Found 7 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50121205
(CHEBI:18295 | Histamine)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
| PDB
Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Binding affinity to histamine H4 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50121205
(CHEBI:18295 | Histamine)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Binding affinity to histamine H3 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50198913
(CHEMBL1179089)Show InChI InChI=1S/C19H20N2O/c1-3-8-16(9-4-1)19(17-10-5-2-6-11-17)22-13-7-12-18-14-20-15-21-18/h1-6,8-11,14-15,19H,7,12-13H2,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Displacement of [125I]iodoproxyfan from human H3 receptor expressed in HEK293 cell membranes after 1 hr |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50198913
(CHEMBL1179089)Show InChI InChI=1S/C19H20N2O/c1-3-8-16(9-4-1)19(17-10-5-2-6-11-17)22-13-7-12-18-14-20-15-21-18/h1-6,8-11,14-15,19H,7,12-13H2,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Antagonist activity at human histamine H3 receptor |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50198914
(CHEMBL3911109)Show InChI InChI=1S/C20H19N3OS/c1-2-7-15(8-3-1)19(24-12-6-9-16-13-21-14-22-16)20-23-17-10-4-5-11-18(17)25-20/h1-5,7-8,10-11,13-14,19H,6,9,12H2,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Displacement of [125I]iodoproxyfan from human H3 receptor expressed in HEK293 cell membranes after 1 hr |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50198912
(CHEBI:29009 | N-Methylhistamine)Show InChI InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Binding affinity to histamine H4 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50198912
(CHEBI:29009 | N-Methylhistamine)Show InChI InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech
Curated by ChEMBL
| Assay Description
Binding affinity to histamine H3 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 5263-5266 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.049
BindingDB Entry DOI: 10.7270/Q2Q52RMS |
More data for this
Ligand-Target Pair | |
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