36,37,40)
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n/an/a 214n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210696
PNG
(CHEMBL3905242)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-13-15-38(16-14-37)12-3-17-41-28-19-26-25(18-27(28)40-2)29(33-20-32-26)34-22-8-10-24(11-9-22)36-30(39)35-23-6-4-21(31)5-7-23/h4-11,18-20H,3,12-17H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 235n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210705
PNG
(CHEMBL3979264)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-12-14-38(15-13-37)11-6-16-41-28-19-26-23(18-27(28)40-2)29(33-20-32-26)34-22-9-10-25(24(31)17-22)36-30(39)35-21-7-4-3-5-8-21/h3-5,7-10,17-20H,6,11-16H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 261n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210694
PNG
(CHEMBL3975598)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1
Show InChI InChI=1S/C27H34N6O5/c1-32-10-12-33(13-11-32)9-4-14-38-24-16-22-21(15-23(24)36-2)26(30-18-29-22)31-20-7-5-19(6-8-20)27(35)28-17-25(34)37-3/h5-8,15-16,18H,4,9-14,17H2,1-3H3,(H,28,35)(H,29,30,31)
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n/an/a 275n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210697
PNG
(CHEMBL3962233)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H33Cl2N7O3/c1-38-11-13-39(14-12-38)10-3-15-42-28-18-26-23(17-27(28)41-2)29(34-19-33-26)35-22-8-9-25(24(32)16-22)37-30(40)36-21-6-4-20(31)5-7-21/h4-9,16-19H,3,10-15H2,1-2H3,(H,33,34,35)(H2,36,37,40)
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n/an/a 279n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210749
PNG
(CHEMBL3904787)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)cc1
Show InChI InChI=1S/C26H31N5O6/c1-34-22-14-20-21(15-23(22)37-11-3-8-31-9-12-36-13-10-31)28-17-29-25(20)30-19-6-4-18(5-7-19)26(33)27-16-24(32)35-2/h4-7,14-15,17H,3,8-13,16H2,1-2H3,(H,27,33)(H,28,29,30)
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n/an/a 404n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210699
PNG
(CHEMBL3896615)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-12-14-38(15-13-37)11-4-16-41-28-19-26-25(18-27(28)40-2)29(33-20-32-26)34-22-7-9-23(10-8-22)35-30(39)36-24-6-3-5-21(31)17-24/h3,5-10,17-20H,4,11-16H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 500n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210706
PNG
(CHEMBL3933568)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O3/c1-22-7-4-5-8-26(22)36-31(39)35-24-11-9-23(10-12-24)34-30-25-19-28(40-3)29(20-27(25)32-21-33-30)41-18-6-13-38-16-14-37(2)15-17-38/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 502n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210701
PNG
(CHEMBL3957025)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C29H30Cl2N6O4/c1-39-26-16-22-25(17-27(26)41-12-2-9-37-10-13-40-14-11-37)32-18-33-28(22)34-21-7-8-24(23(31)15-21)36-29(38)35-20-5-3-19(30)4-6-20/h3-8,15-18H,2,9-14H2,1H3,(H,32,33,34)(H2,35,36,38)
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n/an/a 528n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210707
PNG
(CHEMBL3923551)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H35N7O3/c1-36-14-16-37(17-15-36)13-6-18-40-28-20-26-25(19-27(28)39-2)29(32-21-31-26)33-23-9-11-24(12-10-23)35-30(38)34-22-7-4-3-5-8-22/h3-5,7-12,19-21H,6,13-18H2,1-2H3,(H,31,32,33)(H2,34,35,38)
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n/an/a 576n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210699
PNG
(CHEMBL3896615)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-12-14-38(15-13-37)11-4-16-41-28-19-26-25(18-27(28)40-2)29(33-20-32-26)34-22-7-9-23(10-8-22)35-30(39)36-24-6-3-5-21(31)17-24/h3,5-10,17-20H,4,11-16H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 588n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210694
PNG
(CHEMBL3975598)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1
Show InChI InChI=1S/C27H34N6O5/c1-32-10-12-33(13-11-32)9-4-14-38-24-16-22-21(15-23(24)36-2)26(30-18-29-22)31-20-7-5-19(6-8-20)27(35)28-17-25(34)37-3/h5-8,15-16,18H,4,9-14,17H2,1-3H3,(H,28,35)(H,29,30,31)
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n/an/a 611n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210746
PNG
(CHEMBL3905552)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-22-6-7-26(18-23(22)2)37-32(40)36-25-10-8-24(9-11-25)35-31-27-19-29(41-4)30(20-28(27)33-21-34-31)42-17-5-12-39-15-13-38(3)14-16-39/h6-11,18-21H,5,12-17H2,1-4H3,(H,33,34,35)(H2,36,37,40)
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n/an/a 668n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210749
PNG
(CHEMBL3904787)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)cc1
Show InChI InChI=1S/C26H31N5O6/c1-34-22-14-20-21(15-23(22)37-11-3-8-31-9-12-36-13-10-31)28-17-29-25(20)30-19-6-4-18(5-7-19)26(33)27-16-24(32)35-2/h4-7,14-15,17H,3,8-13,16H2,1-2H3,(H,27,33)(H,28,29,30)
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n/an/a 763n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210696
PNG
(CHEMBL3905242)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C30H34ClN7O3/c1-37-13-15-38(16-14-37)12-3-17-41-28-19-26-25(18-27(28)40-2)29(33-20-32-26)34-22-8-10-24(11-9-22)36-30(39)35-23-6-4-21(31)5-7-23/h4-11,18-20H,3,12-17H2,1-2H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 815n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210698
PNG
(CHEMBL3939588)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C31H35ClN6O3/c1-20-7-8-22(15-21(20)2)36-31(39)37-26-10-9-23(16-25(26)32)35-30-24-17-28(40-3)29(18-27(24)33-19-34-30)41-14-13-38-11-5-4-6-12-38/h7-10,15-19H,4-6,11-14H2,1-3H3,(H,33,34,35)(H2,36,37,39)
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n/an/a 817n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210751
PNG
(CHEMBL3917723)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCN4CCCCC4)c(OC)cc23)cc1
Show InChI InChI=1S/C26H31N5O5/c1-34-22-14-20-21(15-23(22)36-13-12-31-10-4-3-5-11-31)28-17-29-25(20)30-19-8-6-18(7-9-19)26(33)27-16-24(32)35-2/h6-9,14-15,17H,3-5,10-13,16H2,1-2H3,(H,27,33)(H,28,29,30)
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n/an/a 966n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210704
PNG
(CHEMBL3948354)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C29H31ClN6O3/c1-38-26-17-22-25(18-27(26)39-15-14-36-12-6-3-7-13-36)31-19-32-28(22)33-21-10-11-24(23(30)16-21)35-29(37)34-20-8-4-2-5-9-20/h2,4-5,8-11,16-19H,3,6-7,12-15H2,1H3,(H,31,32,33)(H2,34,35,37)
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n/an/a 1.87E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210706
PNG
(CHEMBL3933568)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)cc3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O3/c1-22-7-4-5-8-26(22)36-31(39)35-24-11-9-23(10-12-24)34-30-25-19-28(40-3)29(20-27(25)32-21-33-30)41-18-6-13-38-16-14-37(2)15-17-38/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,32,33,34)(H2,35,36,39)
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n/an/a 1.99E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210703
PNG
(CHEMBL3983460)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H25N5O3/c1-36-26-16-24-25(17-27(26)37-18-20-8-4-2-5-9-20)30-19-31-28(24)32-22-12-14-23(15-13-22)34-29(35)33-21-10-6-3-7-11-21/h2-17,19H,18H2,1H3,(H,30,31,32)(H2,33,34,35)
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n/an/a 2.93E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210693
PNG
(CHEMBL3894623)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H24ClN5O3/c1-37-26-15-24-25(16-27(26)38-17-19-6-3-2-4-7-19)31-18-32-28(24)33-21-10-12-22(13-11-21)34-29(36)35-23-9-5-8-20(30)14-23/h2-16,18H,17H2,1H3,(H,31,32,33)(H2,34,35,36)
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n/an/a 4.65E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210751
PNG
(CHEMBL3917723)
Show SMILES COC(=O)CNC(=O)c1ccc(Nc2ncnc3cc(OCCN4CCCCC4)c(OC)cc23)cc1
Show InChI InChI=1S/C26H31N5O5/c1-34-22-14-20-21(15-23(22)36-13-12-31-10-4-3-5-11-31)28-17-29-25(20)30-19-8-6-18(7-9-19)26(33)27-16-24(32)35-2/h6-9,14-15,17H,3-5,10-13,16H2,1-2H3,(H,27,33)(H,28,29,30)
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n/an/a 9.94E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210693
PNG
(CHEMBL3894623)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H24ClN5O3/c1-37-26-15-24-25(16-27(26)38-17-19-6-3-2-4-7-19)31-18-32-28(24)33-21-10-12-22(13-11-21)34-29(36)35-23-9-5-8-20(30)14-23/h2-16,18H,17H2,1H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210708
PNG
(CHEMBL3914525)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C30H27N5O3/c1-20-8-6-7-11-25(20)35-30(36)34-23-14-12-22(13-15-23)33-29-24-16-27(37-2)28(17-26(24)31-19-32-29)38-18-21-9-4-3-5-10-21/h3-17,19H,18H2,1-2H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210708
PNG
(CHEMBL3914525)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4C)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C30H27N5O3/c1-20-8-6-7-11-25(20)35-30(36)34-23-14-12-22(13-15-23)33-29-24-16-27(37-2)28(17-26(24)31-19-32-29)38-18-21-9-4-3-5-10-21/h3-17,19H,18H2,1-2H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210753
PNG
(CHEMBL3951268)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C31H29N5O3/c1-20-9-10-25(15-21(20)2)36-31(37)35-24-13-11-23(12-14-24)34-30-26-16-28(38-3)29(17-27(26)32-19-33-30)39-18-22-7-5-4-6-8-22/h4-17,19H,18H2,1-3H3,(H,32,33,34)(H2,35,36,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210753
PNG
(CHEMBL3951268)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)c(C)c4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C31H29N5O3/c1-20-9-10-25(15-21(20)2)36-31(37)35-24-13-11-23(12-14-24)34-30-26-16-28(38-3)29(17-27(26)32-19-33-30)39-18-22-7-5-4-6-8-22/h4-17,19H,18H2,1-3H3,(H,32,33,34)(H2,35,36,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210750
PNG
(CHEMBL3965994)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H24ClN5O3/c1-37-26-15-24-25(16-27(26)38-17-19-5-3-2-4-6-19)31-18-32-28(24)33-21-11-13-23(14-12-21)35-29(36)34-22-9-7-20(30)8-10-22/h2-16,18H,17H2,1H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210700
PNG
(CHEMBL3911612)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C29H30Cl2N6O3/c1-39-26-16-22-25(17-27(26)40-14-13-37-11-3-2-4-12-37)32-18-33-28(22)34-21-9-10-24(23(31)15-21)36-29(38)35-20-7-5-19(30)6-8-20/h5-10,15-18H,2-4,11-14H2,1H3,(H,32,33,34)(H2,35,36,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210703
PNG
(CHEMBL3983460)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H25N5O3/c1-36-26-16-24-25(17-27(26)37-18-20-8-4-2-5-9-20)30-19-31-28(24)32-22-12-14-23(15-13-22)34-29(35)33-21-10-6-3-7-11-21/h2-17,19H,18H2,1H3,(H,30,31,32)(H2,33,34,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210750
PNG
(CHEMBL3965994)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C29H24ClN5O3/c1-37-26-15-24-25(16-27(26)38-17-19-5-3-2-4-6-19)31-18-32-28(24)33-21-11-13-23(14-12-21)35-29(36)34-22-9-7-20(30)8-10-22/h2-16,18H,17H2,1H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50210702
PNG
(CHEMBL3942536)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C30H27N5O3/c1-20-8-10-23(11-9-20)34-30(36)35-24-14-12-22(13-15-24)33-29-25-16-27(37-2)28(17-26(25)31-19-32-29)38-18-21-6-4-3-5-7-21/h3-17,19H,18H2,1-2H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system preincubated for ...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210702
PNG
(CHEMBL3942536)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)ncnc2cc1OCc1ccccc1
Show InChI InChI=1S/C30H27N5O3/c1-20-8-10-23(11-9-20)34-30(36)35-24-14-12-22(13-15-24)33-29-25-16-27(37-2)28(17-26(25)31-19-32-29)38-18-21-6-4-3-5-7-21/h3-17,19H,18H2,1-2H3,(H,31,32,33)(H2,34,35,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50210700
PNG
(CHEMBL3911612)
Show SMILES COc1cc2c(Nc3ccc(NC(=O)Nc4ccc(Cl)cc4)c(Cl)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C29H30Cl2N6O3/c1-39-26-16-22-25(17-27(26)40-14-13-37-11-3-2-4-12-37)32-18-33-28(22)34-21-9-10-24(23(31)15-21)36-29(38)35-20-7-5-19(30)6-8-20/h5-10,15-18H,2-4,11-14H2,1H3,(H,32,33,34)(H2,35,36,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human VEGFR-2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated f...

Eur J Med Chem 125: 245-254 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.039
BindingDB Entry DOI: 10.7270/Q2QJ7K9C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%